Microglial senescence: does the brain's immune system have an expiration date?

Streit, 1987, Lectin binding by resting and reactive microglia, J. Neurocytol., 16, 249, 10.1007/BF01795308 Raivich, 2005, Like cops on the beat: the active role of resting microglia, Trends Neurosci., 28, 571, 10.1016/j.tins.2005.09.001 Kreutzberg, 1996, Microglia: a sensor for pathological events in the CNS, Trends Neurosci., 19, 312, 10.1016/0166-2236(96)10049-7 Moran, 2004, The facial nerve axotomy model, Brain Res. Rev., 44, 154, 10.1016/j.brainresrev.2003.11.004 Streit, 1999, Reactive microgliosis, Prog. Neurobiol., 57, 563, 10.1016/S0301-0082(98)00069-0 Giulian, 1987, Ameboid microglia as effectors of inflammation in the central nervous system, J. Neurosci. Res., 18, 155, 10.1002/jnr.490180123 Schwartz, 2006, Microglial phenotype: is the commitment reversible?, Trends Neurosci., 29, 68, 10.1016/j.tins.2005.12.005 Gehrmann, 1995, Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury, J. Neuropathol. Exp. Neurol., 54, 680, 10.1097/00005072-199509000-00010 Polazzi, 2006, Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned medium, J. Neuroimmunol., 172, 104, 10.1016/j.jneuroim.2005.11.005 Polazzi, 2003, Neuron-conditioned media differentially affect the survival of activated or unstimulated microglia: evidence for neuronal control on apoptotic elimination of activated microglia, J. Neuropathol. Exp. Neurol., 62, 351, 10.1093/jnen/62.4.351 Neumann, 2001, Control of glial immune function by neurons, Glia, 36, 191, 10.1002/glia.1108 Graeber, 1988, The microglial cytoskeleton: vimentin is localized within activated cells in situ, J. Neurocytol., 17, 573, 10.1007/BF01189811 Streit, 2002, Physiology and pathophysiology of microglial cell function, 1 Graeber, 1990, New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury, J. Neuroimmunol., 27, 121, 10.1016/0165-5728(90)90061-Q Streit, 1988, Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin, J. Comp. Neurol., 268, 248, 10.1002/cne.902680209 Stolzing, 2002, Degradation of oxidized extracellular proteins by microglia, Arch. Biochem. Biophys., 400, 171, 10.1016/S0003-9861(02)00003-6 Graeber, 1990, Perivascular microglia defined, Trends Neurosci., 13, 366, 10.1016/0166-2236(90)90020-B Ladeby, 2005, Microglial cell population dynamics in the injured adult central nervous system, Brain Res. Rev., 48, 196, 10.1016/j.brainresrev.2004.12.009 Lawson, 1992, Turnover of resident microglia in the normal adult mouse brain, Neuroscience, 48, 405, 10.1016/0306-4522(92)90500-2 Hickey, 1988, Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo, Science, 239, 290, 10.1126/science.3276004 Streit, 1989, Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury, Exp. Neurol., 105, 115, 10.1016/0014-4886(89)90111-8 Priller, 2001, Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment, Nat. Med., 7, 1356, 10.1038/nm1201-1356 Flügel, 2001, Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy, J. Neurosci. Res., 66, 74, 10.1002/jnr.1198 Graeber, 1988, Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy, Neurosci. Lett., 85, 317, 10.1016/0304-3940(88)90585-X Lassmann, 1993, Bone marrow derived elements and resident microglia in brain inflammation, Glia, 7, 19, 10.1002/glia.440070106 Conde, 2005, Effect of aging on the microglial response to peripheral nerve injury, Neurobiol. Aging Flanary, 2004, Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes, Glia, 45, 75, 10.1002/glia.10301 Flanary, 2005, Effects of axotomy on telomere length, telomerase activity and protein in activated microglia, J. Neurosci. Res., 82, 160, 10.1002/jnr.20636 Perry, 1993, Altered antigen expression of microglia in the aged rodent CNS, Glia, 7, 60, 10.1002/glia.440070111 Streit, 2004, Dystrophic microglia in the aging human brain, Glia, 45, 208, 10.1002/glia.10319 Lassmann, 1995, Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ, Acta Neuropathol. (Berl.), 89, 35, 10.1007/BF00294257 v Eitzen, 1998, Microglia and the development of spongiform change in Creutzfeldt-Jakob disease, J. Neuropathol. Exp. Neurol., 57, 246, 10.1097/00005072-199803000-00006 Wierzba-Bobrowicz, 2004, Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics, Folia Neuropathol., 42, 157 Yang, 1998, Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease, Am. J. Pathol., 152, 379 Ferraro, 1931, The origin and formation of senile plaques, Arch. Neurol. Psychiatry, 25, 1042, 10.1001/archneurpsyc.1931.02230050118006 Streit, 2002, Microglia as neuroprotective, immunocompetent cells of the CNS, Glia, 40, 133, 10.1002/glia.10154 Korotzer, 1993, β-Amyloid peptides induce degeneration of cultured rat microglia, Brain Res., 624, 121, 10.1016/0006-8993(93)90068-X Fiala, 2005, Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients, J. Alzheimers Dis., 7, 221, 10.3233/JAD-2005-7304 Streit, 2004, Microglia and Alzheimer's disease pathogenesis, J. Neurosci. Res., 77, 1, 10.1002/jnr.20093 Simard, 2006, Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, Neuron, 49, 489, 10.1016/j.neuron.2006.01.022 Rogers, 2002, Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide, Glia, 40, 260, 10.1002/glia.10153