Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
Tài liệu tham khảo
Centers for Disease Control and Prevention, 2004, Alcohol-attributable death and years of potential life lost—United States, 2001, MMWR Morb. Mortal. Wkly. Rep., 53, 866
Bellentani, 1997, Drinking habits as cofactors of risk for alcohol induced liver damage: the Dionysos Study Group, Gut, 41, 845, 10.1136/gut.41.6.845
Day, 2006, Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease, Liver Int., 26, 1021, 10.1111/j.1478-3231.2006.01323.x
Marrero, 2005, Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma, J. Hepatol., 42, 218, 10.1016/j.jhep.2004.10.005
Carmiel-Haggai, 2003, Binge ethanol exposure increases liver injury in obese rats, Gastroenterology, 125, 1818, 10.1053/j.gastro.2003.09.019
Ludwig, 1980, Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease, Mayo Clin. Proc., 55, 434
Mehta, 2002, Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants, Nutr. Rev., 60, 289, 10.1301/002966402320387224
Ruhl, 2004, Epidemiology of nonalcoholic fatty liver, Clin. Liver Dis., 8, 501, 10.1016/j.cld.2004.04.008
Papandreou, 2007, Update on non-alcoholic fatty liver disease in children, Clin. Nutr., 26, 409, 10.1016/j.clnu.2007.02.002
Bunout, 1999, Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease, Nutrition, 15, 583, 10.1016/S0899-9007(99)00090-8
Howard, 2004, Effect of alcohol consumption on diabetes mellitus: a systematic review, Ann. Intern. Med., 140, 211, 10.7326/0003-4819-140-6-200403160-00011
van de Wiel, 2004, Diabetes mellitus and alcohol, Diabetes Metab. Res. Rev., 20, 263, 10.1002/dmrr.492
Begriche, 2006, Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it, Mitochondrion, 6, 1, 10.1016/j.mito.2005.10.004
Farrell, 2006, Nonalcoholic fatty liver disease: from steatosis to cirrhosis, Hepatology, 43, S99, 10.1002/hep.20973
Feldstein, 2004, Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway, Hepatology, 40, 185, 10.1002/hep.20283
Feldstein, 2006, Bax inhibition protects against free fatty acid-induced lysosomal permeabilization, Am. J. Physiol.: Gastrointest. Liver Physiol., 290, G1339
Wei, 2007, Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells, Mol. Cell. Biochem., 303, 105, 10.1007/s11010-007-9461-2
Wei, 2006, Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells, Am. J. Physiol: Endocrinol. Metab., 291, E275
Joshi-Barve, 2007, Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes, Hepatology, 46, 823, 10.1002/hep.21752
Landar, 2006, Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria, Biochem. J., 394, 185, 10.1042/BJ20051259
Landar, 2006, Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species, Am. J. Physiol., Heart Circ. Physiol., 290, H1777, 10.1152/ajpheart.01087.2005
Fromenty, 2004, The ins and outs of mitochondrial dysfunction in NASH, Diabetes Metab., 30, 121, 10.1016/S1262-3636(07)70098-8
Kang, 2007, Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation, J. Biol. Chem., 282, 28465, 10.1074/jbc.M705503200
He, 2007, Dose dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health, Mol. Endocrinol., 21, 2541, 10.1210/me.2007-0036
He, 2006, Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane: role of TRB3 in inhibition of Akt/protein kinase B activation, J. Biol. Chem., 281, 11126, 10.1074/jbc.M510724200
You, 2002, Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP), J. Biol. Chem., 277, 29342, 10.1074/jbc.M202411200
You, 2004, The role of AMP-activated protein kinase in the action of ethanol in the liver, Gastroenterology, 127, 1798, 10.1053/j.gastro.2004.09.049
Tomita, 2005, AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats, Alcohol. Clin. Exp. Res., 29, 240S, 10.1097/01.alc.0000191126.11479.69
Xu, 2003, The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice, J. Clin. Invest., 112, 91, 10.1172/JCI200317797
You, 2005, Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice, Hepatology, 42, 568, 10.1002/hep.20821
Winder, 1999, AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes, Am. J. Physiol., 277, E1
Yeon, 2003, Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver, Hepatology, 38, 703, 10.1053/jhep.2003.50368
Cidad, 2004, Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5′-AMP-activated protein kinase., Biochem. J., 384, 629, 10.1042/BJ20040886
Hutchinson, 2007, Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase, Cell. Signal., 19, 1610, 10.1016/j.cellsig.2007.02.006
Zou, 2004, Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: role of mitochondrial reactive nitrogen species, J. Biol. Chem., 279, 43940, 10.1074/jbc.M404421200
Pritchard, 2007, Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice, Gastroenterology, 132, 1117, 10.1053/j.gastro.2007.01.053
Bykov, 2007, Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis, J. Hepatol., 46, 907, 10.1016/j.jhep.2006.11.020
Yamaguchi, 2007, Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis, Hepatology, 45, 1366, 10.1002/hep.21655
Damelin, 2007, Fat-loaded HepG2 spheroids exhibit enhanced protection from pro-oxidant and cytokine induced damage, J. Cell. Biochem., 101, 723, 10.1002/jcb.21229
Bailey, 2003, A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction, Free Radic. Res., 37, 585, 10.1080/1071576031000091711
Cunningham, 1990, The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism, Alcohol Alcohol., 25, 127, 10.1093/oxfordjournals.alcalc.a044987
Hoek, 1994, Mitochondrial energy metabolism in chronic alcoholism, Curr. Top. Bioenerg., 17, 197, 10.1016/B978-0-12-152517-0.50012-8
Coleman, 1990, Effects of chronic ethanol consumption on the synthesis of polypeptides encoded by the hepatic mitochondrial genome, Biochim. Biophys. Acta, 1019, 142, 10.1016/0005-2728(90)90136-R
Cahill, 1999, Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats, Hepatology, 30, 881, 10.1002/hep.510300434
Cahill, 1997, Increased oxidative damage to mitochondrial DNA following chronic ethanol consumption, Biochem. Biophys. Res. Commun., 235, 286, 10.1006/bbrc.1997.6774
Venkatraman, 2004, Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity, J. Biol. Chem., 279, 22092, 10.1074/jbc.M402245200
Cahill, 2000, Effects of chronic ethanol feeding on the protein composition of mitochondrial ribosomes, Electrophoresis, 21, 3420, 10.1002/1522-2683(20001001)21:16<3420::AID-ELPS3420>3.0.CO;2-Q
Patel, 2002, Altered hepatic mitochondrial ribosome structure following chronic ethanol consumption, Arch. Biochem. Biophys., 398, 41, 10.1006/abbi.2001.2701
Moon, 2006, Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats, Hepatology, 44, 1218, 10.1002/hep.21372
Venkatraman, 2004, Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption, Am. J. Physiol.: Gastrointest. Liver Physiol., 286, G521
Chavin, 1999, Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion, J. Biol. Chem., 274, 5692, 10.1074/jbc.274.9.5692
Perez-Carreras, 2003, Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis, Hepatology, 38, 999, 10.1053/jhep.2003.50398
Garcia-Ruiz, 2006, Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice, Hepatology, 44, 581, 10.1002/hep.21313
Yang, 1997, Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis, Proc. Natl. Acad. Sci. U. S. A., 94, 2557, 10.1073/pnas.94.6.2557
Yang, 2001, Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology, Hepatology, 34, 694, 10.1053/jhep.2001.28054
Cortez-Pinto, 1999, Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study, JAMA, 282, 1659, 10.1001/jama.282.17.1659
Miyamoto, 1988, Hepatic adenine nucleotide metabolism measured in vivo in rats fed ethanol and a high fat-low protein diet, Hepatology, 8, 53, 10.1002/hep.1840080111
Takahashi, 1990, In vivo hepatic energy metabolism during the progression of alcoholic liver disease: a noninvasive 31P nuclear magnetic resonance study in rats, Hepatology, 11, 65, 10.1002/hep.1840110113
Hoek, 2002, Alcohol and mitochondria: a dysfunctional relationship, Gastroenterology, 122, 2049, 10.1053/gast.2002.33613
Gao, 2004, Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease., Am. J. Physiol.: Gastrointest. Liver Physiol., 287, G1070
Yang, 2000, Mitochondrial adaptations to obesity-related oxidant stress, Arch. Biochem. Biophys., 378, 259, 10.1006/abbi.2000.1829
Bailey, 1998, Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes, Hepatology, 28, 1318, 10.1002/hep.510280521
Fernandez-Checa, 1997, GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect, Am. J. Physiol.: Gastrointest. Liver Physiol., 273, G7
Mantena, 2007, Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver diseases, World J. Gastroenterol., 13, 4967, 10.3748/wjg.v13.i37.4967
Han, 2003, Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria, Mol. Pharmacol., 64, 1136, 10.1124/mol.64.5.1136
2004, Lambert, A.J., Brand, M.D. Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane., Biochem. J., 382, 511, 10.1042/BJ20040485
Hinokio, 1995, A new mitochondrial DNA deletion associated with diabetic amyotrophy, diabetic myoatrophy and diabetic fatty liver, Muscle Nerve, 3, S142, 10.1002/mus.880181428
Kawahara, 2007, Mutation of mitochondrial DNA in livers from patients with alcoholic hepatitis and nonalcoholic steatohepatitis, Alcohol. Clin. Exp. Res., 31, S54, 10.1111/j.1530-0277.2006.00287.x
Robin, 2005, Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes, FEBS Lett., 579, 6895, 10.1016/j.febslet.2005.11.029
Nordblom, 1977, Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450, Arch. Biochem. Biophys., 180, 343, 10.1016/0003-9861(77)90047-9
Adam-Vizi, 2005, Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources, Antioxid. Redox Signal., 7, 1140, 10.1089/ars.2005.7.1140
Tretter, 2005, Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress, Philos. Trans. R. Soc. Lond., B Biol. Sci., 360, 2335, 10.1098/rstb.2005.1764
Tretter, 2007, Characteristics of alpha-glycerophosphate-evoked H2O2 generation in brain mitochondria, J. Neurochem., 100, 650, 10.1111/j.1471-4159.2006.04223.x
Garcia-Ruiz, 2006, Mitochondrial glutathione: hepatocellular survival–death switch, J. Gastroenterol. Hepatol., 21, S3, 10.1111/j.1440-1746.2006.04570.x
Garcia-Ruiz, 1994, Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes, J. Clin. Invest., 94, 193, 10.1172/JCI117306
Colell, 1997, Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-l-methionine, Hepatology, 26, 699
Garcia-Ruiz, 1995, Feeding S-adenosyl-l-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes, Hepatology, 21, 207, 10.1002/hep.1840210133
Colell, 1998, Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor, Gastroenterology, 115, 1541, 10.1016/S0016-5085(98)70034-4
Pastorino, 2000, Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition, Hepatology, 31, 1141, 10.1053/he.2000.7013
Mari, 2006, Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis, Cell Metab., 4, 185, 10.1016/j.cmet.2006.07.006
Bailey, 2001, Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver, Alcohol. Clin. Exp. Res., 25, 726, 10.1111/j.1530-0277.2001.tb02273.x
Bailey, 2006, S-Adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver, Am. J. Physiol.: Gastrointest. Liver Physiol., 291, G857
Deaciuc, 1999, Modulation of capase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide, Alcohol. Clin. Exp. Res., 23, 349, 10.1111/j.1530-0277.1999.tb04121.x
Sastre, 1999, Chronic ethanol feeding causes oxidative stress in rat liver mitochondria: prevention by S-adenosyl methionine, Free Radic. Res., 30, 325, 10.1080/10715769900300371
Mari, 2000, CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase, J. Biol. Chem., 275, 15563, 10.1074/jbc.M907022199
Dickinson, 2003, Cytoprotection against oxidative stress and the regulation of glutathione synthesis, Biol. Chem., 384, 527, 10.1515/BC.2003.061
Gutierrez, 2006, Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells, Circ. Res., 99, 924, 10.1161/01.RES.0000248212.86638.e9
Oz, 2006, Glutathione-enhancing agents protect against steatohepatitis in a dietary model, J. Biochem. Mol. Toxicol., 20, 39, 10.1002/jbt.20109
Nobili, 2005, Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitis, Clin. Chim. Acta, 355, 105, 10.1016/j.cccn.2004.12.022
Venkatraman, 2004, The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction, Hepatology, 40, 565, 10.1002/hep.20326
Osei, 1996, Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxia, Blood, 88, 3583, 10.1182/blood.V88.9.3583.bloodjournal8893583
Buttery, 1994, Immunochemical localization of inducible nitric oxide synthase in endotoxin-treated rats, Lab. Invest., 71, 755
Kuo, 1996, Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation, Transplantation, 61, 305, 10.1097/00007890-199601270-00024
Wei, 2002, Differential expression and localization of nitric oxide synthases in cirrhotic livers of bile duct-ligated rats, Nitric Oxide, 7, 91, 10.1016/S1089-8603(02)00103-9
Koeppel, 2007, Enhanced iNOS gene expression in the steatotic rat liver after normothermic ischemia, Eur. Surg. Res., 39, 303, 10.1159/000104401
Radi, 2004, Nitric oxide, oxidants, and protein tyrosine nitration, Proc. Natl. Acad. Sci. U. S. A., 101, 4003, 10.1073/pnas.0307446101
Radi, 2002, Peroxynitrite reactions and formation in mitochondria, Free Radic. Biol. Med., 33, 1451, 10.1016/S0891-5849(02)01111-5
Lee, 2003, Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite: implications for cytotoxicity and alcohol-induced liver injury, J. Biol. Chem., 278, 51360, 10.1074/jbc.M302332200
Brookes, 2003, Control of mitochondrial respiration by NO⁎, effects of low oxygen and respiratory state, J. Biol. Chem., 278, 31603, 10.1074/jbc.M211784200
Poderoso, 1999, The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol, J. Biol. Chem., 274, 37709, 10.1074/jbc.274.53.37709
Torres, 1995, Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration, Biochem. J., 312, 169, 10.1042/bj3120169
Nisoli, 2004, Mitochondrial biogenesis as a cellular signaling framework, Biochem. Pharmacol., 67, 1, 10.1016/j.bcp.2003.10.015
Venkatraman, 2003, Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide, Hepatology, 38, 141, 10.1053/jhep.2003.50293
Thayer, 1981, Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption, J. Biol. Chem., 256, 6090, 10.1016/S0021-9258(19)69132-5
Shiva, 2005, Nitroxia: the pathological consequence of dysfunction in the nitric oxide–cytochrome c oxidase signaling pathway, Free Radic. Biol. Med., 38, 297, 10.1016/j.freeradbiomed.2004.10.037
McKim, 2003, Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice, Gastroenterology, 125, 1834, 10.1053/j.gastro.2003.08.030
Liu, 2005, Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO, Toxicology, 208, 289, 10.1016/j.tox.2004.11.017
Duranski, 2006, Genetic overexpression of eNOS attenuates hepatic ischemia–reperfusion injury, Am. J. Physiol., Heart Circ. Physiol., 291, H2980, 10.1152/ajpheart.01173.2005
Rivera-Chavez, 2001, Exogenous and endogenous nitric oxide but not iNOS inhibition improves function and survival of ischemically injured livers, J. Invest. Surg., 14, 267, 10.1080/089419301753170048
de Oliveira, 2006, Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats, World J. Gastroenterol., 12, 1905, 10.3748/wjg.v12.i12.1905
de Oliveira, 2006, Hepatic gene expression profile associated with non-alcoholic steatohepatitis protection by S-nitroso-N-acetylcysteine in ob/ob mice, J. Hepatol., 45, 725, 10.1016/j.jhep.2006.05.017
Lang, 2007, Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation, J. Clin. Invest., 117, 2583, 10.1172/JCI31892
Gladwin, 2006, Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation, Am. J. Physiol., Heart Circ. Physiol., 291, H2026, 10.1152/ajpheart.00407.2006
Duranski, 2005, Cytoprotective effects of nitrite during in vivo ischemia–reperfusion of the heart and liver, J. Clin. Invest., 115, 1232, 10.1172/JCI22493
Karaa, 2005, Chronic ethanol sensitizes the liver to endotoxin via effects on endothelial nitric oxide synthase regulation, Shock, 24, 447, 10.1097/01.shk.0000180616.13941.7d
Wang, 2005, Effect of chronic ethanol administration on hepatic eNOS activity and its association with caveolin-1 and calmodulin in female rats, Am. J. Physiol.: Gastrointest. Liver Physiol., 289, G579
Nanji, 1995, Nitric oxide production in experimental alcoholic liver disease: role in protection from injury, Gastroenterology, 109, 899, 10.1016/0016-5085(95)90400-X
Nanji, 2001, Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration, J. Pharmacol. Exp. Ther., 299, 832
Haynes, 2004, Mitochondrial nitric-oxide synthase: enzyme expression, characterization, and regulation, J. Bioenerg. Biomembr., 36, 341, 10.1023/B:JOBB.0000041765.27145.08
Haynes, 2003, Mitochondrial nitric-oxide synthase: role in pathophysiology, IUBMB Life, 55, 599, 10.1080/15216540310001628681
Shiva, 2007, Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration, Circ. Res., 100, 654, 10.1161/01.RES.0000260171.52224.6b
Wilfred de Alwis, 2007, Genetics of alcoholic liver disease and nonalcoholic fatty liver disease, Semin. Liver Dis., 27, 44, 10.1055/s-2006-960170
Stickel, 2006, The role of genetic polymorphisms in alcoholic liver disease, Alcohol Alcohol., 41, 209, 10.1093/alcalc/agl011
Zintzaras, 2006, Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?, Hepatology, 43, 352, 10.1002/hep.21023
Degoul, 2001, Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease, Gastroenterology, 120, 1468, 10.1053/gast.2001.24051
Nahon, 2005, Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death, Clin. Gastroenterol. Hepatol., 3, 292, 10.1016/S1542-3565(04)00718-9
Sutton, 2005, The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability, Pharmacogenet. Genomics, 15, 311, 10.1097/01213011-200505000-00006
Sutton, 2003, The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria, Pharmacogenetics, 13, 145, 10.1097/00008571-200303000-00004
Sutton, 2006, Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis, Cancer Res., 66, 2844, 10.1158/0008-5472.CAN-05-2566
Koch, 2000, Regulation of manganese superoxide dismutase (MnSOD) in chronic experimental alcoholism: effects of vitamin E-supplemented and -deficient diets, Alcohol Alcohol., 35, 159, 10.1093/alcalc/35.2.159
Koch, 1994, Ethanol treatment up-regulates the expression of mitochondrial manganese superoxide dismutase in rat liver, Biochem. Biophys. Res. Commun., 201, 1356, 10.1006/bbrc.1994.1853
Stewart, 2002, Valine–alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis, Hepatology, 36, 1355, 10.1002/hep.1840360610
Namikawa, 2004, Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis, J. Hepatol., 40, 781, 10.1016/j.jhep.2004.01.028
Hines, 2004, Recent advances in alcoholic liver disease. III. Role of the innate immune response in alcoholic hepatitis, Am. J. Physiol.: Gastrointest. Liver Physiol., 287, G310
Thurman, 1998, Mechanisms of hepatic toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin, Am. J. Physiol.: Gastrointest. Liver Physiol., 275, G605
Jarvelainen, 2001, Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease, Hepatology, 33, 1148, 10.1053/jhep.2001.24236
Day, 2002, CD14 promoter polymorphism associated with risk of NASH, J. Hepatol., 36, 21, 10.1016/S0168-8278(02)80059-9
Baldini, 1999, A Polymorphism⁎ in the 5′. flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E, Am. J. Respir. Cell Mol. Biol., 20, 976, 10.1165/ajrcmb.20.5.3494
Leathart, 2001, No association between functional SNP's in the endotoxin receptors CD14 and TLR4 and alcoholic liver disease (ALD): is endotoxin important in the pathogenesis of ALD in humans?, Hepatology, 34, 459A
Martins, 2005, Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?, Eur. J. Gastroenterol. Hepatol., 17, 1099, 10.1097/00042737-200510000-00014
Dixon, 2003, Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese, J. Hepatol., 39, 967, 10.1016/S0168-8278(03)00459-8
Pravenec, 2007, Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains, Genome Res., 17, 1319, 10.1101/gr.6548207
Wallace, 2005, A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine, Annu. Rev. Genet., 39, 359, 10.1146/annurev.genet.39.110304.095751
Tome, 2004, Review article: current management of alcoholic liver disease, Aliment. Pharmacol. Ther., 19, 707, 10.1111/j.1365-2036.2004.01881.x
Bergheim, 2006, Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1, Gastroenterology, 130, 2099, 10.1053/j.gastro.2006.03.020
Hernandez, 2004, Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases, Diabetologia, 47, 1615, 10.1007/s00125-004-1503-7
Iwata, 2001, Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator-activated receptor-gamma, Diabetes, 50, 1083, 10.2337/diabetes.50.5.1083
Murase, 1998, Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats, Diabetologia, 41, 257, 10.1007/s001250050901
Leclercq, 2007, Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone, Lab. Invest., 87, 56, 10.1038/labinvest.3700489
Tahan, 2007, Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis, Dig. Dis. Sci., 10.1007/s10620-007-9756-x
Tomita, 2004, Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met, Gastroenterology, 126, 873, 10.1053/j.gastro.2003.12.008
Fischer, 2003, Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice, J. Biol. Chem., 278, 27997, 10.1074/jbc.M302140200
Garcia-Ruiz, 2007, Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice, Hepatology, 46, 414, 10.1002/hep.21687
Caldwell, 2007, The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis, Hepatology, 46, 1101, 10.1002/hep.21813
Harrison, 2003, Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis, Am. J. Gastroenterol., 98, 2485, 10.1111/j.1572-0241.2003.08699.x
Hasegawa, 2001, Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study, Aliment. Pharmacol. Ther., 15, 1667, 10.1046/j.1365-2036.2001.01083.x
Lavine, 2000, Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study, J. Pediatr., 136, 734, 10.1016/S0022-3476(00)05040-X
Sanyal, 2004, A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis, Clin. Gastroenterol. Hepatol., 2, 1107, 10.1016/S1542-3565(04)00457-4
Devaraj, 2005, Failure of vitamin E in clinical trials: is gamma-tocopherol the answer?, Nutr. Rev., 63, 290, 10.1111/j.1753-4887.2005.tb00143.x
Jiang, 2003, Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats, FASEB J., 17, 816, 10.1096/fj.02-0877com
Brown, 2007, Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative, Free Radic. Biol. Med., 42, 1766, 10.1016/j.freeradbiomed.2007.02.033
Cocheme, 2007, Mitochondrial targeting of quinones: therapeutic implications, Mitochondrion, 7, S94, 10.1016/j.mito.2007.02.007
Murphy, 2007, Targeting antioxidants to mitochondria by conjugation to lipophilic cations, Annu. Rev. Pharmacol. Toxicol., 47, 629, 10.1146/annurev.pharmtox.47.120505.105110
Adlam, 2005, Targeting an antioxidant to mitochondria decreases cardiac ischemia–reperfusion injury, FASEB J., 19, 1088, 10.1096/fj.05-3718com
Covey, 2006, Effect of the mitochondrial antioxidant, mito vitamin E, on hypoxic–ischemic striatal injury in neonatal rats: a dose–response and stereological study, Exp. Neurol., 199, 513, 10.1016/j.expneurol.2005.12.026
Ronis, 2005, Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition, Free Radic. Biol. Med., 39, 619, 10.1016/j.freeradbiomed.2005.04.011
Kang, 2005, Zinc prevention and treatment of alcoholic liver disease, Mol. Aspects Med., 26, 391, 10.1016/j.mam.2005.07.002
Zhou, 2005, Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress, Am. J. Pathol., 166, 1681, 10.1016/S0002-9440(10)62478-9
Song, 2006, Silymarin protects against acute ethanol-induced hepatotoxicity in mice, Alcohol. Clin. Exp. Res., 30, 407, 10.1111/j.1530-0277.2006.00063.x
Lindor, 2004, Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial, Hepatology, 39, 770, 10.1002/hep.20092
Cave, 2007, Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition, J. Nutr. Biochem., 18, 184, 10.1016/j.jnutbio.2006.12.006
Comar, 2006, Review article: Drug therapy for non-alcoholic fatty liver disease, Aliment. Pharmacol. Ther., 23, 207, 10.1111/j.1365-2036.2006.02751.x
Federico, 2006, Treatment of patients with non-alcoholic fatty liver disease: current views and perspectives, Dig. Liver Dis., 38, 789, 10.1016/j.dld.2006.04.009
Reuben, 2007, Alcohol and the liver, Curr. Opin. Gastroenterol., 23, 283, 10.1097/MOG.0b013e3280f27582
Mato, 1997, S-Adenosylmethionine synthesis: molecular mechanisms and clinical implications, Pharmacol. Ther., 73, 265, 10.1016/S0163-7258(96)00197-0
Lu, 2000, Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver, Am. J. Physiol.: Gastrointest. Liver Physiol., 279, G178
Barak, 2002, Methionine synthase: a possible prime site of the ethanolic lesion in liver, Alcohol, 26, 65, 10.1016/S0741-8329(01)00201-4
Perez-Mato, 1999, Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol., J. Biol. Chem., 274, 17075, 10.1074/jbc.274.24.17075
Ruiz, 1998, Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation, Hepatology, 28, 1051, 10.1002/hep.510280420
Lieber, 2002, S-Adenosyl-l-methionine: its role in the treatment of liver disorders, Am. J. Clin. Nutr., 76, 1183S, 10.1093/ajcn/76.5.1183S
Garcia-Ruiz, 1995, Mol. Pharmacol., 48, 825
Lieber, 1990, Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin, Hepatology, 12, 1390, 10.1002/hep.1840120621
Mato, 1999, S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial, J. Hepatol., 30, 1081, 10.1016/S0168-8278(99)80263-3
Lu, 2001, Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation, Proc. Natl. Acad. Sci. U. S. A., 98, 5560, 10.1073/pnas.091016398
Martinez-Chantar, 2002, Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A, FASEB J., 16, 1292, 10.1096/fj.02-0078fje
Santamaria, 2003, Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine, Proc. Natl. Acad. Sci. U. S. A., 100, 3065, 10.1073/pnas.0536625100
Song, 2007, Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport, Biochem. Pharmacol., 74, 521, 10.1016/j.bcp.2007.05.005
Ji, 2003, Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice, Gastroenterology, 124, 1488, 10.1016/S0016-5085(03)00276-2
Kharbanda, 2007, Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, J. Hepatol., 46, 314, 10.1016/j.jhep.2006.08.024
Song, 2007, Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis, Am. J. Physiol. Gastrointest. Liver Physiol., 293, G894, 10.1152/ajpgi.00133.2007
Abdelmalek, 2001, Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study, Am. J. Gastroenterol., 96, 2711, 10.1111/j.1572-0241.2001.04129.x
Mato, 2005, Homocysteine, the bad thiol., Hepatology, 41, 976, 10.1002/hep.20708
Craig, 2004, Betaine in human nutrition, Am. J. Clin. Nutr., 80, 539, 10.1093/ajcn/80.3.539
Werstuck, 2001, Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways, J. Clin. Invest., 107, 1263, 10.1172/JCI11596
Gulsen, 2005, Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease, J. Gastroenterol. Hepatol., 20, 1448, 10.1111/j.1440-1746.2005.03891.x
King, 2006, S-Adenosylmethionine and betaine prevent chronic alcohol associated losses in hepatic mitochondria respiratory complex content, Free Radic. Biol. Med., 41, S23