Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Nature - Tập 467 Số 7319 - Trang 1114-1117 - 2010
Shinichi Yachida1, Siân Jones2, Ivana Božić3, Tibor Antal3, Rebecca J. Leary2, Baojin Fu1, Mihoko Kamiyama1, Ralph H. Hruban1, James R. Eshleman1, Martin A. Nowak3, Victor E. Velculescu2, Kenneth W. Kinzler2, Bert Vogelstein2, Christine A. Iacobuzio‐Donahue4
1Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, 21231, Maryland, USA
2The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, 21231, Maryland, USA
3Department of Mathematics, Department of Organismic and Evolutionary Biology, Program for Evolutionary Dynamics, Harvard University, Cambridge, 02138, Massachusetts, USA
4Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, 21231, Maryland, USA

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