Cutting Edge: TLR3 Stimulation Suppresses Experimental Autoimmune Encephalomyelitis by Inducing Endogenous IFN-β

Journal of Immunology - Tập 177 Số 11 - Trang 7505-7509 - 2006
Tarik Touil1, Denise Fitzgerald2, Guang‐Xian Zhang2, Abdolmohamad Rostami2, Bruno Gran2,3
1Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
2*Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107; and
3Division of Clinical Neurology, University of Nottingham, Nottingham, United Kingdom

Tóm tắt

Abstract Experimental autoimmune encephalomyelitis is a well-characterized model of cell-mediated autoimmunity. TLRs expressed on APCs recognize microbial components and induce innate immune responses, leading to the elimination of invading infectious agents. Certain TLR agonists have been reported to have adjuvant properties in CNS autoimmune inflammatory demyelination. We report in this study that TLR3 stimulation by polyinosinic-polycytidylic acid, a double-stranded RNA analog, suppresses relapsing demyelination in a murine experimental autoimmune encephalomyelitis model. Disease suppression is associated with the induction of endogenous IFN-β and the peripheral induction of the CC chemokine CCL2. These data indicate that a preferential activation of the MyD88-independent, type I IFN-inducing TLR pathway has immunoregulatory potential in this organ-specific autoimmune disease.

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Journal of Immunology

Tập 177 Số 11

7505-7509

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