Contribution of gut microbiota to drug-induced liver injury

Hepatobiliary and Pancreatic Diseases International - Tập 22 - Trang 458-465 - 2023
Hui-Kuan Chu1, Yan Ai1, Zi-Lu Cheng1, Ling Yang1, Xiao-Hua Hou1
1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Tài liệu tham khảo

Hoofnagle, 2019, Drug-induced liver injury - types and phenotypes, N Engl J Med, 381, 264, 10.1056/NEJMra1816149 Björnsson, 2013, Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland, Gastroenterology, 144, 1419, 10.1053/j.gastro.2013.02.006 Sgro, 2002, Incidence of drug-induced hepatic injuries: a French population-based study, Hepatology, 36, 451, 10.1053/jhep.2002.34857 Shen, 2019, Incidence and etiology of drug-induced liver injury in China, Gastroenterology, 156, 2230, 10.1053/j.gastro.2019.02.002 Reuben, 2010, Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study, Hepatology, 52, 2065, 10.1002/hep.23937 Björnsson, 2022, Drug-induced liver injury: pathogenesis, epidemiology, clinical features, and practical management, Eur J Intern Med, 97, 26, 10.1016/j.ejim.2021.10.035 Green, 2013, Oral and intravenous acetylcysteine for treatment of acetaminophen toxicity: a systematic review and meta-analysis, West J Emerg Med, 14, 218, 10.5811/westjem.2012.4.6885 Adak, 2019, An insight into gut microbiota and its functionalities, Cell Mol Life Sci, 76, 473, 10.1007/s00018-018-2943-4 Manzo, 2015, The human microbiome in hematopoiesis and hematologic disorders, Blood, 126, 311, 10.1182/blood-2015-04-574392 Enright, 2016, The impact of the gut microbiota on drug metabolism and clinical outcome, Yale J Biol Med, 89, 375 Chopyk, 2020, Contribution of the intestinal microbiome and gut barrier to hepatic disorders, Gastroenterology, 159, 849, 10.1053/j.gastro.2020.04.077 Albillos, 2020, The gut-liver axis in liver disease: pathophysiological basis for therapy, J Hepatol, 72, 558, 10.1016/j.jhep.2019.10.003 de Oliveira, 2017, Intestinal dysbiosis and probiotic applications in autoimmune diseases, Immunology, 152, 1, 10.1111/imm.12765 Chakaroun, 2020, Gut microbiome, intestinal permeability, and tissue bacteria in metabolic disease: perpetrators or bystanders?, Nutrients, 12, 1082, 10.3390/nu12041082 Okumura, 2017, Roles of intestinal epithelial cells in the maintenance of gut homeostasis, Exp Mol Med, 49, e338, 10.1038/emm.2017.20 Liao, 2019, Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis, Gut, 68, 1477, 10.1136/gutjnl-2018-316670 Wang, 2021, Gut microbiome, liver immunology, and liver diseases, Cell Mol Immunol, 18, 4, 10.1038/s41423-020-00592-6 Reunanen, 2015, Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer, Appl Environ Microbiol, 81, 3655, 10.1128/AEM.04050-14 Wu, 2017, Protective effect of Akkermansia muciniphila against immune-mediated liver injury in a mouse model, Front Microbiol, 8, 1804, 10.3389/fmicb.2017.01804 Schneider, 2021, Intestinal dysbiosis amplifies acetaminophen-induced acute liver injury, Cell Mol Gastroenterol Hepatol, 11, 909, 10.1016/j.jcmgh.2020.11.002 Wang, 2022, Integrated microbiome and metabolome analysis reveals correlations between gut microbiota components and metabolic profiles in mice with methotrexate-induced hepatoxicity, Drug Des Devel Ther, 16, 3877, 10.2147/DDDT.S381667 Fouts, 2012, Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease, J Hepatol, 56, 1283, 10.1016/j.jhep.2012.01.019 Wang, 2021, Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis, Chemosphere, 266, 10.1016/j.chemosphere.2020.129004 Zhang, 2022, Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis, J Hazard Mater, 421, 10.1016/j.jhazmat.2021.126707 Sun, 2020, Gut microbiota participates in antithyroid drug induced liver injury through the lipopolysaccharide related signaling pathway, Front Pharmacol, 11, 10.3389/fphar.2020.598170 Yip, 2018, The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat, Hepatology, 67, 282, 10.1002/hep.29327 Lee, 2016, Characterization of the anti-inflammatory Lactobacillus reuteri BM36301 and its probiotic benefits on aged mice, BMC Microbiol, 16, 69, 10.1186/s12866-016-0686-7 Archer, 2015, Anti-inflammatory potential of probiotic Lactobacillus spp. on carrageenan induced paw edema in Wistar rats, Int J Biol Macromol, 81, 530, 10.1016/j.ijbiomac.2015.08.044 Li, 2016, Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets, BMC Microbiol, 16, 273, 10.1186/s12866-016-0862-9 Han, 2005, Hepatoprotective effect of lactic acid bacteria, inhibitors of beta-glucuronidase production against intestinal microflora, Arch Pharm Res, 28, 325, 10.1007/BF02977800 Gong, 2018, Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice, J Hepatol, 69, 51, 10.1016/j.jhep.2018.02.024 Larsen, 2014, Understanding paracetamol-induced liver failure, Intensive Care Med, 40, 888, 10.1007/s00134-014-3293-9 Bernal, 2010, Acute liver failure, Lancet, 376, 190, 10.1016/S0140-6736(10)60274-7 Kakan, 2011, Clock gene mPer2 functions in diurnal variation of acetaminophen induced hepatotoxicity in mice, Exp Toxicol Pathol, 63, 581, 10.1016/j.etp.2010.04.011 Thaiss, 2014, Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis, Cell, 159, 514, 10.1016/j.cell.2014.09.048 Gong, 2019, Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice, Hepatology, 69, 1751, 10.1002/hep.30361 Cani, 2008, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, 57, 1470, 10.2337/db07-1403 Derrien, 2008, The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract, Appl Environ Microbiol, 74, 1646, 10.1128/AEM.01226-07 Plovier, 2017, A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice, Nat Med, 23, 107, 10.1038/nm.4236 Schneider, 2015, CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: limiting steatohepatitis by maintaining intestinal homeostasis, Hepatology, 62, 1405, 10.1002/hep.27982 Tripathi, 2018, The gut-liver axis and the intersection with the microbiome, Nat Rev Gastroenterol Hepatol, 15, 397, 10.1038/s41575-018-0011-z Henao-Mejia, 2012, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, 482, 179, 10.1038/nature10809 Elinav, 2018, NLRP6 and dysbiosis: avoiding the luring attraction of over-simplification, Immunity, 48, 603, 10.1016/j.immuni.2018.04.002 Di Lorenzo, 2019, Lipopolysaccharide structures of Gram-negative populations in the gut microbiota and effects on host interactions, FEMS Microbiol Rev, 43, 257, 10.1093/femsre/fuz002 Su, 2010, Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity, Am J Physiol Gastrointest Liver Physiol, 299, G1319, 10.1152/ajpgi.00140.2010 Lin, 1995, Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation, J Hepatol, 22, 165, 10.1016/0168-8278(95)80424-2 Du, 2021, Hepatic macrophage activation and the LPS pathway in patients with different degrees of severity and histopathological patterns of drug induced liver injury, Histol Histopathol, 36, 653 Liu, 2023, Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury, FASEB J, 37, e22689 Gong, 2022, Magnesium isoglycyrrhizinate attenuates anti-tuberculosis drug-induced liver injury by enhancing intestinal barrier function and inhibiting the LPS/TLRs/NF-κB signaling pathway in mice, Pharmaceuticals, 15, 1130, 10.3390/ph15091130 Zhang, 2016, Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and SRC, Am J Physiol Gastrointest Liver Physiol, 311, G1091, 10.1152/ajpgi.00159.2016 Shah, 2013, Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure, Liver Transpl, 19, 751, 10.1002/lt.23655 Kitazawa, 2009, Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury, J Gastroenterol Hepatol, 24, 1089, 10.1111/j.1440-1746.2008.05770.x McDonald, 2020, Programing of an intravascular immune firewall by the gut microbiota protects against pathogen dissemination during infection, Cell Host Microbe, 28, 660, 10.1016/j.chom.2020.07.014 Park, 2013, Recognition of lipopolysaccharide pattern by TLR4 complexes, Exp Mol Med, 45, e66, 10.1038/emm.2013.97 Hassan, 2016, Role of inflammatory and oxidative stress, cytochrome P450 2E1, and bile acid disturbance in rat liver injury induced by isoniazid and lipopolysaccharide cotreatment, Antimicrob Agents Chemother, 60, 5285, 10.1128/AAC.00854-16 Enriquez-Cortina, 2013, Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage, Toxicol Sci, 135, 26, 10.1093/toxsci/kft134 Martin-Gallausiaux, 2021, SCFA: mechanisms and functional importance in the gut, Proc Nutr Soc, 80, 37, 10.1017/S0029665120006916 Pirozzi, 2020, Butyrate prevents valproate-induced liver injury: in vitro and in vivo evidence, FASEB J, 34, 676, 10.1096/fj.201900927RR Xia, 2022, Akkermansia muciniphila ameliorates acetaminophen-induced liver injury by regulating gut microbial composition and metabolism, Microbiol Spectr, 10, 10.1128/spectrum.01596-21 Li, 2023, Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction, Liver Int, 43, 865, 10.1111/liv.15512 Hiippala, 2018, The potential of gut commensals in reinforcing intestinal barrier function and alleviating inflammation, Nutrients, 10, 988, 10.3390/nu10080988 Pingitore, 2019, Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: role of free fatty acid receptor 2, Diabetes Obes Metab, 21, 330, 10.1111/dom.13529 Smith, 2013, The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis, Science, 341, 569, 10.1126/science.1241165 Ohira, 2013, Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages, J Atheroscler Thromb, 20, 425, 10.5551/jat.15065 Thangaraju, 2009, GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon, Cancer Res, 69, 2826, 10.1158/0008-5472.CAN-08-4466 Chiang, 2009, Bile acids: regulation of synthesis, J Lipid Res, 50, 1955, 10.1194/jlr.R900010-JLR200 Fitzpatrick, 2020, IBD and bile acid absorption: focus on pre-clinical and clinical observations, Front Physiol, 11, 564, 10.3389/fphys.2020.00564 Di Vincenzo, 2022, Bile acid-related regulation of mucosal inflammation and intestinal motility: from pathogenesis to therapeutic application in IBD and microscopic colitis, Nutrients, 14, 2664, 10.3390/nu14132664 Chiang, 2020, Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy, Am J Physiol Gastrointest Liver Physiol, 318, G554, 10.1152/ajpgi.00223.2019 Quintás, 2021, Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes, Arch Toxicol, 95, 3049, 10.1007/s00204-021-03114-z Zhao, 2022, Alteration of bile acids and omega-6 PUFAs are correlated with the progression and prognosis of drug-induced liver injury, Front Immunol, 13 Xie, 2021, Targeted metabolomics analysis of bile acids in patients with idiosyncratic drug-induced liver injury, Metabolites, 11, 852, 10.3390/metabo11120852 Ridlon, 2016, Consequences of bile salt biotransformations by intestinal bacteria, Gut Microbes, 7, 22, 10.1080/19490976.2015.1127483 Kaplowitz, 2015, Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity, J Hepatol, 63, 5, 10.1016/j.jhep.2015.02.050 Win, 2011, c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice, J Biol Chem, 286, 35071, 10.1074/jbc.M111.276089 Han, 2013, Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria, Trends Pharmacol Sci, 34, 243, 10.1016/j.tips.2013.01.009 Gunawan, 2006, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity, Gastroenterology, 131, 165, 10.1053/j.gastro.2006.03.045 Kim, 2015, Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice, J Hepatol, 63, 75, 10.1016/j.jhep.2015.02.008 Zhang, 2017, The role of MAP2 kinases and p38 kinase in acute murine liver injury models, Cell Death Dis, 8, e2903, 10.1038/cddis.2017.295 Li, 2022, The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity, Cell Biosci, 12, 187, 10.1186/s13578-022-00921-4 Kumar, 2011, Pathogen recognition by the innate immune system, Int Rev Immunol, 30, 16, 10.3109/08830185.2010.529976 Biagioli, 2019, GPBAR1 functions as gatekeeper for liver NKT cells and provides counterregulatory signals in mouse models of immune-mediated hepatitis, Cell Mol Gastroenterol Hepatol, 8, 447, 10.1016/j.jcmgh.2019.06.003 Mizuno, 2017, The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models, PLoS One, 12, 10.1371/journal.pone.0173032 Low, 2020, Drug induced liver injury: East versus West - a systematic review and meta-analysis, Clin Mol Hepatol, 26, 142, 10.3350/cmh.2019.1003 Zheng, 2020, Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid, J Pharm Anal, 10, 560, 10.1016/j.jpha.2019.11.003 Ahrne, 2011, Effect of lactobacilli on paracellular permeability in the gut, Nutrients, 3, 104, 10.3390/nu3010104 Tamtaji, 2019, Clinical and metabolic response to probiotic administration in people with Parkinson's disease: a randomized, double-blind, placebo-controlled trial, Clin Nutr, 38, 1031, 10.1016/j.clnu.2018.05.018 Bjarnason, 2019, A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn's disease, Inflammopharmacology, 27, 465, 10.1007/s10787-019-00595-4 Kalliomäki, 2001, Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial, Lancet, 357, 1076, 10.1016/S0140-6736(00)04259-8 Xia, 2022, Modulation of gut microbiota by magnesium isoglycyrrhizinate mediates enhancement of intestinal barrier function and amelioration of methotrexate-induced liver injury, Front Immunol, 13 Xiong, 2021, Lactobacillus casei alleviated the abnormal increase of cholestasis-related liver indices during tuberculosis treatment: a post hoc analysis of randomized controlled trial, Mol Nutr Food Res, 65 Keshavarz Azizi Raftar, 2021, The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury, Microbiol Spectr, 9, 10.1128/Spectrum.00484-21 Paramsothy, 2019, Specific bacteria and metabolites associated with response to fecal microbiota transplantation in patients with ulcerative colitis, Gastroenterology, 156, 1440, 10.1053/j.gastro.2018.12.001 Vendrik, 2020, Fecal microbiota transplantation in neurological disorders, Front Cell Infect Microbiol, 10, 98, 10.3389/fcimb.2020.00098 El-Salhy, 2020, Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study, Gut, 69, 859, 10.1136/gutjnl-2019-319630 Hong, 2021, Oridonin alters hepatic urea cycle via gut microbiota and protects against acetaminophen-induced liver injury, Oxid Med Cell Longev, 2021, 10.1155/2021/3259238 Liu, 2021, Fecal transplantation alleviates acute liver injury in mice through regulating Treg/Th17 cytokines balance, Sci Rep, 11, 1611, 10.1038/s41598-021-81263-y