Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function

Stephens, 2008, Cachexia, survival and the acute phase response, Curr Opin Support Palliat Care, 2, 267, 10.1097/SPC.0b013e3283186be2 Fearon, 2011, Definition and classification of cancer cachexia: an international consensus, Lancet Oncol, 10.1016/S1470-2045(10)70218-7 Prado, 2007, Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity, Clin Cancer Res, 13, 3264, 10.1158/1078-0432.CCR-06-3067 Pisot, 2008, Whole muscle contractile parameters and thickness loss during 35-day bed rest, Eur J Appl Physiol, 104, 409, 10.1007/s00421-008-0698-6 Maughan, 1983, Strength and cross-sectional area of human skeletal muscle, J Physiol, 338, 37, 10.1113/jphysiol.1983.sp014658 Weber, 2009, Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia, Acta Oncol, 48, 116, 10.1080/02841860802130001 Acharyya, 2005, Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia, Cancer Cell, 8, 421, 10.1016/j.ccr.2005.10.004 Windsor, 1988, Weight loss with physiologic impairment. A basic indicator of surgical risk, Ann Surg, 207, 290, 10.1097/00000658-198803000-00011 Evans, 2008, Cachexia: a new definition, Clin Nutr, 27, 793, 10.1016/j.clnu.2008.06.013 Ho, 2006, Calculated free testosterone in men: comparison of four equations and with free androgen index, Ann Clin Biochem, 43, 389, 10.1258/000456306778520115 Edwards, 1977, Human skeletal muscle function: description of tests and normal values, Clin Sci Mol Med, 52, 283 Bassey, 1990, A new method for measuring power output in a single leg extension: feasibility, reliability and validity, Eur J Appl Physiol Occup Physiol, 60, 385, 10.1007/BF00713504 Gray, 2011, Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia, Clin Nutr, 30, 106, 10.1016/j.clnu.2010.07.012 VanItallie, 1990, Height-normalized indices of the body’s fat-free mass and fat mass: potentially useful indicators of nutritional status, Am J Clin Nutr, 52, 953, 10.1093/ajcn/52.6.953 Aaronson, 1993, The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology, J Natl Cancer Inst, 85, 365, 10.1093/jnci/85.5.365 Peng, 2007, Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study, Am J Clin Nutr, 85, 1257, 10.1093/ajcn/85.5.1257 Palomares, 1996, Gender influence on weight-loss pattern and survival of nonsmall cell lung carcinoma patients, Cancer, 78, 2119, 10.1002/(SICI)1097-0142(19961115)78:10<2119::AID-CNCR12>3.0.CO;2-1 Baracos, 2010, Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis, Am J Clin Nutr, 91, 1133S, 10.3945/ajcn.2010.28608C Thomas, 2007, Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia, Clin Nutr, 26, 389, 10.1016/j.clnu.2007.03.008 Skipworth, 2011, Interaction of gonadal status with systemic inflammation and opioid use in determining nutritional status and prognosis in advanced pancreatic cancer, Support Care Cancer, 19, 391, 10.1007/s00520-010-0832-y Oberaigner, 2010, Do women with cancer have better survival as compared to men after adjusting for staging distribution?, Eur J Public Health Goodpaster, 2006, The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study, J Gerontol A Biol Sci Med Sci, 61, 1059, 10.1093/gerona/61.10.1059 Yasuda, 2005, Sex-based differences in skeletal muscle function and morphology with short-term limb immobilization, J Appl Physiol, 99, 1085, 10.1152/japplphysiol.00247.2005 Hakkinen, 1993, Neuromuscular fatigue and recovery in male and female athletes during heavy resistance exercise, Int J Sports Med, 14, 53, 10.1055/s-2007-1021146 Moses, 2004, Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids, Br J Cancer, 90, 996, 10.1038/sj.bjc.6601620 Lauretani, 2003, Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia, J Appl Physiol, 95, 1851, 10.1152/japplphysiol.00246.2003 Fearon, 2006, Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis, Am J Clin Nutr, 83, 1345, 10.1093/ajcn/83.6.1345 Allan, 2008, Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men, J Clin Endocrinol Metab, 93, 139, 10.1210/jc.2007-1291 Aloia, 1991, Relationship of menopause to skeletal and muscle mass, Am J Clin Nutr, 53, 1378, 10.1093/ajcn/53.6.1378 Lewis, 2011, Is fatigue after stroke associated with physical deconditioning? A cross-sectional study in ambulatory stroke survivors, Arch Phys Med Rehabil, 92, 295, 10.1016/j.apmr.2010.10.030