Novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates: Synthesis and pharmacological activity

Adebayo, 2006, Is non-steroidal anti-inflammatory drug (NSAID) enteropathy clinically more important than NSAID gastropathy, Postgrad. Med. J., 82, 186, 10.1136/pgmj.2005.039586 Bekhit, 2008, Syntheses and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as antiinflammatory and antimicrobial agents, Eur. J. Med. Chem., 43, 456, 10.1016/j.ejmech.2007.03.030 Botting, 2006, Cyclooxygenase: past, present and future, J. Therm. Biol., 31, 208, 10.1016/j.jtherbio.2005.11.008 Dogne, 2005, Adverse cardiovascular effects of the coxibs, J. Med. Chem., 48, 2251, 10.1021/jm0402059 Ganguly, 1973, Effect of bilateral adrenalectomy on production of restraint ulcers in the stomach of albino rats, Can. J. Physiol. Pharmacol., 51, 748, 10.1139/y73-113 Goyal, 1985, The effect of biological variables on the antiulcerogenic effect of vegetable plantain banana, Planta Med., 29, 85, 10.1055/s-2007-969412 Gyorgy, 2008, New celecoxib derivatives as anti-inflammatory agents, J. Med. Chem., 51, 142, 10.1021/jm070821f Jensen, 1968, Studies of thioacids and their derivatives: reactions of carbon disulphide with active methylene compounds, Acta Chem. Scand., 22, 1107, 10.3891/acta.chem.scand.22-1107 Koster, 1959, Drug discovery and evaluation: pharmacological assays, Fed. Proc., 18, 412 Morshed, 2009, Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase, J. Med. Chem., 52, 1525, 10.1021/jm8015188 Park, 2005, Identification of antitumor activity of pyrazole oxime ethers, Bioorg. Med. Chem. Lett., 15, 3307, 10.1016/j.bmcl.2005.03.082 Pimerova, 2001, Syntheses of some new 1H-pyrazole, pyridazin-3(2H)-one, and oxazin-4-one derivatives, Pharm. Chem., 35, 18, 10.1023/A:1010494525001 Prokopp, 2006, A pyrazolyl-thiazole derivative causes antinociception in mice, Braz. J. Med. Biol. Res., 39, 795, 10.1590/S0100-879X2006000600013 Schneider, 2006, Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure, Am. J. Epidemiol., 164, 881, 10.1093/aje/kwj331 Shay, 1945, A simple method for the uniform production of gastric ulceration in the rats, Gastroenterology, 5, 43 Singh, 1999, Epidemiology of NSAID induced gastrointestinal complications, Rheumatology, 56, 18 Sung, 2011, Synthesis and structure activity relationship studies of urea containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase, J. Med. Chem., 54, 3037, 10.1021/jm2001376 Weilin, 1992, Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal antiinflammatory drugs, Drug Dev. Res., 25, 249, 10.1002/ddr.430250402 Winter, 1962, Carrageenin-induced edema in hind paws of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol., 111, 544, 10.3181/00379727-111-27849