High density of nicotinic receptors in the cingulo-insular network

Aleksandrov, 2000, Identification of a respiratory related area in the rat insular cortex, Can. J. Physiol. Pharmacol., 78, 582, 10.1139/y00-031

Alkondon, 2000, Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks, J. Neurosci., 20, 66, 10.1523/JNEUROSCI.20-01-00066.2000

An, 1998, Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in macaque monkeys, J. Comp. Neurol., 401, 455, 10.1002/(SICI)1096-9861(19981130)401:4<455::AID-CNE3>3.0.CO;2-6

Anderson, 2012, Low dose nicotine and antagonism of beta2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice, PLoS One, 7, e48665, 10.1371/journal.pone.0048665

Blum, 2009, Respiratory physiology of seizures, J. Clin. Neurophysiol., 26, 309, 10.1097/WNP.0b013e3181b7f14d

Brody, 2006, Functional brain imaging of tobacco use and dependence, J. Psychiatr. Res., 40, 404, 10.1016/j.jpsychires.2005.04.012

Brown, 2010, Nicotinic modulation of auditory attentional shift in the rat, Behav. Brain Res., 210, 273, 10.1016/j.bbr.2010.02.046

Chang, 2013, Decoding the role of the insula in human cognition: functional parcellation and large-scale reverse inference, Cereb. Cortex, 23, 739, 10.1093/cercor/bhs065

Changeux, 2010, Nicotine addiction and nicotinic receptors: lessons from genetically modified mice, Nat. Rev. Neurosci., 11, 389, 10.1038/nrn2849

Chefer, 1999, 2-[18F]F-A-85380: a PET radioligand for alpha4beta2 nicotinic acetylcholine receptors, Neuroreport, 10, 2715, 10.1097/00001756-199909090-00005

Contreras, 2007, Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium, Science, 318, 655, 10.1126/science.1145590

Craig, 2009, How do you feel—now? The anterior insula and human awareness, Nat. Rev. Neurosci., 10, 59, 10.1038/nrn2555

Critchley, 2004, Neural systems supporting interoceptive awareness, Nat. Neurosci., 7, 189, 10.1038/nn1176

Dani, 2001, Overview of nicotinic receptors and their roles in the central nervous system, Biol. Psychiatry, 49, 166, 10.1016/S0006-3223(00)01011-8

Dani, 2007, Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system, Annu. Rev. Pharmacol. Toxicol., 47, 699, 10.1146/annurev.pharmtox.47.120505.105214

Dobesberger, 2008, Successful surgical treatment of insular epilepsy with nocturnal hypermotor seizures, Epilepsia, 49, 159, 10.1111/j.1528-1167.2007.01426.x

Doll, 1999, Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors, J. Med. Chem., 42, 2251, 10.1021/jm9910223

Domino, 1992, Effects of tobacco smoking on the topographic EEG II, Prog. Neuropsychopharmacol. Biol. Psychiatry, 16, 463, 10.1016/0278-5846(92)90053-H

Dosenbach, 2006, A core system for the implementation of task sets, Neuron, 50, 799, 10.1016/j.neuron.2006.04.031

Dosenbach, 2007, Distinct brain networks for adaptive and stable task control in humans, Proc. Natl. Acad. Sci. U. S. A., 104, 11073, 10.1073/pnas.0704320104

Drake, 2010, Neural control of the lower urinary and gastrointestinal tracts: supraspinal CNS mechanisms, Neurourol. Urodyn., 29, 119, 10.1002/nau.20841

Evans, 2002, BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger, J. Neurophysiol., 88, 1500, 10.1152/jn.2002.88.3.1500

Fadel, 2011, Regulation of cortical acetylcholine release: insights from in vivo microdialysis studies, Behav. Brain Res., 221, 527, 10.1016/j.bbr.2010.02.022

Frouin, 2002, Correction of partial-volume effect for PET striatal imaging: fast implementation and study of robustness, J. Nucl. Med., 43, 1715

Gallezot, 2005, In vivo imaging of human cerebral nicotinic acetylcholine receptors with 2-18F-fluoro-A-85380 and PET, J. Nucl. Med., 46, 240

Gallezot, 2008, Quantification of cerebral nicotinic acetylcholine receptors by PET using 2-[18F]fluoro-A-85380 and the multiinjection approach, J. Cereb. Blood Flow Metab., 28, 172, 10.1038/sj.jcbfm.9600505

Gao, 2008, J. Med. Chem., 51, 4751, 10.1021/jm800323d

Goldstein, 2009, The neurocircuitry of impaired insight in drug addiction, Trends Cogn. Sci., 13, 372, 10.1016/j.tics.2009.06.004

Gray, 2007, Interoceptive basis to craving, Neuron, 54, 183, 10.1016/j.neuron.2007.03.024

Guenot, 2008, Epilepsy and insula, Neurochirurgie, 54, 374, 10.1016/j.neuchi.2008.02.010

Hasenkamp, 2012, Mind wandering and attention during focused meditation: a fine-grained temporal analysis of fluctuating cognitive states, Neuroimage, 59, 750, 10.1016/j.neuroimage.2011.07.008

Horti, 1998, 2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors, Nucl. Med. Biol., 25, 599, 10.1016/S0969-8051(98)00031-6

Impey, 2013, Effects of nicotine on visuospatial attentional orienting in non-smokers, Pharmacol. Biochem. Behav., 106, 1, 10.1016/j.pbb.2013.02.015

Isnard, 2004, Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study, Epilepsia, 45, 1079, 10.1111/j.0013-9580.2004.68903.x

Jones, 2011, Imaging for autonomic dysfunction, Cleve. Clin. J. Med., 78, S69, 10.3949/ccjm.78.s1.12

Kaido, 2006, Complex behavioral automatism arising from insular cortex, Epilepsy Behav., 8, 315, 10.1016/j.yebeh.2005.10.006

Kimes, 2003, 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans, FASEB J., 17, 1331, 10.1096/fj.02-0492fje

Knott, 1988, Dynamic EEG changes during cigarette smoking, Neuropsychobiology, 19, 54, 10.1159/000118434

Knott, 1998, The cholinergic basis of the smoking-induced EEG activation profile, Neuropsychobiology, 38, 97, 10.1159/000026524

Knott, 1999, Transdermal nicotine: single dose effects on mood, EEG, performance, and event-related potentials, Pharmacol. Biochem. Behav., 63, 253, 10.1016/S0091-3057(99)00006-4

Kobiella, 2011, Nicotine increases neural response to unpleasant stimuli and anxiety in non-smokers, Addict. Biol., 16, 285, 10.1111/j.1369-1600.2010.00237.x

Kurth, 2010, A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis, Brain Struct. Funct., 214, 519, 10.1007/s00429-010-0255-z

Lamm, 2010, The role of anterior insular cortex in social emotions, Brain Struct. Funct., 214, 579, 10.1007/s00429-010-0251-3

Li, 2009, New insights into the genetics of addiction, Nat. Rev. Genet., 10, 225, 10.1038/nrg2536

Lindgren, 1999, Electroencephalographic effects of intravenous nicotine—a dose–response study, Psychopharmacology (Berl), 145, 342, 10.1007/s002130051067

Mancuso, 1999, Selective effects of nicotine on attentional processes, Psychopharmacology (Berl), 146, 199, 10.1007/s002130051107

Meinke, 2006, Effects of nicotine on visuo-spatial selective attention as indexed by event-related potentials, Neuroscience, 141, 201, 10.1016/j.neuroscience.2006.03.072

Menon, 2010, Saliency, switching, attention and control: a network model of insula function, Brain Struct. Funct., 214, 655, 10.1007/s00429-010-0262-0

Mesulam, 1995, Structure and function of cholinergic pathways in the cerebral cortex, limbic system, basal ganglia, and thalamus of the human brain, 135

Mitkovski, 2005, Simplified quantification of nicotinic receptors with 2[18F]F-A-85380 PET, Nucl. Med. Biol., 32, 585, 10.1016/j.nucmedbio.2005.04.013

Mobbs, 2009, From threat to fear: the neural organization of defensive fear systems in humans, J. Neurosci., 29, 12236, 10.1523/JNEUROSCI.2378-09.2009

Moser, 2007, Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures, J. Neurochem., 102, 479, 10.1111/j.1471-4159.2007.04498.x

Mosteller, 1977, Two- and more-way tables, 165

Mutschler, 2009, Functional organization of the human anterior insular cortex, Neurosci. Lett., 457, 66, 10.1016/j.neulet.2009.03.101

Naqvi, 2007, Damage to the insula disrupts addiction to cigarette smoking, Science, 315, 531, 10.1126/science.1135926

Nelson, 2010, Role of the anterior insula in task-level control and focal attention, Brain Struct. Funct., 214, 669, 10.1007/s00429-010-0260-2

Newhouse, 2012, Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial, Neurology, 78, 91, 10.1212/WNL.0b013e31823efcbb

Oppenheimer, 2007, Cortical control of the heart, Cleve. Clin. J. Med., 74, S27, 10.3949/ccjm.74.Suppl_1.S27

Penfield, 1955, The insula; further observations on its function, Brain, 78, 445, 10.1093/brain/78.4.445

Perry, 2002, Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography, J. Neurochem., 82, 468, 10.1046/j.1471-4159.2002.00951.x

Petrovsky, 2012, Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy, Psychopharmacology (Berl), 221, 27, 10.1007/s00213-011-2540-9

Picard, 2007, Familial frontal lobe epilepsies, 2495

Picard, 2000, Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European families, Brain, 123, 1247, 10.1093/brain/123.6.1247

Picard, 2006, Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study, Brain, 129, 2047, 10.1093/brain/awl156

Poltavski, 2006, Effects of transdermal nicotine on attention in adult non-smokers with and without attentional deficits, Physiol. Behav., 87, 614, 10.1016/j.physbeh.2005.12.011

Power, 2013, Control-related systems in the human brain, Curr. Opin. Neurobiol., 23, 223, 10.1016/j.conb.2012.12.009

Power, 2011, Functional network organization of the human brain, Neuron, 72, 665, 10.1016/j.neuron.2011.09.006

Rose, 2010, Nicotine modulation of information processing is not limited to input (attention) but extends to output (intention), Psychopharmacology (Berl), 209, 291, 10.1007/s00213-010-1788-9

Rousset, 1998, Correction for partial volume effects in PET: principle and validation, J. Nucl. Med., 39, 904

Rubboli, 1994, Distribution of neuronal nicotinic receptor subunits in human brain, Neurochem. Int., 25, 69, 10.1016/0197-0186(94)90055-8

Ryvlin, 2006, Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula, Epilepsia, 47, 755, 10.1111/j.1528-1167.2006.00510.x

Sadaghiani, 2010, The relation of ongoing brain activity, evoked neural responses, and cognition, Front. Syst. Neurosci., 4, 20

Sadaghiani, 2010, Intrinsic connectivity networks, alpha oscillations, and tonic alertness: a simultaneous electroencephalography/functional magnetic resonance imaging study, J. Neurosci., 30, 10243, 10.1523/JNEUROSCI.1004-10.2010

Sadaghiani, 2012, Alpha-band phase synchrony is related to activity in the fronto-parietal adaptive control network, J. Neurosci., 32, 14305, 10.1523/JNEUROSCI.1358-12.2012

Schroder, 1989, Immunohisto- and cytochemical localization of cortical nicotinic cholinoceptors in rat and man, Brain Res., 502, 287, 10.1016/0006-8993(89)90624-0

Seeley, 2010, Anterior insula degeneration in frontotemporal dementia, Brain Struct. Funct., 214, 465, 10.1007/s00429-010-0263-z

Seeley, 2007, Dissociable intrinsic connectivity networks for salience processing and executive control, J. Neurosci., 27, 2349, 10.1523/JNEUROSCI.5587-06.2007

Smith, 2009, Correspondence of the brain's functional architecture during activation and rest, Proc. Natl. Acad. Sci. U. S. A., 106, 13040, 10.1073/pnas.0905267106

Soros, 2012, Cardiovascular and neurological causes of sudden death after ischaemic stroke, Lancet Neurol., 11, 179, 10.1016/S1474-4422(11)70291-5

Sturm, 2004, Network for auditory intrinsic alertness: a PET study, Neuropsychologia, 42, 563, 10.1016/j.neuropsychologia.2003.11.004

Valette, 1999, Imaging central nicotinic acetylcholine receptors in baboons with [18F]fluoro-A-85380, J. Nucl. Med., 40, 1374

Wevers, 2011, Localisation of pre- and postsynaptic cholinergic markers in the human brain, Behav. Brain Res., 221, 341, 10.1016/j.bbr.2010.02.025

Yasui, 1991, Autonomic responses and efferent pathways from the insular cortex in the rat, J. Comp. Neurol., 303, 355, 10.1002/cne.903030303

Zhang, 2008, A hypermotor seizure with a focal orbital frontal lesion originating in the insula: a case report, Epilepsy Res., 82, 211, 10.1016/j.eplepsyres.2008.06.013

Zilles, 2004, Transmitter receptors and functional anatomy of the cerebral cortex, J. Anat., 205, 417, 10.1111/j.0021-8782.2004.00357.x