A Secreted Bacterial Protease Tailors the Staphylococcus aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis

Alexander, 2003, Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts, BMC Microbiol., 3, 5, 10.1186/1471-2180-3-5

Arvidson, 1973, Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease, Biochim. Biophys. Acta, 302, 149, 10.1016/0005-2744(73)90017-X

Beenken, 2010, Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation, PLoS ONE, 5, e10790, 10.1371/journal.pone.0010790

Belthur, 2012, Pathologic fractures in children with acute Staphylococcus aureus osteomyelitis, J. Bone Joint Surg. Am., 94, 34, 10.2106/JBJS.J.01915

Benson, 2012, Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins, J. Bacteriol., 194, 4355, 10.1128/JB.00706-12

Boles, 2010, Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation, PLoS ONE, 5, e10146, 10.1371/journal.pone.0010146

Carrillo-Marquez, 2009, USA300 is the predominant genotype causing Staphylococcus aureus septic arthritis in children, Pediatr. Infect. Dis. J., 28, 1076, 10.1097/INF.0b013e3181adbcfe

Claro, 2013, Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection, Microbiology, 159, 147, 10.1099/mic.0.063016-0

Corbin, 2008, Metal chelation and inhibition of bacterial growth in tissue abscesses, Science, 319, 962, 10.1126/science.1152449

Ellington, 1999, Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts, Microb. Pathog., 26, 317, 10.1006/mpat.1999.0272

Gerber, 2009, Trends in the incidence of methicillin-resistant Staphylococcus aureus infection in children’s hospitals in the United States, Clin. Infect. Dis., 49, 65, 10.1086/599348

Goerke, 2005, Role of Staphylococcus aureus global regulators sae and sigmaB in virulence gene expression during device-related infection, Infect. Immun., 73, 3415, 10.1128/IAI.73.6.3415-3421.2005

Gonzalez, 2006, Venous thrombosis associated with staphylococcal osteomyelitis in children, Pediatrics, 117, 1673, 10.1542/peds.2005-2009

Gonzalez, 2012, Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry, J. Biol. Chem., 287, 13889, 10.1074/jbc.M112.349860

Hudson, 1995, Internalization of Staphylococcus aureus by cultured osteoblasts, Microb. Pathog., 19, 409, 10.1006/mpat.1995.0075

Kaito, 2011, Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence, PLoS Pathog., 7, e1001267, 10.1371/journal.ppat.1001267

Lew, 1997, Osteomyelitis, N. Engl. J. Med., 336, 999, 10.1056/NEJM199704033361406

Lew, 2004, Osteomyelitis, Lancet, 364, 369, 10.1016/S0140-6736(04)16727-5

Li, 2009, Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus, Proc. Natl. Acad. Sci. USA, 106, 5883, 10.1073/pnas.0900743106

Li, 2010, Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling, J. Proteome Res., 9, 4295, 10.1021/pr100527g

Liang, 2006, Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus, Infect. Immun., 74, 4655, 10.1128/IAI.00322-06

Ma, 2009, IDPicker 2.0: Improved protein assembly with high discrimination peptide identification filtering, J. Proteome Res., 8, 3872, 10.1021/pr900360j

MacCoss, 2002, Shotgun identification of protein modifications from protein complexes and lens tissue, Proc. Natl. Acad. Sci. USA, 99, 7900, 10.1073/pnas.122231399

Marriott, 2004, Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue, Am. J. Pathol., 164, 1399, 10.1016/S0002-9440(10)63226-9

Martinez, 2012, Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones, J. Lipid Res., 53, 379, 10.1194/jlr.M019752

Mazmanian, 2003, Passage of heme-iron across the envelope of Staphylococcus aureus, Science, 299, 906, 10.1126/science.1081147

Mrak, 2012, saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus, PLoS ONE, 7, e38453, 10.1371/journal.pone.0038453

Nickerson, 2007, Activation of the SspA serine protease zymogen of Staphylococcus aureus proceeds through unique variations of a trypsinogen-like mechanism and is dependent on both autocatalytic and metalloprotease-specific processing, J. Biol. Chem., 282, 34129, 10.1074/jbc.M705672200

Nygaard, 2010, SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis, J. Infect. Dis., 201, 241, 10.1086/649570

Peyrani, 2012, Clinical outcomes of osteomyelitis patients infected with methicillin-resistant Staphylococcus aureus USA-300 strains, Am. J. Orthop., 41, 117

Rogasch, 2006, Influence of the two-component system SaeRS on global gene expression in two different Staphylococcus aureus strains, J. Bacteriol., 188, 7742, 10.1128/JB.00555-06

Somayaji, 2008, Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts, Infect. Immun., 76, 5120, 10.1128/IAI.00228-08

Voyich, 2009, The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus, J. Infect. Dis., 199, 1698, 10.1086/598967

Wang, 2007, Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA, Nat. Med., 13, 1510, 10.1038/nm1656

Weichert, 2008, Acute haematogenous osteomyelitis in children: is there any evidence for how long we should treat?, Curr. Opin. Infect. Dis., 21, 258, 10.1097/QCO.0b013e3283005441

Xiong, 2006, Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis, J. Infect. Dis., 194, 1267, 10.1086/508210

Yates, 1995, Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database, Anal. Chem., 67, 1426, 10.1021/ac00104a020

Young, 2011, Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts, Bone, 48, 857, 10.1016/j.bone.2010.11.015

Zielinska, 2011, Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus, J. Bacteriol., 193, 2948, 10.1128/JB.01517-10

Zielinska, 2012, sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates, Mol. Microbiol., 86, 1183, 10.1111/mmi.12048