Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients

PLoS ONE - Tập 16 Số 3 - Trang e0245424
Daniela Frasca1,2, Lisa Reidy3, Carolyn Cray3, Alain Diaz1, Maria Romero1, Kristin Kahl3, Bonnie B. Blomberg1,2
1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States of America
2Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States of America
3Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, United States of America

Tóm tắt

SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.

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