Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors

Imig, 1996, Am. J. Physiol. 270, R217. Ito, 1998, Am. J. Physiol. 274, F395. Gebremedhin, 2000, Circ. Res., 87, 60, 10.1161/01.RES.87.1.60 Powell, 1998, J. Pharmacol. Exp. Ther., 285, 1327 Omata, 1992, Am. J. Physiol. 262, F591. Zou, 1994, Am. J. Physiol., 266, F275 Lin, 1995, Am. J. Physiol., 269, F806 Muerhoff, 1989, J. Biol. Chem., 264, 749, 10.1016/S0021-9258(19)85006-8 Su, 1998, Am. J. Physiol., 275, R426 Zou, 1994, J. Pharmacol. Exp. Ther., 268, 474 Xu, 2002, Am. J. Physiol. Regul. Integr. Comp. Physiol, 283, R710, 10.1152/ajpregu.00522.2001 Sato, 2001, Bioorg. Med. Chem. Lett., 11, 2993, 10.1016/S0960-894X(01)00614-X Miyata, 2001, Br. J. Pharmacol., 133, 325, 10.1038/sj.bjp.0704101 Kehl, 2002, Am. J. Physiol. Heart Circ. Physiol, 282, H1556, 10.1152/ajpheart.00924.2001 Nakamura, T.; Sato, M.; Kakinuma, H.; Miyata, N.; Taniguchi, K.; Bando, K.; Koda, A.; Kameo, K. J. Med. Chem., in press. Yamaguchi, 1997, Nihon Yakuzaishikai Zasshi, 49, 1829 Gall, 1988, J. Heterocycl. Chem., 25, 1649, 10.1002/jhet.5570250610 Kiyomori, 1999, Tetrahedron Lett., 40, 2657, 10.1016/S0040-4039(99)00291-9 Upthagrove, 2001, Drug Metab. Dispos., 29, 1389 Crespi, 1997, Anal. Biochem., 248, 188, 10.1006/abio.1997.2145