Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation

Elsevier BV - Tập 5 - Trang 988-995 - 2015
Michael Fatt1,2, Karolynn Hsu3, Ling He4, Fredric Wondisford5, Freda D. Miller1,2,6,7, David R. Kaplan1,2,6, Jing Wang3,8,9
1Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
2Institute of Medical Science, University of Toronto, Toronto, ON M5G 1X5, Canada
3Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
4Department of Pediatrics and Medicine, Johns Hopkins Medical School, Baltimore, MD 21287, USA
5Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
6Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada
7Department of Physiology, University of Toronto, Toronto, ON M5G 1X5, Canada
8Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
9Brain and Mind Research Institute, University of Ottawa, Ottawa, ON K1H 8M5, Canada

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