Drug resistance in liver flukes

Abdelaal, 2017, Ultrastructural changes to the tegumental system and gastrodermal cells of adult Fasciola hepatica following treatment in vivo with a commercial preparation of myrrh (Mirazid), J. Helminthol., 91, 672, 10.1017/S0022149X16000705 Abdelaal, 2017, Disruption of egg production by triclabendazole-resistant Fasciola hepatica following treatment with a commercial preparation of myrrh (Mirazid), Acta Parasitol., 62, 336, 10.1515/ap-2017-0041 Aguayo-Ortiz, 2013, Towards the identification of the binding site of benzimidazoles to β-tubulin of Trichinella spiralis: insights from computational and experimental data, J. Mol. Graph. Model., 41, 12, 10.1016/j.jmgm.2013.01.007 Aguayo-Ortiz, 2013, Molecular basis for benzimidazole resistance from a novel β–tubulin binding site model, J. Mol. Graph. Model., 45, 26, 10.1016/j.jmgm.2013.07.008 Aguayo-Ortiz, 2017, Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors, Chem. Biol. Drug Des., 90, 40, 10.1111/cbdd.12926 Alcalá-Canto, 2006, Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis, Parasitol. Res., 98, 438, 10.1007/s00436-005-0046-2 Alcalá-Canto, 2007, Effect of a cysteine protease inhibitor on Fasciola hepatica (liver fluke) fecundity, egg viability, parasite burden, and size in experimentally infected sheep, Parasitol. Res., 100, 461, 10.1007/s00436-006-0308-7 Alvarez, 2005, Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes, Parasitology, 131, 501, 10.1017/S0031182005007997 Alvarez, 2009, Comparative assessment of albendazole and triclabendazole ovicidal activity on Fasciola hepatica eggs, Vet. Parasitol., 164, 211, 10.1016/j.vetpar.2009.05.014 Alvarez-Mercado, 2015, In vitro antihelmintic effect of fifteen tropical plant extracts on excysted flukes of Fasciola hepatica, BMC Vet. Res., 11, 45, 10.1186/s12917-015-0362-4 Álvarez-Sánchez, 2006, Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain, Vet. Rec., 159, 424, 10.1136/vr.159.13.424 Andrews, 2008, Opisthorchis viverrini: an underestimated parasite in world health, Trends Parasitol., 24, 497, 10.1016/j.pt.2008.08.011 Anon, 1995, 1 Arafa, 2015, Comparing an in vivo egg reduction test and in vitro egg hatching assay for different anthelmintics against Fasciola species in cattle, Vet. Parasitol., 214, 152, 10.1016/j.vetpar.2015.09.023 Arbabi, 2011, Prevalence and intensity of Dicrocoelium dendriticum in sheep and goats of Iran, J. Parasitol., 6, 160, 10.3923/jp.2011.160.167 Arifin, 2016, Comparison of molecular and conventional methods for the diagnosis of Fasciola hepatica infection in the field, Vet. Parasitol., 232, 8, 10.1016/j.vetpar.2016.11.003 Bartram, 2012, The role of combination anthelmintic formulations in the sustainable control of sheep nematodes, Vet. Parasitol., 186, 151, 10.1016/j.vetpar.2011.11.030 Beckham, 2009, A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites, Int. J. Biochem. Cell Biol., 41, 1601, 10.1016/j.biocel.2009.02.003 Beesley, 2017, Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance, Int. J. Parasitol., 47, 11, 10.1016/j.ijpara.2016.09.007 Beesley, 2018, Fasciola and fasciolosis in ruminants in Europe: identifying research needs, Transbound. Emerg. Dis., 65, 199, 10.1111/tbed.12682 Besier, 2006, New anthelmintics for livestock: the time is right, Trends Parasitol., 23, 21, 10.1016/j.pt.2006.11.004 Boray, 1971, Fortschritte in der Bekämpfung der Fasciolose. Schweiz, Arch. Tierheilkd., 113, 361 Boray, 1990, Drug resistance in Fasciola hepatica, 51 Boray, 1994, 49 Boray, 1997, Chemotherapy of infections with fasciolidae, 83 Borgsteede, 2005, Lack of reversion in triclabendazole-resistant Fasciola hepatica, Vet. Rec., 156, 350, 10.1136/vr.156.11.350 Botros, 2004, Lack of evidence for an antischistosomal activity of myrrh in experimental animals, Am. J. Trop. Med. Hyg., 71, 206, 10.4269/ajtmh.2004.71.206 Bousquet-Mélou, 2004, Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin, Int. J. Parasitol., 34, 1299, 10.1016/j.ijpara.2004.08.005 Brockwell, 2013, Comparative kinetics of serological and coproantigen ELISA and faecal egg count in cattle experimentally infected with Fasciola hepatica and following treatment with triclabendazole, Vet. Parasitol., 196, 417, 10.1016/j.vetpar.2013.04.012 Brockwell, 2014, Confirmation of Fasciola hepatica resistant to triclabendazole in naturally infected Australian beef and dairy cattle, Int. J. Parasitol. Drugs Drug Resist., 4, 48, 10.1016/j.ijpddr.2013.11.005 Büscher, 1999, Efficacy of triclabendazole, its metabolites and other compounds in sheep Byrne, 2018, Seasonal variation of Fasciola hepatica antibodies in dairy herds in Northern Ireland measured by bulk tank ELISA, Parasitol. Res., 117, 2725, 10.1007/s00436-018-5961-0 Cabada, 2016, Treatment failure after multiple courses of triclabendazole among patients with fascioliasis in Cusco, Peru: a case series, PLoS Negl. Trop. Dis., 10, 10.1371/journal.pntd.0004361 Cabada, 2017, Recombinase polymerase amplification compared to real-time polymerase chain reaction test for the detection of Fasciola hepatica in human stool, Am. J. Trop. Med. Hyg., 96, 341, 10.4269/ajtmh.16-0601 Calvani, 2018, Comparison of early detection of Fasciola hepatica in experimentally infected Merino sheep by real-time PCR, coproantigen ELISA and sedimentation, Vet. Parasitol., 251, 85, 10.1016/j.vetpar.2018.01.004 Cancela, 2008, A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica, Biochimie, 90, 1461, 10.1016/j.biochi.2008.04.020 Canevari, 2014, Testing albendazole resistance in Fasciola hepatica: validation of an egg hatch test with isolates from South America and the United Kingdom, J. Helminthol., 88, 286, 10.1017/S0022149X13000163 Carmona, 2017, Fasciolosis in South America: epidemiology and control challenges, J. Helminthol., 91, 99, 10.1017/S0022149X16000560 Ceballos, 2010, Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes, BMC Vet. Res., 6, 8, 10.1186/1746-6148-6-8 Ceballos, 2017, Understanding the main route of drug entry in adult Fasciola hepatica: further insights into closantel pharmacological activity, Vet. Parasitol., 181, 23 Ceballos, 2019, The egg hatch test: a useful tool for albendazole resistance diagnosis in Fasciola hepatica, Vet. Parasitol., 271, 7, 10.1016/j.vetpar.2019.06.001 Chambers, 2010, Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug, Parasitol. Res., 107, 1257, 10.1007/s00436-010-1997-5 Charlier, 2007, Association between anti-Fasciola hepatica antibody levels in bulk-tank milk samples and production parameters in dairy herds, Prev. Vet. Med., 78, 57, 10.1016/j.prevetmed.2006.09.010 Charlier, 2008, Qualitative and quantitative evaluation of coprological and serological techniques for the diagnosis of fasciolosis in cattle, Vet. Parasitol., 153, 44, 10.1016/j.vetpar.2008.01.035 Charlier, 2012, ParaCalc®-A novel tool to evaluate the economic importance of worm infections on the dairy farms, Vet. Parasitol., 184, 204, 10.1016/j.vetpar.2011.09.008 Chaturvedi, 2010, Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents, Chem. Soc. Rev., 39, 435, 10.1039/B816679J Chávez, 2012, Resistance to anthelmintics and prevalence of bovine fasciolosis in dairy farms in Juaja, Peru, Rev. Inv. Vet. Peru, 23, 90 Chemale, 2010, Comparative proteomic analysis of triclabendazole response in the liver fluke Fasciola hepatica, J. Proteome Res., 9, 4940, 10.1021/pr1000785 Coles, 1978, Benzimidazoles and fluke eggs, Vet. Rec., 103, 360, 10.1136/vr.103.16.360 Coles, 2001, Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole-resistant Fasciola hepatica, Vet. Rec., 148, 723, 10.1136/vr.148.23.723 Coles, 1992, World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance, Vet. Parasitol., 44, 35, 10.1016/0304-4017(92)90141-U Coles, 2000, Activity of closantel against adult triclabendazole-resistant Fasciola hepatica, Vet. Rec., 146, 504, 10.1136/vr.146.17.504-a Coles, 2006, The detection of anthelmintic resistance in nematodes of veterinary importance, Vet. Parasitol., 136, 167, 10.1016/j.vetpar.2005.11.019 Crilly, 2015, Triclabendazole-resistant liver fluke: issues and strategies, Livestock, 20, 86, 10.12968/live.2015.20.2.86 Cringoli, 2006, A dual anthelmintic strategic scheme for the control of fasciolosis in dairy sheep farms, Parasitol. Res., 99, 700, 10.1007/s00436-006-0223-y Cringoli, 2010, FLOTAC: new multivalent techniques for qualitative and quantitative coproscopic diagnosis of parasites in animals and humans, Nat. Protoc., 5, 503, 10.1038/nprot.2009.235 Cringoli, 2017, The Mini-FLOTAC technique for the diagnosis of helminth and protozoan infections in humans and animals, Nat. Protoc., 12, 1723, 10.1038/nprot.2017.067 Crusco, 2018, Design, synthesis and anthelmintic activity of 7-sempervirol analogues, Eur. J. Med. Chem., 152, 87, 10.1016/j.ejmech.2018.04.032 Cupit, 2015, What is the mechanism of action of praziquantel and how might resistance strike?, Future Med. Chem., 7, 701, 10.4155/fmc.15.11 Cwiklinski, 2016, A prospective view of animal and human fasciolosis, Parasite Immunol., 38, 558, 10.1111/pim.12343 David, 2016, In silico analysis of the binding of anthelmintics to Caenorhabditis elegans P-glycoprotein 1, Int. J. Parasitol. Drugs Drug Resist., 6, 299, 10.1016/j.ijpddr.2016.09.001 Daniel, 2012, Composite faecal egg count reduction test to detect resistance to triclabendazole in Fasciola hepatica, Vet. Rec., 171, 153, 10.1136/vr.100588 Devine, 2009, Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica, Parasitology, 136, 183, 10.1017/S0031182008005222 Devine, 2010, Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole, Parasitology, 137, 871, 10.1017/S003118200999148X Devine, 2010, Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica, Parasitol. Res., 106, 1351, 10.1007/s00436-010-1806-1 Devine, 2010, Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole, Parasitol. Res., 107, 337, 10.1007/s00436-010-1866-2 Devine, 2011, Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica, Parasitology, 138, 224, 10.1017/S0031182010001125 Devine, 2011, Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole, Vet. Parasitol., 177, 305, 10.1016/j.vetpar.2010.12.002 Devine, 2011, Erratum to: inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica, Parasitol. Res., 109, 1209, 10.1007/s00436-011-2554-6 Devine, 2012, Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole, Vet. Parasitol., 184, 37, 10.1016/j.vetpar.2011.08.006 Ding, 2011, Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets, Trends Parasitol., 27, 73, 10.1016/j.pt.2010.11.006 Dorléans, 2009, Variations in the colchicine-binding domain provide an insight into the structural switch of tubulin, Proc. Natl. Acad. Sci. U.S.A., 106, 10.1073/pnas.0904223106 Dupuy, 2010, Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells, Chem. Biol. Interact., 186, 280, 10.1016/j.cbi.2010.05.013 Duthaler, 2010, In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78, Antimicrob. Agents Chemother., 54, 4596, 10.1128/AAC.00828-10 Edwards, 2015, The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica, PLoS Negl. Trop. Dis., 9, 10.1371/journal.pntd.0003604 Elitok, 2006, Field trial on comparative efficacy of four fasciolicides against natural liver fluke infection in cattle, Vet. Parasitol., 135, 279, 10.1016/j.vetpar.2005.10.008 Elliott, 2014, The T687G SNP in a P-glycoprotein gene of Fasciola hepatica is not associated with resistance to triclabendazole in two resistant Australian populations, Mol. Biochem. Parasitol., 198, 45, 10.1016/j.molbiopara.2014.11.006 Elliott, 2015, High prevalence of fasciolosis and evaluation of drug efficacy against Fasciola hepatica in dairy cattle in the Maffra and Bairnsdale districts of Gippland, Victoria, Australia, Vet. Parasitol., 209, 117, 10.1016/j.vetpar.2015.02.014 Fairweather, 2004, Signalling mechanisms in platyhelminths, 141 Fairweather, 2005, Triclabendazole: new skills to unravel an old(ish) enigma, J. Helminthol., 79, 227, 10.1079/JOH2005298 Fairweather, 2009, Triclabendazole progress report, 2005-2009: an advancement of learning?, J. Helminthol., 83, 139, 10.1017/S0022149X09321173 Fairweather, 2011, Liver fluke isolates: a question of provenance, Vet. Parasitol., 176, 1, 10.1016/j.vetpar.2010.12.011 Fairweather, 2011, Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?, Vet. Parasitol., 180, 133, 10.1016/j.vetpar.2011.05.034 Fairweather, 2011, Raising the bar on reporting “triclabendazole resistance”, Vet. Rec., 168, 514, 10.1136/vr.d2867 Fairweather, 1999, Fasciolicides: efficacy, actions, resistance and its management, Vet. J., 158, 81, 10.1053/tvjl.1999.0377 Fairweather, 1999, Development of Fasciola hepatica in the mammalian host, 47 Fairweather, 2012, Development of an in vitro egg hatch assay for the diagnosis of triclabendazole resistance in Fasciola hepatica: proof of concept, Vet. Parasitol., 183, 249, 10.1016/j.vetpar.2011.07.023 Fanke, 2017, Economic assessment of Ostertgia ostertagi and Fasciola hepatica infections in dairy cattle herds in Germany using Paracalc®, Vet. Parasitol., 240, 39, 10.1016/j.vetpar.2017.03.018 Favennec, 2003, Double-blind, randomized, placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from Northern Peru, Aliment. Pharm. Ther, 17, 265, 10.1046/j.1365-2036.2003.01419.x Fennell, 2008, Microtubules as antiparasitic drug targets, Expert Opin. Drug Dis., 3, 501, 10.1517/17460441.3.5.501 Fernández, 2014, Differential activities of glutathione S-transferase isoenzymes in strains of Fasciola hepatica susceptible and resistant to triclabendazole, Am. J. Anim. Vet. Sci., 9, 177, 10.3844/ajavsp.2014.177.181 Fernández, 2015, A multienzyme response is involved in the phenomenon of Fasciola hepatica resistance to triclabendazole, J. Drug Metab. Toxicol., 6, 192 Fernández, 2015, A single amino acid substitution in isozyme GST mu in triclabendazole resistant Fasciola hepatica (Sligo strain) can substantially influence the manifestation of anthelmintic resistance, Exp. Parasitol., 159, 274, 10.1016/j.exppara.2015.10.007 Ferraro, 2016, Identification of chalcones as Fasciola hepatica cathepsin L inhibitors using a comprehensive experimental and computational approach, PLoS Negl. Trop. Dis., 10, 10.1371/journal.pntd.0004834 Flanagan, 2010 Flanagan, 2011, Standardisation of a coproantigen reduction test (CRT) protocol for the diagnosis of resistance to triclabendazole in Fasciola hepatica, Vet. Parasitol., 176, 34, 10.1016/j.vetpar.2010.10.037 Flanagan, 2011, Comparison of two assays, a faecal egg count reduction test (FECRT) and a coproantigen reduction test (CRT), for the diagnosis of resistance to triclabendazole in Fasciola hepatica in sheep, Vet. Parasitol., 176, 170, 10.1016/j.vetpar.2010.10.057 Fletcher, 2004, The occurrence and significance of triploidy in the liver fluke, Fasciola hepatica, Parasitology, 128, 69, 10.1017/S003118200300427X Flores-Ramos, 2014, A highly water soluble benzimidazole derivative useful for the treatment of fasciolosis, Bioorg. Med. Chem. Lett, 24, 5814, 10.1016/j.bmcl.2014.10.017 Flores-Ramos, 2017, Novel triclabendazole prodrug: a highly water soluble alternative for the treatment of fasciolosis, Bioorg. Med. Chem. Lett, 27, 616, 10.1016/j.bmcl.2016.12.004 Forbes, 2013, Liver fluke control in cattle: why, when and how?, Cattle Pract., 21, 150 Forbes, 2017, Grassland management and helminth control on livestock farms, Livestock, 22, 81, 10.12968/live.2017.22.2.81 Forbes, 2017, Liver fluke infections in cattle and sheep, Livestock, 22, 250, 10.12968/live.2017.22.5.250 Forbes, 2014, No evidence for synergy between nitroxynil and triclabendazole against juvenile, 4-week-old, triclabendazole-resistant Fasciola hepatica in sheep, Int. J. Appl. Res. Vet. Med., 12, 85 Forbes, 2015, Efficacy of treatment of cattle for liver fluke at housing: influence of differences in flukicidal activity against juvenile Fasciola hepatica, Vet. Rec., 176, 333, 10.1136/vr.102720 French, 2016, Prevalence of liver fluke (Fasciola hepatica) in wild red deer (Cervus elaphus): coproantigen ELISA is a practicable alternative to faecal egg counting for surveillance in remote populations, PLoS One, 11, 10.1371/journal.pone.0162420 Fuchs, 2013, Differential expression of liver fluke β–tubulin isotypes at selected life cycle stages, Int. J. Parasitol., 43, 1133, 10.1016/j.ijpara.2013.08.007 Furmaga, 1982, Systamex in the treatment of parasitoses of sheep, Med. Weter., 38, 269 Gaasenbeek, 2001, An experimental study on triclabendazole resistance of Fasciola hepatica in sheep, Vet. Parasitol., 95, 37, 10.1016/S0304-4017(00)00413-1 Geary, 2003, Development of antiparasitic drugs in the 21st century, Vet. Parasitol., 115, 167, 10.1016/S0304-4017(03)00205-X Geary, 2012, World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline: anthelmintic combination products targeting nematode infections of ruminants and horses, Vet. Parasitol., 190, 306, 10.1016/j.vetpar.2012.09.004 Geary, 2015, Anthelmintic drug discovery: into the future, J. Parasitol., 101, 125, 10.1645/14-703.1 George, 2017, Application of a coproantigen ELISA as an indicator of efficacy against multiple life stages of Fasciola hepatica infections in sheep, Vet. Parasitol., 246, 60, 10.1016/j.vetpar.2017.08.028 George, 2019, Comparative assessment of faecal diagnostics for detection and predictive modelling of endemic Fasciola hepatica in sheep and cattle on Australian farms, Vet. Parasitol. X, 1, 100001, 10.1016/j.vpoa.2018.100001 Geurden, 2012, Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle, Vet. Parasitol., 189, 227, 10.1016/j.vetpar.2012.04.019 Gherbawy, 2013, The anti-fasciolasis properties of silver nanoparticles produced by Trichoderma harzianum and their improvement of the anti-fasciolasis drug triclabendazole, Int. J. Mol. Sci., 14, 21887, 10.3390/ijms141121887 Ghodsian, 2019, Detection of spiked Fasciola hepatica eggs in stool specimens using LAMP technique. Iran, J. Parasitol., 14, 387 Gil, 2014, Resistant human fasciolasis. Report of four patients, Rev. Med. Chile, 142, 1330, 10.4067/S0034-98872014001000014 Gilles, 2002, Treatment of intestinal parasitic infections: a review of nitazoxanide, Trends Parasitol., 18, 95, 10.1016/S1471-4922(01)02205-X Gomez-Puerta, 2012, Short report: efficacy of a single oral dose of oxfendazole against Fasciola hepatica in naturally infected sheep, Am. J. Trop. Med. Hyg., 86, 486, 10.4269/ajtmh.2012.11-0476 Gordon, 2012, Confirmation of triclabendazole resistance in liver fluke in the UK, Vet. Rec., 171, 159, 10.1136/vr.e5381 Gordon, 2012, On farm evaluation of the coproantigen ELISA and coproantigen reduction test in Scottish sheep naturally infected with Fasciola hepatica, Vet. Parasitol., 187, 436, 10.1016/j.vetpar.2012.02.009 Gordon, 2013, Identification of the rumen fluke, Calicophoron daubneyi, in GB livestock: possible implications for liver fluke diagnosis, Vet. Parasitol., 195, 65, 10.1016/j.vetpar.2013.01.014 Gottstein, 2014, Comparative assessment of ELISAs using recombinant saposin-like protein 2 and recombinant cathepsin L-1 from Fasciola hepatica for the serodiagnosis of human fasciolosis, PLoS Negl. Trop. Dis., 8, 10.1371/journal.pntd.0002860 Gülhan, 2015, Partial hepatectomy for the resistant Fasciola hepatica infection in a child, APSP J. Case Rep., 6, 27 Guzmán-Ocampo, 2018, Effects of the protonation state of titratable residues and the presence of water molecules on nocodazole binding to β-tubulin, ChemMedChem, 13, 20, 10.1002/cmdc.201700530 Hanna, 2015, Fasciola hepatica: histology of the reproductive organs and differential effects of triclabendazole on drug-sensitive and drug-resistant fluke isolates and on flukes from selected field cases, Pathogens, 4, 431, 10.3390/pathogens4030431 Hanna, 2010, Fasciola hepatica: histological changes in the reproductive structures of triclabendazole (TCBZ)–sensitive and TCBZ-resistant flukes after treatment in vivo with TCBZ and the related benzimidazole derivative, Compound Alpha, Vet. Parasitol., 168, 240, 10.1016/j.vetpar.2009.11.014 Hanna, 2011, Fasciola hepatica: comparative effects of host resistance and parasite intra-specific interactions on size and reproductive histology in flukes from rats infected with isolates differing in triclabendazole sensitivity, Vet. Parasitol., 178, 251, 10.1016/j.vetpar.2011.01.045 Hanna, 2013, Vet. Parasitol., 191, 240, 10.1016/j.vetpar.2012.09.014 Hanna, 2015, Fasciola hepatica: a comparative survey of adult fluke resistance to triclabendazole, nitroxynil and closantel on selected upland and lowland sheep farms in Northern Ireland using faecal egg counting, coproantigen ELISA testing and fluke histology, Vet. Parasitol., 207, 34, 10.1016/j.vetpar.2014.11.016 Happich, 1969, Quantitative diagnosis of chronic fasciolosis. 2. The estimation of daily total egg production of Fasciola hepatica and the number of adult flukes in sheep by faecal egg counts, Aust. Vet. J., 45, 329, 10.1111/j.1751-0813.1969.tb05012.x Hassell, 2012, Case report: suspect lack of triclabendazole efficacy in liver fluke in sheep in the Taranaki, Proc. Soc. Sheep Beef Cattle Vet. New Zealand Vet. Assoc., 2012 Hegazi, 2018, Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs, Vet. World, 11, 215, 10.14202/vetworld.2018.215-220 Hemphill, 2006, Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections, Expert Opin. Pharmaco, 7, 953, 10.1517/14656566.7.7.953 Hien, 2008, A randomized controlled pilot study of artesunate versus triclabendazole for human fascioliasis in Central Vietnam, Am. J. Trop. Med. Hyg., 78, 388, 10.4269/ajtmh.2008.78.388 Hopkins, 1992, Homing in on helminths, Am. Trop. Med. Hyg., 46, 626, 10.4269/ajtmh.1992.46.626 Hutchinson, 2009, Efficacy of an injectable combination anthelmintic (nitroxynil + clorsulon + ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle, Vet. Parasitol., 162, 278, 10.1016/j.vetpar.2009.03.032 Ibarra-Velarde, 2018, Assessment of the effective dose of an experimental intramuscular formulation against immature and adult Fasciola hepatica in sheep, Vet. Parasitol., 260, 38, 10.1016/j.vetpar.2018.04.012 Iqbal, 2003, Herbal dewormers in livestock – a traditional therapy, Int. J. Agric. Biol., 2, 199 Jones, 2018, Detection of Galba truncatula, Fasciola hepatica and Calicophoron daubneyi environmental DNA within water sources on pasture land, a future tool for fluke control?, Parasit. Vectors, 11, 342, 10.1186/s13071-018-2928-z Juhásová, 2016, Population structure and dispersal routes of an invasive parasite, Fascioloides magna, in North America and Europe, Parasit. Vectors, 9, 57, 10.1186/s13071-016-1811-z Kabil, 2000, An open-label clinical study of nitazoxanide in the treatment of human fascioliasis, Curr. Ther. Res., 61, 339, 10.1016/S0011-393X(00)80003-X Kajugu, 2012, Specificity of a coproantigen ELISA test for fasciolosis: lack of cross-reactivity with Paramphistomum cervi and Taenia hydatigena, Vet. Rec., 171, 502, 10.1136/vr.101041 Kajugu, 2015, Fasciola hepatica: specificity of a coproantigen ELISA test for diagnosis of fasciolosis in faecal samples from cattle and sheep concurrently infected with gastrointestinal nematodes, coccidians and/or rumen flukes (paramphistomes), under field conditions, Vet. Parasitol., 212, 181, 10.1016/j.vetpar.2015.07.018 Kamaludeen, 2019, Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales, Vet. Rec., 184, 502, 10.1136/vr.105209 Kaplan, 2002, Anthelmintic resistance in nematodes of horses, Vet. Res., 33, 491, 10.1051/vetres:2002035 Kayser, 2003, Natural products as antiparasitic drugs, Parasitol. Res., 90, S55, 10.1007/s00436-002-0768-3 Keiser, 2005, Emerging foodborne trematodiasis, Emerg. Infect. Dis., 11, 1503, 10.3201/eid1110.050614 Keiser, 2009, Food-Borne trematodiases, Clin. Microbiol. Rev., 22, 466, 10.1128/CMR.00012-09 Keiser, 2012, Antimalarials in the treatment of schistosomiasis, Curr. Pharm. Des., 18, 3531 Keiser, 2006, The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica, J. Antimicrob. Chemother., 58, 1193, 10.1093/jac/dkl408 Keiser, 2006, Artesunate and artemether are effective fasciolicides in the rat model and in vitro, J. Antimicrob. Chemother., 57, 1139, 10.1093/jac/dkl125 Keiser, 2007, Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica, Trans. R. Soc. Trop. Med. Hyg., 101, 1219, 10.1016/j.trstmh.2007.07.012 Keiser, 2007, Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini, Antimicrob. Agents Chemother., 51, 1096, 10.1128/AAC.01366-06 Keiser, 2008, Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep, Parasitol. Res., 103, 517, 10.1007/s00436-008-0998-0 Keiser, 2010, Efficacy, safety and pharmacokinetics of 1,2,4-trioxalane OZ78 against an experimental infection with Fasciola hepatica in sheep, Vet. Parasitol., 173, 228, 10.1016/j.vetpar.2010.06.031 Keiser, 2010, Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep, Res. Vet. Sci., 88, 107, 10.1016/j.rvsc.2009.05.007 Keiser, 2011, Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials, PLoS Negl. Trop. Dis., 5, e1285, 10.1371/journal.pntd.0001285 Kelley, 2016, Current threat of triclabendazole resistance in Fasciola hepatica, Trends Parasitol., 32, 458, 10.1016/j.pt.2016.03.002 Keyyu, 2008, Comparative efficacy of anthelmintics against Fasciola gigantica and amphistomes in naturally infected cattle in Kilolo District, Tanzania, Tanz. Vet. J., 25, 40, 10.4314/tvj.v25i1.42027 Khan, 2013, The global burden of fasciolosis in domestic animals with an outlook on the contribution of new approaches for diagnosis and control, Parasitol. Res., 112, 2421, 10.1007/s00436-013-3464-6 Khan, 2017, Comparative efficacy of six anthelmintic treatments against natural infection of Fasciola species in sheep, Pak. Vet. J., 37, 65 Kirchofer, 2011, Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni, Acta Trop., 118, 56, 10.1016/j.actatropica.2011.02.003 Knubben-Schweizer, 2015, Bovine fasciolosis: control strategies based on the location of Galba truncatula habitats on farms, Vet. Parasitol., 208, 77, 10.1016/j.vetpar.2014.12.019 Knubben-Schweizer, 2010, Control of bovine fasciolosis in dairy cattle in Switzerland with emphasis on pasture management, Vet. J., 186, 188, 10.1016/j.tvjl.2009.08.003 Kotze, 2014, Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions, Int. J. Parasitol. Drugs Drug Resist., 4, 164, 10.1016/j.ijpddr.2014.07.007 Lam, 2018, Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis, Pharmacol. Res., 133, 77, 10.1016/j.phrs.2018.04.025 Lanusse, 2015, Basic and clinical pharmacology contributing to extend anthelmintic molecules lifespan, Vet. Parasitol., 212, 35, 10.1016/j.vetpar.2015.07.015 Lanusse, 2018, Strategies to optimize the efficacy of anthelmintic drugs in ruminants, Trends Parasitol., 34, 664, 10.1016/j.pt.2018.05.005 Lee, 2013, The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae, PLoS One, 8 Lifschitz, 2009, Combined use of ivermectin and triclabendazole in sheep: in vitro and in vivo characterisation of their pharmacological interaction, Vet. J., 182, 261, 10.1016/j.tvjl.2008.06.001 Lorsuwannarat, 2014, The in vitro anthelmintic effects of plumbagin on newly excysted and 4-weeks-old juvenile parasites of Fasciola gigantica, Exp. Parasitol., 136, 5, 10.1016/j.exppara.2013.10.004 McConville, 2009, An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica, Vet. Parasitol., 162, 75, 10.1016/j.vetpar.2009.02.004 McConville, 2012, Impact of compound alpha treatment in vivo on egg production by the liver fluke, Fasciola hepatica, Vet. Parasitol., 187, 183, 10.1016/j.vetpar.2011.12.028 McCoy, 2005, The efficacy of nitroxynil and triclabendazole administered synchronously against juvenile triclabendazole-resistant Fasciola hepatica in sheep, Res. Vet. Sci., 78, 33 McKinstry, 2009, Morphological response of triclabendazole-susceptible and triclabendazole-resistant isolates of Fasciola hepatica to treatment in vitro with nitroxynil (Trodax), Parasitol. Res., 104, 645, 10.1007/s00436-008-1241-8 McMahon, 2016, Liver fluke control on sheep farms in Northern Ireland: a survey of changing management practices in relation to disease prevalence and perceived triclabendazole resistance, Vet. Parasitol., 216, 72, 10.1016/j.vetpar.2015.11.018 MacGillivray, 2013, An abattoir survey to determine the population profile in the autumn of Fasciola hepatica in condemned bovine livers from Ireland and the United Kingdom, Int. J. Appl. Res. Vet. Med, 11, 1 Mahlau, 1970, Liver fluke survey in zebu cattle of Iringa region, Tanzania and first finding of the small fluke Dicrocoelium hospes Looss, Bull. Epizoot. Dis. Afr., 18, 21 Malik, 2017, Phenotyping of amphistomes, and pathological, haematological and bile biochemical response to Gigantocotyle explanatum infection in buffaloes, Pak. J. Zool., 49, 979, 10.17582/journal.pjz/2017.49.3.979.987 Mamani, 2009, Anthelmintic resistance (Fasciola hepatica) in sheep against albendazole and triclabendazole, La Paz-Bolivia, Rev. Inv. Vet. Peru, 20, 254 Martin, 2009, Efficacy against Fasciola hepatica and the pharmacokinetics of triclabendazole administered by oral and topical routes, Aust. Vet. J., 87, 200, 10.1111/j.1751-0813.2009.00425.x Martínez-Pérez, 2012, Comparison of three different techniques to diagnose Fasciola hepatica infection in experimentally and naturally infected sheep, Vet. Parasitol., 190, 80, 10.1016/j.vetpar.2012.06.002 Martínez-Sernández, 2011, Development and evaluation of a new lateral flow immunoassay for serodiagnosis of human fasciolosis, PLoS Negl. Trop. Dis., 5, e1376, 10.1371/journal.pntd.0001376 Martínez-Sernández, 2016, Rapid enhanced MM3-COPRO ELISA for detection of Fasciola coproantigen, PLoS Negl. Trop. Dis., 10, 10.1371/journal.pntd.0004872 Martínez-Valladares, 2016, Loop-mediated isothermal amplification (LAMP) assay for the diagnosis of fasciolosis in sheep and its application under field conditions, Parasit. Vectors, 9, 73, 10.1186/s13071-016-1355-2 Martínez-Valladares, 2014, Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon, Exp. Parasitol., 136, 59, 10.1016/j.exppara.2013.10.010 Martínez-Valladares, 2010, Efficacy of nitroxynil against Fasciola hepatica resistant to triclabendazole in a naturally infected sheep flock, Parasitol. Res., 107, 1205, 10.1007/s00436-010-1989-5 Mas-Coma, 2014, Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario, Parasitology, 141, 1918, 10.1017/S0031182014000869 Massarotti, 2012, The tubulin colchicine domain: a molecular modelling perspective, ChemMedChem, 7, 33, 10.1002/cmdc.201100361 Mazeri, 2016, Evaluation of the performance of 5 diagnostic tests for Fasciola hepatica infection in naturally infected cattle using a Bayesian no gold standard approach, PLoS One, 11, 10.1371/journal.pone.0161621 Meaney, 2006, Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke, Parasitol. Res., 99, 609, 10.1007/s00436-006-0222-z Meaney, 2007, Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke, Parasitol. Res., 100, 1091, 10.1007/s00436-006-0378-6 Meaney, 2013, Increased susceptibility of a triclabendazole (TCBZ)-resistant isolate of Fasciola hepatica to TCBZ following co-incubation in vitro with the P-glycoprotein inhibitor, R(+)-verapamil, Parasitology, 140, 1287, 10.1017/S0031182013000759 Mehmood, 2017, A review on epidemiology, global prevalence and economic losses of fasciolosis in ruminants, Microb. Pathogenesis, 109, 253, 10.1016/j.micpath.2017.06.006 Meister, 2013, Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep, Vet. Parasitol., 198, 102, 10.1016/j.vetpar.2013.08.007 Mezo, 2004, An ultrasensitive capture ELISA for detection of Fasciola hepatica coproantigens in sheep and cattle using a new monoclonal antibody (MM3), J. Parasitol., 90, 845, 10.1645/GE-192R Miller, 1994, Glutathione S-transferases as markers of salicylanilide resistance in isolates of Fasciola hepatica, Int. J. Parasitol., 24, 533, 10.1016/0020-7519(94)90145-7 Mitchell, 1998, Triclabendazole-resistant liver fluke in Scottish sheep, Vet. Rec., 143, 399 Molina-Hernández, 2015, Fasciola hepatica vaccine: we may not be there yet but we’re on the right road, Vet. Parasitol., 208, 101, 10.1016/j.vetpar.2015.01.004 Moll, 2000, Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The Netherlands, Vet. Parasitol., 91, 153, 10.1016/S0304-4017(00)00267-3 Mooney, 2009, The comparative efficacy of four anthelmintics against a natural acquired Fasciola hepatica infection in hill sheep flock in the west of Ireland, Vet. Parasitol., 164, 201, 10.1016/j.vetpar.2009.05.017 Mordvinov, 2017, ABC transporters in the liver fluke Opisthorchis felineus, Mol. Biochem. Parasitol., 216, 60, 10.1016/j.molbiopara.2017.07.001 Mordvinov, 2017, Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus, Int. J. Antimicrob. Ag., 50, 97, 10.1016/j.ijantimicag.2017.01.037 Moreno, 2014, Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep, Exp. Parasitol., 136, 14, 10.1016/j.exppara.2013.10.014 Mottier, 2006, Resistance-induced changes in triclabendazole transport in Fasciola hepatica: ivermectin reversal effect, J. Parasitol., 92, 1355, 10.1645/GE-922R.1 Muiño, 2011, Molecular and immunological characterization of Fasciola antigens recognized by the MM3 monoclonal antibody, Mol. Biochem. Parasitol., 179, 80, 10.1016/j.molbiopara.2011.06.003 Mungube, 2006, The prevalence and economic significance of Fasciola gigantica and Stilesia hepatica in slaughtered animals in the semi-arid coastal Kenya, Trop. Anim. Health Prod., 38, 475, 10.1007/s11250-006-4394-4 Ndjonka, 2013, Natural products as a source for treating neglected parasitic diseases, Int. J. Mol. Sci., 14, 3395, 10.3390/ijms14023395 Novobilský, 2015, First report of closantel treatment failure against Fasciola hepatica in cattle, Int. J. Parasitol. Drugs Drug Resist., 5, 172, 10.1016/j.ijpddr.2015.07.003 Novobilský, 2012, The field evaluation of albendazole and triclabendazole efficacy against Fasciola hepatica by coproantigen ELISA in naturally infected sheep, Vet. Parasitol., 190, 272, 10.1016/j.vetpar.2012.06.022 Novobilský, 2016, Assessment of flukicide efficacy against Fasciola hepatica in sheep in Sweden in the absence of a standardised test, Int. J. Parasitol. Drugs Drug Resist., 6, 141, 10.1016/j.ijpddr.2016.06.004 Nwofor, 2018, Inhibitory activities of ethanol extracts of two macrofungi against eggs and miracidia of Fasciola spp, Open Life Sci., 13, 504, 10.1515/biol-2018-0060 Nyindo, 2015, Fascioliasis: an ongoing zoonotic trematode infection, BioMed Res. Int., 2015, 8, 10.1155/2015/786195 Nzalawahe, 2018, Evaluating the effectiveness of trematocides against Fasciola gigantica and amphistomes infections in cattle, using faecal egg count reduction tests in Iringa Rural and Arumeru Districts, Tanzania, Parasit. Vectors, 11, 384, 10.1186/s13071-018-2965-7 Olaechea, 2011, Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina), Vet. Parasitol., 178, 364, 10.1016/j.vetpar.2010.12.047 Oliveira, 2008, Triclabendazole resistance involving Fasciola hepatica in sheep and goats during an outbreak in Almirante Tamandare, Paraná, Brazil, Brazil J. Vet. Parasitol., 17, 149 O'Neill, 2015, A comparative study on the impact of two artemisinin derivatives, artemether and artesunate, on the female reproductive system of Fasciola hepatica, Vet. Parasitol., 211, 182, 10.1016/j.vetpar.2015.05.027 Ortiz, 2013, Resistance of Fasciola hepatica against triclabendazole in cattle in Cajamarca (Peru): a clinical trial and an in vivo efficacy test in sheep, Vet. Parasitol., 195, 118, 10.1016/j.vetpar.2013.01.001 Ortiz, 2014, Oxfendazole flukicidal activity in pigs, Acta Trop., 136, 10, 10.1016/j.actatropica.2014.03.024 Otranto, 2002, A review of dicrocoeliosis of ruminants including recent advances in the diagnosis and treatment, Vet. Parasitol., 107, 317, 10.1016/S0304-4017(02)00121-8 Overend, 1995, Resistance of Fasciola hepatica to triclabendazole, Aust. Vet. J., 72, 275, 10.1111/j.1751-0813.1995.tb03546.x Pakharukova, 2012, Cytochrome P450 in fluke Opisthorchis felineus: identification and characterisation, Mol. Biochem. Parasitol., 181, 190, 10.1016/j.molbiopara.2011.11.005 Pakharukova, 2015, Functional analysis of the unique cytochrome P450 of the liver fluke Opisthorchis felineus, PLoS Negl. Trop. Dis., 9, 10.1371/journal.pntd.0004258 Pakharukova, 2018, Effects of miconazole/clotrimazole and praziquantel combinations against the liver fluke Opisthorchis felineus in vivo and in vitro, Parasitol. Res., 117, 2327, 10.1007/s00436-018-5895-6 Pakharukova, 2019, A study of tribendimidine effects in vitro and in vivo on the liver fluke Opisthorchis felineus, Parasit. Vectors, 12, 23, 10.1186/s13071-019-3288-z Palmer, 2014, Evaluation of a copro-antigen ELISA to detect Fasciola hepatica infection in sheep, cattle and horses, Aust. Vet. J., 92, 357, 10.1111/avj.12224 Panic, 2014, Repurposing drugs for the treatment and control of helminth infections, Int. J. Parasitol. Drugs Drug Resist., 4, 185, 10.1016/j.ijpddr.2014.07.002 Paredes, 2018, Albendazole nanocrystals with improved pharmacokinetic performance in mice, Ther. Deliv., 9, 89, 10.4155/tde-2017-0090 Paredes, 2018, A nanocrystal-based formulation improves the pharmacokinetic performance and therapeutic response of albendazole in dogs, J. Pharm. Pharmacol., 70, 51, 10.1111/jphp.12834 Pensel, 2018, Albendazole nanocrystals in experimental alveolar echinococcosis: enhanced chemoprophylactic and clinical efficacy in infected mice, Vet. Parasitol., 251, 78, 10.1016/j.vetpar.2017.12.022 Pereira, 2016, Anti-helminthic activity of Momordica charantia L. against Fasciola hepatica eggs after twelve days of incubation in vitro, Vet. Parasitol., 228, 160, 10.1016/j.vetpar.2016.08.025 Prichard, 1980, The problem of anthelmintic resistance in nematodes, Aust. Vet. J., 56, 239, 10.1111/j.1751-0813.1980.tb15983.x Prueksapanich, 2018, Liver fluke-associated biliary tract cancer, Gut Liver, 12, 236, 10.5009/gnl17102 Qian, 2013, Efficacy and safety of tribendimidine against Clonorchis sinensis, Clin. Infect. Dis., 56, E76, 10.1093/cid/cis1011 Radio, 2018, Pleiotropic alterations in gene expression in Latin American Fasciola hepatica with different susceptibility to drugs, Parasit. Vectors, 11, 56, 10.1186/s13071-017-2553-2 Ramadan, 2019, Evaluation of nitazoxanide treatment following triclabendazole failure in an outbreak of human fascioliasis in Upper Egypt, PLoS Negl. Trop. Dis., 13, 10.1371/journal.pntd.0007779 Ranjan, 2017, Exploration of interaction zones of β-tubulin colchicine binding domain of helminths and binding mechanism of anthelmintics, Comput. Biol. Chem., 68, 78, 10.1016/j.compbiolchem.2017.02.008 Rapic, 1988, Comparative efficacy of triclabendazole, nitroxynil and rafoxanide against immature and mature Fasciola hepatica in naturally infected cattle, Vet. Rec., 122, 59, 10.1136/vr.122.3.59 Rathinasamy, 2018, Development of a multiplex quantitative PCR assay for detection and quantification of DNA from Fasciola hepatica and the intermediate snail host, Austropeplea tomentosa, in water samples, Vet. Parasitol., 259, 17, 10.1016/j.vetpar.2018.06.018 Ravelli, 2004, Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain, Nature, 428, 198, 10.1038/nature02393 Real, 2018, Chitosan-based nanodelivery systems applied to the development of novel triclabendazole formulations, PLoS One, 13, 10.1371/journal.pone.0207625 Real, 2018, Solving the delivery problems of triclabendazole using cyclodextrins, AAPS PharmSciTech, 19, 2311, 10.1208/s12249-018-1057-5 Rim, 1994, Food-borne trematodes: ignored or emerging?, Parasitol. Today, 10, 207, 10.1016/0169-4758(94)90111-2 Rinaldi, 2015, Sheep and Fasciola hepatica in Europe: the GLOWORM experience, Geospat. Health, 9, 309, 10.4081/gh.2015.353 Rivero, 2015, Accidental and experimental Closantel intoxication in Uruguayan sheep, Pesqui. Vet. Brasil, 35, 599, 10.1590/S0100-736X2015000700001 Robinson, 2001, Characterisation of a β-tubulin gene from the liver fluke, Fasciola hepatica, Int. J. Parasitol., 31, 1264, 10.1016/S0020-7519(01)00240-5 Robinson, 2002, Triclabendazole-resistant Fasciola hepatica: β-tubulin and response to in vitro treatment with triclabendazole, Parasitology, 124, 325, 10.1017/S003118200100124X Robinson, 2004, The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica, Parasitol. Res., 92, 205, 10.1007/s00436-003-1003-6 Robinson, 2004, A possible model of benzimidazole binding to β-tubulin disclosed by invoking an inter-domain movement, J. Mol. Graph. Model., 23, 275, 10.1016/j.jmgm.2004.08.001 Robinson, 2008, Helminth pathogen cathepsin proteases: it’s a family affair, Trends Biochem. Sci., 33, 601, 10.1016/j.tibs.2008.09.001 Robinson, 2008, Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica, Mol. Cell. Proteom., 7, 1111, 10.1074/mcp.M700560-MCP200 Robinson, 2009, An integrated transcriptomic and proteomic analysis of the secretome of the helminth pathogen, Fasciola hepatica: proteins associated with invasion and infection of the mammalian host, Mol. Cell. Proteom., 8, 1891, 10.1074/mcp.M900045-MCP200 Robles-Pérez, 2013, The diagnosis of fasciolosis in faeces of sheep by means of a PCR and its application in the detection of anthelmintic resistance in sheep flocks naturally infected, Vet. Parasitol., 197, 277, 10.1016/j.vetpar.2013.05.006 Robles-Pérez, 2014, Development of an egg hatch assay for the detection of anthelmintic resistance to albendazole in Fasciola hepatica isolated from sheep, Vet. Parasitol., 203, 217, 10.1016/j.vetpar.2013.11.020 Robles-Pérez, 2015, Screening anthelmintic resistance to triclabendazole in Fasciola hepatica isolated from sheep by means of an egg hatch assay, BMC Vet. Res., 11, 226, 10.1186/s12917-015-0543-1 Rojas, 2014, Techniques for the diagnosis of Fasciola infections in animals: room for improvement, Adv. Parasit., 85, 65, 10.1016/B978-0-12-800182-0.00002-7 Rojas, 2012, Resistance of Fasciola hepatica to triclabendazole in cattle of the Cajamarca countryside, Rev. Vet. Argentina, 7, 71 Rojas-Campos, 2019, Effectiveness of the experimental Fosfatriclaben in comparison with two commercial fasciolicides in cattle, Pharmacol. Pharm., 10, 498, 10.4236/pp.2019.1011041 Romero, 2019, Flukicide efficacy against Fasciola hepatica of triclabendazole and nitroxynil in cattle of the central valley of Chile, Brazil J. Vet. Parasitol., 28, 164, 10.1590/s1984-296120180089 Rossignol, 1998, Successful treatment of human fascioliasis with nitazoxanide, Trans. R. Soc. Trop. Med. Hyg., 92, 103, 10.1016/S0035-9203(98)90974-9 Ryan, 2008, Fasciola hepatica expresses multiple α- and β-tubulin isotypes, Mol. Biochem. Parasitol., 159, 73, 10.1016/j.molbiopara.2008.02.001 Sabourin, 2018, Impact of human activities on fasciolosis transmission, Trends Parasitol., 34, 891, 10.1016/j.pt.2018.08.004 Sanabria, 2013, Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole, Vet. Parasitol., 193, 105, 10.1016/j.vetpar.2012.11.033 Sargison, 2011, Diagnosis and economic consequences of triclabendazole resistance in Fasciola hepatica in a sheep flock in south-east Scotland, Vet. Rec., 168, 159, 10.1136/vr.c5332 Sariözkan, 2011, Estimating the total cost of bovine fasciolosis in Turkey, Ann. Trop. Med. Parasit., 105, 439, 10.1179/1364859411Y.0000000031 Savage, 2013, Effect of the P-glycoprotein inhibitor, R(+)-verapamil on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica, Vet. Parasitol., 195, 72, 10.1016/j.vetpar.2013.03.007 Savage, 2013, Increased action of triclabendazole (TCBZ) in vitro against a TCBZ-resistant isolate of Fasciola hepatica following its co-incubation with the P-glycoprotein inhibitor, R(+)-verapamil, Exp. Parasitol., 135, 642, 10.1016/j.exppara.2013.09.015 Savage, 2014, Disruption of vitellogenesis and spermatogenesis by triclabendazole (TCBZ) in a TCBZ-resistant isolate of Fasciola hepatica following incubation in vitro with a P-glycoprotein inhibitor, Parasitology, 141, 1064, 10.1017/S0031182014000377 Sayasone, 2016, Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomized, parallel-group , single-blind, dose-ranging, phase 2 trials, Lancet Infect. Dis., 16, 1145, 10.1016/S1473-3099(16)30198-0 Sayasone, 2018, Efficacy and safety of tribendimidine versus praziquantel against Opisthorchis viverrini in Laos: an open-label, randomized, non-inferiority, phase 2 trial, Lancet Infect. Dis., 18, 155, 10.1016/S1473-3099(17)30624-2 Scarcella, 2012, Expression differential of microsomal and cytosolic glutathione-S-transferases in Fasciola hepatica resistant at triclabendazole, Mol. Biochem. Parasitol., 181, 37, 10.1016/j.molbiopara.2011.09.011 Schweizer, 2005, Estimating the financial losses due to bovine fasciolosis in Switzerland, Vet. Rec., 157, 188, 10.1136/vr.157.7.188 Shokier, 2013, Efficacy of five anthelmintics against a natural Fasciola species infection in cattle, Beni-Suef Univ. J. Basic Appl. Sci., 2, 41, 10.1016/j.bjbas.2013.09.006 Shukla, 2018, Identification of novel natural inhibitors of Opisthorchis felineus cytochrome P450 using structure-based screening and molecular dynamic simulation, J. Biomol. Struct. Dyn., 36, 3541, 10.1080/07391102.2017.1392897 Simonazzi, 2018, Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior, Ther. Deliv., 9, 623, 10.4155/tde-2018-0037 Sithithaworn, 2012, The current status of opisthorchiasis and clonorchiasis in the Mekong Basin, Parasitol. Int., 61, S10, 10.1016/j.parint.2011.08.014 Smooker, 2010, Cathepsin B proteases of flukes: the key to facilitating parasite control?, Trends Parasitol., 26, 506, 10.1016/j.pt.2010.06.001 Solana, 2016, In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs, Exp. Parasitol., 160, 49, 10.1016/j.exppara.2015.10.010 Solana, 2018, Different SNPs in Fasciola hepatica P-glycoprotein from diverse Latin American populations are not associated with triclabendazole resistance, Mol. Biochem. Parasitol., 224, 57, 10.1016/j.molbiopara.2018.07.005 Soukhathammavong, 2011, Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomized, exploratory, open-label, phase 2 trial, Lancet Infect. Dis., 11, 110, 10.1016/S1473-3099(10)70250-4 Statham, 2015, Control of liver fluke: an emerging issue in terms of veterinary residues, Vet. Rec., 177, 519, 10.1136/vr.h6287 Tagboto, 2001, Antiparasitic properties of medicinal plants and other naturally occurring products, Adv. Parasit., 50, 198 Thomas, 2018, The mechanism of action of praziquantel: six hypotheses, Curr. Top. Med. Chem., 18, 1606, 10.2174/1568026618666181029143214 Thomas, 2000, Triclabendazole-resistant Fasciola hepatica in South-west Wales, Vet. Rec., 146, 200 Toet, 2014, Liver fluke vaccines in ruminants: strategies, progress and future opportunities, Int. J. Parasitol., 44, 915, 10.1016/j.ijpara.2014.07.011 Toner, 2011, Disruption of egg formation by Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host, Vet. Parasitol., 177, 79, 10.1016/j.vetpar.2010.11.032 Toutain, 2012, Should licking behavior be considered in the bioavailability evaluation of transdermal products?, J. Vet. Pharmacol. Ther., 35, 39, 10.1111/j.1365-2885.2012.01380.x Utzinger, 2007, Artemisinins for schistosomiasis and beyond, Curr. Opin. Investig. Drugs, 8, 109 Vale, 2017, Praziquantel for schistosomiasis: single-drug metabolism revisited, mode of action, and resistance, Antimicrob. Agents Chemother., 61, 10.1128/AAC.02582-16 Valero, 2009, MM3-ELISA evaluation of coproantigen release and serum antibody production in sheep experimentally infected with Fasciola hepatica and F. gigantica, Vet. Parasitol., 159, 77, 10.1016/j.vetpar.2008.10.014 Valero, 2012, Field evaluation of a coproantigen detection test for fascioliasis diagnosis and surveillance in human hyperendemic areas of Andean countries, PLoS Negl. Trop. Dis., 6, 10.1371/journal.pntd.0001812 Van der Lugt, 2007, Myelin vacuolation, optic neuropathy and retinal degeneration after closantel overdosage in sheep and in a goat, J. Comp. Pathol., 136, 87, 10.1016/j.jcpa.2006.11.007 Venturina, 2015, Evidence of Fasciola spp. resistance to albendazole, triclabendazole and bromofenofos in water buffaloes (Bubalus bubalis), Ann. Parasitol., 61, 283 Vercruysse, 2001, Treatment vs non-treatment of helminth infections in cattle: defining the threshold, Vet. Parasitol., 98, 195, 10.1016/S0304-4017(01)00431-9 Vercruysse, 2018, Control of helminth ruminant infections by 2030, Parasitology, 145, 1655, 10.1017/S003118201700227X Vidyashankar, 2012, Statistical and biological considerations in evaluating drug efficacy in equine strongyle parasites using fecal egg count data, Vet. Parasitol., 185, 45, 10.1016/j.vetpar.2011.10.011 Virkel, 2009, Inhibition of cytochrome P450 activity enhances the systemic availability of triclabendazole metabolites in sheep, J. Vet. Pharmacol. Ther., 32, 79, 10.1111/j.1365-2885.2008.01006.x Walker, 2004, Response of two isolates of Fasciola hepatica to treatment with triclabendazole in vivo and in vitro, Parasitol. Res., 94, 427, 10.1007/s00436-004-1222-5 Walker, 2007, Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep, Parasitol. Res., 101, 117, 10.1007/s00436-006-0440-4 Walker, 2011, Population dynamics of the liver fluke, Fasciola hepatica: the effect of time and spatial separation on the genetic diversity of fluke populations in The Netherlands, Parasitology, 138, 215, 10.1017/S0031182010001149 Wamae, 1998, Comparison of production losses caused by chronic Fasciola gigantica infection in yearling Friesan and Boran cattle, Trop. Anim. Health Prod., 30, 23, 10.1023/A:1005057225427 Wang, 2011, The activity of dispiro peroxides against Fasciola hepatica, Bioorg. Med. Chem. Lett, 21, 5320, 10.1016/j.bmcl.2011.07.024 Whiteland, 2018, An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side-chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni, Int. J. Parasitol. Drugs Drug Resist., 8, 465, 10.1016/j.ijpddr.2018.10.009 Wilkinson, 2012, An amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations, Mol. Biochem. Parasitol., 186, 69, 10.1016/j.molbiopara.2012.08.008 Winkelhagen, 2012, Apparent triclabendazole-resistant human Fasciola hepatica infection, The Netherlands, Emerg. Infect. Dis., 18, 1028, 10.3201/eid1806.120302 Wood, 1995, World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine), Vet. Parasitol., 58, 181, 10.1016/0304-4017(95)00806-2 Woods, 2010, Discovery of veterinary antiparasitic agents in the 21st century: a view from industry, Int. J. Parasitol., 40, 1177, 10.1016/j.ijpara.2010.04.005 Woods, 2007, Anthelmintic discovery and development in the animal health industry, Expert Opin. Drug Discov., 2, S25, 10.1517/17460441.2.S1.S25 Xiao, 2013, Advances with the Chinese anthelmintic drug tribendimidine in clinical trials and laboratory investigations, Acta Trop., 126, 115, 10.1016/j.actatropica.2013.01.009 Zhao, 2010, Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica, J. Med. Chem., 53, 4223, 10.1021/jm100226t Zumquero-Ríos, 2013, Fascioliasis and intestinal parasitoses affecting schoolchildren in Atlixo, Puebla State, Mexico: epidemiology and treatment with nitazoxanide, PLoS Negl. Trop. Dis., 7