The comparison of thyrotropin releasing hormone, luteinising hormone-releasing hormone and placebo in depressive patients using a double-blind cross-over technique
Tóm tắt
Twelve female endogenous-depressed patients, 9 unipolar and 3 bipolar, were treated in randomised order with a single injection of 600 Μg THR, 500 Μg LH-RH and placebo and rated for changes in depression scores over a 6-day period. No significant differences could be seen between the treatments although transient elevations in mood were subjectively observed. These results are discussed in relation to other reports on the therapeutic benefit of peptide hormones in psychiatry.
Tài liệu tham khảo
Benkert, O.: Presented to the 1st International Symposium on the Pharmacology of Sexual Behavior, Cagliari 1974
Burg, W. van den, Praag, H. M. van, Bos, E. R. H., Zanten, A. K. van, Piers, D. A., Doorenbos, H.: TRH as a possible quick-acting but short-lasting anti-depressant. Presented to the 5th International Congress on Psychoneuroendocrinology, Nijmegen 1974
Cassano, G. B., Castrogiovanni, P., Carrara, S., Martino, E., Loi, A. M., Ambrosino, N., Pinchera, A., Baschieri, L.: Effetti del TRH in soggetti con sindrome depressiva. Giornata Endocrinologica, Pisana 1973
Dimitrikoudi, M., Hanson-Nortz, E., Jenner, F. A.: TRH in psychoses. Lancet 1974 I, 456
Drayson, A. M.: Thyrotropin releasing hormone in cyclical psychoses. Lancet 1974 I, 312
Ehrensing, R. H., Kastin, A. J.: Melanocyte-stimulating hormone-release inhibiting hormone as an antidepressant. Arch. gen. Psychiat. 30, 63–65 (1974)
Fischer, P. A., Schneider, E., Jacobi, P., Maxion, H.: Die Wirkung von MIF beim Parkinson-Syndrom. (In press)
Hine, B., Sanghvi, I., Gershon, S.: Evaluation of thyrotropin-releasing hormone as a potential anti-depressant agent in the conscious dog. Life Sci. 13, 1789–1797 (1973)
Itil, T. M.: Summary of clinical, psychopharmacological and neurophysical studies. ECDEU II Progress Report NIMH, Washington 1973
Kastin, A. J., Ehrensing, R. H., Schalch, D. S., Anderson, M. S.: Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet 1972 II, 740–742
Kruse, H. J.: Neurotrope Wirkungen von TRH. Presented to the 15th German Pharmacological Meeting, Mainz 1974
Maggini, C., Guazzelli, M., Mauri, M., Carrara, S., Fornaro, P., Martino, E., Macchia, E., Bascheri, L.: Sleep, clinical and endocrine studies in depressive patients treated with thyrotropin releasing hormone. Presented to the 2nd European Congress on Sleep Research, Rome 1974
Obiols, J., Pujol Doménech, J., Gonzáles MonclÚs, E., Ferrer Ralduá, J., Sarró Martin, B.: Experienca clinica con thyrotropin-releasing hormone en enfermos depressivos. Med. clin. (Barcelona) 62, 52–56 (1974)
Plotnikoff, N. P.: TRH and MIF: Brain dopamine and behavior. Presented to the 5th International Congress of the Society of Psychoneuroendocrinology, Utrecht 1974
Plotnikoff, N. P., Prange, A. J., Jr., Breese, G. R., Anderson, M. S., Wilson, I. C., Lipton, M. A.: Thyrotropin-releasing hormone: Enhancement of Dopa activity in normal intact, hypophysectomised and thyroidectomised animals. Thyrotropin-releasing hormones and thyroid hormones: Dopa response and Dopa metabolism. Psychopharmacol. Bull. 9, 27–28 (1973)
Prange, A. J., Jr., Breese, G. R., Cott, J. M., Martin, B. R., Cooper, B. R., Wilson, I. C., Plotnikoff, N. P.: Thyrotropin-releasing-hormone: Antagonism of pentobarbital in rodents. Life Sci. (in press) (1974)
Prange, A. J., Jr., Lara, P. P., Wilson, I. C., Alltrop, L. B., Breese, G. R.: Effects of thyrotropin-releasing hormone in depression. Lancet 1972 II, 999–1002
Tiwary, C. M., Frias, J. L., Rosenbloom, A. L.: Response to thyrotropin in depressed patients. Lancet 1972 II, 1086
Tiwary, C. M., Rosenbloom, A. L., Robertson, M. F., Parker, J. C.: Improved behaviour of hyperkinetic children given thyrotropin-releasing hormone (TRH). Presented to the 4th International Congress of the International Society of Psychoneuroendocrinology, Berkeley, California 1973
Wilson, I. C.: Thyrotropin-releasing hormone (lopremone): Psychobiological responses of normal women. I. Subjective experiences. Arch. gen. Psychiat. 29, 15–21, 28–32 (1973a)
Wilson, I. C., Lara, P. P., Prange, A. J., Jr.: Thyrotropin-releasing hormone in schizophrenia. Lancet 1973 II, 43–44
Vis Melsen, M. J. E., van der Wiener, J. D.: Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet 1972 II, 1415