Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B
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Shepard, 2006, Hepatitis B virus infection: epidemiology and vaccination, Epidemiol Rev, 28, 112, 10.1093/epirev/mxj009
2012, EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection, J Hepatol, 57, 167, 10.1016/j.jhep.2012.02.010
Newbold, 1995, The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes, J Virol, 69, 3350, 10.1128/JVI.69.6.3350-3357.1995
Pollicino, 2006, Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones, Gastroenterology, 130, 823, 10.1053/j.gastro.2006.01.001
Levrero, 2009, Control of cccDNA function in hepatitis B virus infection, J Hepatol, 51, 581, 10.1016/j.jhep.2009.05.022
Delmas, 2002, Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro, Antimicrob Agents Chemother, 46, 425, 10.1128/AAC.46.2.425-433.2002
Zoulim, 2009, Hepatitis B virus resistance to nucleos(t)ide analogues, Gastroenterology, 137, 1593, 10.1053/j.gastro.2009.08.063
Werle-Lapostolle, 2004, Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy, Gastroenterology, 126, 1750, 10.1053/j.gastro.2004.03.018
Revill, 2013, New insights into how HBV manipulates the innate immune response to establish acute and persistent infection, Antivir Ther, 18, 1, 10.3851/IMP2542
Christen, 2007, Inhibition of alpha interferon signaling by hepatitis B virus, J Virol, 81, 159, 10.1128/JVI.01292-06
Luangsay, 2015, Early inhibition of hepatocyte innate responses by hepatitis B virus, J Hepatol, 63, 1314, 10.1016/j.jhep.2015.07.014
Wei, 1950, The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein, J Immunol, 2010, 1158
Bertoletti, 2012, Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection, Gut, 61, 1754, 10.1136/gutjnl-2011-301073
Martinot-Peignoux, 2013, Prediction of disease reactivation in asymptomatic hepatitis B e antigen-negative chronic hepatitis B patients using baseline serum measurements of HBsAg and HBV-DNA, J Clin Virol, 10.1016/j.jcv.2013.08.010
Iloeje, 2012, Natural history of chronic hepatitis B: what exactly has REVEAL revealed?, Liver Int, 32, 1333, 10.1111/j.1478-3231.2012.02805.x
Brunetto, 2010, Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers, Gastroenterology, 139, 483, 10.1053/j.gastro.2010.04.052
Moucari, 2009, Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients, Hepatology, 49, 1151, 10.1002/hep.22744
Volz, 2007, Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients, Gastroenterology, 133, 843, 10.1053/j.gastro.2007.06.057
Thompson, 2010, Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers, Hepatology, 51, 1933, 10.1002/hep.23571
Lin, 2010, Relationship between serum hepatitis B virus DNA and surface antigen with covalently closed circular DNA in HBeAg-negative patients, J Med Virol, 82, 1494, 10.1002/jmv.21863
Fisicaro, 2010, Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B, Gastroenterology, 138, 693, 10.1053/j.gastro.2009.09.052
Guidotti, 1996, Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes, Immunity, 4, 25, 10.1016/S1074-7613(00)80295-2
McClary, 2000, Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines, J Virol, 74, 2255, 10.1128/JVI.74.5.2255-2264.2000
Wieland, 2004, Genomic analysis of the host response to hepatitis B virus infection, Proc Natl Acad Sci U S A, 101, 6669, 10.1073/pnas.0401771101
Guy, 2008, Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus, J Virol, 82, 8579, 10.1128/JVI.01022-08
Fletcher, 2012, Transcriptomic analysis of the woodchuck model of chronic hepatitis B, Hepatology, 56, 820, 10.1002/hep.25730
Menne, 2015, Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B, J Hepatol, 62, 1237, 10.1016/j.jhep.2014.12.026
Lanford, 2013, GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees, Gastroenterology, 144, 1508, 10.1053/j.gastro.2013.02.003
Gane, 2015, The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection, J Hepatol, 63, 320, 10.1016/j.jhep.2015.02.037
Vanwolleghem, 2015, Re-evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells, Hepatology, 10.1002/hep.27805
Lampertico, 2015, Optimal management of hepatitis B virus infection - EASL Special Conference, J Hepatol, 63, 1238, 10.1016/j.jhep.2015.06.026
Bedossa, 1996, An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group, Hepatology, 24, 289, 10.1002/hep.510240201
Pollicino, 2011, Replicative and transcriptional activities of hepatitis B virus in patients coinfected with hepatitis B and hepatitis delta viruses, J Virol, 85, 432, 10.1128/JVI.01609-10
Hayer, 2013, HBVdb: a knowledge database for Hepatitis B Virus, Nucleic Acids Res, 41, D566, 10.1093/nar/gks1022
Jansen, 2015, An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B, Liver Int, 35, 1824, 10.1111/liv.12768
Galmozzi, 2014, Systematic review with meta-analysis: do interferon lambda 3 polymorphisms predict the outcome of interferon-therapy in hepatitis B infection?, Aliment Pharmacol Ther, 39, 569, 10.1111/apt.12631
Al-Qahtani, 2014, Genetic variation in interleukin 28B and correlation with chronic hepatitis B virus infection in Saudi Arabian patients, Liver Int, 34, e208, 10.1111/liv.12347
Karataylı, 2015, Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B, Liver Int, 35, 846, 10.1111/liv.12595
Limothai, 2015, Single nucleotide polymorphism of interferon lambda-4 gene is not associated with treatment response to pegylated interferon in thai patients with chronic hepatitis B, Asian Pac J Cancer Prev, 16, 5515, 10.7314/APJCP.2015.16.13.5515
Mason, 2005, Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection, Proc Natl Acad Sci U S A, 102, 1139, 10.1073/pnas.0409332102
Rehermann, 2015, Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections, Hepatology, 61, 712, 10.1002/hep.27323
Stacey, 2009, Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections, J Virol, 83, 3719, 10.1128/JVI.01844-08
Guidotti, 2006, Immunobiology and pathogenesis of viral hepatitis, Annu Rev Pathol, 1, 23, 10.1146/annurev.pathol.1.110304.100230
Fisicaro, 2009, Early kinetics of innate and adaptive immune responses during hepatitis B virus infection, Gut, 58, 974, 10.1136/gut.2008.163600
Hösel, 2009, Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection, Hepatology, 50, 1773, 10.1002/hep.23226
Lucifora, 2010, Control of hepatitis B virus replication by innate response of HepaRG cells, Hepatology, 51, 63, 10.1002/hep.23230
Isorce, 2015, Immune-modulators to combat hepatitis B virus infection: From IFN-α to novel investigational immunotherapeutic strategies, Antiviral Res, 122, 69, 10.1016/j.antiviral.2015.08.008
Read, 2015, Hepatitis C virus driven AXL expression suppresses the hepatic type I interferon response, PLoS One, 10, 10.1371/journal.pone.0136227
Huang, 2015, Feedback regulation of IFN-α/β signaling by Axl receptor tyrosine kinase modulates HBV immunity, Eur J Immunol, 45, 1696, 10.1002/eji.201445239
Choi, 2003, Association of hepatitis B virus polymerase with promyelocytic leukemia nuclear bodies mediated by the S100 family protein p11, Biochem Biophys Res Commun, 305, 1049, 10.1016/S0006-291X(03)00881-7
Chung, 2009, Promyelocytic leukemia nuclear bodies link the DNA damage repair pathway with hepatitis B virus replication: implications for hepatitis B virus exacerbation during chemotherapy and radiotherapy, Mol Cancer Res, 7, 1672, 10.1158/1541-7786.MCR-09-0112
Vivekanandan, 2010, Hepatitis B virus replication induces methylation of both host and viral DNA, J Virol, 84, 4321, 10.1128/JVI.02280-09
Zhu, 2010, Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis, J Viral Hepat, 17, 98, 10.1111/j.1365-2893.2009.01156.x
Park, 2007, Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein, Gastroenterology, 132, 1476, 10.1053/j.gastro.2007.01.034
Testoni, 2011, Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2, J Biol Chem, 286, 20217, 10.1074/jbc.M111.231068
Thomas, 2012, HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons, Gastroenterology, 142, 978, 10.1053/j.gastro.2011.12.055
Asselah, 2009, Gene expression and hepatitis C virus infection, Gut, 58, 846, 10.1136/gut.2008.166348
Sarasin-Filipowicz, 2008, Interferon signaling and treatment outcome in chronic hepatitis C, Proc Natl Acad Sci U S A, 105, 7034, 10.1073/pnas.0707882105
Chen, 2005, Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection, Gastroenterology, 128, 1437, 10.1053/j.gastro.2005.01.059
Asahina, 2012, Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response, Hepatology, 55, 20, 10.1002/hep.24623
Manesis, 2011, Hepatitis B surface antigen: relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B, J Hepatol, 55, 61, 10.1016/j.jhep.2010.10.027
Chen, 2002, Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection, Gastroenterology, 123, 1084, 10.1053/gast.2002.36026
Zhang, 2016, In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection, J Clin Invest, 126, 1079, 10.1172/JCI83339
Yao, 2011, Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex, J Med Virol, 83, 78, 10.1002/jmv.21949
Jiang, 2014, Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen, J Viral Hepat, 21, 860, 10.1111/jvh.12216
Visvanathan, 2007, Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein, Hepatology, 45, 102, 10.1002/hep.21482
Liu, 2013, Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes, PLoS Pathog, 9, 10.1371/journal.ppat.1003613
Belloni, 2012, IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome, J Clin Invest, 122, 529, 10.1172/JCI58847