Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
Tài liệu tham khảo
Kessler, 2003, The epidemiology of major depressive disorder: results for the National Comorbidity Survey Replication (NCS-R), JAMA, 289, 3095, 10.1001/jama.289.23.3095
Lopez, 1998, The global burden of disease, 1990–2020, Nat. Med., 4, 1241, 10.1038/3218
Pincus, 2001, The societal costs of chronic major depression, J. Clin. Psychiatry, 62, 5
Krishnan, 2008, The molecular neurobiology of depression, Nature, 455, 894, 10.1038/nature07455
Trivedi, 2006, Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice, Am. J. Psychiatry, 163, 28, 10.1176/appi.ajp.163.1.28
Duman, 1997, A molecular and cellular theory of depression, Arch. Gen. Psychiatry, 54, 597, 10.1001/archpsyc.1997.01830190015002
Berman, 2000, Antidepressant effects of ketamine in depressed patients, Biol. Psychiatry, 47, 351, 10.1016/S0006-3223(99)00230-9
Zarate, 2006, A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression, Arch. Gen. Psychiatry, 63, 856, 10.1001/archpsyc.63.8.856
Li, 2010, mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists, Science, 329, 959, 10.1126/science.1190287
Mayberg, 2009, Targeted electrode-based modulation of neural circuits for depression, J. Clin. Invest., 119, 717, 10.1172/JCI38454
Savitz, 2009, Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide, Neurosci. Biobehav. Rev., 33, 699, 10.1016/j.neubiorev.2009.01.004
Macqueen, 2008, Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder, Biol. Psychiatry, 64, 880, 10.1016/j.biopsych.2008.06.027
Sheline, 2003, Untreated depression and hippocampal volume loss, Am. J. Psychiatry, 160, 1516, 10.1176/appi.ajp.160.8.1516
Rajkowska, 2007, GABAengic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression, Neuropsychopharmacology, 32, 471, 10.1038/sj.npp.1301234
Banasr, 2007, Chronic stress decreases cell proliferation in adult cerebral cortex of rat: reversal by antidepressant treatment, Biol. Psychiatry, 62, 496, 10.1016/j.biopsych.2007.02.006
Duman, 2006, A neurotrophic model for stress-related mood disorders, Biol. Psychiatry, 59, 1116, 10.1016/j.biopsych.2006.02.013
McEwen, 2008, Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators, Eur. J. Pharmacol., 583, 174, 10.1016/j.ejphar.2007.11.071
Shansky, 2009, Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest, Brain Res., 1293, 108, 10.1016/j.brainres.2009.03.062
Roozendaal, 2009, Stress, memory and the amygdala, Nat. Rev. Neurosci., 10, 423, 10.1038/nrn2651
Sotres-Bayon, 2010, Prefrontal control of fear: more than just extinction, Curr. Opin. Neurobiol., 20, 231, 10.1016/j.conb.2010.02.005
Berton, 2006, Essential role of BDNF in the misolimbic dopamine pathway in social defeat stress, Science, 311, 868, 10.1126/science.1120972
Covington, 2009, Antidepressant actions of histone deacetylase inhibitors, J. Neurosci., 29, 11451, 10.1523/JNEUROSCI.1758-09.2009
Krishnan, 2008, AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli, Biol. Psychiatry, 64, 691, 10.1016/j.biopsych.2008.06.003
Krishnan, 2010, Linking molecules to mood: new insight into the biology of depression, Am. J. Psychiatry, 167, 1305, 10.1176/appi.ajp.2009.10030434
Lindsay, 1994, Neurotrophic factors: from molecule to man, Trends Neurosci., 17, 182, 10.1016/0166-2236(94)90099-X
Arancio, 2007, Neurotrophins, synaptic plasticity and dementia, Curr. Opin. Neurobiol., 17, 325, 10.1016/j.conb.2007.03.013
Greenberg, 2009, New insights in the biology of BDNF synthesis and release: implications in CNS function, J. Neurosci., 29, 12764, 10.1523/JNEUROSCI.3566-09.2009
Lu, 2008, BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?, Neurobiol. Learn. Mem., 89, 312, 10.1016/j.nlm.2007.08.018
Martinovich, 2008, Interaction between BDNF and serotonin: role in mood disorders, Neuropsychopharmacology, 33, 73, 10.1038/sj.npp.1301571
Minichiello, 2009, TrkB signalling pathways in LTP and learning, Nat. Rev. Neurosci., 10, 850, 10.1038/nrn2738
Akil, 2008, The fibroblast growth factor family and mood disorders, Novartis Found. Symp., 289, 94, 10.1002/9780470751251.ch8
Duman, 2009, Peripheral IGF-1 produces antidepressant-like behavior and is required for the effect of exercise, Behav. Brain Res., 198, 366, 10.1016/j.bbr.2008.11.016
Schmidt, 2011, Functional markers of depression: diagnosis, treatment and pathophysiology, Neuropsychopharmacology, 36, 2375, 10.1038/npp.2011.151
Warner-Schmidt, 2007, VEGF is an essential mediator of neurogenic and behavioral actions of antidepressants, PNAS, 104, 4647, 10.1073/pnas.0610282104
Castren, 2010, The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity, Dev. Neurobiol., 70, 289, 10.1002/dneu.20758
Schmidt, 2007, The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior, Behav. Pharmacol., 18, 391, 10.1097/FBP.0b013e3282ee2aa8
Autry, 2009, Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior, Biol. Psychiatry, 66, 84, 10.1016/j.biopsych.2009.02.007
Monteggia, 2007, Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors, Biol. Psychiatry, 61, 187, 10.1016/j.biopsych.2006.03.021
Taliaz, 2010, Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis, Mol. Psychiatry, 15, 80, 10.1038/mp.2009.67
Hoshaw, 2005, Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects, Brain Res., 1037, 204, 10.1016/j.brainres.2005.01.007
Schmidt, 2010, Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models, Neuropsychopharmacology, 35, 2378, 10.1038/npp.2010.114
Duman, 2007, Blockade of ERK produces a pro-depressive effect and blocks the behavioral actions of antidepressants, Biol. Psychiatry, 61, 661, 10.1016/j.biopsych.2006.05.047
Casey, 2009, Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development, Neuroscience, 164, 108, 10.1016/j.neuroscience.2009.03.081
Egan, 2003, The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function, Cell, 112, 257, 10.1016/S0092-8674(03)00035-7
Chiaruttini, 2009, Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation, PNAS, 106, 16481, 10.1073/pnas.0902833106
Frodl, 2006, Reduced hhippocampal vollume correlates with executive dysfunctioning in major depression, J. Psychiatry Neurosci., 31, 316
Hajek, 2011, Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis, World J. Biol. Psychiatry, 1, 10.3109/15622975.2011.580005
Tsai, 2010, Effects of BDNF polymorphisms on antidepressant action, Psychiatry Investig., 7, 236, 10.4306/pi.2010.7.4.236
Matsuo, 2009, Neuronal correlates of brain-derived neurotrophic factor Val66Met polymorphism and morphometric abnormalities in bipolar disorder, Neuropsychopharmacology, 34, 1904, 10.1038/npp.2009.23
Soliman, 2010, A genetic variant BDNF polymorphism alters extinction learning in both mouse and human, Science, 327, 863, 10.1126/science.1181886
Clasen, 2011, 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination, Genes Brain Behav., 10, 740, 10.1111/j.1601-183X.2011.00715.x
Gatt, 2009, Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety, Mol. Psychiatry, 14, 681, 10.1038/mp.2008.143
Chen, 2006, Hippocampal cell proliferation regulation by repeated stress and antidepressants, Neuroreport, 17, 863, 10.1097/01.wnr.0000221827.03222.70
Chen, 2006, Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior, Science, 314, 140, 10.1126/science.1129663
Spencer, 2010, BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function, PNAS, 107, 4395, 10.1073/pnas.0915105107
Liu, 2011, Brain-derived neurotrophic factor val66met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex, Biol. Psychiatry, 10.1016/j.biopsych.2011.09.030
Li, 2011, Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress. Exposure, Biol. Psychiatry, 69, 754, 10.1016/j.biopsych.2010.12.015
Magariños, 2010, Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons, Hippocampus, 21, 253, 10.1002/hipo.20744
Bath, 2008, Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination, J. Neurosci., 28, 2383, 10.1523/JNEUROSCI.4387-07.2008
Sairanen, 2005, Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus, J. Neurosci., 25, 1089, 10.1523/JNEUROSCI.3741-04.2005
Li, 2008, TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment, Neuron, 59, 399, 10.1016/j.neuron.2008.06.023
Einat, 2003, The role of the extracellular signal-regulated kinase signaling pathway in mood modulation, J. Neurosci., 23, 7311, 10.1523/JNEUROSCI.23-19-07311.2003
Galeotti, 2011, Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation, Int. J. Neuropsychopharmacol., 20, 1, 10.1017/S1461145711000897
First, 2011, The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression, J. Mol. Neurosci., 45, 246, 10.1007/s12031-011-9515-5
Qi, 2008, A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior, Behav. Brain Res., 199, 203, 10.1016/j.bbr.2008.11.051
Dwivedi, 2001, Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects, J. Neurochem., 77, 916, 10.1046/j.1471-4159.2001.00300.x
Dwivedi, 2006, ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf, Mol. Psychiatry, 11, 86, 10.1038/sj.mp.4001744
Yuan, 2010, Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia, J. Affect. Disord., 124, 164, 10.1016/j.jad.2009.10.017
Duric, 2010, Negative regulator of MAP kinase is increased in depression and is necessary and sufficient for depressive behavior, Nat. Med., 16, 1328, 10.1038/nm.2219
Hsiung, 2003, Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase, J. Neurochem., 87, 182, 10.1046/j.1471-4159.2003.01987.x
Karege, 2007, Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims, Biol. Psychiatry, 61, 240, 10.1016/j.biopsych.2006.04.036
Dwivedi, 2010, Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subjects, Biol. Psychiatry, 67, 1017, 10.1016/j.biopsych.2009.12.031
De Sarno, 2002, Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium, Neuropharmacology, 43, 1158, 10.1016/S0028-3908(02)00215-0
Klein, 1996, A molecular mechanism for the effect of lithium on development, PNAS, 93, 8455, 10.1073/pnas.93.16.8455
Beaulieu, 2008, Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency, PNAS, 105, 1333, 10.1073/pnas.0711496105
Li, 2010, Is glycogen synthase kinase-3 a central modulator in mood regulation?, Neuropsychopharmacology, 35, 2143, 10.1038/npp.2010.105
Henderson, 2000, Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover, Nat. Cell Biol., 2, 653, 10.1038/35023605
Carlezon, 2005, The many faces of CREB, Trends Neurosci., 28, 436, 10.1016/j.tins.2005.06.005
Phiel, 2003, GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides, Nature, 423, 435, 10.1038/nature01640
Beurel, 2009, Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3, J. Neuroinflamm., 11, 6
Martin, 2005, Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3, Nat. Immunol., 6, 777, 10.1038/ni1221
Miller, 2009, Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression, Biol. Psychiatry, 65, 732, 10.1016/j.biopsych.2008.11.029
Mao, 2009, Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling, Cell, 136, 1017, 10.1016/j.cell.2008.12.044
Inkster, 2009, Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder, Arch. Gen. Psychiatry, 66, 721, 10.1001/archgenpsychiatry.2009.70
Saus, 2010, A haplotype of glycogen synthase kinase 3β is associated with early onset of unipolar major depression, Genes Brain Behav., 9, 799, 10.1111/j.1601-183X.2010.00617.x
Beaulieu, 2004, Lithium antagonizes dopamine- dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade, PNAS, 101, 5099, 10.1073/pnas.0307921101
Gould, 2004, AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test, Int. J. Neuropsychopharmacol., 7, 387, 10.1017/S1461145704004535
Rosa, 2008, Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice, Biol. Psychiatry, 32, 1549
Der-Avakian, 2012, The neurobiology of anhedonia and other reward-related deficits, Trends Neurosci., 10.1016/j.tins.2011.11.005
Beurel, 2011, Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice, Mol. Psychiatry, 16, 1068, 10.1038/mp.2011.47
Jourdi, 2009, Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation, J. Neurosci., 29, 8688, 10.1523/JNEUROSCI.6078-08.2009
Wang, 2011, Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response, J. Immunol., 186, 5217, 10.4049/jimmunol.1002513
Phiel, 2001, Molecular targets of lithium action, Annu. Rev. Pharmacol. Toxicol., 41, 789, 10.1146/annurev.pharmtox.41.1.789
Aubry, 2009, Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation, Psychopharmacology, 205, 419, 10.1007/s00213-009-1551-2
Lamarre, 2008, Up-regulation of protein l-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization, Neuropharmacology, 55, 669, 10.1016/j.neuropharm.2008.05.033
Hu, 2011, The role of Wnt signaling and its interaction with diverse mechanisms of cellular apoptosis in the pathophysiology of bipolar disorder, Prog. Neuropsychopharmcol. Biol. Psychiatry, 35, 11, 10.1016/j.pnpbp.2010.08.031
Budnik, 2011, Wnt signaling during synaptic development and plasticity, Curr. Opin. Neurobiol., 21, 151, 10.1016/j.conb.2010.12.002
Inestrosa, 2010, Emerging roles of Wnts in the adult nervous system, Nat. Rev. Neurosci., 11, 77, 10.1038/nrn2755
Lie, 2005, Wnt signalling regulates adult hippocampal neurogenesis, Nature, 437, 1370, 10.1038/nature04108
Tissir, 2006, Expression of planar cell polarity genes during development of mouse CNS, Eur. J. Neurosci., 23, 597, 10.1111/j.1460-9568.2006.04596.x
Okamoto, 2010, Wnt2 expression and signaling is increased by different classes of antidepressants, Biol. Psychiatry, 68, 521, 10.1016/j.biopsych.2010.04.023
Pinnock, 2011, The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine, PLoS ONE, 5, e13652, 10.1371/journal.pone.0013652
Voleti, 2011, Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression, Biol. Psychiatry
Wilkinson, 2011, A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression, J. Neurosci., 31, 9084, 10.1523/JNEUROSCI.0039-11.2011
Diazgranados, 2010, A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression, Arch. Gen. Psych., 67, 793, 10.1001/archgenpsychiatry.2010.90
Larkin, 2011, A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department, Int. J. Neuropsychopharmacol., 14, 1127, 10.1017/S1461145711000629
Price, 2009, Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression, Biol. Psychiatry, 66, 522, 10.1016/j.biopsych.2009.04.029
Hoeffer, 2010, mTOR signaling: at the crossroads of plasticity, memory and disease, Trends Neurosci., 33, 67, 10.1016/j.tins.2009.11.003
Zarate, 2006, Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder, Biol. Psychiatry, 59, 1006, 10.1016/j.biopsych.2005.10.021
Koike, 2011, Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists, Neuropharmacology, 61, 1419, 10.1016/j.neuropharm.2011.08.034
Kelleher, 2008, The autistic neuron: troubled translation?, Cell, 135, 401, 10.1016/j.cell.2008.10.017
Bove, 2011, Fighting neurodegeneration with rapamycin: mechanistic insights, Nat. Rev. Neurosci., 12, 437, 10.1038/nrn3068
Moghaddam, 1997, Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex, J. Neurosci., 17, 2912, 10.1523/JNEUROSCI.17-08-02921.1997
Homayoun, 2007, NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons, J. Neurosci., 27, 11496, 10.1523/JNEUROSCI.2213-07.2007
Maeng, 2008, Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors, Biol. Psychiatry, 63, 349, 10.1016/j.biopsych.2007.05.028
Autry, 2011, NMDA receptor blockade at rest triggers rapid behavioural anatidepressant responses, Nature, 475, 91, 10.1038/nature10130
Behrens, 2007, Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase, Science, 318, 1645, 10.1126/science.1148045
Preskorn, 2008, An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-asparate antagonist, CP-101, 606, in patients with treatment-refractory major depressive dosorder, J. Clin. Psychopharmacol., 28, 631, 10.1097/JCP.0b013e31818a6cea
Dwyer, 2011, mTOR activation is required for the antidepressant effects of mGluR2/3 blockade, Int. J. Neuropsychopharmacol., 10.1017/S1461145711001702