Causes and Management of Intestinal Failure in Children

Nordgarrd, 1996, Importance of colonic support for energy absorption as small-bowel failure, Am J Clin Nutr, 64, 222, 10.1093/ajcn/64.2.222 Crenn, 2000, Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans, Gastroenterology, 119, 1496, 10.1053/gast.2000.20227 Crenn, 2003, Plasma citrulline, Gastroenterology, 124, 1210, 10.1016/S0016-5085(03)00170-7 Pappas, 2001, Serum citrulline and rejection in small bowel transplantation, Transplantation, 72, 1212, 10.1097/00007890-200110150-00005 Dabbas-Tyan, 2000, Evaluation of the effect of recombinant human growth hormone (rhGH) treatment of children with short bowel syndrome, J Pediatr Gastroenterol Nutr, 31, 5165 Howard, 1995, Current use and clinical outcome of home parenteral and enteral nutrition therapies in the United States, Gastroenterology, 109, 355, 10.1016/0016-5085(95)90321-6 Colomb, 1998, Home enteral and PN, Baillieres Clin Gastroenterol, 122, 877, 10.1016/S0950-3528(98)90012-4 Scolapio, 2004, A review of the trends in the use of enteral and parenteral nutrition support, J Clin Gastroenterol, 38, 403, 10.1097/00004836-200405000-00003 Colomb V, Dabbas-Tyan M, Goulet O, Landais P, Corriol O, Lamor M, Ricour C. Long-term home parenteral nutrition in children: 20 years of experience in 305 patients in a single center. (in press) Walker-Smith, 1993, Diarrhoeal disease: current concepts and future challenges. Malnutrition and infection, Trans R Soc Trop Med Hyg, 87, 13, 10.1016/0035-9203(93)90530-4 Vanderhoof, 2003, Enteral and parenteral nutrition in the care of patients with short-bowel syndrome, Best Pract Res Clin Gastroenterol, 17, 997, 10.1016/S1521-6918(03)00082-9 Goulet, 1991, Neonatal short bowel syndrome, J Pediatr, 119, 18, 10.1016/S0022-3476(05)81032-7 Goulet, 1998, Intestinal failure in children, Transplant Proc, 30, 2523, 10.1016/S0041-1345(98)00709-X Georgeson, 1992, Outcome and intestinal adaptation in neonatal short-bowel syndrome, J Pediatr Surg, 27, 344, 10.1016/0022-3468(92)90859-6 Liefaard, 1995, Prospective evaluation of the absorptive capacity of the bowel after major and minor resections in the neonates, J Pediatr Surg, 30, 388, 10.1016/0022-3468(95)90038-1 Sondheimer, 1998, Predicting the duration of dependence on PN after neonatal intestinal resection, J Pediatr, 132, 80, 10.1016/S0022-3476(98)70489-5 Leonberg, 1998, Long-term growth and development in children after home PN, J Pediatr, 132, 461, 10.1016/S0022-3476(98)70021-6 Festen, 2002, Excellent long-term outcome for survivors of apple peel atresia, J Pediatr Surg, 37, 61, 10.1053/jpsu.2002.29428 Goulet, 2005, Outcome and long-term growth after extensive small bowel resection in the neonatal period, Eur J Pediatr Surg, 15, 95, 10.1055/s-2004-821214 Salihu, 2004, Omphalocele and gastroschisis, Birth Defects Res A Clin Mol Teratol, 70, 586, 10.1002/bdra.20067 Hackam, 2004, Diagnosis and outcome of Hirschsprung’s disease, Pediatr Surg Int, 20, 319, 10.1007/s00383-004-1188-5 2004, Variations in incidence of necrotizing enterocolitis in Canadian neonatal intensive care units, J Pediatr Gastroenterol Nutr, 39, 366, 10.1097/00005176-200410000-00012 Neu, 2004, The ‘myth’ of asphyxia and hypoxia-ischemia as primary causes of necrotizing enterocolitis, Biol Neonate, 87, 97, 10.1159/000081898 Bryant, 1924, Observations upon the growth and length of the human intestine, Am J Med Sci, 167, 499, 10.1097/00000441-192404000-00003 Siebert, 1980, Small intestine length in infants and children, Am J Dis Child, 134, 593 Touloukian, 1983, Normal intestinal length in preterm infants, J Pediatr Surg, 18, 720, 10.1016/S0022-3468(83)80011-6 Dellert, 1998, Bone mineral content in children with short bowel syndrome after discontinuation of PN, J Pediatr, 132, 516, 10.1016/S0022-3476(98)70031-9 Nordgaard, 1994, Colon as a digestive organ in patients with short bowel, Lancet, 343, 373, 10.1016/S0140-6736(94)91220-3 Briet, 1995, Bacterial adaptation in patients with short bowel and colon in continuity, Gastroenterology, 109, 1446, 10.1016/0016-5085(95)90629-0 Rajendran, 2000, Characterization and molecular localization of anion transporters in colonic epithelial cells, Ann N Y Acad Sci, 915, 15, 10.1111/j.1749-6632.2000.tb05220.x Wolf, 1989, Bacterial infection, J Pediatr Gastroenterol Nutr, 8, 297, 10.1097/00005176-198904000-00006 Braxton, 1995, PN and liver dysfunction—new insight?, JPEN J Parenter Enteral Nutr, 19, 3, 10.1177/014860719501900103 Kaufman, 1997, Influence of bacterial overgrowth and intestinal inflammation on duration of PN in children with short bowel syndrome, J Pediatr, 131, 356, 10.1016/S0022-3476(97)80058-3 Sondheimer, 1998, Infection and cholestasis in neonates with intestinal resection and long-term PN, J Pediatr Gastroenterol Nutr, 27, 131, 10.1097/00005176-199808000-00001 Forchielli, 2003, Nutritional factors contributing to the development of cholestasis during total parenteral nutrition, Adv Pediatr, 50, 245, 10.1016/S0065-3101(23)00063-4 Mitchell, 1980, The colon influences ileal resection diarrhea, Dig Dis Sci, 25, 33, 10.1007/BF01312730 Kaufman, 1997, Influence of bacterial overgrowth and intestinal inflammation on duration of PN in children with short bowel syndrome, J Pediatr, 131, 356, 10.1016/S0022-3476(97)80058-3 Goulet, 1992, Which patients need small bowel transplantation for neonatal short bowel syndrome?, Transplant Proc, 24, 1058 Warner, 1994, Non-transplant surgical options for management of the short bowel syndrome, J Pediatr Gastroenterol Nutr, 17, 1, 10.1097/00005176-199307000-00001 Briet, 1997, Segmental reversal of the small bowel as an alternative to intestinal transplantation in patients with short bowel syndrome, Ann Surg, 225, 401, 10.1097/00000658-199704000-00009 Bianchi, 1980, Intestinal loop lengthening a technique for increasing small intestinal length, J Pediatr Surg, 15, 145, 10.1016/S0022-3468(80)80005-4 Georgeson, 1994, Sequential intestinal lengthening procedures for refractory short bowel syndrome, J Pediatr Surg, 29, 316, 10.1016/0022-3468(94)90339-5 Thompson, 1995, Surgical approach to short-bowel syndrome. Experience in a population of 160 patients, Ann Surg, 222, 600, 10.1097/00000658-199522240-00016 Weber, 1999, Isoperistaltic bowel lengthening for short bowel syndrome in children, Am J Surg, 178, 600, 10.1016/S0002-9610(99)00218-4 Waag, 1999, What do children look like after longitudinal intestinal lengthening?, Eur J Pediatr Surg, 9, 260, 10.1055/s-2008-1072259 Thompson, 2000, Long-term outcome of intestinal lengthening, Transplant Proc, 32, 1242, 10.1016/S0041-1345(00)01207-0 Bianchi, 1997, Longitudinal intestinal lengthening and tailoring, J R Soc Med, 90, 429, 10.1177/014107689709000804 Figueroa-Colon, 1996, Impact of intestinal lengthening on the nutritional outcome for children with short bowel syndrome, J Pediatr Surg, 31, 912, 10.1016/S0022-3468(96)90409-1 Kim, 2003, Serial transverse enteroplasty (STEP), J Pediatr Surg, 38, 425, 10.1053/jpsu.2003.50073 Tannuri, 2003, Serial transverse enteroplasty (STEP), J Pediatr Surg, 38, 1845, 10.1016/j.jpedsurg.2003.08.023 Byrne, 1995, A new treatment for patients with short bowel syndrome, Ann Surg, 222, 243, 10.1097/00000658-199509000-00003 Scolapio, 1997, Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome, Gastroenterology, 113, 1074, 10.1053/gast.1997.v113.pm9322500 Ellegard, 1997, Low-dose recombinant human growth hormone increases body weight and lean body mass in patients with short bowel syndrome, Ann Surg, 225, 88, 10.1097/00000658-199701000-00010 Szkudlarek, 2000, Effect of high dose growth hormone with glutamine and no change in diet on intestinal absoption in short bowel patients, Gut, 47, 199, 10.1136/gut.47.2.199 Seguy, 2003, Low-dose growth hormone in adult home PN-dependent short bowel patients, Gastroenterology, 124, 293, 10.1053/gast.2003.50057 Socha, 1996, Is growth hormone a feasible adjuvant in the treatment of children after small bowel resection, Clin Nutr, 15, 185, 10.1016/S0261-5614(96)80239-1 Dabbas-Tyan, 2000, Evaluation of the effect of recombinant human growth hormone treatment in children with short bowel syndrome, J Pediatr Gastroenterol Nutr, 31, 5165 Lifschitz, 2003, Growth Hormone (GH) therapy in children with short bowel syndrome (SBS), Digestive Disease Week, A100 Drucker, 2002, Biological actions and therapeutic potential of the glucagon-like peptides, Gastroenterology, 122, 531, 10.1053/gast.2002.31068 Jeppesen, 1999, Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure, Gut, 45, 559, 10.1136/gut.45.4.559 Jeppesen, 2001, Glucagon-like peptide 2 improves nutrient absorption in short-bowel patients with no colon, Gastroenterology, 120, 806, 10.1053/gast.2001.22555 Haderslev, 2002, Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients without colon, Scand J Gastroenterol, 37, 392, 10.1080/003655202317316006 Wilmore, 2003, Indications for specific therapy in the rehabilitation of patients with the short-bowel syndrome, Best Pract Res Clin Gastroenterol, 17, 895, 10.1016/S1521-6918(03)00083-0 Doray, 1998, Mutation of the RET ligand, meurturin, supports multigenic inheritance in Hirschsprung disease, Hum Mol Genet, 7, 1831, 10.1093/hmg/7.9.1449 Fortuna, 1996, Critical analysis of the operative treatment of Hirschsprung’s disease, Arch Surg, 131, 520, 10.1001/archsurg.1996.01430170066013 Marty, 1995, Gastrointestinal function after surgical correction of Hirschsprung’s disease, J Pediatr Surg, 30, 655, 10.1016/0022-3468(95)90682-7 Ziegler, 1993, Extended myectomy-myotomy. A therapeutic alternative for total intestinal aganglionosis, Ann Surg, 218, 504, 10.1097/00000658-199310000-00010 Saxton, 2000, Near total intestinal agangionosis, J Pediatr Surg, 35, 669, 10.1053/jpsu.2000.5939 Fouquet, 2002, Do pronostic factors exist for total colonic aganglionosis with ileal involvement?, J Pediatr Surg, 37, 71, 10.1053/jpsu.2002.29430 Sharif, 2003, New perspective for the management of near-total or total intestinal aganglionosis in infants, J Pediatr Surg, 38, 25, 10.1053/jpsu.2003.50004 Révillon, 2003, Improved quality of life by combined transplantation in Hirschsprung’s disease with a very long aganglionic segment, J Pediatr Surg, 38, 422, 10.1053/jpsu.2003.50072 Goulet, 1999, Chronic intestinal pseudoobstruction syndrome in pediatric patients, Eur J Pediatr Surg, 9, 83, 10.1055/s-2008-1072218 Faure, 1999, Chronic intestinal pseudoobstruction syndrome, Dig Dis Sci, 44, 953, 10.1023/A:1026656513463 Heneyke, 1999, Chronic intestinal pseudo-obstruction, Arch Dis Child, 81, 21, 10.1136/adc.81.1.21 Masetti, 1999, Multivisceral transplantation for megacystis microcolon intestinal hypoperistalsis syndrome, Transplantation, 68, 228, 10.1097/00007890-199907270-00011 Iyer, 2001, Long-term results of intestinal transplantation for pseudo-obstruction in children, J Pediatr Surg, 36, 174, 10.1053/jpsu.2001.20046 Phillips, 1992, Familial microvillus atrophy, J Pediatr Gastroenterol Nutr, 14, 380, 10.1097/00005176-199205000-00003 Goulet, 1995, Intractable diarrhea of infancy, J Pediatr, 127, 212, 10.1016/S0022-3476(95)70297-0 Patey, 1997, Distribution of cell adhesion molecules in infants with intestinal epithelial dysplasia (tufting enteropathy), Gastroenterology, 113, 833, 10.1016/S0016-5085(97)70178-1 Oliva, 1994, Successful intestinal transplantation for microvillus inclusion disease, Gastroenterology, 106, 771, 10.1016/0016-5085(94)90714-5 Herzog, 1996, Combined bowel-liver transplantation in an infant with microvillus inclusion disease, J Pediatr Gastroenterol Nutr, 22, 405, 10.1097/00005176-199605000-00013 Randak, 1998, Pretransplant management and small bowel-liver transplantation in an infant with microvillus inclusion disease, J Pediatr Gastroenterol Nutr, 27, 333, 10.1097/00005176-199809000-00012 Bunn, 2000, Treatment of microvillous inclusion disease by intestinal transplantation, J Pediatr Gastroenterol Nutr, 31, 176, 10.1097/00005176-200008000-00016 Ruemmele, 2004, New perspectives for children with microvillous inclusion disease, Transplantation, 77, 1024, 10.1097/01.TP.0000119163.30745.C1 Lacaille, 1998, Successful combined liver and small bowel transplantation in a child with epithelial dysplasia, J Pediatr Gastroenterol Nutr, 2, 230, 10.1097/00005176-199808000-00021 Paramesh, 2003, Isolated small bowel transplantation for tufting enteropathy, J Pediatr Gastroenterol Nutr, 36, 138, 10.1097/00005176-200301000-00026 Unsworth, 1985, Auto-immunity in diarrheal disease, J Pediatr Gastroenterol Nutr, 4, 375, 10.1097/00005176-198506000-00009 Ruemmele, 2004, Autoimmune enteropathy, 959 Wildin, 2001, X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy, Nat Genet, 27, 18, 10.1038/83707 Wildin, 2002, Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome, J Med Genet, 39, 537, 10.1136/jmg.39.8.537 Kobayashi, 2001, Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX), J Med Genet, 38, 874, 10.1136/jmg.38.12.874 Gambineri, 2003, Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis, Curr Opin Rheumatol, 15, 430, 10.1097/00002281-200307000-00010 Baud, 2001, Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX) by allogeneic bone marrow transplantation, N Engl J Med, 344, 1758, 10.1056/NEJM200106073442304 Shulman, 2003, Parenteral nutrition in infants and children, J Pediatr Gastroenterol Nutr, 36, 587, 10.1097/00005176-200305000-00002 Colomb, 2000, Central venous catheter-related infections in children on long-term home PN, Clin Nutr, 19, 355, 10.1054/clnu.2000.0132 Colomb, 1992, Long term parenteral nutrition in children, Transplant Proc, 24, 1054 Moss, 1993, Total parenteral nurition-associated cholestasis, J Pediatr Surg, 28, 1270, 10.1016/S0022-3468(05)80311-2 Fouin Fortunet, 1982, Hepatic alterations during total parenteral nutrition in patients with inflammatory bowel disease, Gastroenterology, 82, 932, 10.1016/S0016-5085(82)80258-8 Colomb, 2000, Role of lipid emulsions in cholestasis associated with long-term PN in children, JPEN J Parenter Enteral Nutr, 24, 345, 10.1177/0148607100024006345 Beath, 1996, Parenteral nutrition-related cholestasis in postsurgical neonates, J Pediatr Surg, 31, 604, 10.1016/S0022-3468(96)90507-2 Moseley, 1997, Sepsis-associated cholestasis, Gastroenterology, 112, 302, 10.1016/S0016-5085(97)70250-6 Lienhardt, 1998, Insulin secretion and sensitivity in children on cyclic total PN, JPEN J Parenter Enteral Nutr, 22, 382, 10.1177/0148607198022006382 Forchielli, 1995, Aminosyn PF or Trophamine, J Pediatr Gastroenterol Nutr, 21, 374, 10.1097/00005176-199511000-00002 Belli, 1987, Total parenteral nutrition-associated cholestasis in rats, JPEN J Parenter Enteral Nutr, 11, 67, 10.1177/014860718701100167 Goulet, 1999, Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients, Am J Clin Nutr, 70, 338, 10.1093/ajcn/70.3.338 Clayton, 1998, The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition, Nutrition, 14, 158, 10.1016/S0899-9007(97)00233-5 Klein, 1998, Aluminum in large and small volume parenterals used in total PN, J Pediatr Gastroenterol Nutr, 27, 457, 10.1097/00005176-199810000-00019 Popinska, 1999, Aluminum contamination of PN additives, amino acid solutions, and lipid emulsions, Nutrition, 15, 683, 10.1016/S0899-9007(99)00124-0 Ben Hariz, 1993, Iron overload in children receiving prolonged PN, J Pediatr, 123, 238, 10.1016/S0022-3476(05)81694-4 Moukarzel, 1992, Excessive chromium intake in children receiving total PN, Lancet, 339, 385, 10.1016/0140-6736(92)90078-H Ling, 2001, Cholecystokinin (CCK) secretion in patients with severe short bowel syndrome (SSBS), Dig Dis Sci, 46, 859, 10.1023/A:1010772922341 Capron, 1983, Herve MA. Metronidazole in prevention of cholestasis associated with total PN, Lancet, I, 446, 10.1016/S0140-6736(83)91442-3 Spagnuolo, 1996, Ursodeoxycholic acid for treatment of cholestasis in children on long-term total PN, Gastroenterology, 111, 716, 10.1053/gast.1996.v111.pm8780577 Heubi, 2002, Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease, J Pediatr, 141, 237, 10.1067/mpd.2002.125802 Bresson, 1989, Energy substrate utilization in infants receiving total PN with different glucose to fat ratios, Pediatr Res, 25, 645, 10.1203/00006450-198906000-00018 Salas, 1991, Energy expenditure and substrate utilization in the course or renutrition of malnourished children, JPEN J Parenter Enter Nutr, 15, 288, 10.1177/0148607191015003288 Gramlich, 1994, Cyclic PN, Nutr Clin Pract, 9, 49, 10.1177/011542659400900249 Beghin, 2003, Total energy expenditure and physical activity in children treated with home PN, Pediatr Res, 53, 684, 10.1203/01.PDR.0000057208.05549.3B Kaufman, 2002, Prevention of PN-associated liver disease in children, Pediatr Transplant, 6, 37, 10.1034/j.1399-3046.2002.1o061.x Matuchansky, 1992, Cyclical parenteral nutrition, Lancet, 340, 588, 10.1016/0140-6736(92)92116-W MacFie, 1997, Cyclic parenteral nutrition, Nutrition, 13, 46, 10.1016/S0899-9007(96)00378-4 Ben Hariz, 1997, Inapropriate iron intake in children on long-term PN, Clin Nutr, 16, 251, 10.1016/S0261-5614(97)80235-X Advenier, 2003, Aluminum contamination of PN and aluminum loading in children on long-term PN, J Pediatr Gastroenterol Nutr, 36, 448, 10.1097/00005176-200304000-00005 Kaufman, 2001, Indications for pediatric intestinal transplantation, Pediatr Transplant, 5, 80, 10.1034/j.1399-3046.2001.005002080.x Iyer, 2003, Histology is not predictive of functional liver recovery in parenteral-nutrition associated liver dysfunction, Pediatr Transplant, 7, 69 Beath, 1998, Demand for pediatric small bowel transplantation in the United Kingdom, Transplant Proc, 30, 2531, 10.1016/S0041-1345(98)00713-1 Bueno, 1999, Factors impacting the survival of children with intestinal failure referred for intestinal transplantation, J Pediatr Surg, 34, 27, 10.1016/S0022-3468(99)90223-3 Lawrence, 1994, Isolated liver transplantation for liver failure in patients with short bowel syndrome, J Pediatr Surg, 29, 751, 10.1016/0022-3468(94)90361-1 Gottrand, 1999, Favourable nutritional outcome after isolated liver transplantation for liver failure in a child with short bowel syndrome, Transplantation, 67, 632, 10.1097/00007890-199902270-00025 Horslen, 2002, Isolated liver transplantation in infants with end-stage liver disease associated with short bowel syndrome, Ann Surg, 235, 435, 10.1097/00000658-200203000-00016 Hassan, 2002, Difficult management choices for infants with short bowel syndrome and liver failure, J Pediatr Gastroenterol Nutr, 35, 216, 10.1097/00005176-200208000-00022 Fryer, 2003, Mortality in candidates waiting for combined liver-intestine transplants exceeds that for other candidates waiting for liver transplants, Liver Transplant, 9, 748, 10.1053/jlts.2003.50151 Nishida, 2002, Ninety-five cases of intestinal transplantation at the University of Miami, J Gastrointest Surg, 6, 233, 10.1016/S1091-255X(01)00073-7 Iyer, 2002, Late graft loss and long-term outcome after isolated intestinal transplantation in children, J Pediatr Surg, 37, 151, 10.1053/jpsu.2002.30240 Fishbein, 2003, Isolated intestinal transplantation, Transplantation, 76, 636, 10.1097/01.TP.0000083042.03188.6C Grant, 1999, Intestinal transplantation, Transplantation, 67, 1061, 10.1097/00007890-199904150-00021 Grant, 2005, 2003 report of the Intestine Transplant Registry, Ann Surg, 241, 607, 10.1097/01.sla.0000157265.85388.a1 Iyer, 2002, Nutritional outcome and growth of children after intestinal transplantation, J Pediatr Surg, 37, 464, 10.1053/jpsu.2002.30864 Nucci, 2002, Long-term nutritional outcome after pediatric intestinal transplantation, J Pediatr Surg, 37, 460, 10.1053/jpsu.2002.30863 Sudan, 2002, Assessment of quality of life after pediatric intestinal transplantation by parents and pediatric recipients using the child health questionnaire, Transplant Proc, 34, 963, 10.1016/S0041-1345(02)02718-5 Beath, 1995, Nutritional care and candidates for small bowel transplantation, Arch Dis Child, 73, 348, 10.1136/adc.73.4.348 Fishbein, 2002, An integrated approach to intestinal failure. Results of a new program with total PN, bowel rehabilitation, and transplantation, J Gastrointest Surg, 6, 554, 10.1016/S1091-255X(01)00026-9 Buchman, 2003, AGA technical review on short bowel syndrome and intestinal transplantation, Gastroenterology, 124, 1111, 10.1016/S0016-5085(03)70064-X Guarino, 2003, Natural history of intestinal failure, investigated through a national network-based approach, J Pediatr Gastroenterol Nutr, 37, 136, 10.1097/00005176-200308000-00010 Henry, 2004, Current issues in the management of necrotizing enterocolitis, Semin Perinatol, 28, 221, 10.1053/j.semperi.2004.03.010 Salihu, 2004, Mode of delivery and neonatal survival of infants with isolated gastroschisis, Obstet Gynecol, 104, 678, 10.1097/01.AOG.0000139513.93115.81 Kocoshis, 2004, Intestinal failure and small bowel transplantation, including clinical nutrition, J Pediatr Gastroeneterol Nutr, 39, S655, 10.1097/00005176-200406002-00012