Pirenzepine Affects Scleral Metabolic Changes in Myopia through a Non-toxic Mechanism

Bonner, 1987, Identification of a family of muscarinic acetylcholine receptor genes, Science, 237, 527, 10.1126/science.3037705 Bonner, 1988, Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes, Neuron, 1, 403, 10.1016/0896-6273(88)90190-0 Chou, 1997, The effectiveness of 0.5% atropine in controlling high myopia in children, J. Ocul. Pharmacol. Ther., 13, 61, 10.1089/jop.1997.13.61 Chua, 1999, One-year results of topical atropine for the control of rapidly progressive school myopia, Invest. Ophthalmol. Vis. Sci., 40, S694 Cottriall, 1996, The M1muscarinic antagonist pirenzepine reduces myopia and eye enlargement in the tree shrew, Invest. Ophthalmol. Vis. Sci., 37, 1368 Cottriall, 1999, Prevention of form-deprivation myopia with pirenzepine: a study of drug delivery and distribution, Ophthalmic Physiol. Opt., 19, 327, 10.1016/S0275-5408(98)00079-9 Eastman, 1992, The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis?, Cancer Invest., 10, 229, 10.3109/07357909209032765 Fischer, 1998, Immunocytochemical characterization of quisqualic acid- and N -methyl- D -aspartate-induced excitotoxicity in the retina of chicks, J. Comp. Neurol., 393, 1, 10.1002/(SICI)1096-9861(19980330)393:1<1::AID-CNE1>3.0.CO;2-3 Iuvone, 1991, Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia, Invest. Ophthalmol. Vis. Sci., 32, 1674 Kusakari, 1997, Regional scleral changes in form-deprivation myopia in chicks, Exp. Eye Res., 34, 465, 10.1006/exer.1996.0242 Labarca, 1980, A simple, rapid, and sensitive DNA assay procedure, Anal. Biochem., 102, 344, 10.1016/0003-2697(80)90165-7 Leech, 1995, Pirenzepine prevents form deprivation myopia in a dose dependent manner, Ophthalmic Physiol. Opt., 15, 351, 10.1016/0275-5408(95)00074-N Lind, 1998, Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes, Invest. Ophthalmol. Vis. Sci., 39, 2217 Masuda, 1994, Quantification of35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates, Anal. Biochem., 217, 167, 10.1006/abio.1994.1105 McBrien, 1999, Optical correction of induced axial myopia in the tree shrew: implications for emmetropization, Optom. Vis. Sci., 76, 419, 10.1097/00006324-199906000-00022 McBrien, 2000, Scleral remodelling in the development of and recovery from axial myopia in the tree shrew, Invest. Ophthalmol. Vis. Sci., 41, 3713 McBrien, 1995, The effects of blockade of retinal cell action potentials on ocular growth, emmetropization and form deprivation myopia in young chicks, Vision Res., 35, 1141, 10.1016/0042-6989(94)00237-G McBrien, 1993, Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism, Invest. Ophthalmol. Vis. Sci., 34, 205 McKanna, 1981, Atropine affects lid suture myopia development, Doc. Ophthalmol. Proc. Series, 28, 187, 10.1007/978-94-009-8662-6_27 Napper, 1995, The duration of normal visual exposure necessary to prevent form deprivation myopia in chicks, Vision Res., 35, 1337, 10.1016/0042-6989(94)00226-C Nickla, 1989, What attributes of visual stimulation determine whether chick eyes develop deprivation myopia?, Invest. Ophthalmol. Vis. Sci., 30, S31 Peralta, 1987, Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors, EMBO J., 6, 3923, 10.1002/j.1460-2075.1987.tb02733.x Rada, 1992, Proteoglycan synthesis by scleral chondrocytes is modulated by a vision dependent mechanism, Curr. Eye Res., 11, 767, 10.3109/02713689209000750 Rada, 2000, Decreased proteoglycan synthesis associated with form deprivation myopia in mature primate eyes, Invest. Ophthalmol. Vis. Sci., 41, 2050 Raviola, 1985, An animal model of myopia, N. Engl. J. Med., 312, 1609, 10.1056/NEJM198506203122505 Rickers, 1995, Dose-dependent effects of intravitreal pirenzepine on deprivation myopia and lens-induced refractive errors in chickens, Exp. Eye Res., 61, 509, 10.1016/S0014-4835(05)80147-2 Rohrer, 1993, Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium, Vis. Neurosci., 10, 447, 10.1017/S0952523800004673 Schaeffel, 1990, Developing eyes that lack accommodation grow to compensate for imposed defocus, Vis. Neurosci., 4, 177, 10.1017/S0952523800002327 Stone, 1991, Muscarinic antagonist effects on experimental chick myopia, Exp. Eye Res., 52, 755, 10.1016/0014-4835(91)90027-C Troilo, 1987, Visual deprivation causes myopia in chicks with optic nerve section, Curr. Eye Res., 6, 993, 10.3109/02713688709034870 Wiesel, 1977, Myopia and eye enlargement after neonatal lid fusion in monkeys, Nature, 266, 66, 10.1038/266066a0