Update on the genetic and molecular regulation of the biosynthetic pathways underlying pepper fruit color and pungency
Tài liệu tham khảo
FAO, 2023
Lee, 2016, Genetic diversity and population structure analysis to construct a core collection from a large Capsicum germplasm, BMC Genet., 17, 1, 10.1186/s12863-016-0452-8
Carvalho, 2015, Bioactive compounds and antioxidant activity of pepper (Capsicum sp.) genotypes, J. Food Sci. Technol., 52, 7457, 10.1007/s13197-015-1833-0
Badia, 2017, Capsicum annuum L.: an overview of biological activities and potential nutraceutical properties in humans and animals, J. Nutr. Ecol. Food Res., 4, 167
Takemura, 2021, Violaxanthin: natural function and occurrence, biosynthesis, and heterologous production, Appl. Microbiol. Biotechnol., 105, 6133, 10.1007/s00253-021-11452-2
Antonio, 2018, The genus Capsicum: A phytochemical review of bioactive secondary metabolites, RSC Adv., 8, 25767, 10.1039/C8RA02067A
Baenas, 2019, Industrial use of pepper (Capsicum annum L.) derived products: technological benefits and biological advantages, Food Chem., 274, 872, 10.1016/j.foodchem.2018.09.047
Fayos, 2019, Assessment of capsaicinoid and capsinoid accumulation patterns during fruit development in three chili pepper genotypes (Capsicum spp.) carrying Pun1 and pAMT alleles related to pungency, J. Agric. Food Chem., 67, 12219, 10.1021/acs.jafc.9b05332
Heath, 2013, The role of carotenoids and their derivatives in mediating interactions between insects and their environment, Arthropod-Plant Interact., 7, 1, 10.1007/s11829-012-9239-7
Li, 2013, A further analysis of the relationship between yellow ripe-fruit color and the capsanthin-capsorubin synthase gene in pepper (Capsicum sp.) indicated a new mutant variant in C. annuum and a tandem repeat structure in promoter region, PLoS One, 8, 10.1371/journal.pone.0061996
Borovsky, 2013, Induced mutation in β-CAROTENE HYDROXYLASE results in accumulation of β-carotene and conversion of red to orange color in pepper fruit, Theor. Appl. Genet., 126, 557, 10.1007/s00122-012-2001-9
Tian, 2015, The relationship between red fruit colour formation and key genes of capsanthin biosynthesis pathway in Capsicum annuum, Biol. Plant., 59, 507, 10.1007/s10535-015-0529-7
Guzman, 2010, Variability of carotenoid biosynthesis in orange colored Capsicum spp, Plant Sci., 179, 49, 10.1016/j.plantsci.2010.04.014
Kilcrease, 2015, Correlations of carotenoid content and transcript abundances for fibrillin and carotenogenic enzymes in Capsicum annum fruit pericarp, Plant Sci., 232, 57, 10.1016/j.plantsci.2014.12.014
de Azevedo‐Meleiro, 2009, Qualitative and quantitative differences in the carotenoid composition of yellow and red peppers determined by HPLC‐DAD‐MS, J. Sep. Sci., 32, 3652, 10.1002/jssc.200900311
Borovsky, 2004, The A locus that controls anthocyanin accumulation in pepper encodes a MYB transcription factor homologous to Anthocyanin2 of Petunia, Theor. Appl. Genet., 109, 23, 10.1007/s00122-004-1625-9
Liu, 2018, Anthocyanin biosynthesis and degradation mechanisms in Solanaceous vegetables: a review, Front. Chem., 6, 52, 10.3389/fchem.2018.00052
Lightbourn, 2008, Effects of anthocyanin and carotenoid combinations on foliage and immature fruit color of Capsicum annuum L, J. Hered., 99, 105, 10.1093/jhered/esm108
Borovsky, 2008, Chlorophyll breakdown during pepper fruit ripening in the chlorophyll retainer mutation is impaired at the homolog of the senescence-inducible stay-green gene, Theor. Appl. Genet., 117, 235, 10.1007/s00122-008-0768-5
Pan, 2013, Network inference analysis identifies an APRR2-like gene linked to pigment accumulation in tomato and pepper fruits, Plant Physiol., 161, 1476, 10.1104/pp.112.212654
Jung, 2019, A non-LTR retrotransposon activates anthocyanin biosynthesis by regulating a MYB transcription factor in Capsicum annuum, Plant Sci., 287, 10.1016/j.plantsci.2019.110181
Wahyuni, 2013, Secondary metabolites of Capsicum species and their importance in the human diet, J. Nat. Prod., 76, 783, 10.1021/np300898z
Aza-González, 2011, Molecular biology of capsaicinoid biosynthesis in chili pepper (Capsicum spp.), Plant Cell Rep., 30, 695, 10.1007/s00299-010-0968-8
Bosland, 2012, ‘Trinidad Moruga Scorpion’pepper is the world’s hottest measured chile pepper at more than two million scoville heat units, HortTechnology, 22, 534, 10.21273/HORTTECH.22.4.534
Buchanan, 2020, Some like it hot, Nat. Phys., 16, 112-112, 10.1038/s41567-019-0766-3
Rodriguez-Concepcion, 2018, A global perspective on carotenoids: metabolism, biotechnology, and benefits for nutrition and health, Prog. Lipid Res., 70, 62, 10.1016/j.plipres.2018.04.004
Sadali, 2019, Differentiation of chromoplasts and other plastids in plants, Plant Cell Rep., 38, 803, 10.1007/s00299-019-02420-2
Nisar, 2015, Carotenoid metabolism in plants, Mol. Plant., 8, 68, 10.1016/j.molp.2014.12.007
Chesterfield, 2020, Translation of strigolactones from plant hormone to agriculture: achievements, future perspectives, and challenges, Trends Plant Sci., 25, 1087, 10.1016/j.tplants.2020.06.005
Watkins, 2020, Prospects for carotenoid biofortification targeting retention and catabolism, Trends Plant Sci., 25, 501, 10.1016/j.tplants.2019.12.021
Hornero-Méndez, 2000, Carotenoid biosynthesis changes in five red pepper (Capsicum annuum L.) cultivars during ripening. Cultivar selection for breeding, J. Agric. Food Chem., 48, 3857, 10.1021/jf991020r
Morales-Soriano, 2019, Carotenoid profile and basic structural indicators of native Peruvian chili peppers, Eur. Food Res. Technol., 245, 717, 10.1007/s00217-018-3193-2
Zhou, 2022, Phytoene synthase: the key rate-limiting enzyme of carotenoid biosynthesis in plants, Front. Plant Sci., 13
Gómez-García, 2013, Biochemistry and molecular biology of carotenoid biosynthesis in chili peppers (Capsicum spp.), Int. J. Mol. Sci., 14, 19025, 10.3390/ijms140919025
Sathasivam, 2021, An update on biosynthesis and regulation of carotenoids in plants, S. Afr. J. Bot., 140, 290, 10.1016/j.sajb.2020.05.015
Moise, 2014, Mechanistic aspects of carotenoid biosynthesis, Chem. Rev., 114, 164, 10.1021/cr400106y
Alcaíno, 2016, Carotenoid distribution in nature, Vol. 79, 3, 10.1007/978-3-319-39126-7_1
Deli, 2001, Carotenoid composition in the fruits of red paprika (Capsicum annuum var. lycopersiciforme rubrum) during ripening; biosynthesis of carotenoids in red paprika, J. Agric. Food Chem., 49, 1517, 10.1021/jf000958d
Kim, 2016, Carotenoid profiling from 27 types of paprika (Capsicum annuum L.) with different colors, shapes, and cultivation methods, Food Chem., 201, 64, 10.1016/j.foodchem.2016.01.041
Lee, 2021, A mutation in Zeaxanthin epoxidase contributes to orange coloration and alters carotenoid contents in pepper fruit (Capsicum annuum), Plant J., 106, 1692, 10.1111/tpj.15264
Wahyuni, 2011, Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: Variation in health-related compounds and implications for breeding, Phytochemistry, 72, 1358, 10.1016/j.phytochem.2011.03.016
da Silveira Agostini-Costa, 2017, Carotenoid and total vitamin C content of peppers from selected Brazilian cultivars, J. Food Compos. Anal., 57, 73, 10.1016/j.jfca.2016.12.020
Shu, 2023, Fine mapping and identification of candidate genes for fruit color in pepper (Capsicum chinense), Sci. Hortic., 310, 10.1016/j.scienta.2022.111724
Jeong, 2020, Candidate gene analysis reveals that the fruit color locus C1 corresponds to PRR2 in pepper (Capsicum frutescens), Front. Plant Sci., 11, 399, 10.3389/fpls.2020.00399
Hurtado-Hernandez, 1985, Inheritance of mature fruit color in Capsicum annuum L, J. Hered., 76, 211, 10.1093/oxfordjournals.jhered.a110070
Huh, 2001, A candidate gene approach identified phytoene synthase as the locus for mature fruit color in red pepper (Capsicum spp.), Theor. Appl. Genet., 102, 524, 10.1007/s001220051677
Lee, 2020, Uncovering candidate genes controlling major fruit-related traits in pepper via genotype-by-sequencing based QTL mapping and genome-wide association study, Front. Plant Sci., 11, 1100, 10.3389/fpls.2020.01100
Rodriguez-Uribe, 2014, Capsaicinoid and carotenoid composition and genetic diversity of Kas I and Ccs in New Mexican Capsicum annuum L. Landraces, HortScience, 49, 1370, 10.21273/HORTSCI.49.11.1370
Rodriguez-Uribe, 2012, Carotenoid accumulation in orange-pigmented Capsicum annuum fruit, regulated at multiple levels, J. Exp. Bot., 63, 517, 10.1093/jxb/err302
Thorup, 2000, Candidate gene analysis of organ pigmentation loci in the Solanaceae, Proc. Natl. Acad. Sci. USA, 97, 11192, 10.1073/pnas.97.21.11192
Jang, 2020, Phytoene synthase 2 can compensate for the absence of PSY1 in the control of color in Capsicum fruit, J. Exp. Bot., 71, 3417, 10.1093/jxb/eraa155
Jeong, 2019, Single‐molecule real‐time sequencing reveals diverse allelic variations in carotenoid biosynthetic genes in pepper (Capsicum spp.), Plant Biotechnol. J., 17, 1081, 10.1111/pbi.13039
Ma, 2023, The transcription factor CaBBX20 regulates capsanthin accumulation in pepper (Capsicum annuum L.), Sci. Hortic., 314, 10.1016/j.scienta.2023.111907
Wu, 2022, Mapping of CaPP2C35 involved in the formation of light-green immature pepper (Capsicum annuum L.) fruits via GWAS and BSA, Theor. Appl. Genet., 135, 591, 10.1007/s00122-021-03987-9
Borovsky, 2019, The zinc-finger transcription factor CcLOL1 controls chloroplast development and immature pepper fruit color in Capsicum chinense and its function is conserved in tomato, Plant J., 99, 41, 10.1111/tpj.14305
Liu, 2023, A novel single-base mutation in CaSGR1 confers the stay-green phenotype in pepper, Hortic. Plant J., 9, 293, 10.1016/j.hpj.2022.04.002
Brand, 2014, CaGLK2 regulates natural variation of chlorophyll content and fruit color in pepper fruit, Theor. Appl. Genet., 127, 2139, 10.1007/s00122-014-2367-y
Lee, 2020, Genetic mapping of the c1 locus by GBS-based BSA-seq revealed Pseudo-Response Regulator 2 as a candidate gene controlling pepper fruit color, Theor. Appl. Genet., 133, 1897, 10.1007/s00122-020-03565-5
Wang, 2019, Manipulation of carotenoid metabolic flux by lycopene cyclization in ripening red pepper (Capsicum annuum var. Conoides) fruits, J. Agric. Food Chem., 67, 4300, 10.1021/acs.jafc.9b00756
Berry, 2019, Carotenoid biosynthesis and sequestration in red chilli pepper fruit and its impact on colour intensity traits, J. Exp. Bot., 70, 2637, 10.1093/jxb/erz086
Konishi, 2019, Detection of quantitative trait loci for capsanthin content in pepper (Capsicum annuum L.) at different fruit ripening stages, Breed. Sci., 69, 30, 10.1270/jsbbs.18070
Jang, 2022, Investigation of genetic factors regulating chlorophyll and carotenoid biosynthesis in red pepper fruit, Front. Plant Sci., 13, 10.3389/fpls.2022.922963
Ruiz-Sola, 2016, Arabidopsis geranylgeranyl diphosphate synthase 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids, New Phytol., 209, 252, 10.1111/nph.13580
Ma, 2022, The pepper MYB transcription factor CaMYB306 accelerates fruit coloration and negatively regulates cold resistance, Sci. Hortic., 295, 10.1016/j.scienta.2022.110892
Wang, 2018, Heteromeric geranylgeranyl diphosphate synthase contributes to carotenoid biosynthesis in ripening fruits of red pepper (Capsicum annuum var. Conoides), J. Agric. Food Chem., 66, 11691, 10.1021/acs.jafc.8b04052
Cazzonelli, 2010, Source to sink: regulation of carotenoid biosynthesis in plants, Trends Plant Sci., 15, 266, 10.1016/j.tplants.2010.02.003
Römer, 2000, Elevation of the provitamin A content of transgenic tomato plants, Nat. Biotechnol., 18, 666, 10.1038/76523
Qin, 2007, Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis, Cell Res., 17, 471, 10.1038/cr.2007.40
Bai, 2009, Novel lycopene epsilon cyclase activities in maize revealed through perturbation of carotenoid biosynthesis, Plant J., 59, 588, 10.1111/j.1365-313X.2009.03899.x
Welsch, 2008, A third phytoene synthase is devoted to abiotic stress-induced abscisic acid formation in rice and defines functional diversification of phytoene synthase genes, Plant Physiol., 147, 367, 10.1104/pp.108.117028
Song, 2023, An R‐R‐type MYB transcription factor promotes nonclimacteric pepper fruit carotenoid pigment biosynthesis, Plant J., 10.1111/tpj.16257
Barry, 2008, Amino acid substitutions in homologs of the STAY-GREEN protein are responsible for the green-flesh and chlorophyll retainer mutations of tomato and pepper, Plant Physiol., 147, 179, 10.1104/pp.108.118430
Hou, 2018, Characterization of the hot pepper (Capsicum frutescens) fruit ripening regulated by ethylene and ABA, BMC Plant Biol., 18, 162, 10.1186/s12870-018-1377-3
Efrati, 2005, Molecular mapping of the chlorophyll retainer (cl) mutation in pepper (Capsicum spp.) and screening for candidate genes using tomato ESTs homologous to structural genes of the chlorophyll catabolism pathway, Genome, 48, 347, 10.1139/g04-119
Roca, 2006, Stay-Green phenotype slows the carotenogenic process in Capsicum annuum (L.) Fruits, J. Agric. Food Chem., 54, 8782, 10.1021/jf062007r
Naing, 2018, Roles of R2R3-MYB transcription factors in transcriptional regulation of anthocyanin biosynthesis in horticultural plants, Plant Mol. Biol., 98, 1, 10.1007/s11103-018-0771-4
Marszałek, 2017, The effect of high pressure techniques on the stability of anthocyanins in fruit and vegetables, Int. J. Mol. Sci., 18, 277, 10.3390/ijms18020277
Yousuf, 2016, Health benefits of anthocyanins and their encapsulation for potential use in food systems: a review, Crit. Rev. Food Sci. Nutr., 56, 2223, 10.1080/10408398.2013.805316
Nakabayashi, 2014, Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids, Plant J., 77, 367, 10.1111/tpj.12388
Zhang, 2022, The bHLH1-DTX35/DFR module regulates pollen fertility by promoting flavonoid biosynthesis in Capsicum annuum L, Hortic. Res., 9, 10.1093/hr/uhac172
Petroni, 2011, Recent advances on the regulation of anthocyanin synthesis in reproductive organs, Plant Sci., 181, 219, 10.1016/j.plantsci.2011.05.009
Strygina, 2019, Genetic control of anthocyanin pigmentation of potato tissues, BMC Genet., 20, 27, 10.1186/s12863-019-0728-x
Niu, 2010, Coordinated regulation of anthocyanin biosynthesis in Chinese bayberry (Myrica rubra) fruit by a R2R3 MYB transcription factor, Planta, 231, 887, 10.1007/s00425-009-1095-z
Zhao, 2012, The UDP glucose: flavonoid-3-O-glucosyltransferase (UFGT) gene regulates anthocyanin biosynthesis in litchi (Litchi chinesis Sonn.) during fruit coloration, Mol. Biol. Rep., 39, 6409, 10.1007/s11033-011-1303-3
Aza-González, 2013, Anthocyanin accumulation and expression analysis of biosynthesis-related genes during chili pepper fruit development, Biol. Plant., 57, 49, 10.1007/s10535-012-0265-1
Zhang, 2015, VIGS approach reveals the modulation of anthocyanin biosynthetic genes by CaMYB in chili pepper leaves, Front. Plant Sci., 6, 500
Passeri, 2016, New challenges for the design of high value plant products: stabilization of anthocyanins in plant vacuoles, Front. Plant Sci., 7, 153, 10.3389/fpls.2016.00153
Stommel, 2009, Transcription factor families regulate the anthocyanin siosynthetic pathway in Capsicum annuum, J. Am. Soc. Hort. Sci., 134, 244, 10.21273/JASHS.134.2.244
Gonzali, 2009, Purple as a tomato: towards high anthocyanin tomatoes, Trends Plant Sci., 14, 237, 10.1016/j.tplants.2009.02.001
Dubos, 2010, MYB transcription factors in Arabidopsis, Trends Plant Sci., 15, 573, 10.1016/j.tplants.2010.06.005
Liu, 2020, Fine mapping of the Ca3GT gene controlling anthocyanin biosynthesis in mature unripe fruit of Capsicum annuum L, Theor. Appl. Genet., 133, 2729, 10.1007/s00122-020-03628-7
Lu, 2019, CaMYC, a novel transcription factor, regulates anthocyanin biosynthesis in color-leaved pepper (Capsicum annuum L.), J. Plant Growth Regul., 38, 574, 10.1007/s00344-018-9871-2
Zhang, 2020, Assessing the functional role of color-related CaMYB gene under cold stress using virus-induced gene silencing in the fruit of pepper (Capsicum annuum L.), Sci. Hortic., 272, 10.1016/j.scienta.2020.109504
Zhao, 2013, The R2R3-MYB, bHLH, WD40, and related transcription factors in flavonoid biosynthesis, Funct. Integr. Genom., 13, 75, 10.1007/s10142-012-0301-4
Montefiori, 2015, In the Solanaceae, a hierarchy of bHLHs confer distinct target specificity to the anthocyanin regulatory complex, J. Exp. Bot., 66, 1427, 10.1093/jxb/eru494
Docimo, 2016, Phenylpropanoids accumulation in eggplant fruit: characterization of biosynthetic genes and regulation by a MYB transcription factor, Front. Plant Sci., 6, 1233, 10.3389/fpls.2015.01233
Stommel, 2015, Coordinated regulation of biosynthetic and regulatory genes coincides with anthocyanin accumulation in developing eggplant fruit, J. Am. Soc. Hort. Sci., 140, 129, 10.21273/JASHS.140.2.129
Kobayashi, 2005, Association of VvmybA1 gene expression with anthocyanin production in grape (Vitis vinifera) skin-color mutants, J. Jpn. Soc. Hortic. Sci., 74, 196, 10.2503/jjshs.74.196
Guo, 2021, Accumulation characteristics of carotenoids and adaptive fruit color variation in ornamental pepper, Sci. Hortic., 275, 10.1016/j.scienta.2020.109699
Villa-Rivera, 2021, Transcriptional regulation of ripening in chili pepper fruits (Capsicum spp.), Int. J. Mol. Sci., 22, 12151, 10.3390/ijms222212151
Byun, 2022, Identification of CaAN3 as a fruit-specific regulator of anthocyanin biosynthesis in pepper (Capsicum annuum), Theor. Appl. Genet., 135, 2197, 10.1007/s00122-022-04106-y
Li, 2023, Identification of CaPs locus involving in purple stripe formation on unripe fruit, reveals allelic variation and alternative splicing of R2R3-MYB transcription factor in pepper (Capsicum annuum L.), Front. Plant Sci., 14, 1140851, 10.3389/fpls.2023.1140851
Chen, 2022, Induced mutation in ELONGATED HYPOCOTYL5 abolishes anthocyanin accumulation in the hypocotyl of pepper, Theor. Appl. Genet., 135, 3455, 10.1007/s00122-022-04192-y
Aguilar-Barragán, 2014, Virus-induced silencing of MYB and WD40 transcription factor genes affects the accumulation of anthocyanins in chilli pepper fruit, Biol. Plant., 58, 567, 10.1007/s10535-014-0427-4
Liu, 2021, Genome-wide characterization of the R2R3-MYB transcription factors in pepper (Capsicum spp.) unveils the role of CaMYB101 as repressor in anthocyanin biosynthesis, bioRxiv
Albert, 2014, A conserved network of transcriptional activators and repressors regulates anthocyanin pigmentation in eudicots, Plant Cell, 26, 962, 10.1105/tpc.113.122069
Albert, 2015, Subspecialization of R2R3-MYB repressors for anthocyanin and proanthocyanidin regulation in forage legumes, Front. Plant Sci., 6, 1165, 10.3389/fpls.2015.01165
Zhu, 2019, Natural variations in the MYB transcription factor MYB31 determine the evolution of extremely pungent peppers, New Phytol., 223, 922, 10.1111/nph.15853
Stewart, 2005, The Pun1 gene for pungency in pepper encodes a putative acyltransferase, Plant J., 42, 675, 10.1111/j.1365-313X.2005.02410.x
Tanaka, 2010, Newly mutated putative-aminotransferase in nonpungent pepper (Capsicum annuum) results in biosynthesis of capsinoids, capsaicinoid analogues, J. Agric. Food Chem., 58, 1761, 10.1021/jf903282r
Zsiborás, 2018, Capsaicin and capsiate could be appropriate agents for treatment of obesity: a meta-analysis of human studies, Crit. Rev. Food Sci. Nutr., 58, 1419, 10.1080/10408398.2016.1262324
Uarrota, 2021, Factors affecting the capsaicinoid profile of hot peppers and biological activity of their non-pungent analogs (Capsinoids) present in sweet peppers, Crit. Rev. Food Sci. Nutr., 61, 649, 10.1080/10408398.2020.1743642
Yazawa, 1989, Content of capsaicinoids and capsaicinoid-like substances in fruit of pepper (Capsicum annuum L.) hybrids made with′ CH-19 Sweet′ as a parent., J. Jpn. Soc. Hortic. Sci., 58, 601, 10.2503/jjshs.58.601
Sano, 2022, Vanillin reduction in the biosynthetic pathway of capsiate, a non-pungent component of Capsicum fruits, is catalyzed by cinnamyl alcohol dehydrogenase, Sci. Rep., 12, 12384, 10.1038/s41598-022-16150-1
Stewart, 2007, Genetic control of pungency in C. chinense via the Pun1 locus, J. Exp. Bot., 58, 979, 10.1093/jxb/erl243
Cisneros-Pineda, 2007, Capsaicinoids quantification in chili peppers cultivated in the state of Yucatan, Mexico, Food Chem., 104, 1755, 10.1016/j.foodchem.2006.10.076
Mazourek, 2009, A dynamic interface for capsaicinoid systems biology, Plant Physiol., 150, 1806, 10.1104/pp.109.136549
Bosland, 2015, Novel formation of ectopic (nonplacental) capsaicinoid secreting vesicles on fruit walls explains the morphological mechanism for super-hot chile peppers, J. Am. Soc. Hort. Sci., 140, 253, 10.21273/JASHS.140.3.253
Tanaka, 2017, Difference in capsaicinoid biosynthesis gene expression in the pericarp reveals elevation of capsaicinoid contents in chili peppers (Capsicum chinense), Plant Cell Rep., 36, 267, 10.1007/s00299-016-2078-8
Tanaka, 2021, Capsaicinoid biosynthesis in the pericarp of chili pepper fruits is associated with a placental septum-like transcriptome profile and tissue structure, Plant Cell Rep., 40, 1859, 10.1007/s00299-021-02750-0
Sugiyama, 2017, Capsaicinoids production and accumulation in epidermal cells on the internal side of the fruit pericarp in ‘Bhut Jolokia’ (Capsicum chinense), Cytologia, 82, 303, 10.1508/cytologia.82.303
Zewdie, 2000, Evaluation of genotype, environment, and genotype-by-environment interaction for capsaicinoids in Capsicum annuum L, Euphytica, 111, 185, 10.1023/A:1003837314929
Stellari, 2010, Contrasting modes for loss of pungency between cultivated and wild species of Capsicum, Heredity, 104, 460, 10.1038/hdy.2009.131
Han, 2019, A MYB transcription factor is a candidate to control pungency in Capsicum annuum, Theor. Appl. Genet., 132, 1235, 10.1007/s00122-018-03275-z
Yi, 2022, Genetic mapping revealed that the Pun2 gene in Capsicum chacoense encodes a putative aminotransferase, Front. Plant Sci., 13, 1039393, 10.3389/fpls.2022.1039393
Lang, 2009, Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv. CH-19 Sweet, Plant J., 59, 953, 10.1111/j.1365-313X.2009.03921.x
Tanaka, 2010, Novel loss-of-function putative aminotransferase alleles cause biosynthesis of capsinoids, nonpungent capsaicinoid analogues, in mildly pungent chili peppers (Capsicum chinense), J. Agric. Food Chem., 58, 11762, 10.1021/jf1019642
Koeda, 2014, Analysis of non-pungency, aroma and provenance of Caribbean native Capsicum chinese varieties, J. Jpn. Soc. Hortic. Sci., 83, 244, 10.2503/jjshs1.CH-105
Park, 2015, A low-pungency S3212 genotype of Capsicum frutescens caused by a mutation in the putative aminotransferase (p-AMT) gene, Mol. Genet. Genom., 290, 2217, 10.1007/s00438-015-1071-1
Jang, 2015, Substitution of a dysfunctional pAMT allele results in low-pungency but high levels of capsinoid in Capsicum chinense ‘Habanero’, Plant Breed. Biotechnol., 3, 119, 10.9787/PBB.2015.3.2.119
Tanaka, 2015, Multiple loss-of-function putative aminotransferase alleles contribute to low pungency and capsinoid biosynthesis in Capsicum chinense, Mol. Breed., 35, 142, 10.1007/s11032-015-0339-9
Tanaka, 2018, Identification of a novel mutant pAMT allele responsible for low-pungency and capsinoid production in chili pepper: accession 'No. 4034'(Capsicum chinense), Hortic. J., 87, 222, 10.2503/hortj.OKD-115
Arce-Rodríguez, 2019, Biochemistry and molecular biology of capsaicinoid biosynthesis: recent advances and perspectives, Plant Cell Rep., 38, 1017, 10.1007/s00299-019-02406-0
Jeong, 2015, Marker-assisted backcross breeding for development of pepper varieties (Capsicum annuum) containing capsinoids, Mol. Breed., 35, 226, 10.1007/s11032-015-0417-z
Arce-Rodríguez, 2017, An R2R3-MYB transcription factor regulates capsaicinoid biosynthesis, Plant Physiol., 174, 1359, 10.1104/pp.17.00506
Arce-Rodríguez, 2015, Silencing AT3 gene reduces the expression of pAmt, BCAT, Kas, and Acl genes involved in capsaicinoid biosynthesis in chili pepper fruits, Biol. Plant., 59, 477, 10.1007/s10535-015-0525-y
Koeda, 2019, Mutation in the putative ketoacyl-ACP reductase CaKR1 induces loss of pungency in Capsicum, Theor. Appl. Genet., 132, 65, 10.1007/s00122-018-3195-2
Aluru, 2003, Differential expression of fatty acid synthase genes, Acl, Fat and Kas, in Capsicum fruit, J. Exp. Bot., 54, 1655, 10.1093/jxb/erg176
Koeda, 2015, A Comt1 loss of function mutation is insufficient for loss of pungency in Capsicum, Am. J. Plant Sci., 68, 1243, 10.4236/ajps.2015.68127
Ma Rosario Abraham-Juárez, 2008, Virus-induced silencing of Comt, pAmt and Kas genes results in a reduction of capsaicinoid accumulation in chili pepper fruits, Planta, 227, 681, 10.1007/s00425-007-0651-7
Kim, 2009, Characterization of putative capsaicin synthase promoter activity, Mol. Cells, 28, 331, 10.1007/s10059-009-0128-6
Yarnes, 2013, Identification of QTLs for capsaicinoids, fruit quality, and plant architecture-related traits in an interspecific Capsicum RIL population, Genome, 56, 61, 10.1139/gen-2012-0083
Ben-Chaim, 2006, QTL analysis for capsaicinoid content in Capsicum, Theor. Appl. Genet., 113, 1481, 10.1007/s00122-006-0395-y
Blum, 2003, Molecular mapping of capsaicinoid biosynthesis genes and quantitative trait loci analysis for capsaicinoid content in Capsicum, Theor. Appl. Genet., 108, 79, 10.1007/s00122-003-1405-y
Han, 2018, QTL mapping and GWAS reveal candidate genes controlling capsaicinoid content in Capsicum, Plant Biotechnol. J., 16, 1546, 10.1111/pbi.12894
Lee, 2016, QTL mapping for capsaicin and dihydrocapsaicin content in a population of Capsicum annuum ‘NB1’ × Capsicum chinense ‘Bhut Jolokia’, Plant Breed., 135, 376, 10.1111/pbr.12355
Nimmakayala, 2016, Genome-wide diversity and association mapping for capsaicinoids and fruit weight in Capsicum annuum L, Sci. Rep., 6, 38081, 10.1038/srep38081
Hill, 2017, Regions underlying population structure and the genomics of organ size determination in Capsicum annuum, Plant Genome, 10, 1, 10.3835/plantgenome2017.03.0026
Park, 2019, A major QTL and candidate genes for capsaicinoid biosynthesis in the pericarp of Capsicum chinense revealed using QTL-seq and RNA-seq, Theor. Appl. Genet., 132, 515, 10.1007/s00122-018-3238-8
Han, 2013, Biosynthesis of capsinoid is controlled by the Pun1 locus in pepper, Mol. Breed., 31, 537, 10.1007/s11032-012-9811-y
Ogawa, 2015, Evidence of capsaicin synthase activity of the Pun1-encoded protein and its role as a determinant of capsaicinoid accumulation in pepper, BMC Plant Biol., 15, 93, 10.1186/s12870-015-0476-7
Egan, 2019, Tandem gene duplication and recombination at the AT3 locus in the Solanaceae, a gene essential for capsaicinoid biosynthesis in Capsicum, PLoS One, 14, 10.1371/journal.pone.0210510
Kirii, 2017, Non-pungency in a Japanese chili pepper landrace (Capsicum annuum) is caused by a novel loss-of-function Pun1 allele, Hortic. J., 86, 61, 10.2503/hortj.MI-148
Kondo, 2023, Genetic analysis of pungency deficiency in Japanese chili pepper ‘Shishito’ (Capsicum annuum) revealed its unique heredity and brought the discovery of two genetic loci involved with the reduction of pungency, Mol. Genet. Genom., 298, 201, 10.1007/s00438-022-01975-2
Tanaka, 2019, Positional differences of intronic transposons in pAMT affect the pungency level in chili pepper through altered splicing efficiency, Plant J., 100, 693, 10.1111/tpj.14462
Tsurumaki, 2019, Discovery of novel unfunctional pAMT allele pamt10 causing loss of pungency in sweet bell pepper (Capsicum annuum L.), Breed Sci., 69, 133, 10.1270/jsbbs.18150
Tohge, 2016, Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae, Nat. Commun.., 7, 12399, 10.1038/ncomms12399
Fritz, 2006, Regulation of secondary metabolism by the carbon–nitrogen status in tobacco: nitrate inhibits large sectors of phenylpropanoid metabolism, Plant J., 46, 533, 10.1111/j.1365-313X.2006.02715.x
Schulz, 2016, Flavonoids are determinants of freezing tolerance and cold acclimation in Arabidopsis thaliana, Sci. Rep., 6, 34027, 10.1038/srep34027
Treutter, 2005, Significance of flavonoids in plant resistance and enhancement of their biosynthesis, Plant Biol., 7, 581, 10.1055/s-2005-873009
Campos‐Vargas, 2005, Heat shock treatments delay the increase in wound‐induced phenylalanine ammonia‐lyase activity by altering its expression, not its induction in Romaine lettuce (Lactuca sativa) tissue, Physiol. Plant., 123, 82, 10.1111/j.1399-3054.2005.00446.x
Teklemariam, 2004, Phenylalanine ammonia‐lyase‐induced freezing tolerance in jack pine (Pinus banksiana) seedlings treated with low, ambient levels of ultraviolet‐B radiation, Physiol. Plant., 122, 244, 10.1111/j.0031-9317.2004.00396.x
Sanchez-Ballesta, 2000, Accumulation of PAL transcript and PAL activity as affected by heat-conditioning and low-temperature storage and its relation to chilling sensitivity in mandarin fruits, J. Agric. Food Chem., 48, 2726, 10.1021/jf991141r
Lafuente, 2004, Active oxygen detoxifying enzymes and phenylalanine ammonia-lyase in the ethylene-induced chilling tolerance in citrus fruit, J. Agric. Food Chem., 52, 3606, 10.1021/jf035185i
Chen, 2006, Effect of salicylic acid on phenylpropanoids and phenylalanine ammonia-lyase in harvested grape berries, Postharvest Biol. Technol., 40, 64, 10.1016/j.postharvbio.2005.12.017
Murakami, 2006, Fruit pungency of ‘Shishito’pepper as affected by a dark interval in continuous fluorescent illumination with temperature alteration, J. Soc. High Tech. Agric., 18, 284, 10.2525/shita.18.284
Estrada, 1999, Pungency level in fruits of the Padrón pepper with different water supply, Sci. Hortic., 81, 385, 10.1016/S0304-4238(99)00029-1
Chabaane, 2022, Altered capsaicin levels in domesticated chili pepper varieties affect the interaction between a generalist herbivore and its ectoparasitoid, J. Pest Sci., 95, 735, 10.1007/s10340-021-01399-8
Bonaventure, 2012, Perception of insect feeding by plants, Plant Biol., 14, 872, 10.1111/j.1438-8677.2012.00650.x
Gutiérrez-Carbajal, 2010, Induction of capsaicinoid synthesis in Capsicum chinense cell cultures by salicylic acid or methyl jasmonate, Biol. Plant., 54, 430, 10.1007/s10535-010-0078-z
Sudha, 2003, Influence of methyl jasmonate and salicylic acid in the enhancement of capsaicin production in cell suspension cultures of Capsicum frutescens Mill, Curr. Sci., 1212
Ochoa-Alejo, 1993, Activity of enzymes involved in capsaicin biosynthesis in callus tissue and fruits of chili pepper (Capsicum annuum L.), J. Plant Physiol., 141, 147, 10.1016/S0176-1617(11)80751-0
Meng, 2022, Anthocyanins accumulation analysis of correlated genes by metabolome and transcriptome in green and purple peppers (Capsicum annuum), BMC Plant Biol., 22, 358, 10.1186/s12870-022-03746-y
Giovannoni, 2017, The epigenome and transcriptional dynamics of fruit ripening, Annu. Rev. Plant Biol., 68, 61, 10.1146/annurev-arplant-042916-040906
Jones, 2002, Down-regulation of DR12, an auxin-response-factor homolog, in the tomato results in a pleiotropic phenotype including dark green and blotchy ripening fruit, Plant J., 32, 603, 10.1046/j.1365-313X.2002.01450.x
Böttcher, 2010, Sequestration of auxin by the indole-3-acetic acid-amido synthetase GH3-1 in grape berry (Vitis vinifera L.) and the proposed role of auxin conjugation during ripening, J. Exp. Bot., 61, 3615, 10.1093/jxb/erq174
Sun, 2012, Fruit-specific RNAi-mediated suppression of SlNCED1 increases both lycopene and β-carotene contents in tomato fruit, J. Exp. Bot., 63, 3097, 10.1093/jxb/ers026
Itkin, 2009, TOMATO AGAMOUS-LIKE1 is a component of the fruit ripening regulatory network, Plant J., 60, 1081, 10.1111/j.1365-313X.2009.04064.x
Vrebalov, 2009, Fleshy fruit expansion and ripening are regulated by the tomato SHATTERPROOF gene TAGL1, Plant Cell, 21, 3041, 10.1105/tpc.109.066936
Bemer, 2012, Rossetto PdB, Angenent GC, de Maagd RA: the tomato FRUITFULL homologs TDR4/FUL1 and MBP7/FUL2 regulate ethylene-independent aspects of fruit ripening, Plant Cell, 24, 4437, 10.1105/tpc.112.103283
Fujisawa, 2014, Transcriptional regulation of fruit ripening by tomato FRUITFULL homologs and associated MADS box proteins, Plant Cell, 26, 89, 10.1105/tpc.113.119453
Cheval, 2017, PRR2, a pseudo-response regulator, promotes salicylic acid and camalexin accumulation during plant immunity, Sci. Rep., 7, 6979, 10.1038/s41598-017-07535-8