Antithrombotic Therapy for VTE Disease

Chest - Tập 141 - Trang e419S-e496S - 2012
Clive Kearon1, Elie A. Akl2, Anthony J. Comerota3, Paolo Prandoni4, Henri Bounameaux5, Samuel Z. Goldhaber6, Michael E. Nelson7, Philip S. Wells8, Michael K. Gould9, Francesco Dentali10, Mark Crowther11, Susan R. Kahn12
1Department of Medicine and Clinical Epidemiology and Biostatistics, Michael De Groote School of Medicine, McMaster University, Hamilton, ON, Canada
2Department of Medicine, Family Medicine, and Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY
3Department of Surgery, Jobst Vascular Center, Toledo, OH
4Department of Cardiothoracic and Vascular Sciences, University of Padua, Padua, Italy
5Department of Medical Specialties, University Hospitals of Geneva, Geneva, Switzerland
6Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
7Department of Medicine, Shawnee Mission Medical Center, Shawnee Mission, KS
8Department of Medicine, University of Ottawa, Ottawa, ON, Canada
9Department of Medicine and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
10Department of Medicine, University of Insubria, Varese, Italy
11Department of Medicine, Michael De Groote School of Medicine, McMaster University, Hamilton, ON, Canada
12Department of Medicine and Clinical Epidemiology and Biostatistics, McGill University, Montreal, QC, Canada

Tài liệu tham khảo

Garcia, 2012, Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e24S, 10.1378/chest.11-2291 Ageno, 2012, Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e44S, 10.1378/chest.11-2292 Holbrook, 2012, Evidence-based management of anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e152S, 10.1378/chest.11-2295 Bates, 2012, VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e691S, 10.1378/chest.11-2300 Monagle, 2012, Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e737S, 10.1378/chest.11-2308 Kearon, 2008, Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition), Chest, 133, 454S, 10.1378/chest.08-0658 Kearon, 2003, Natural history of venous thromboembolism, Circulation, 107, I-22-I30 Stein, 2010, Silent pulmonary embolism in patients with deep venous thrombosis: a systematic review, Am J Med, 123, 426, 10.1016/j.amjmed.2009.09.037 Murin, 2002, Comparison of outcomes after hospitalization for deep venous thrombosis or pulmonary embolism, Thromb Haemost, 88, 407, 10.1055/s-0037-1613230 Baglin, 2010, Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis, J Thromb Haemost, 8, 2436, 10.1111/j.1538-7836.2010.04022.x Douketis, 1998, Risk of fatal pulmonary embolism in patients with treated venous thromboembolism, JAMA, 279, 458, 10.1001/jama.279.6.458 Carrier, 2010, Systematic review: case-fatality rates of recurrent venous thromboembolism and major bleeding events among patients treated for venous thromboembolism, Ann Intern Med, 152, 578, 10.7326/0003-4819-152-9-201005040-00008 Linkins, 2010, Intracranial and fatal bleeding according to indication for long-term oral anticoagulant therapy, J Thromb Haemost, 8, 2201, 10.1111/j.1538-7836.2010.04016.x Linkins, 2003, Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis, Ann Intern Med, 139, 893, 10.7326/0003-4819-139-11-200312020-00007 MacLean, 2012, Patient values and preferences for decision making in antithrombotic therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e1S, 10.1378/chest.11-2290 Guyatt, 2012, Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, 53S, 10.1378/chest.11-2288 van der Meer, 1993, Bleeding complications in oral anticoagulant therapy. An analysis of risk factors, Arch Intern Med, 153, 1557, 10.1001/archinte.1993.00410130073007 Beyth, 1998, Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin, Am J Med, 105, 91, 10.1016/S0002-9343(98)00198-3 Douketis, 2006, Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding, Arch Intern Med, 166, 853, 10.1001/archinte.166.8.853 Kuijer, 1999, Prediction of the risk of bleeding during anticoagulant treatment for venous thromboembolism, Arch Intern Med, 159, 457, 10.1001/archinte.159.5.457 Landefeld, 1990, A bleeding risk index for estimating the probability of major bleeding in hospitalized patients starting anticoagulant therapy, Am J Med, 89, 569, 10.1016/0002-9343(90)90174-C Palareti, 1996, Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT), Lancet, 348, 423, 10.1016/S0140-6736(96)01109-9 Torn, 2005, Risks of oral anticoagulant therapy with increasing age, Arch Intern Med, 165, 1527, 10.1001/archinte.165.13.1527 White, 1999, Major bleeding after hospitalization for deep-venous thrombosis, Am J Med, 107, 414, 10.1016/S0002-9343(99)00267-3 Olesen, 2011, Bleeding risk in ‘real world’ patients with atrial fibrillation: comparison of two established bleeding prediction schemes in a nationwide cohort, J Thromb Haemost, 9, 1460, 10.1111/j.1538-7836.2011.04378.x Fihn, 1996, The risk for and severity of bleeding complications in elderly patients treated with warfarin, Ann Intern Med, 124, 970, 10.7326/0003-4819-124-11-199606010-00004 Gage, 2006, Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF), Am Heart J, 151, 713, 10.1016/j.ahj.2005.04.017 Lip, 2011, J Am Coll Cardiol, 57, 173, 10.1016/j.jacc.2010.09.024 Nieto, 2006, Acute venous thromboembolism in patients with recent major bleeding. The influence of the site of bleeding and the time elapsed on outcome, J Thromb Haemost, 4, 2367, 10.1111/j.1538-7836.2006.02188.x Ruíz-Giménez, 2008, Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry, Thromb Haemost, 100, 26, 10.1160/TH08-03-0193 van der Meer, 1996, Assessment of a bleeding risk index in two cohorts of patients treated with oral anticoagulants, Thromb Haemost, 76, 12, 10.1055/s-0038-1650514 Pengo, 2001, Oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and risk of bleeding. A Multicenter Inception Cohort Study, Thromb Haemost, 85, 418, 10.1055/s-0037-1615599 Fang, 2011, A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study, J Am Coll Cardiol, 58, 395, 10.1016/j.jacc.2011.03.031 Shireman, 2006, Development of a contemporary bleeding risk model for elderly warfarin recipients, Chest, 130, 1390, 10.1378/chest.130.5.1390 Fihn, 1993, Risk factors for complications of chronic anticoagulation. A multicenter study, Ann Intern Med, 118, 511, 10.7326/0003-4819-118-7-199304010-00005 Nieto, 2010, Fatal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: findings from the RIETE registry, J Thromb Haemost, 8, 1216, 10.1111/j.1538-7836.2010.03852.x Hutten, 2000, Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis, J Clin Oncol, 18, 3078, 10.1200/JCO.2000.18.17.3078 Prandoni, 2002, Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis, Blood, 100, 3484, 10.1182/blood-2002-01-0108 Hylek, 1994, Risk factors for intracranial hemorrhage in outpatients taking warfarin, Ann Intern Med, 120, 897, 10.7326/0003-4819-120-11-199406010-00001 Dentali, 2010, Prevalence and clinical history of incidental, asymptomatic pulmonary embolism: a meta-analysis, Thromb Res, 125, 518, 10.1016/j.thromres.2010.03.016 Hull, 1990, Heparin for 5 days as compared with 10 days in the initial treatment of proximal venous thrombosis, N Engl J Med, 322, 1260, 10.1056/NEJM199005033221802 Dahri, 2007, The risk of bleeding with warfarin: a systematic review and performance analysis of clinical prediction rules, Thromb Haemost, 98, 980, 10.1160/TH07-04-0297 Palareti, 2009, Bleeding with anticoagulation therapy-who is at risk, and how best to identify such patients, Thromb Haemost, 102, 268 Kearon, 2003, Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism, N Engl J Med, 349, 631, 10.1056/NEJMoa035422 Collins, 1996, Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials, BMJ, 313, 652, 10.1136/bmj.313.7058.652 Yusuf, 2005, Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation, JAMA, 293, 427, 10.1001/jama.293.4.427 Prandoni, 1996, The long-term clinical course of acute deep venous thrombosis, Ann Intern Med, 125, 1, 10.7326/0003-4819-125-1-199607010-00001 Palareti, 2006, D-dimer testing to determine the duration of anticoagulation therapy, N Engl J Med, 355, 1780, 10.1056/NEJMoa054444 Wells, 2003, The outpatient bleeding risk index: validation of a tool for predicting bleeding rates in patients treated for deep venous thrombosis and pulmonary embolism, Arch Intern Med, 163, 917, 10.1001/archinte.163.8.917 Barritt, 1960, Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial, Lancet, 1, 1309, 10.1016/S0140-6736(60)92299-6 Brandjes, 1992, Acenocoumarol and heparin compared with acenocoumarol alone in the initial treatment of proximal-vein thrombosis, N Engl J Med, 327, 1485, 10.1056/NEJM199211193272103 Hull, 1986, Continuous intravenous heparin compared with intermittent subcutaneous heparin in the initial treatment of proximal-vein thrombosis, N Engl J Med, 315, 1109, 10.1056/NEJM198610303151801 Raschke, 1993, The weight-based heparin dosing nomogram compared with a “standard care” nomogram. A randomized controlled trial, Ann Intern Med, 119, 874, 10.7326/0003-4819-119-9-199311010-00002 Wells, 1998, A simple clinical model for the diagnosis of deep-vein thrombosis combined with impedance plethysmography: potential for an improvement in the diagnostic process, J Intern Med, 243, 15, 10.1046/j.1365-2796.1998.00249.x Le Gal, 2006, Prediction of pulmonary embolism in the emergency department: the revised Geneva score, Ann Intern Med, 144, 165, 10.7326/0003-4819-144-3-200602070-00004 Wells, 2000, Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer, Thromb Haemost, 83, 416, 10.1055/s-0037-1613830 Bates, 2012, Diagnosis of DVT: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e351S, 10.1378/chest.11-2299 Johnson, 2010, Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis, JAMA, 303, 438, 10.1001/jama.2010.43 Bernardi, 2008, Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial, JAMA, 300, 1653, 10.1001/jama.300.14.1653 Masuda, 2010, The case for managing calf vein thrombi with duplex surveillance and selective anticoagulation, Dis Mon, 56, 601, 10.1016/j.disamonth.2010.06.011 Palareti, 2010, Evolution of untreated calf deep-vein thrombosis in high risk symptomatic outpatients: the blind, prospective CALTHRO study, Thromb Haemost, 104, 1063, 10.1160/TH10-06-0351 Righini, 2006, Clinical relevance of distal deep vein thrombosis. Review of literature data, Thromb Haemost, 95, 56, 10.1160/TH05-08-0588 Macdonald, 2003, Short-term natural history of isolated gastrocnemius and soleal vein thrombosis, J Vasc Surg, 37, 523, 10.1067/mva.2003.149 Parisi, 2009, Isolated distal deep vein thrombosis: efficacy and safety of a protocol of treatment. Treatment of Isolated Calf Thrombosis (TICT) Study, Int Angiol, 28, 68 Schwarz, 2010, Therapy of isolated calf muscle vein thrombosis: a randomized, controlled study, J Vasc Surg, 52, 1246, 10.1016/j.jvs.2010.05.094 Lagerstedt, 1985, Need for long-term anticoagulant treatment in symptomatic calf-vein thrombosis, Lancet, 2, 515, 10.1016/S0140-6736(85)90459-3 Gallus, 1986, Safety and efficacy of warfarin started early after submassive venous thrombosis or pulmonary embolism, Lancet, 2, 1293, 10.1016/S0140-6736(86)91431-5 Leroyer, 1998, Early versus delayed introduction of oral vitamin K antagonists in combination with low-molecular-weight heparin in the treatment of deep vein thrombosis. a randomized clinical trial, Haemostasis, 28, 70 Linkins, 2012, Treatment and prevention of heparin-induced thrombocytopenia: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e495S, 10.1378/chest.11-2303 Prandoni, 2004, Subcutaneous adjusted-dose unfractionated heparin vs fixed-dose low-molecular-weight heparin in the initial treatment of venous thromboembolism, Arch Intern Med, 164, 1077, 10.1001/archinte.164.10.1077 Kearon, 2006, Comparison of fixed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism, JAMA, 296, 935, 10.1001/jama.296.8.935 Dolovich, 2000, A meta-analysis comparing low-molecular-weight heparins with unfractionated heparin in the treatment of venous thromboembolism: examining some unanswered questions regarding location of treatment, product type, and dosing frequency, Arch Intern Med, 160, 181, 10.1001/archinte.160.2.181 Gould, 1999, Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis. A meta-analysis of randomized, controlled trials, Ann Intern Med, 130, 800, 10.7326/0003-4819-130-10-199905180-00003 van Dongen, 2004, Lensing AW. Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism, Cochrane Database Syst Rev, CD001100 Erkens, 2010, Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism, Cochrane Database Syst Rev, CD001100 Faivre, 1988, [A new treatment of deep venous thrombosis: low molecular weight heparin fractions. Randomized study], Presse Med, 17, 197 Lopaciuk, 1992, Subcutaneous low molecular weight heparin versus subcutaneous unfractionated heparin in the treatment of deep vein thrombosis: a Polish multicenter trial, Thromb Haemost, 68, 14, 10.1055/s-0038-1656309 Büller, 2004, Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial, Ann Intern Med, 140, 867, 10.7326/0003-4819-140-11-200406010-00007 Büller, 2003, Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism, N Engl J Med, 349, 1695, 10.1056/NEJMoa035451 Couturaud, 2001, Low molecular weight heparin administered once versus twice daily in patients with venous thromboembolism: a meta-analysis, Thromb Haemost, 86, 980, 10.1055/s-0037-1616520 van Dongen, 2005, Once versus twice daily LMWH for the initial treatment of venous thromboembolism, Cochrane Database Syst Rev, CD003074 Breddin, 2001, Effects of a low-molecular-weight heparin on thrombus regression and recurrent thromboembolism in patients with deep-vein thrombosis, N Engl J Med, 344, 626, 10.1056/NEJM200103013440902 Charbonnier, 1998, Comparison of a once daily with a twice daily subcutaneous low molecular weight heparin regimen in the treatment of deep vein thrombosis. FRAXODI group, Thromb Haemost, 79, 897, 10.1055/s-0037-1615089 Holmoström, 1992, Fragmin once or twice daily subcutaneously in the treatment of deep venous thrombosis of the leg, Thromb Res, 67, 49, 10.1016/0049-3848(92)90257-B Merli, 2001, Subcutaneous enoxaparin once or twice daily compared with intravenous unfractionated heparin for treatment of venous thromboembolic disease, Ann Intern Med, 134, 191, 10.7326/0003-4819-134-3-200102060-00009 Partsch, 1996, Frequency of pulmonary embolism in patients who have iliofemoral deep vein thrombosis and are treated with once- or twice-daily low-molecular-weight heparin, J Vasc Surg, 24, 774, 10.1016/S0741-5214(96)70012-5 Siegbahn, 1989, Subcutaneous treatment of deep venous thrombosis with low molecular weight heparin. A dose finding study with LMWH-Novo, Thromb Res, 55, 767, 10.1016/0049-3848(89)90307-1 Bauersachs, 2010, Oral rivaroxaban for symptomatic venous thromboembolism, N Engl J Med, 363, 2499, 10.1056/NEJMoa1007903 Boccalon, 2000, Clinical outcome and cost of hospital vs home treatment of proximal deep vein thrombosis with a low-molecular-weight heparin: the Vascular Midi-Pyrenees study, Arch Intern Med, 160, 1769, 10.1001/archinte.160.12.1769 Chong, 2005, Once-daily enoxaparin in the outpatient setting versus unfractionated heparin in hospital for the treatment of symptomatic deep-vein thrombosis, J Thromb Thrombolysis, 19, 173, 10.1007/s11239-005-1848-x Daskalopoulos, 2005, Long-term treatment of deep venous thrombosis with a low molecular weight heparin (tinzaparin): a prospective randomized trial, Eur J Vasc Endovasc Surg, 29, 638, 10.1016/j.ejvs.2004.02.029 Koopman, 1996, Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home, N Engl J Med, 334, 682, 10.1056/NEJM199603143341102 Levine, 1996, A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis, N Engl J Med, 334, 677, 10.1056/NEJM199603143341101 Ramacciotti, 2004, An open-label, comparative study of the efficacy and safety of once-daily dose of enoxaparin versus unfractionated heparin in the treatment of proximal lower limb deep-vein thrombosis, Thromb Res, 114, 149, 10.1016/j.thromres.2004.05.009 Bäckman, 2004, Deep venous thrombosis: a new task for primary health care. A randomised economic study of outpatient and inpatient treatment, Scand J Prim Health Care, 22, 44, 10.1080/02813430310003543 O'Brien, 1999, Economic evaluation of outpatient treatment with low-molecular-weight heparin for proximal vein thrombosis, Arch Intern Med, 159, 2298, 10.1001/archinte.159.19.2298 Huse, 2002, Outpatient treatment of venous thromboembolism with low-molecular-weight heparin: an economic evaluation, Am J Manag Care, 8, S10 Spyropoulos, 2002, Management of acute proximal deep vein thrombosis: pharmacoeconomic evaluation of outpatient treatment with enoxaparin vs inpatient treatment with unfractionated heparin, Chest, 122, 108, 10.1378/chest.122.1.108 Tillman, 2000, Effectiveness and economic impact associated with a program for outpatient management of acute deep vein thrombosis in a group model health maintenance organization, Arch Intern Med, 160, 2926, 10.1001/archinte.160.19.2926 Rodger, 1998, Cost-effectiveness of low-molecular-weight heparin and unfractionated heparin in treatment of deep vein thrombosis, CMAJ, 159, 931 van den Belt, 1998, Replacing inpatient care by outpatient care in the treatment of deep venous thrombosis—an economic evaluation, Thromb Haemost, 79, 259, 10.1055/s-0037-1614975 Kahn, 2008, Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis, Ann Intern Med, 149, 698, 10.7326/0003-4819-149-10-200811180-00004 Sharifi, 2010, Endovenous therapy for deep venous thrombosis: the TORPEDO trial, Catheter Cardiovasc Interv, 76, 316, 10.1002/ccd.22638 Jaff, 2011, Circulation, 123, 1788, 10.1161/CIR.0b013e318214914f Elsharawy, 2002, Early results of thrombolysis vs anticoagulation in iliofemoral venous thrombosis. A randomised clinical trial, Eur J Vasc Endovasc Surg, 24, 209, 10.1053/ejvs.2002.1665 Enden, 2009, Catheter-directed thrombolysis vs. anticoagulant therapy alone in deep vein thrombosis: results of an open randomized, controlled trial reporting on short-term patency, J Thromb Haemost, 7, 1268, 10.1111/j.1538-7836.2009.03464.x Enden, 2007, Catheter-directed venous thrombolysis in acute iliofemoral vein thrombosis—the CaVenT study: rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771), Am Heart J, 154, 808, 10.1016/j.ahj.2007.07.010 Douketis, 2000, Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy, Arch Intern Med, 160, 3431, 10.1001/archinte.160.22.3431 Comerota, 2000, Catheter-directed thrombolysis for iliofemoral deep venous thrombosis improves health-related quality of life, J Vasc Surg, 32, 130, 10.1067/mva.2000.105664 Brass, 2000, Intracranial hemorrhage associated with thrombolytic therapy for elderly patients with acute myocardial infarction: results from the Cooperative Cardiovascular Project, Stroke, 31, 1802, 10.1161/01.STR.31.8.1802 Mehta, 2011, Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy, Am J Med, 124, 48, 10.1016/j.amjmed.2010.07.028 1994, Lancet, 343, 311, 10.1016/S0140-6736(94)91161-4 Piazza, 2010, Fibrinolysis for acute pulmonary embolism, Vasc Med, 15, 419, 10.1177/1358863X10380304 Todd, 2009, Thrombolytic therapy for acute pulmonary embolism: a critical appraisal, Chest, 135, 1321, 10.1378/chest.08-2125 Kasirajan, 2001, Percutaneous AngioJet thrombectomy in the management of extensive deep venous thrombosis, J Vasc Interv Radiol, 12, 179, 10.1016/S1051-0443(07)61823-5 Vedantham, 2002, Lower extremity venous thrombolysis with adjunctive mechanical thrombectomy, J Vasc Interv Radiol, 13, 1001, 10.1016/S1051-0443(07)61864-8 Delomez, 2001, Mechanical thrombectomy in patients with deep venous thrombosis, Cardiovasc Intervent Radiol, 24, 42, 10.1007/s002700001658 Kinney, 2000, Pulmonary embolism from pulse-spray pharmacomechanical thrombolysis of clotted hemodialysis grafts: urokinase versus heparinized saline, J Vasc Interv Radiol, 11, 1143, 10.1016/S1051-0443(07)61355-4 Arnesen, 1978, A prospective study of streptokinase and heparin in the treatment of deep vein thrombosis, Acta Med Scand, 203, 457 Arnesen, 1982, Streptokinase of heparin in the treatment of deep vein thrombosis. Follow-up results of a prospective study, Acta Med Scand, 211, 65 Browse, 1968, Streptokinase and deep vein thrombosis, BMJ, 3, 717, 10.1136/bmj.3.5620.717 Duckert, 1975, Treatment of deep vein thrombosis with streptokinase, BMJ, 1, 479, 10.1136/bmj.1.5956.479 Elliot, 1979, A comparative randomized trial of heparin versus streptokinase in the treatment of acute proximal venous thrombosis: an interim report of a prospective trial, Br J Surg, 66, 838, 10.1002/bjs.1800661203 Goldhaber, 1990, Randomized controlled trial of tissue plasminogen activator in proximal deep venous thrombosis, Am J Med, 88, 235, 10.1016/0002-9343(90)90148-7 Kakkar, 1969, Treatment of deep vein thrombosis. A trial of heparin, streptokinase, and arvin, BMJ, 1, 806, 10.1136/bmj.1.5647.806 Kiil, 1981, Urokinase or heparin in the management of patients with deep vein thrombosis?, Acta Chir Scand, 147, 529 Laiho, 2004, Preservation of venous valve function after catheter-directed and systemic thrombolysis for deep venous thrombosis, Eur J Vasc Endovasc Surg, 28, 391, 10.1016/j.ejvs.2004.06.007 Marder, 1977, Quantitative venographic assessment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy, J Lab Clin Med, 89, 1018 Porter, 1975, Comparison of heparin and streptokinase in the treatment of venous thrombosis, Am Surg, 41, 511 Robertson, 1968, Value of streptokinase and heparin in treatment of acute deep venous thrombosis. A coded investigation, Acta Chir Scand, 134, 203 Schulman, 1986, Long-term sequelae of calf vein thrombosis treated with heparin or low-dose streptokinase, Acta Med Scand, 219, 349, 10.1111/j.0954-6820.1986.tb03323.x Schweizer, 1998, Comparative results of thrombolysis treatment with rt-PA and urokinase: a pilot study, Vasa, 27, 167 Schweizer, 2000, Short- and long-term results after thrombolytic treatment of deep venous thrombosis, J Am Coll Cardiol, 36, 1336, 10.1016/S0735-1097(00)00863-9 Tsapogas, 1973, Controlled study of thrombolytic therapy in deep vein thrombosis, Surgery, 74, 973 Turpie, 1990, Tissue plasminogen activator (rt-PA) vs heparin in deep vein thrombosis. Results of a randomized trial, Chest, 97, 172S Verhaeghe, 1989, Multicenter pilot study of the efficacy and safety of systemic rt-PA administration in the treatment of deep vein thrombosis of the lower extremities and/or pelvis, Thromb Res, 55, 5, 10.1016/0049-3848(89)90451-9 Watz, 1979, Rapid thrombolysis and preservation of valvular venous function in high deep vein thrombosis. A comparative study between streptokinase and heparin therapy, Acta Med Scand, 205, 293 Watson, 2004, Thrombolysis for acute deep vein thrombosis, Cochrane Database Syst Rev, CD002783 Common, 1976, Deep vein thrombosis treated with streptokinase or heparin. Follow-up of a randomized study, Angiology, 27, 645, 10.1177/000331977602701105 Comerota, 2006, Technique of contemporary iliofemoral and infrainguinal venous thrombectomy, J Vasc Surg, 43, 185, 10.1016/j.jvs.2005.09.036 Karp, 1966, Recurrent thrombosis after iliofemoral venous thrombectomy, Surg Forum, 17, 147 Lansing, 1968, Five-year follow-up study of iliofemoral venous thrombectomy, Ann Surg, 168, 620, 10.1097/00000658-196810000-00009 Plate, 1990, Long-term results of venous thrombectomy combined with a temporary arterio-venous fistula, Eur J Vasc Surg, 4, 483, 10.1016/S0950-821X(05)80788-1 Plate, 1984, Thrombectomy with temporary arteriovenous fistula: the treatment of choice in acute iliofemoral venous thrombosis, J Vasc Surg, 1, 867, 10.1016/0741-5214(84)90019-3 Plate, 1997, Venous thrombectomy for iliofemoral vein thrombosis—10-year results of a prospective randomised study, Eur J Vasc Endovasc Surg, 14, 367, 10.1016/S1078-5884(97)80286-9 Decousus, 1998, A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. Prévention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group, N Engl J Med, 338, 409, 10.1056/NEJM199802123380701 Mismetti, 2007, A prospective long-term study of 220 patients with a retrievable vena cava filter for secondary prevention of venous thromboembolism, Chest, 131, 223, 10.1378/chest.06-0631 Athanasoulis, 2000, Inferior vena caval filters: review of a 26-year single-center clinical experience, Radiology, 216, 54, 10.1148/radiology.216.1.r00jl1254 Cosmi, 2005, D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis, Thromb Haemost, 94, 969 Streiff, 2000, Vena caval filters: a comprehensive review, Blood, 95, 3669, 10.1182/blood.V95.12.3669 Hajduk, 2010, Vena cava filter occlusion and venous thromboembolism risk in persistently anticoagulated patients: a prospective, observational cohort study, Chest, 137, 877, 10.1378/chest.09-1533 Fox, 2008, Postthrombotic syndrome in relation to vena cava filter placement: a systematic review, J Vasc Interv Radiol, 19, 981, 10.1016/j.jvir.2008.03.022 Usoh, 2010, Prospective randomized study comparing the clinical outcomes between inferior vena cava Greenfield and TrapEase filters, J Vasc Surg, 52, 394, 10.1016/j.jvs.2010.02.280 Nicholson, 2010, Prevalence of fracture and fragment embolization of Bard retrievable vena cava filters and clinical implications including cardiac perforation and tamponade, Arch Intern Med, 170, 1827, 10.1001/archinternmed.2010.316 Dabbagh, 2010, Retrievable inferior vena cava filters are not getting retrieved: where is the gap?, Thromb Res, 126, 493, 10.1016/j.thromres.2010.08.024 Aissaoui, 2009, A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both, Int J Cardiol, 137, 37, 10.1016/j.ijcard.2008.06.020 Kahn, 2008, Physical activity in patients with deep venous thrombosis: a systematic review, Thromb Res, 122, 763, 10.1016/j.thromres.2007.10.011 Hull, 1979, Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis, N Engl J Med, 301, 855, 10.1056/NEJM197910183011602 Levine, 1995, Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis, Thromb Haemost, 74, 606, 10.1055/s-0038-1649783 Research Committee of the British Thoracic Society, 1992, Optimum duration of anticoagulation for deep-vein thrombosis and pulmonary embolism, Lancet, 340, 873, 10.1016/0140-6736(92)93285-U Schulman, 1997, The duration of oral anticoagulant therapy after a second episode of venous thromboembolism, N Engl J Med, 336, 393, 10.1056/NEJM199702063360601 Baglin, 2003, Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study, Lancet, 362, 523, 10.1016/S0140-6736(03)14111-6 Christiansen, 2005, Thrombophilia, clinical factors, and recurrent venous thrombotic events, JAMA, 293, 2352, 10.1001/jama.293.19.2352 Hansson, 2000, Recurrent venous thromboembolism after deep vein thrombosis: incidence and risk factors, Arch Intern Med, 160, 769, 10.1001/archinte.160.6.769 Heit, 2000, Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study, Arch Intern Med, 160, 761, 10.1001/archinte.160.6.761 Palareti, 2002, Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped, Thromb Haemost, 87, 7, 10.1055/s-0037-1612936 Pinede, 2001, Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis, Circulation, 103, 2453, 10.1161/01.CIR.103.20.2453 Pini, 1994, Low molecular weight heparin versus warfarin in the prevention of recurrences after deep vein thrombosis, Thromb Haemost, 72, 191, 10.1055/s-0038-1648837 Schulman, 1995, A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism, N Engl J Med, 332, 1661, 10.1056/NEJM199506223322501 Boutitie, 2011, Influence of preceding duration of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping therapy: analysis of individual participants' data from seven trials, BMJ, 342, d3036, 10.1136/bmj.d3036 Iorio, 2010, Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review, Arch Intern Med, 170, 1710, 10.1001/archinternmed.2010.367 Palareti, 2000, A comparison of the safety and efficacy of oral anticoagulation for the treatment of venous thromboembolic disease in patients with or without malignancy, Thromb Haemost, 84, 805 Lee, 2003, Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer, N Engl J Med, 349, 146, 10.1056/NEJMoa025313 Ridker, 2003, Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism, N Engl J Med, 348, 1425, 10.1056/NEJMoa035029 Schulman, 2003, Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran, N Engl J Med, 349, 1713, 10.1056/NEJMoa030104 Eichinger, 2003, D-dimer levels and risk of recurrent venous thromboembolism, JAMA, 290, 1071, 10.1001/jama.290.8.1071 Palareti, 2003, Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia, Circulation, 108, 313, 10.1161/01.CIR.0000079162.69615.0F Shrivastava, 2006, D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism, J Thromb Haemost, 4, 1208, 10.1111/j.1538-7836.2006.01935.x Cosmi, 2010, Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study, Blood, 115, 481, 10.1182/blood-2009-08-237354 Douketis, 2010, Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism, Ann Intern Med, 153, 523, 10.7326/0003-4819-153-8-201010190-00009 Verhovsek, 2008, Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism, Ann Intern Med, 149, 481, 10.7326/0003-4819-149-7-200810070-00008 Kearon, 1999, A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism, N Engl J Med, 340, 901, 10.1056/NEJM199903253401201 Schulman, 2006, Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months, J Thromb Haemost, 4, 734, 10.1111/j.1538-7836.2006.01795.x Schulman, 1998, Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy, Am J Med, 104, 332, 10.1016/S0002-9343(98)00060-6 Rodger, 2008, Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy, CMAJ, 179, 417, 10.1503/cmaj.080493 Eichinger, 1997, The risk of recurrent venous thromboembolism in patients with and without factor V Leiden, Thromb Haemost, 77, 624, 10.1055/s-0038-1656023 Ho, 2006, Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review, Arch Intern Med, 166, 729, 10.1001/archinte.166.7.729 Lindmarker, 1999, The risk of recurrent venous thromboembolism in carriers and non-carriers of the G1691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene. DURAC Trial Study Group. Duration of Anticoagulation, Thromb Haemost, 81, 684, 10.1055/s-0037-1614554 Segal, 2009, Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review, JAMA, 301, 2472, 10.1001/jama.2009.853 Kearon, 2008, Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial, Blood, 112, 4432, 10.1182/blood-2008-06-163279 McRae, 2006, Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis, Lancet, 368, 371, 10.1016/S0140-6736(06)69110-1 Douketis, 2011, Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis, BMJ, 342, d813, 10.1136/bmj.d813 White, 1998, Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California, Ann Intern Med, 128, 737, 10.7326/0003-4819-128-9-199805010-00006 Agnelli, 2003, Extended oral anticoagulant therapy after a first episode of pulmonary embolism, Ann Intern Med, 139, 19, 10.7326/0003-4819-139-1-200307010-00008 Kearon, 2004, Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor, J Thromb Haemost, 2, 743, 10.1046/j.1538-7836.2004.00698.x Piovella, 2002, Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with recurrence and new thrombosis, Haematologica, 87, 515 Prandoni, 2002, Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism, Ann Intern Med, 137, 955, 10.7326/0003-4819-137-12-200212170-00008 Carrier, 2011, Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysis, J Thromb Haemost, 9, 1119, 10.1111/j.1538-7836.2011.04254.x Eichinger, 2010, Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model, Circulation, 121, 1630, 10.1161/CIRCULATIONAHA.109.925214 Stain, 2005, The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease, J Thromb Haemost, 3, 2671, 10.1111/j.1538-7836.2005.01648.x Brandjes, 1997, Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis, Lancet, 349, 759, 10.1016/S0140-6736(96)12215-7 Prandoni, 2004, Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial, Ann Intern Med, 141, 249, 10.7326/0003-4819-141-4-200408170-00004 Campbell, 2007, Anticoagulation for three versus six months in patients with deep vein thrombosis or pulmonary embolism, or both: randomised trial, BMJ, 334, 674, 10.1136/bmj.39098.583356.55 Agnelli, 2001, Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis, N Engl J Med, 345, 165, 10.1056/NEJM200107193450302 Siragusa, 2008, Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study, Blood, 112, 511, 10.1182/blood-2008-01-131656 Prandoni, 2009, Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial, Ann Intern Med, 150, 577, 10.7326/0003-4819-150-9-200905050-00003 Farraj, 2004, Anticoagulation period in idiopathic venous thromboembolism. How long is enough?, Saudi Med J, 25, 848 Prandoni, 2007, The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients, Haematologica, 92, 199, 10.3324/haematol.10516 van Dongen, 2005, Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome, J Thromb Haemost, 3, 939, 10.1111/j.1538-7836.2005.01333.x Locadia, 2004, Treatment of venous thromboembolism with vitamin K antagonists: patients' health state valuations and treatment preferences, Thromb Haemost, 92, 1336 Hull, 2007, Self-managed long-term low-molecular-weight heparin therapy: the balance of benefits and harms, Am J Med, 120, 72, 10.1016/j.amjmed.2006.03.030 Beyth, 1995, Long-term outcomes of deep-vein thrombosis, Arch Intern Med, 155, 1031, 10.1001/archinte.1995.00430100053006 Hull, 2009, Home therapy of venous thrombosis with long-term LMWH versus usual care: patient satisfaction and post-thrombotic syndrome, Am J Med, 122, 762, 10.1016/j.amjmed.2008.12.023 Kahn, 2004, Relationship between deep venous thrombosis and the postthrombotic syndrome, Arch Intern Med, 164, 17, 10.1001/archinte.164.1.17 Hull, 1982, Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis, N Engl J Med, 306, 189, 10.1056/NEJM198201283060401 Monreal, 1994, Comparison of subcutaneous unfractionated heparin with a low molecular weight heparin (Fragmin) in patients with venous thromboembolism and contraindications to coumarin, Thromb Haemost, 71, 7, 10.1055/s-0038-1642376 Buller, 2007, Idraparinux versus standard therapy for venous thromboembolic disease, N Engl J Med, 357, 1094, 10.1056/NEJMoa064247 Iorio, 2003, Low-molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: meta-analysis of the randomized comparisons with oral anticoagulants, J Thromb Haemost, 1, 1906, 10.1046/j.1538-7836.2003.00364.x van der Heijden, 2002, Prins MH Vitamin K antagonists or low-molecular-weight heparin for the long term treatment of symptomatic venous thromboembolism, Cochrane Database Syst Rev, CD002001 Gonzalez-Fajardo, 1999, Venographic comparison of subcutaneous low-molecular weight heparin with oral anticoagulant therapy in the long-term treatment of deep venous thrombosis, J Vasc Surg, 30, 283, 10.1016/S0741-5214(99)70139-4 Hull, 2000, Long-term low molecular weight heparin treatment versus oral anticoagulant therapy for proximal deep vein thrombosis [abstract], Blood, 96, 449a Lopaciuk, 1999, Low molecular weight heparin versus acenocoumarol in the secondary prophylaxis of deep vein thrombosis, Thromb Haemost, 81, 26, 10.1055/s-0037-1614412 López-Beret, 2001, Low molecular weight heparin versus oral anticoagulants in the long-term treatment of deep venous thrombosis, J Vasc Surg, 33, 77, 10.1067/mva.2001.109336 Veiga, 2000, Low molecular weight heparin (enoxaparin) versus oral anticoagulant therapy (acenocoumarol) in the long-term treatment of deep venous thrombosis in the elderly: a randomized trial, Thromb Haemost, 84, 559 Deitcher, 2006, Secondary prevention of venous thromboembolic events in patients with active cancer: enoxaparin alone versus initial enoxaparin followed by warfarin for a 180-day period, Clin Appl Thromb Hemost, 12, 389, 10.1177/1076029606293692 Meyer, 2002, Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study, Arch Intern Med, 162, 1729, 10.1001/archinte.162.15.1729 Romera, 2009, A randomised open-label trial comparing long-term sub-cutaneous low-molecular-weight heparin compared with oral-anticoagulant therapy in the treatment of deep venous thrombosis, Eur J Vasc Endovasc Surg, 37, 349, 10.1016/j.ejvs.2008.11.030 Varki, 2007, Trousseau's syndrome: multiple definitions and multiple mechanisms, Blood, 110, 1723, 10.1182/blood-2006-10-053736 Falck-Ytter, 2012, Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines, Chest, 141, e278S, 10.1378/chest.11-2404 Robinson, 1997, Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the post-arthroplasty screening study. A randomized, controlled trial, Ann Intern Med, 127, 439, 10.7326/0003-4819-127-6-199709150-00004 Kahn, 2002, The post-thrombotic syndrome: current knowledge, controversies, and directions for future research, Blood Rev, 16, 155, 10.1016/S0268-960X(02)00008-5 Ginsberg, 2001, Prevention and treatment of postphlebitic syndrome: results of a 3-part study, Arch Intern Med, 161, 2105, 10.1001/archinte.161.17.2105 Partsch, 2004, Immediate mobilisation in acute vein thrombosis reduces post-thrombotic syndrome, Int Angiol, 23, 206 Aschwanden, 2008, Effect of prolonged treatment with compression stockings to prevent post-thrombotic sequelae: a randomized controlled trial, J Vasc Surg, 47, 1015, 10.1016/j.jvs.2008.01.008 Roumen-Klappe, 2009, Multilayer compression bandaging in the acute phase of deep-vein thrombosis has no effect on the development of the post-thrombotic syndrome, J Thromb Thrombolysis, 27, 400, 10.1007/s11239-008-0229-7 Ten Cate-Hoek, 2010, Individually tailored duration of elastic compression therapy in relation to incidence of the postthrombotic syndrome, J Vasc Surg, 52, 132, 10.1016/j.jvs.2010.01.089 Frulla, 2005, Elastic stockings, hydroxyethylrutosides or both for the treatment of post-thrombotic syndrome, Thromb Haemost, 93, 183, 10.1055/s-0037-1616166 Ginsberg, 1999, Intermittent compression units for severe post-phlebitic syndrome: a randomized crossover study, CMAJ, 160, 1303 O'Donnell, 2008, Evaluation of a venous-return assist device to treat severe post-thrombotic syndrome (VENOPTS). A randomized controlled trial, Thromb Haemost, 99, 623, 10.1160/TH07-09-0546 Lyseng-Williamson, 2003, Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids, Drugs, 63, 71, 10.2165/00003495-200363010-00005 Shoab, 1999, Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease—a prospective study, Eur J Vasc Endovasc Surg, 17, 313, 10.1053/ejvs.1998.0751 de Jongste, 1989, A double blind three center clinical trial on the short-term efficacy of 0-(beta-hydroxyethyl)-rutosides in patients with post-thrombotic syndrome, Thromb Haemost, 62, 826, 10.1055/s-0038-1651011 Monreal, 1994, A prospective study of the long-term efficacy of two different venoactive drugs in patients with post-thrombotic syndrome, Phlebology, 9, 37, 10.1177/026835559400900111 Campbell, 1998, Duration of hospital stay in patients with pulmonary venous thromboembolism: a randomized comparison of unfractionated heparinversus low molecular weight heparin [Abstract], Thorax, 53, 254 Duroux, 1991, A randomised trial of subcutaneous low molecular weight heparin (CY 216) compared with intravenous unfractionated heparin in the treatment of deep vein thrombosis. A collaborative European multicentre study, Thromb Haemost, 65, 251, 10.1055/s-0038-1647660 Hull, 1992, Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis, N Engl J Med, 326, 975, 10.1056/NEJM199204093261502 Kirchmaier, 1998, Efficacy of a low molecular weight heparin administered intravenously or subcutaneously in comparison with intravenous unfractionated heparin in the treatment of deep venous thrombosis, Int Angiol, 17, 135 Kuijer, 1995, Randomized comparison of LMWH versus standard heparin in the initial treatment of pulmonary embolism [Abstract], Thromb Haemost, 73, 974 Meyer, 1995, Subcutaneous low-molecular-weight heparin fragmin versus intravenous unfractionated heparin in the treatment of acute non massive pulmonary embolism: an open randomized pilot study, Thromb Haemost, 74, 1432, 10.1055/s-0038-1649960 Pérez de Llano, 2003, Multicenter, prospective study comparing enoxaparin with unfractionated heparin in the treatment of submassive pulmonary thromboembolism [in Spanish], Arch Bronconeumol, 39, 341, 10.1016/S0300-2896(03)75401-5 Simonneau, 1997, A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. Tinzaparine ou Heparine Standard: Evaluations dans l'Embolie Pulmonaire, N Engl J Med, 337, 663, 10.1056/NEJM199709043371002 The Columbus Investigators, 1997, Low-molecular-weight heparin in the treatment of patients with, N Engl J Med, 337, 657, 10.1056/NEJM199709043371001 Théry, 1992, Randomized trial of subcutaneous low-molecular-weight heparin CY 216 (Fraxiparine) compared with intravenous unfractionated heparin in the curative treatment of submassive pulmonary embolism. A dose-ranging study, Circulation, 85, 1380, 10.1161/01.CIR.85.4.1380 Quinlan, 2004, Low-molecular-weight heparin compared with intravenous unfractionated heparin for treatment of pulmonary embolism: a meta-analysis of randomized, controlled trials, Ann Intern Med, 140, 175, 10.7326/0003-4819-140-3-200402030-00008 Otero, 2010, Home treatment in pulmonary embolism, Thromb Res, 126, e1, 10.1016/j.thromres.2009.09.026 Aujesky, 2011, Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial, Lancet, 378, 41, 10.1016/S0140-6736(11)60824-6 Uresandi, 2007, [A clinical prediction rule for identifying short-term risk of adverse events in patients with pulmonary thromboembolism], Arch Bronconeumol, 43, 617, 10.1157/13111348 Wicki, 2000, Predicting adverse outcome in patients with acute pulmonary embolism: a risk score, Thromb Haemost, 84, 548, 10.1055/s-0037-1614065 Aujesky, 2005, Derivation and validation of a prognostic model for pulmonary embolism, Am J Respir Crit Care Med, 172, 1041, 10.1164/rccm.200506-862OC Jiménez, 2007, Prognostic models for selecting patients with acute pulmonary embolism for initial outpatient therapy, Chest, 132, 24, 10.1378/chest.06-2921 Jiménez, 2010, Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism, Arch Intern Med, 170, 1383, 10.1001/archinternmed.2010.199 Jakobsson, 2010, Validation of a clinical algorithm to identify low-risk patients with pulmonary embolism, J Thromb Haemost, 8, 1242, 10.1111/j.1538-7836.2010.03836.x Chan, 2010, The validation and reproducibility of the pulmonary embolism severity index, J Thromb Haemost, 8, 1509, 10.1111/j.1538-7836.2010.03888.x Moores, 2010, Pulmonary Embolism Severity Index and troponin testing for the selection of low-risk patients with acute symptomatic pulmonary embolism, J Thromb Haemost, 8, 517, 10.1111/j.1538-7836.2009.03725.x Fraga, 2010, The inter-rater reliability of the Pulmonary Embolism Severity Index, Thromb Haemost, 104, 1258, 10.1160/TH10-07-0426 Squizzato, 2009, Outpatient treatment and early discharge of symptomatic pulmonary embolism: a systematic review, Eur Respir J, 33, 1148, 10.1183/09031936.00133608 Erkens, 2010, Safety of outpatient treatment in acute pulmonary embolism, J Thromb Haemost, 8, 2412, 10.1111/j.1538-7836.2010.04041.x Kovacs, 2010, Ambulatory management of pulmonary embolism: a pragmatic evaluation, J Thromb Haemost, 8, 2406, 10.1111/j.1538-7836.2010.03981.x Zondag, 2011, Outpatient treatment in patients with acute pulmonary embolism: the Hestia Study, J Thromb Haemost, 9, 1500, 10.1111/j.1538-7836.2011.04388.x Agterof, 2010, Out of hospital treatment of acute pulmonary embolism in patients with a low NT-proBNP level, J Thromb Haemost, 8, 1235, 10.1111/j.1538-7836.2010.03831.x Baglin, 2010, Fifty per cent of patients with pulmonary embolism can be treated as outpatients, J Thromb Haemost, 8, 2404, 10.1111/j.1538-7836.2010.04055.x Dong, 2006, Wu T Thrombolytic treatment for pulmonary embolism, Cochrane Database Syst Rev, CD004437 Wood, 2002, Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism, Chest, 121, 877, 10.1378/chest.121.3.877 McIntyre, 1974, Determinants of right ventricular function and hemodynamics after pulmonary embolism, Chest, 65, 534, 10.1378/chest.65.5.534 Goldhaber, 1999, Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER), Lancet, 353, 1386, 10.1016/S0140-6736(98)07534-5 Laporte, 2008, Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry, Circulation, 117, 1711, 10.1161/CIRCULATIONAHA.107.726232 Pollack, 2011, Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department: initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry), J Am Coll Cardiol, 57, 700, 10.1016/j.jacc.2010.05.071 Sanchez, 2010, Prognostic factors for pulmonary embolism: the prep study, a prospective multicenter cohort study, Am J Respir Crit Care Med, 181, 168, 10.1164/rccm.200906-0970OC Kucher, 2006, Massive pulmonary embolism, Circulation, 113, 577, 10.1161/CIRCULATIONAHA.105.592592 Torbicki, 2008, Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC), Eur Heart J, 29, 2276, 10.1093/eurheartj/ehn310 Douketis, 2005, The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism, J Thromb Haemost, 3, 508, 10.1111/j.1538-7836.2005.01189.x Giannitsis, 2005, Risk stratification in pulmonary embolism based on biomarkers and echocardiography, Circulation, 112, 1520, 10.1161/CIRCULATIONAHA.105.566182 Konstantinides, 2002, Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism, Circulation, 106, 1263, 10.1161/01.CIR.0000028422.51668.A2 Scridon, 2005, Prognostic significance of troponin elevation and right ventricular enlargement in acute pulmonary embolism, Am J Cardiol, 96, 303, 10.1016/j.amjcard.2005.03.062 Becattini, 2007, Prognostic value of troponins in acute pulmonary embolism: a meta-analysis, Circulation, 116, 427, 10.1161/CIRCULATIONAHA.106.680421 Lankeit, 2010, Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism, Eur Heart J, 31, 1836, 10.1093/eurheartj/ehq234 Lega, 2009, Natriuretic peptides and troponins in pulmonary embolism: a meta-analysis, Thorax, 64, 869, 10.1136/thx.2008.110965 Bova, 2009, Risk stratification and outcomes in hemodynamically stable patients with acute pulmonary embolism: a prospective, multicentre, cohort study with three months of follow-up, J Thromb Haemost, 7, 938, 10.1111/j.1538-7836.2009.03345.x Stein, 2010, Outcome in stable patients with acute pulmonary embolism who had right ventricular enlargement and/or elevated levels of troponin I, Am J Cardiol, 106, 558, 10.1016/j.amjcard.2010.03.071 Sanchez, 2008, Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review, Eur Heart J, 29, 1569, 10.1093/eurheartj/ehn208 Goldhaber, 2002, Echocardiography in the management of pulmonary embolism, Ann Intern Med, 136, 691, 10.7326/0003-4819-136-9-200205070-00012 Schoepf, 2004, Right ventricular enlargement on chest computed tomography: a predictor of early death in acute pulmonary embolism, Circulation, 110, 3276, 10.1161/01.CIR.0000147612.59751.4C ten Wolde, 2004, Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism, Arch Intern Med, 164, 1685, 10.1001/archinte.164.15.1685 Frémont, 2008, Prognostic value of echocardiographic right/left ventricular end-diastolic diameter ratio in patients with acute pulmonary embolism: results from a monocenter registry of 1,416 patients, Chest, 133, 358, 10.1378/chest.07-1231 Vanni, 2009, Prognostic value of ECG among patients with acute pulmonary embolism and normal blood pressure, Am J Med, 122, 257, 10.1016/j.amjmed.2008.08.031 Stein, 2008, Enlarged right ventricle without shock in acute pulmonary embolism: prognosis, Am J Med, 121, 34, 10.1016/j.amjmed.2007.06.032 Fiumara, 2006, Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism, Am J Cardiol, 97, 127, 10.1016/j.amjcard.2005.07.117 Kanter, 1997, Thrombolytic therapy for pulmonary embolism. Frequency of intracranial hemorrhage and associated risk factors, Chest, 111, 1241, 10.1378/chest.111.5.1241 1973, The urokinase pulmonary embolism trial. A national cooperative study, Circulation, 47, II1 Dalla-Volta, 1992, PAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen activator Italian multicenter study 2, J Am Coll Cardiol, 20, 520, 10.1016/0735-1097(92)90002-5 Dotter, 1979, Streptokinase and heparin in the treatment of pulmonary embolism: a randomized comparison, Vasc Surg, 13, 42, 10.1177/153857447901300107 PIOPED Investigators, 1990, Tissue plasminogen activator for the treatment of acute pulmonary embolism. A collaborative study by the PIOPED Investigators, Chest, 97, 528, 10.1378/chest.97.3.528 Jerjes-Sanchez, 1995, Streprokinase and heparin versus heparin alone in massive pulmonary embolism: a randomized controlled trial, J Thromb Thrombolysis, 2, 227, 10.1007/BF01062714 Ly, 1978, A controlled clinical trial of streptokinase and heparin in the treatment of major pulmonary embolism, Acta Med Scand, 203, 465 Marini, 1988, Fibrinolytic effects of urokinase and heparin in acute pulmonary embolism: a randomized clinical trial, Respiration, 54, 162, 10.1159/000195517 Tibbutt, 1974, Comparison by controlled clinical trial of streptokinase and heparin in treatment of life-threatening pulmonay embolism, BMJ, 1, 343, 10.1136/bmj.1.5904.343 1970, Urokinase pulmonary embolism trial. Phase I results: a cooperative study, JAMA, 214, 2163, 10.1001/jama.1970.03180120035007 Becattini, 2010, Bolus tenecteplase for right ventricle dysfunction in hemodynamically stable patients with pulmonary embolism, Thromb Res, 125, e82, 10.1016/j.thromres.2009.09.017 Fasullo, 2010, Six-month echocardiographic study in patients with submassive pulmonary embolism and right ventricle dysfunction: comparison of thrombolysis with heparin, Am J Med Sci, 341, 33, 10.1097/MAJ.0b013e3181f1fc3e Goldhaber, 1993, Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion, Lancet, 341, 507, 10.1016/0140-6736(93)90274-K Konstantinides, 2002, Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism, N Engl J Med, 347, 1143, 10.1056/NEJMoa021274 Levine, 1990, A randomized trial of a single bolus dosage regimen of recombinant tissue plasminogen activator in patients with acute pulmonary embolism, Chest, 98, 1473, 10.1378/chest.98.6.1473 Agnelli, 2002, Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis, Arch Intern Med, 162, 2537, 10.1001/archinte.162.22.2537 Wan, 2004, Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials, Circulation, 110, 744, 10.1161/01.CIR.0000137826.09715.9C 1974, Urokinase-streptokinase embolism trial. Phase 2 results. A cooperative study, JAMA, 229, 1606, 10.1001/jama.1974.03230500024021 Goldhaber, 1994, Reduced dose bolus alteplase vs conventional alteplase infusion for pulmonary embolism thrombolysis. An international multicenter randomized trial, Chest, 106, 718, 10.1378/chest.106.3.718 Goldhaber, 1988, Randomised controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism, Lancet, 2, 293, 10.1016/S0140-6736(88)92354-9 Goldhaber, 1992, Recombinant tissue-type plasminogen activator versus a novel dosing regimen of urokinase in acute pulmonary embolism: a randomized controlled multicenter trial, J Am Coll Cardiol, 20, 24, 10.1016/0735-1097(92)90132-7 Meneveau, 1997, Streptokinase vs alteplase in massive pulmonary embolism. A randomized trial assessing right heart haemodynamics and pulmonary vascular obstruction, Eur Heart J, 18, 1141, 10.1093/oxfordjournals.eurheartj.a015410 Meyer, 1992, Effects of intravenous urokinase versus alteplase on total pulmonary resistance in acute massive pulmonary embolism: a European multicenter double-blind trial, J Am Coll Cardiol, 19, 239, 10.1016/0735-1097(92)90472-Y Sors, 1994, Hemodynamic effects of bolus vs 2-h infusion of alteplase in acute massive pulmonary embolism. A randomized controlled multicenter trial, Chest, 106, 712, 10.1378/chest.106.3.712 Tebbe, 2009, Desmoteplase in acute massive pulmonary thromboembolism, Thromb Haemost, 101, 557, 10.1160/TH08-10-0638 Tebbe, 1999, Hemodynamic effects of double bolus reteplase versus alteplase infusion in massive pulmonary embolism, Am Heart J, 138, 39, 10.1016/S0002-8703(99)70243-7 Wang, 2010, Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism: a randomized, multicenter, controlled trial, Chest, 137, 254, 10.1378/chest.09-0765 Wang, 2009, Efficacy and safety of 2-hour urokinase regime in acute pulmonary embolism: a randomized controlled trial, Respir Res, 10, 128, 10.1186/1465-9921-10-128 Meneveau, 1998, Comparative efficacy of a two-hour regimen of streptokinase versus alteplase in acute massive pulmonary embolism: immediate clinical and hemodynamic outcome and one-year follow-up, J Am Coll Cardiol, 31, 1057, 10.1016/S0735-1097(98)00068-0 Verstraete, 1988, Intravenous and intrapulmonary recombinant tissue-type plasminogen activator in the treatment of acute massive pulmonary embolism, Circulation, 77, 353, 10.1161/01.CIR.77.2.353 de Gregorio, 2001, [Mechanical fragmentation and intrapulmonary fibrinolysis in the treatment of massive pulmonary embolism hemodynamic repercussions], Arch Bronconeumol, 37, 58, 10.1016/S0300-2896(01)75015-6 Fava, 1997, Mechanical fragmentation and pharmacologic thrombolysis in massive pulmonary embolism, J Vasc Interv Radiol, 8, 261, 10.1016/S1051-0443(97)70552-9 Schmitz-Rode, 2000, Massive pulmonary embolism: percutaneous emergency treatment by pigtail rotation catheter, J Am Coll Cardiol, 36, 375, 10.1016/S0735-1097(00)00734-8 Schmitz-Rode, 1998, Fragmentation of massive pulmonary embolism using a pigtail rotation catheter, Chest, 114, 1427, 10.1378/chest.114.5.1427 Kucher, 2007, Catheter embolectomy for acute pulmonary embolism, Chest, 132, 657, 10.1378/chest.07-0665 Kuo, 2009, Catheter-directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques, J Vasc Interv Radiol, 20, 1431, 10.1016/j.jvir.2009.08.002 Margheri, 2008, Early and long-term clinical results of AngioJet rheolytic thrombectomy in patients with acute pulmonary embolism, Am J Cardiol, 101, 252, 10.1016/j.amjcard.2007.07.087 Zhou, 2009, Value of percutanous catheter fragmentation in the management of massive pulmonary embolism, Chin Med J (Engl), 122, 1723 Leacche, 2005, Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach, J Thorac Cardiovasc Surg, 129, 1018, 10.1016/j.jtcvs.2004.10.023 Meneveau, 2006, Management of unsuccessful thrombolysis in acute massive pulmonary embolism, Chest, 129, 1043, 10.1378/chest.129.4.1043 Sukhija, 2005, Association of right ventricular dysfunction with in-hospital mortality in patients with acute pulmonary embolism and reduction in mortality in patients with right ventricular dysfunction by pulmonary embolectomy, Am J Cardiol, 95, 695, 10.1016/j.amjcard.2004.10.055 Fukuda, 2011, Improved outcome of surgical pulmonary embolectomy by aggressive intervention for critically ill patients, Ann Thorac Surg, 91, 728, 10.1016/j.athoracsur.2010.10.086 Beckman, 2003, Enoxaparin monotherapy without oral anticoagulation to treat acute symptomatic pulmonary embolism, Thromb Haemost, 89, 953, 10.1055/s-0037-1613395 Kucher, 2005, Extended enoxaparin monotherapy for acute symptomatic pulmonary embolism, Vasc Med, 10, 251, 10.1191/1358863x05vm634oa Schulman, 2009, Dabigatran versus warfarin in the treatment of acute venous thromboembolism, N Engl J Med, 361, 2342, 10.1056/NEJMoa0906598 Gosselin, 1998, Unsuspected pulmonary embolism: prospective detection on routine helical CT scans, Radiology, 208, 209, 10.1148/radiology.208.1.9646815 O'Connell, 2006, Unsuspected pulmonary emboli in cancer patients: clinical correlates and relevance, J Clin Oncol, 24, 4928, 10.1200/JCO.2006.06.5870 Sebastian, 2006, Clinically unsuspected pulmonary embolism—an important secondary finding in oncology CT, Clin Radiol, 61, 81, 10.1016/j.crad.2005.09.002 Storto, 2005, Incidental detection of pulmonary emboli on routine MDCT of the chest, AJR Am J Roentgenol, 184, 264, 10.2214/ajr.184.1.01840264 Douma, 2010, Incidental venous thromboembolism in cancer patients: prevalence and consequence, Thromb Res, 125, e306, 10.1016/j.thromres.2010.02.010 Farrell, 2010, Unsuspected pulmonary embolism identified using multidetector computed tomography in hospital outpatients, Clin Radiol, 65, 1, 10.1016/j.crad.2009.09.003 Hui, 2008, The prevalence of symptomatic and coincidental pulmonary embolism on computed tomography, J Comput Assist Tomogr, 32, 783, 10.1097/RCT.0b013e31815a7aea den Exter, 2011, Risk of recurrent venous thromboembolism and mortality in patients with cancer incidentally diagnosed with pulmonary embolism: a comparison with symptomatic patients, J Clin Oncol, 29, 2405, 10.1200/JCO.2010.34.0984 Dentali, 2011, Prognostic relevance of an asymptomatic venous thromboembolism in patients with cancer, J Thromb Haemost, 9, 1081, 10.1111/j.1538-7836.2011.04259.x O'Connell, 2011, Unsuspected pulmonary emboli adversely impact survival in patients with cancer undergoing routine staging multi-row detector computed tomography scanning, J Thromb Haemost, 9, 305, 10.1111/j.1538-7836.2010.04114.x Becattini, 2006, Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism, Chest, 130, 172, 10.1378/chest.130.1.172 Pengo, 2004, Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism, N Engl J Med, 350, 2257, 10.1056/NEJMoa032274 Ribeiro, 1999, Pulmonary embolism: one-year follow-up with echocardiography Doppler and five-year survival analysis, Circulation, 99, 1325, 10.1161/01.CIR.99.10.1325 Dentali, 2009, Incidence of chronic pulmonary hypertension in patients with previous pulmonary embolism, Thromb Res, 124, 256, 10.1016/j.thromres.2009.01.003 Kline, 2009, Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure, Chest, 136, 1202, 10.1378/chest.08-2988 Hoeper, 2006, Chronic thromboembolic pulmonary hypertension, Circulation, 113, 2011, 10.1161/CIRCULATIONAHA.105.602565 Jamieson, 2003, Pulmonary endarterectomy: experience and lessons learned in 1,500 cases, Ann Thorac Surg, 76, 1457, 10.1016/S0003-4975(03)00828-2 Fedullo, 2001, Chronic thromboembolic pulmonary hypertension, N Engl J Med, 345, 1465, 10.1056/NEJMra010902 Bernard, 2007, Pulmonary thromboendarterectomy: a clinicopathologic study of 200 consecutive pulmonary thromboendarterectomy cases in one institution, Hum Pathol, 38, 871, 10.1016/j.humpath.2006.11.017 Thistlethwaite, 2008, Technique and outcomes of pulmonary endarterectomy surgery, Ann Thorac Cardiovasc Surg, 14, 274 Doyle, 2004, Surgical treatments/interventions for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines, Chest, 126, 63S, 10.1378/chest.126.1_suppl.63S Mehta, 2010, Diagnostic evaluation and management of chronic thromboembolic pulmonary hypertension: A clinical practice guideline, Can Respir J, 17, 301, 10.1155/2010/704258 Mayer, 2011, Surgical management and outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective registry, J Thorac Cardiovasc Surg, 141, 702, 10.1016/j.jtcvs.2010.11.024 Pepke-Zaba, 1973, Chronic thromboembolic pulmonary hypertension (CTEPH). Results from an international prospective registry, Circulation, 124, 10.1161/CIRCULATIONAHA.110.015008 Feinstein, 2001, Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension, Circulation, 103, 10, 10.1161/01.CIR.103.1.10 Bresser, 2006, Medical therapies for chronic thromboembolic pulmonary hypertension: an evolving treatment paradigm, Proc Am Thorac Soc, 3, 594, 10.1513/pats.200605-115LR Becattini, 2010, Bosentan for chronic thromboembolic pulmonary hypertension: findings from a systematic review and meta-analysis, Thromb Res, 126, e51, 10.1016/j.thromres.2010.01.007 Decousus, 2003, Superficial vein thrombosis: risk factors, diagnosis, and treatment, Curr Opin Pulm Med, 9, 393, 10.1097/00063198-200309000-00009 Wichers, 2005, Treatment of superficial vein thrombosis to prevent deep vein thrombosis and pulmonary embolism: a systematic review, Haematologica, 90, 672 Quenet, 2003, Factors predictive of venous thrombotic complications in patients with isolated superficial vein thrombosis, J Vasc Surg, 38, 944, 10.1016/S0741-5214(03)00607-4 Decousus, 2010, Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study, Ann Intern Med, 152, 218, 10.7326/0003-4819-152-4-201002160-00006 Di Nisio, 2007, Treatment for superficial thrombophlebitis of the leg, Cochrane Database Syst Rev, CD004982 Superficial Thrombophlebitis Treated By Enoxaparin Study Group, 2003, A pilot randomized double-blind comparison of a low-molecular-weight heparin, a nonsteroidal anti-inflammatory agent, and placebo in the treatment of superficial vein thrombosis, Arch Intern Med, 163, 1657, 10.1001/archinte.163.14.1657 Titon, 1994, [Therapeutic management of superficial venous thrombosis with calcium nadroparin. Dosage testing and comparison with a non-steroidal anti-inflammatory agent], Ann Cardiol Angeiol (Paris), 43, 160 Prandoni, 2005, High vs. low doses of low-molecular-weight heparin for the treatment of superficial vein thrombosis of the legs: a double-blind, randomized trial, J Thromb Haemost, 3, 1152, 10.1111/j.1538-7836.2005.01391.x Marchiori, 2002, High versus low doses of unfractionated heparin for the treatment of superficial thrombophlebitis of the leg. A prospective, controlled, randomized study, Haematologica, 87, 523 Belcaro, 1999, Superficial thrombophlebitis of the legs: a randomized, controlled, follow-up study, Angiology, 50, 523, 10.1177/000331979905000701 Andreozzi, 1996, Tolerability and clinical efficacy of desmin in the treatment of superficial thrombovaricophlebitis, Angiology, 47, 887, 10.1177/000331979604700907 Decousus, 2010, Fondaparinux for the treatment of superficial-vein thrombosis in the legs, N Engl J Med, 363, 1222, 10.1056/NEJMoa0912072 Blondon M, Righini M, Bounameaux H, et al. Fondaparinux for isolated superficial-vein thrombosis of the legs: a cost-effectiveness analysis. Chest, In press. 10.1378/chest.11-0625 Lozano, 2003, Low-molecular-weight heparin versus saphenofemoral disconnection for the treatment of above-knee greater saphenous thrombophlebitis: a prospective study, Vasc Endovascular Surg, 37, 415, 10.1177/153857440303700605 Sullivan, 2001, Ligation versus anticoagulation: treatment of above-knee superficial thrombophlebitis not involving the deep venous system, J Am Coll Surg, 193, 556, 10.1016/S1072-7515(01)01043-2 Flinterman, 2008, Current perspective of venous thrombosis in the upper extremity, J Thromb Haemost, 6, 1262, 10.1111/j.1538-7836.2008.03017.x Lechner, 2008, Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrence, J Thromb Haemost, 6, 1269, 10.1111/j.1538-7836.2008.02998.x Spencer, 2007, Upper extremity deep vein thrombosis: a community-based perspective, Am J Med, 120, 678, 10.1016/j.amjmed.2006.06.046 Owens, 2010, Pulmonary embolism from upper extremity deep vein thrombosis and the role of superior vena cava filters: a review of the literature, J Vasc Interv Radiol, 21, 779, 10.1016/j.jvir.2010.02.021 Mai, 2011, Upper-extremity deep venous thrombosis: a review, Am J Med, 124, 402, 10.1016/j.amjmed.2010.11.022 Becker, 1991, Axillary and subclavian venous thrombosis. Prognosis and treatment, Arch Intern Med, 151, 1934, 10.1001/archinte.1991.00400100022004 Joffe, 2004, Upper-extremity deep vein thrombosis: a prospective registry of 592 patients, Circulation, 110, 1605, 10.1161/01.CIR.0000142289.94369.D7 Prandoni, 1997, Upper-extremity deep vein thrombosis. Risk factors, diagnosis, and complications, Arch Intern Med, 157, 57, 10.1001/archinte.1997.00440220061008 Kucher, 2011, Clinical practice. Deep-vein thrombosis of the upper extremities, N Engl J Med, 364, 861, 10.1056/NEJMcp1008740 Prandoni, 2004, The long term clinical course of acute deep vein thrombosis of the arm: prospective cohort study, BMJ, 329, 484, 10.1136/bmj.38167.684444.3A Elman, 2006, The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review, Thromb Res, 117, 609, 10.1016/j.thromres.2005.05.029 Baskin, 2009, Management of occlusion and thrombosis associated with long-term indwelling central venous catheters, Lancet, 374, 159, 10.1016/S0140-6736(09)60220-8 Saber, 2011, Risk factors for catheter-related thrombosis (CRT) in cancer patients: a patient-level data (IPD) meta-analysis of clinical trials and prospective studies, J Thromb Haemost, 9, 312, 10.1111/j.1538-7836.2010.04126.x Savage, 1999, Outpatient use of low molecular weight heparin (Dalteparin) for the treatment of deep vein thrombosis of the upper extremity, Thromb Haemost, 82, 1008, 10.1055/s-0037-1614319 Karabay, 2004, Upper extremity deep vein thrombosis: clinical and treatment characteristics, J Int Med Res, 32, 429, 10.1177/147323000403200413 Kovacs, 2007, A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study), J Thromb Haemost, 5, 1650, 10.1111/j.1538-7836.2007.02613.x AbuRahma, 1996, Treatment alternatives for axillary-subclavian vein thrombosis: long-term follow-up, Cardiovasc Surg, 4, 783, 10.1016/S0967-2109(96)00025-7 Horne, 2000, Intraclot recombinant tissue plasminogen activator in the treatment of deep venous thrombosis of the lower and upper extremities, Am J Med, 108, 251, 10.1016/S0002-9343(99)00407-6 Lee, 2006, Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome, J Vasc Surg, 43, 1236, 10.1016/j.jvs.2006.02.005 Lokanathan, 2001, Outcome after thrombolysis and selective thoracic outlet decompression for primary axillary vein thrombosis, J Vasc Surg, 33, 783, 10.1067/mva.2001.112708 Pegis, 1997, [In situ thrombolysis in the treatment of venous thrombosis of effort in the arm [in French], J Mal Vasc, 22, 187 Petrakis, 2000, Two Different Therapeutic Modalities in the Treatment of the Upper Extremity Deep Vein Thrombosis: Preliminary Investigation With 20 Case Reports, Int J Angiol, 9, 46, 10.1007/BF01616331 Sabeti, 2002, Treatment of subclavian-axillary vein thrombosis: long-term outcome of anticoagulation versus systemic thrombolysis, Thromb Res, 108, 279, 10.1016/S0049-3848(03)00093-8 Schindler, 1999, Regional thrombolysis with urokinase for central venous catheter-related thrombosis in patients undergoing high-dose chemotherapy with autologous blood stem cell rescue, Clin Appl Thromb Hemost, 5, 25, 10.1177/107602969900500106 Kahn, 2005, Post-thrombotic syndrome, functional disability and quality of life after upper extremity deep venous thrombosis in adults, Thromb Haemost, 93, 499, 10.1160/TH04-10-0640 Machleder, 1993, Evaluation of a new treatment strategy for Paget-Schroetter syndrome: spontaneous thrombosis of the axillary-subclavian vein, J Vasc Surg, 17, 305, 10.1016/0741-5214(93)90416-J Schneider, 2004, Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty, J Vasc Surg, 40, 599, 10.1016/j.jvs.2004.07.028 Spence, 1999, Acute upper extremity deep venous thrombosis: safety and effectiveness of superior vena caval filters, Radiology, 210, 53, 10.1148/radiology.210.1.r99ja1353 Feugier, 2001, Long-term results of venous revascularization for Paget-Schroetter syndrome in athletes, Ann Vasc Surg, 15, 212, 10.1007/s100160010043 Lee, 1998, Early operative intervention after thrombolytic therapy for primary subclavian vein thrombosis: an effective treatment approach, J Vasc Surg, 27, 1101, 10.1016/S0741-5214(98)70012-6 Malcynski, 1993, Long-term results of treatment for axillary subclavian vein thrombosis, Can J Surg, 36, 365 Meier, 1996, Initial experience with venous stents in exertional axillary-subclavian vein thrombosis, J Vasc Surg, 24, 974, 10.1016/S0741-5214(96)70043-5 Sanders, 1995, Surgical management of subclavian vein obstruction, including six cases of subclavian vein bypass, Surgery, 118, 856, 10.1016/S0039-6060(05)80276-4 Sheeran, 1997, Local thrombolytic therapy as part of a multidisciplinary approach to acute axillosubclavian vein thrombosis (Paget-Schroetter syndrome), J Vasc Interv Radiol, 8, 253, 10.1016/S1051-0443(97)70551-7 Urschel, 2003, Paget-Schroetter syndrome therapy: failure of intravenous stents, Ann Thorac Surg, 75, 1693, 10.1016/S0003-4975(03)00116-4 Yilmaz, 2000, Long-term results of local thrombolysis followed by first rib resection: an encouraging clinical experience in treatment of subclavian vein thrombosis, Vasc Surg, 34, 17, 10.1177/153857440003400105 Usoh, 2009, Long-term follow-up for superior vena cava filter placement, Ann Vasc Surg, 23, 350, 10.1016/j.avsg.2008.08.012 Martinelli, 2004, Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities, Circulation, 110, 566, 10.1161/01.CIR.0000137123.55051.9B Berzaczy, 2010, Quality of life in patients with idiopathic subclavian vein thrombosis, Thromb Res, 125, 25, 10.1016/j.thromres.2009.04.015 Dentali, 2009, Natural history of mesenteric venous thrombosis in patients treated with vitamin K antagonists: a multi-centre, retrospective cohort study, Thromb Haemost, 102, 501 Kumar, 2001, Mesenteric venous thrombosis, N Engl J Med, 345, 1683, 10.1056/NEJMra010076 Martinelli, 2008, How I treat rare venous thromboses, Blood, 112, 4818, 10.1182/blood-2008-07-165969 Plessier, 2010, Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study, Hepatology, 51, 210, 10.1002/hep.23259 Amitrano, 2007, Prognostic factors in noncirrhotic patients with splanchnic vein thromboses, Am J Gastroenterol, 102, 2464, 10.1111/j.1572-0241.2007.01477.x Condat, 2001, Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy, Gastroenterology, 120, 490, 10.1053/gast.2001.21209 Amitrano, 2010, Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis, J Clin Gastroenterol, 44, 448, 10.1097/MCG.0b013e3181b3ab44 Darwish Murad, 2009, Etiology, management, and outcome of the Budd-Chiari syndrome, Ann Intern Med, 151, 167, 10.7326/0003-4819-151-3-200908040-00004 Darwish Murad, 2004, Determinants of survival and the effect of portosystemic shunting in patients with Budd-Chiari syndrome, Hepatology, 39, 500, 10.1002/hep.20064 Othieno, 2007, Home versus in-patient treatment for deep vein thrombosis, Cochrane Database Syst Rev, CD003076 PREPIC Study Group, 2005, Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d'Embolie Pulmonaire par Interruption Cave) randomized study, Circulation, 112, 416, 10.1161/CIRCULATIONAHA.104.512834 Kolbach, 2003, Compression therapy for treating stage I and II (Widmer) post-thrombotic syndrome, Cochrane Database Syst Rev, CD004177 Das, 1996, Low-molecular-weight heparin versus warfarin for prevention of recurrent venous thromboembolism: a randomized trial, World J Surg, 20, 521, 10.1007/s002689900081 Mohiuddin, 1992, Efficacy and safety of early versus late initiation of warfarin during heparin therapy in acute thromboembolism, Am Heart J, 123, 729, 10.1016/0002-8703(92)90513-U van Dongen, 2004, Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism, Cochrane Database Syst Rev, CD001100 Fiessinger, 1996, Once-daily subcutaneous dalteparin, a low molecular weight heparin, for the initial treatment of acute deep vein thrombosis, Thromb Haemost, 76, 195, 10.1055/s-0038-1650553 Harenberg, 2000, Fixed-dose, body weight-independent subcutaneous LMW heparin versus adjusted dose unfractionated intravenous heparin in the initial treatment of proximal venous thrombosis, Thromb Haemost, 83, 652, 10.1055/s-0037-1613886 Lindmarker, 1994, Comparison of once-daily subcutaneous Fragmin with continuous intravenous unfractionated heparin in the treatment of deep vein thrombosis, Thromb Haemost, 72, 186, 10.1055/s-0038-1648836 Prandoni, 1992, Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis, Lancet, 339, 441, 10.1016/0140-6736(92)91054-C Riess, 2003, Fixed-dose, body weight-independent subcutaneous low molecular weight heparin Certoparin compared with adjusted-dose intravenous unfractionated heparin in patients with proximal deep venous thrombosis, Thromb Haemost, 90, 252, 10.1160/TH02-09-0061 Simonneau, 1993, Subcutaneous low-molecular-weight heparin compared with continuous intravenous unfractionated heparin in the treatment of proximal deep vein thrombosis, Arch Intern Med, 153, 1541, 10.1001/archinte.1993.00410130045005 Aschwanden, 2001, Acute deep vein thrombosis: early mobilization does not increase the frequency of pulmonary embolism, Thromb Haemost, 85, 42, 10.1055/s-0037-1612901 Blättler, 2003, Leg compression and ambulation is better than bed rest for the treatment of acute deep venous thrombosis, Int Angiol, 22, 393 Jünger, 2006, Mobilization versus immobilization in the treatment of acute proximal deep venous thrombosis: a prospective, randomized, open, multicentre trial, Curr Med Res Opin, 22, 593, 10.1185/030079906X89838 Partsch, 2000, Compression and walking versus bed rest in the treatment of proximal deep venous thrombosis with low molecular weight heparin, J Vasc Surg, 32, 861, 10.1067/mva.2000.110352 Schellong, 1999, Bed rest in deep vein thrombosis and the incidence of scintigraphic pulmonary embolism, Thromb Haemost, 82, 127 Hull, 2006, Long-term low-molecular-weight heparin versus usual care in proximal-vein thrombosis patients with cancer, Am J Med, 119, 1062, 10.1016/j.amjmed.2006.02.022 Kakkar, 2003, Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis, Thromb Haemost, 89, 674, 10.1055/s-0037-1613574 Belcaro, 1993, Prophylaxis of recurrent deep venous thrombosis. A randomized, prospective study using indobufen and graduated elastic compression stockings, Angiology, 44, 695, 10.1177/000331979304400904 Arpaia, 2007, Efficacy of elastic compression stockings used early or after resolution of the edema on recanalization after deep venous thrombosis: the COM.PRE Trial, Blood Coagul Fibrinolysis, 18, 131, 10.1097/MBC.0b013e328011f2dd