Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

Immunity - Tập 34 - Trang 554-565 - 2011
Samuel Huber1,2, Nicola Gagliani3,4, Enric Esplugues1,5,6, William O'Connor1, Francis J. Huber1, Ashutosh Chaudhry7, Masahito Kamanaka1, Yasushi Kobayashi1, Carmen J. Booth8, Alexander Y. Rudensky9, Maria Grazia Roncarolo4,10, Manuela Battaglia3, Richard A. Flavell1,11
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
2I. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany
3San Raffaele Diabetes Research Institute (HSR-DRI), Milan 20132, Italy
4Universita Vita-Salute San Raffaele, Milan 20132, Italy
5German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin 10117, Germany
6Cluster of Excellence NeuroCure, Charite-Universitätsmedizin Berlin, Berlin 10117, Germany
7Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
8Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
9Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
10Department of Regenerative Medicine, Stem Cells and Gene Therapy (HSR-TGET), Milan 20132, Italy
11Howard Hughes Medical Institute

Tài liệu tham khảo

Ahern, 2008, The interleukin-23 axis in intestinal inflammation, Immunol. Rev., 226, 147, 10.1111/j.1600-065X.2008.00705.x Ahern, 2010, Interleukin-23 drives intestinal inflammation through direct activity on T cells, Immunity, 33, 279, 10.1016/j.immuni.2010.08.010 Annunziato, 2007, Phenotypic and functional features of human Th17 cells, J. Exp. Med., 204, 1849, 10.1084/jem.20070663 Annunziato, 2009, Type 17 T helper cells-origins, features and possible roles in rheumatic disease, Nat. Rev. Rheumatol., 5, 325, 10.1038/nrrheum.2009.80 Becker, 2006, High resolution colonoscopy in live mice, Nat. Protoc., 1, 2900, 10.1038/nprot.2006.446 Berg, 1996, Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses, J. Clin. Invest., 98, 1010, 10.1172/JCI118861 Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, 441, 235, 10.1038/nature04753 Bettelli, 2007, T(H)-17 cells in the circle of immunity and autoimmunity, Nat. Immunol., 8, 345, 10.1038/ni0407-345 Chatenoud, 2007, CD3-specific antibodies: A portal to the treatment of autoimmunity, Nat. Rev. Immunol., 7, 622, 10.1038/nri2134 Chaudhry, 2009, CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner, Science, 326, 986, 10.1126/science.1172702 Darrah, 2010, IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform, J. Exp. Med., 207, 1421, 10.1084/jem.20092532 Ding, 1992, IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function, J. Immunol., 148, 3133, 10.4049/jimmunol.148.10.3133 Duerr, 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene, Science, 314, 1461, 10.1126/science.1135245 El-behi, 2009, Differential effect of IL-27 on developing versus committed Th17 cells, J. Immunol., 183, 4957, 10.4049/jimmunol.0900735 Elson, 2007, Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice, Gastroenterology, 132, 2359, 10.1053/j.gastro.2007.03.104 Fiorentino, 1991, IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells, J. Immunol., 146, 3444, 10.4049/jimmunol.146.10.3444 Fitzgerald, 2007, Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells, Nat. Immunol., 8, 1372, 10.1038/ni1540 Gagliani, 2010, Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant, Diabetes, 59, 433, 10.2337/db09-1168 Glocker, 2009, Inflammatory bowel disease and mutations affecting the interleukin-10 receptor, N. Engl. J. Med., 361, 2033, 10.1056/NEJMoa0907206 Groux, 1997, A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature, 389, 737, 10.1038/39614 Gu, 2008, Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells, Eur. J. Immunol., 38, 1807, 10.1002/eji.200838331 Ivanov, 2006, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, 126, 1121, 10.1016/j.cell.2006.07.035 Kamanaka, 2006, Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse, Immunity, 25, 941, 10.1016/j.immuni.2006.09.013 Kamanaka, 2011, Memory/ effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22 dependent colitis, J. Exp. Med., 10.1084/jem.20102149 Kühn, 1993, Interleukin-10-deficient mice develop chronic enterocolitis, Cell, 75, 263, 10.1016/0092-8674(93)80068-P Lee, 2009, Late developmental plasticity in the T helper 17 lineage, Immunity, 30, 92, 10.1016/j.immuni.2008.11.005 Littman, 2010, Th17 and regulatory T cells in mediating and restraining inflammation, Cell, 140, 845, 10.1016/j.cell.2010.02.021 Liu, 2010, Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease, Nat. Med., 16, 191, 10.1038/nm.2077 Mangan, 2006, Transforming growth factor-beta induces development of the T(H)17 lineage, Nature, 441, 231, 10.1038/nature04754 Maynard, 2007, Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10, Nat. Immunol., 8, 931, 10.1038/ni1504 McGeachy, 2007, TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology, Nat. Immunol., 8, 1390, 10.1038/ni1539 McGeachy, 2009, The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo, Nat. Immunol., 10, 314, 10.1038/ni.1698 Miossec, 2009, Interleukin-17 and type 17 helper T cells, N. Engl. J. Med., 361, 888, 10.1056/NEJMra0707449 Murai, 2009, Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis, Nat. Immunol., 10, 1178, 10.1038/ni.1791 Naundorf, 2009, IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells, Eur. J. Immunol., 39, 1066, 10.1002/eji.200838773 O'Connor, 2009, A protective function for interleukin 17A in T cell-mediated intestinal inflammation, Nat. Immunol., 10, 603, 10.1038/ni.1736 Ogawa, 2004, Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice, Clin. Immunol., 110, 55, 10.1016/j.clim.2003.09.013 Okamura, 2009, CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2, Proc. Natl. Acad. Sci. USA, 106, 13974, 10.1073/pnas.0906872106 Roncarolo, 2007, Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans, Nat. Rev. Immunol., 7, 585, 10.1038/nri2138 Rubtsov, 2008, Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces, Immunity, 28, 546, 10.1016/j.immuni.2008.02.017 Spencer, 1998, The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor, J. Exp. Med., 187, 571, 10.1084/jem.187.4.571 Stumhofer, 2006, Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system, Nat. Immunol., 7, 937, 10.1038/ni1376 Stumhofer, 2007, Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10, Nat. Immunol., 8, 1363, 10.1038/ni1537 Sutton, 2006, A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis, J. Exp. Med., 203, 1685, 10.1084/jem.20060285 Veldhoen, 2006, TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, 24, 179, 10.1016/j.immuni.2006.01.001 Wan, 2005, Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter, Proc. Natl. Acad. Sci. USA, 102, 5126, 10.1073/pnas.0501701102 Wang, 2009, The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut, Mucosal Immunol., 2, 173, 10.1038/mi.2008.84 Zenewicz, 2008, Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease, Immunity, 29, 947, 10.1016/j.immuni.2008.11.003 Zheng, 2010, Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate, Nature, 463, 808, 10.1038/nature08750 Zhou, 2004, IL-10 modulates intestinal damage and epithelial cell apoptosis in T cell-mediated enteropathy, Am. J. Physiol. Gastrointest. Liver Physiol., 287, G599, 10.1152/ajpgi.00063.2004