Conventional and nonconventional roles of the nucleolus

Alberts, 1994, The Molecular Biology of the Cell, 378 Allain, 2000, Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin, EMBO J., 19, 6870, 10.1093/emboj/19.24.6870 Allain, 2000, Solution structure of the two N-terminal RNA-binding domains of nucleolin and NMR study of the interaction with its RNA target, J. Mol. Biol., 303, 227, 10.1006/jmbi.2000.4118 Allmang, 2000, Degradation of ribosomal RNA precursors by the exosome, Nucleic Acids Res., 28, 1684, 10.1093/nar/28.8.1684 Almeida, 1998, Microinjection of anti-coilin antibodies affects the structure of coiled bodies, J. Cell Biol., 142, 899, 10.1083/jcb.142.4.899 Anastassova-Kristeva, 1977, The nucleolar cycle in man, J. Cell Sci., 25, 103, 10.1242/jcs.25.1.103 Andersen, 2002, Directed proteomic analysis of the human nucleolus, Curr Biol., 12, 1, 10.1016/S0960-9822(01)00650-9 Arnett, 1997, Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases, Arthritis Rheum., 40, 1487 Azum-Gelade, 1994, Cell cycle redistribution of U3 snRNA and fibrillarin. Presence in the cytoplasmic nucleolus remnant and in the prenucleolar bodies at telophase, J. Cell Sci., 107, 463, 10.1242/jcs.107.2.463 Ballal, 1974, The dynamic state of liver nucleolar proteins as reflected by their changes during administration of thioacetamide, Life Sci., 14, 1835, 10.1016/0024-3205(74)90401-9 Barneche, 2000, Fibrillarin genes encode both a conserved nucleolar protein and a novel small nucleolar RNA involved in ribosomal RNA methylation in Arabidopsis thaliana, J. Biol. Chem., 275, 27212, 10.1016/S0021-9258(19)61499-7 Bassler, 2001, Identification of a 60S preribosomal particle that is closely linked to nuclear export, Mol. Cell, 8, 517, 10.1016/S1097-2765(01)00342-2 Beckmann, 1992, Nuclear substrate of protein kinase C, Eur. J. Biochem., 210, 45, 10.1111/j.1432-1033.1992.tb17388.x Bertrand, 1998, Nucleolar localization of early tRNA processing, Genes Dev., 12, 2463, 10.1101/gad.12.16.2463 Biggiogera, 1991, Distribution of nucleolar protein B23 and nucleolin during mouse spermatogenesis, Chromosoma, 100, 162, 10.1007/BF00337245 Bird, 1980, Gene reiteration and gene amplification, Vol. 3, 62 Borer, 1989, Major nucleolar proteins shuttle between nucleus and cytoplasm, Cell, 56, 379, 10.1016/0092-8674(89)90241-9 Borggrefe, 1998, A B-cell-specific DNA recombination complex, J. Biol. Chem., 273, 17025, 10.1074/jbc.273.27.17025 Borovjagin, 1999, U3 Small nucleolar RNA is essential for cleavage at sites 1, 2 and 3 in pre-rRNA and determines which rRNA processing pathway is taken in Xenopus oocytes, J. Mol. Biol., 286, 1347, 10.1006/jmbi.1999.2527 Borovjagin, 2001, Xenopus U3 snoRNA GAC-box A′ and box A sequences play distinct functional roles in rRNA processing, Mol. Cell. Biol., 21, 6210, 10.1128/MCB.21.18.6210-6221.2001 Boudonck, 1999, The movement of coiled bodies visualized in living plant cells by the green fluorescent protein, Mol. Biol. Cell, 10, 2297, 10.1091/mbc.10.7.2297 Bousquet-Antonelli, 2000, Rrp8p is a yeast nucleolar protein functionally linked to Garlp and involved in pre-rRNA cleavage at site A2, RNA, 6, 826, 10.1017/S1355838200992288 Bouvet, 1998, Nucleolin interacts with several ribosomal proteins through its RGG domain, J. Biol. Chem., 273, 19025, 10.1074/jbc.273.30.19025 Bouvet, 2001, Recognition of pre-formed and flexible elements of an RNA stem-loop by nucleolin, J. Mol. Biol., 309, 763, 10.1006/jmbi.2001.4691 Brasch, 1992, Nuclear bodies (NBs): A newly “rediscovered” organelle, Exp. Cell Res., 202, 211, 10.1016/0014-4827(92)90068-J Brodsky, 2000, Pre-mRNA processing factors are required for nuclear export, RNA, 6, 1737, 10.1017/S1355838200001059 Brosh, 2001, Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases, J. Biol. Chem., 276, 3024, 10.1074/jbc.M006784200 Brouwer, 2001, Three novel components of the human exosome, J. Biol. Chem., 276, 6177, 10.1074/jbc.M007603200 Brun, 1994, Factor C∗ the specific initiation component of the mouse RNA polymerase I holoenzyme, is inactivated early in the transcription process, Mol. Cell. Biol., 14, 5010, 10.1128/MCB.14.7.5010 Bugler, 1987, RNA binding fragments from nucleolin contain the ribonucleoprotein consensus sequence, J. Biol. Chem., 262, 10922, 10.1016/S0021-9258(18)60904-4 Busch, 1970 Busch, 1984, Actinomycin D inhibition of monoclonal antibody binding to nucleolar phosphoprotein B23 (37/5.2), Life Sci., 35, 1777, 10.1016/0024-3205(84)90275-3 Carmo-Fonseca, 2000, To be or not to be in the nucleolus, Nat. Cell Biol., 2, E107, 10.1038/35014078 Cavaille, 2000, Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization, 97, 14311 Chan, 1985, Alterations in immunolocalization of the phosphoprotein B23 in HeLa cells during serum starvation, Exp. Cell. Res., 161, 101, 10.1016/0014-4827(85)90494-X Chan, 1986, Amino acid sequence of protein B23 phosphorylation site, J. Biol. Chem., 261, 1868, 10.1016/S0021-9258(17)36022-2 Chan, 1997, Isolation and characterization of the human nucleophosminB23 (NPM) gene: Identification of the YY1 binding site at the 5′ enhancer region, Nucleic Acids Res., 25, 1225, 10.1093/nar/25.6.1225 Chan, 1989, Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth, Biochemistry, 28, 1033, 10.1021/bi00429a017 Chan, 1989, Cross-linkage of nucleophosmin in tumor cells by nitrogen mustard, Cancer Res., 4, 3721 Chang, 1990, Structure of the gene of rat nucleolar protein B23, J. Biol. Chem., 265, 18227, 10.1016/S0021-9258(17)44742-9 Chang, 1998, Evidence for the ability of nucleophosmin/B23 to bind ATP, Biochem. J., 329, 539, 10.1042/bj3290539 Charroux, 2000, Gemin4: A novel component of the SMN complex that is found in both gems and nucleoli, J. Cell Biol., 148, 1177, 10.1083/jcb.148.6.1177 Chekanova, 2000, Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells, J. Biol. Chem., 275, 33158, 10.1074/jbc.M005493200 Chen, 2001, Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells, J. Cell Biol., 153, 169, 10.1083/jcb.153.1.169 Chooi, 1981, An electron microscopic method for localization of ribosomal proteins during transcription of ribosomal DNA: A method for studying protein assembly, 78, 4823 Chou, 2001, Increased stability of nucleophosminB23 in anti-apoptotic effect of Ras during serum deprivation, Mol. Pharmacol., 59, 38, 10.1124/mol.59.1.38 Christensen, 1988, The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins, Biochem. Biophys. Res. Commun., 155, 1278, 10.1016/S0006-291X(88)81279-8 Christensen, 1977, Identification of NG, NG-dimethylarginine in a nuclear protein from the lower eukaryote Physarum polycephalum homologous to the major proteins of mammalian 40S ribonucleoprotein particles, Biochem. Biophys. Res. Commun., 74, 621, 10.1016/0006-291X(77)90348-5 Cockell, 1999, The nucleolus: Nucleolar space for rent, Curr Biol., 9, R575, 10.1016/S0960-9822(99)80359-5 Colley, 2000, Dhrlp, a putative DEAH-Box RNA helicase, is associated with the box C+D snoRNP U3, Mol. Cell. Biol., 20, 7238, 10.1128/MCB.20.19.7238-7246.2000 Corporeau, 2000, HSP70 is involved in the control of chromosomal transcription in the amphibian oocyte, Exp. Cell Res., 260, 222, 10.1006/excr.2000.5003 Davis, 1998, Characterization of HDJ-2, a human 40 kD heat shock protein, Int. J. Biochem. Cell Biol., 30, 1203, 10.1016/S1357-2725(98)00091-0 De Cárcer, 2000, Simultaneous localization of transcription and early processing markers allows dissection of functional domains in the plant cell nucleolus, J. Struct Biol., 128, 139, 10.1006/jsbi.1999.4187 Dechampesme, 1999, Assembly of 5S ribosomal RNA is required at a specific step of the pre-rRNA processing pathway, J. Cell Biol., 145, 1369, 10.1083/jcb.145.7.1369 Defossez, 1999, Elimination of replication block protein Fobl extends the life span of yeast mother cells, Mol. Cell, 3, 447, 10.1016/S1097-2765(00)80472-4 De la Cruz, 1999, Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families, Trends Biochem. Sci., 24, 192, 10.1016/S0968-0004(99)01376-6 Dempsey, 1998, A specific isoform of hnRNP D interacts with DNA in the LR1 heterodimer: Canonical RNA binding motifs in a sequence-specific duplex DNA binding protein, J. Biol. Chem., 273, 29224, 10.1074/jbc.273.44.29224 Deshmukh, 1993, Yeast ribosomal protein L1 is required for the stability of newly synthesized 5S rRNA and the assembly of 60S ribosomal subunits, Mol. Cell. Biol., 13, 2835, 10.1128/MCB.13.5.2835 Dez, 2001, Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p, Nucleic Acids Res., 29, 598, 10.1093/nar/29.3.598 Dick, 1997, Exchangeability of Qsr1p, a large ribosomal subunit protein required for subunit joining, suggests a novel translational regulatory mechanism, FEBS Lett., 419, 1, 10.1016/S0014-5793(97)01402-6 Dousset, 2000, Initiation of nucleolar assembly is independent of RNA polymerase I transcription, Mol. Biol. Cell, 11, 2705, 10.1091/mbc.11.8.2705 Dragon, 2000, In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs, Mol. Cell. Biol., 20, 3037, 10.1128/MCB.20.9.3037-3048.2000 Dreyfuss, 1993, hnRNP proteins and biogenesis of mRNA, Annu. Rev. Biochem., 62, 289, 10.1146/annurev.bi.62.070193.001445 Dumbar, 1989, Interaction of nucleolar phosphoprotein B23 with nucleic acids, Biochemistry, 28, 9495, 10.1021/bi00450a037 Dunbar, 2000, Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei—Sequence conservation and implications for 2′-O-ribose methylation of rRNA, J. Biol. Chem., 275, 14767, 10.1074/jbc.M001180200 Dundr, 1998, Partially processed pre-rRNA is preserved in association with processing components in nucleolus-derived foci during mitosis, Mol. Biol. Cell., 9, 2407, 10.1091/mbc.9.9.2407 Dundr, 1995, The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein, J. Cell Sci., 108, 2811, 10.1242/jcs.108.8.2811 Dundr, 1997, A class of nonribosomal nucleolar components is located in chromosome periphery and in nucleolus-derived foci during anaphase and telophase, Chromosoma, 105, 407, 10.1007/BF02510477 Dundr, 2000, The dynamics of postmitotic re-assembly of the nucleolus, J. Cell. Biol., 150, 443, 10.1083/jcb.150.3.433 Dutta, 2001, The crystal structure of nucleoplasmin-core. Implications for histone binding and nucleosome assembly, Mol. Cell, 8, 841, 10.1016/S1097-2765(01)00354-9 Eichler, 1994, Processing of eukaryotic ribosomal RNA, Prog. Nucleic Acid Res. Mol. Biol., 49, 197, 10.1016/S0079-6603(08)60051-3 Elicieri, 1999, Small nucleolar RNAs, Cell. Mol. Life Sci., 56, 22, 10.1007/s000180050003 Ellis, 1997, Molecular chaperones: Avoiding the crowd, Curr. Biol., 7, R531, 10.1016/S0960-9822(06)00273-9 Eppens, 1999, The roles of Rrp5p in the synthesis of yeast 18S and 5.8S rRNA can be functionally and physically separated, RNA, 5, 779, 10.1017/S1355838299990313 Fan, 1971, Regulation of synthesis and processing of nucleolar components in metaphase-attested cells, J. Mol. Biol., 59, 27, 10.1016/0022-2836(71)90411-6 Fankhauser, 1991, Specific complex of human immunodeficiency virus type 1 Rev and nucleolar B23 proteins: Dissociation by the Rev response element, Mol. Cell. Biol., 11, 2567, 10.1128/MCB.11.5.2567 Fatica, 2000, Fibrillarin binds directly and specifically to U16 box C/D snoRNA, RNA, 6, 88, 10.1017/S1355838200991623 Feuerstein, 1987, “Numatrin”, a nuclear matrix protein associated with induction of proliferation in B lymphocytes, J. Biol. Chem., 262, 11389, 10.1016/S0021-9258(18)60972-X Feuerstein, 1988, The nuclear matrix protein, numatrin (1323), is associated with growth factor induced mitogenesis in swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody, J. Cell Biol., 107, 1629, 10.1083/jcb.107.5.1629 Feuerstein, 1990, Evidence for DNA binding activity of ntmiatrin (B23), a cell-cycle regulated nuclear matrix protein, Biophys. Biochim. Acta, 1087, 127, 10.1016/0167-4781(90)90196-9 Fields, 1986, Analysis of the internal nuclear matrix, oligomers of a 38 kD nucleolar polypeptide stabilized by disulfide bonds, Exp. Cell Res., 164, 139, 10.1016/0014-4827(86)90461-1 Filipowicz, 2000, Imprinted expression of small nucleolar RNAs in brain: Time for RNomics, 97, 14035 Filippini, 2000, p62, a novel Xenopus laevis component of box C/D snoRNPs, RNA, 6, 391, 10.1017/S135583820099174X Finch, 1997, Structural and functional relationships of toyocamycin on NPM translocation, Anti-Cancer Drug Design., 12, 205 Fischer, 2001, C7, a novel nucleolar protein, is the mouse homologue of the Drosophila late puff product L82 and an isoform of human OXRL, Biochem. Biophys. Res. Commun., 281, 795, 10.1006/bbrc.2001.4345 Fontana, 1781, Traité sur le venin de la vipère, 268 Franke, 1988, Matthias Jacob Schleiden and the definition of the cell nucleus, Eur. J. Cell. Biol., 47, 45 Gall, 2001, A role for Cajal bodies in assembly of the nuclear transcription machinery, FEBS Lett, 498, 164, 10.1016/S0014-5793(01)02461-9 Ganot, 1999, Nucleolar factors direct the 2′-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA, Mol. Cell. Biol., 19, 6906, 10.1128/MCB.19.10.6906 Gao, 2000, Identification of casein kinase I substrates by in vitro expression cloning screening, Biochem. Biophys. Res. Commun., 268, 562, 10.1006/bbrc.2000.2168 Garcia, 2000, Unique epitopes in RNA helicase II/Gu protein recognized by serum from a watermelon stomach patient, Mol. Immunol., 37, 351, 10.1016/S0161-5890(00)00062-6 Gautier, 1994, Fate of specific nucleolar perichromosomal proteins during mitosis: Cellular distribution and association with U3 snoRNA, Biol. Cell, 82, 81, 10.1016/S0248-4900(94)80010-3 Geerlings, 2000, The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5′ → 3′ exonucleases, RNA, 6, 1698, 10.1017/S1355838200001540 Ghisolfi-Nieto, 1996, Nucleolin is a sequence-specific RNA-binding protein: Characterization of targets on pre-ribosomal RNA, J. Mol. Biol., 260, 34, 10.1006/jmbi.1996.0380 Ginisty, 1998, Nucleolin functions in the first step of ribosomal RNA processing, EMBO J., 17, 1476, 10.1093/emboj/17.5.1476 Ginisty, 1999, Structure and functions of nucleolin, J. Cell Sci., 112, 761, 10.1242/jcs.112.6.761 Ginisty, 2000, Interaction of nucleolin with an evolutionarily conserved pre-ribosomal RNA sequence is required for the assembly of the primary processing complex, J. Biol. Chem., 275, 18845, 10.1074/jbc.M002350200 Grein, 1999, Searching interaction partners of protein kinase CK2 subunit by two-hybrid screening, Mol. Cell. Biochem., 191, 105, 10.1023/A:1006814428582 Grosshans, 2001, Biogenesis,of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export, J. Cell Biol., 153, 745, 10.1083/jcb.153.4.745 Grummt, 1999, Regulation of mammalian ribosomal gene transcription by RNA polymerase I, Prog. Nucleic Acid Res. Mol. Biol., 62, 109, 10.1016/S0079-6603(08)60506-1 Guarente, 1997, Link between aging and the nucleolus, Genes Dev., 11, 2449, 10.1101/gad.11.19.2449 Hadjiolov, 1985 Hanakahi, 1997, Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LRl, 94, 3605 Hanakahi, 2000, The C-terminal domain of nucleolin accelerates nucleic acid annealing, Biochemistry, 39, 15493, 10.1021/bi001683y Hannan, 1996, Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: Implications for cardiac hypertrophy, 93, 8750 Hannan, 1998, Regulation of ribosomal DNA transcription by insulin, Am. J. Physiol. Cell Physiol., 275, C130, 10.1152/ajpcell.1998.275.1.C130 Hannan, 1998, UBF and the regulation of ribosomal DNA transcription, 221 Hannan, 2000, RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest, Oncogene, 19, 3487, 10.1038/sj.onc.1203690 Harnpicharnchai, 2001, Composition and functional characterization of yeast 66s ribosome assembly intermediates, Mol. Cell, 8, 505, 10.1016/S1097-2765(01)00344-6 Hebert, 2000, Self-association of coilin reveals a common theme in nuclear body localization, Mol. Biol. Cell., 11, 4159, 10.1091/mbc.11.12.4159 Herrera, 1986, Association of protein C23 with rapidly labeled nucleolar RNA, Biochemistry, 25, 6258, 10.1021/bi00368a063 Herrera, 1995, The ribonuclease activity of nucleolar protein B23, Nucleic Acids Res., 23, 3974, 10.1093/nar/23.19.3974 Herrera, 1996, Sedimentation analyses of the salt and divalent metal ion induced oligomerization of nucleolar protein B23, Biochemistry, 35, 2668, 10.1021/bi9523320 Hickey, 2000, Identification of genes in the genome of the archaeon Methanosarcina mazeii that code for homologs of nuclear eukaryotic molecules involved in RNA processing, Gene, 253, 77, 10.1016/S0378-1119(00)00235-3 Hingorani, 2000, Mapping the functional domains of nucleolar protein B23, J. Biol. Chem., 275, 24451, 10.1074/jbc.M003278200 Hiscox, 2001, The coronavirus infectious bronchitis virus nucleoprotein localizes to the nucleolus, J. Virol., 75, 506, 10.1128/JVI.75.1.506-512.2001 Ho, 2000, Nmd3p is a Crmlp-dependent adapter protein for nuclear export of the large ribosomal subunit, J. Cell Biol., 151, 1057, 10.1083/jcb.151.5.1057 Ho, 2000, Nascent 60S ribosomal subunits enter the free pool bound by Nmd3p, RNA, 6, 1625, 10.1017/S1355838200001291 Hozak, 1995, Catching RNA polymerase I in Flagranti: Ribosomal genes are transcribed in the dense fibrillar component of the nucleolus, Exp. Cell Res., 216, 285, 10.1006/excr.1995.1036 Huang, 2001, The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication, J. Biol. Chem ., 276, 25166, 10.1074/jbc.M010087200 Hurt, 1999, A novel in vivo assay reveals inhibition of ribosomal nuclear export in Ran-cycle and nucleoporin mutants, J. Cell Biol., 144, 389, 10.1083/jcb.144.3.389 Hyttel, 2000, Nucleolar proteins and ultrastructure in preimplantation porcine embryos developed in vivo, Biol. Reprod., 63, 1848, 10.1095/biolreprod63.6.1848 Iborra, 2001, Coupled transcription and translation within nuclei of mammalian cells, Science, 293, 1139, 10.1126/science.1061216 Imai, 1992, Nucleolar antigens and autoantibodies in hepatocellular carcinoma and other malignancies, Am. J. Pathol., 140, 859 Isaac, 1998, Nopp140 functions as a molecular link between the nucleolus and the coiled bodies, J. Cell Biol., 142, 319, 10.1083/jcb.142.2.319 Jacob, 1999, Control of RNA polymerase I-directed transcription: Recent trends, J. Cell. Biochem. Suppl., 32–33, 41, 10.1002/(SICI)1097-4644(1999)75:32+<41::AID-JCB6>3.0.CO;2-W Jacobson, 1998, Localization of signal recognition particle RNA in the nucleolus of mammalian cells, 95, 7981 Jankowsky, 2001, Active disruption of an RNA-protein interaction by a DExH/D RNA helicase, Science, 291, 121, 10.1126/science.291.5501.121 Jansen, 1993, A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing, EMBO J., 12, 2549, 10.1002/j.1460-2075.1993.tb05910.x Jarrous, 1999, Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P, J. Cell Biol., 146, 559, 10.1083/jcb.146.3.559 Jimenez-Garcia, 1994, Nucleologenesis: U3 snRNA-containing prenucleolar bodies move to sites of active pre-rRNA transcription after mitosis, Mol. Biol. Cell, 5, 955, 10.1091/mbc.5.9.955 Jones, 1981, Sequence of a phosphorylation site in nucleolar protein B23, Biochim. Biophys. Acta, 667, 209, 10.1016/0005-2795(81)90081-7 Karpen, 1988, A Drosophila rRNA gene located in euchromatin is active in transcription and nucleolus formation, Genes Dev., 2, 1745, 10.1101/gad.2.12b.1745 Kass, 1990, The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processing, Cell, 60, 897, 10.1016/0092-8674(90)90338-F Kendall, 2000, A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses tRNA gene-mediated transcriptional silencing, 97, 3108 Kiss, 2001, Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs, EMBO J. 2, 20, 3617, 10.1093/emboj/20.14.3617 Kjems, 2000, Rev protein and its cellular partners, Adv. Pharmacol., 48, 251, 10.1016/S1054-3589(00)48009-9 Klein, 1999, Cell cycle-dependent regulation of ma polymerase I transcription. The nucleolar transcription factor UBF is inactive in mitosis and early G1, 96, 6096 Knowlton, 1999, Mutation of amino acids 246–251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability, J. Mol. Cell Cardiol., 31, 523, 10.1006/jmcc.1998.0883 Kondo, 1997, Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity, Oncogene, 15, 1275, 10.1038/sj.onc.1201286 Kressler, 1999, Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae, Mol. Cell. Biol., 19, 7897, 10.1128/MCB.19.12.7897 Kubota, 1989, Function similarity of HIV 1 and HTLV 1 Rex proteins: Identification of a new nucleolar targeting signal in rev protein, Biochem. Biophys. Res. Commun., 162, 963, 10.1016/0006-291X(89)90767-5 Kuhn, 1998, Regulation of rRNA transcription in vertebrates., 201 Lafontaine, 2001, The function and synthesis of ribosomes, Nat. Rev. Mol. Cell Biol., 2, 514, 10.1038/35080045 Lalev, 2001, A chaperone for ribosome maturation, J. Biol. Chem., 276, 16655, 10.1074/jbc.M101157200 Lange, 2000, Transient nucleolar localization of U6 small nuclear RNA in Xenopus laevis oocytes, Mol. Biol. Cell., 11, 2419, 10.1091/mbc.11.7.2419 Lazdins, 1997, Analysis of nucleolar transcription and processing domains and pre-rRNA movements by in situ hybridization, Chromosoma, 105, 481, 10.1007/BF02510485 Lee, 1997, Functional separation of pre-rRNA processing steps revealed by truncation of the U3 small nucleolar ribonucleoprotein component, Mpp10, 94, 13536 Lee, 1999, Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing, Mol. Cell. Biol., 19, 5441, 10.1128/MCB.19.8.5441 Léger-Silvestre, 1997, Structural and functional analysis of the nucleolus of the fission yeast Schizosaccharomyces pombe, Eur. J. Cell Biol., 72, 13 Le Pause, 1999, 3-D organization of ribosomal transcription units after DRB inhibition of RNA polymerase II transcription, J. Cell Sci., 112, 2145, 10.1242/jcs.112.13.2145 Lepoint, 1978, Nucleologenesis in Ehrlich tumour cells, Exp. Cell Res., 117, 89, 10.1016/0014-4827(78)90430-5 Li, 1996, C23 interacts with B23, a putative nucleolar-localization-signal-binding protein, Eur. J. Biochem., 237, 153, 10.1111/j.1432-1033.1996.0153n.x Lindstrω, 2000, Immunolocalization of human p14ARF to the granular component of the interphase nucleolus, Exp. Cell Res., 256, 400, 10.1006/excr.2000.4854 Lischwe, 1985, Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pl, 8.5) rich in NG,NG-dimethylarginine, J. Biol. Chem., 260, 14304, 10.1016/S0021-9258(17)38718-5 Liu, 1991, Formation of nucleophosmin/B23 oligomers requires both the amino- and the carboxyl-terminal domains of the protein, Eur. J. Biochem., 200, 715, 10.1111/j.1432-1033.1991.tb16236.x Liu, 1999, The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBFI transcription factor and inhibits ribosomal RNA transcription, EMBO J., 18, 2845, 10.1093/emboj/18.10.2845 Llanos, 2001, Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus, Nat. Cell Biol., 3, 445, 10.1038/35074506 Lucchini, 1998, The dynamic structure of ribosomal RNA gene chromatin, 255 Lukowiak, 2000, Interaction of the U3–55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3–55k, Nucleic Acids Res., 28, 3462, 10.1093/nar/28.18.3462 Luo, 2001, Negative control of p53 by Sir2alpha promotes cell survival under stress, Cell, 107, 137, 10.1016/S0092-8674(01)00524-4 MacCallum, 2000, The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle, J. Pathol., 190, 537, 10.1002/(SICI)1096-9896(200004)190:5<537::AID-PATH577>3.0.CO;2-W Machwe, 2000, Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts, FASEB, 14, 1715, 10.1096/fj.99-0926com Maden, 1997, Eukaryotic ribosomal RNA: The recent excitement in the nucleotide modification problem, Chromosoma, 105, 391, 10.1007/BF02510475 Mahajan, 1990, Hormonal regulation of transcription of rDNA. Purification and characterization of the hormone-regulated transcription factor IC, J. Biol. Chem., 265, 16225, 10.1016/S0021-9258(17)46212-0 Maiorano, 1999, Functional conservation and cell cycle localization of the Nhp2 core component of H + ACA snoRNPs in fission and budding yeasts, Exp. Cell Res., 252, 165, 10.1006/excr.1999.4607 Marciniak, 1998, Nucleolar localization of the Werner syndrome protein in human cells, 95, 6887 Martelli, 2000, Behavior of nucleolar proteins during the course of apoptosis in camptothecintreated HL60 cells, J. Cell. Biochem., 78, 264, 10.1002/(SICI)1097-4644(20000801)78:2<264::AID-JCB9>3.0.CO;2-3 Martelli, 2001, p19ARF targets certain E2F species for degradation, 98, 4455 Matera, 1999, Nuclear bodies: Multifaceted subdomains of the interchromatin space, Trends Cell Biol., 9, 302, 10.1016/S0962-8924(99)01606-2 Matthews, 2001, Adenovirus protein V induces redistribution of nucleolin and B23 from nucleolus to cytoplasm, J. Wrol., 75, 1031 Maxwell, 1995, The small nucleolar RNAs, Annu. Rev. Biochem., 35, 897, 10.1146/annurev.bi.64.070195.004341 McArthur, 1997, Npm3: A novel, widely expressed gene encoding a protein related to the molecular chaperones nucleplasmin and nucleophosmin, Genomics, 42, 137, 10.1006/geno.1997.4353 McDonald, 1992, Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding site, J. Virol., 66, 7232, 10.1128/JVI.66.12.7232-7238.1992 Medina, 1995, Components of the nucleolar processing complex (Pre-rRNA, fibrillarin, and nucleolin) colocalize during mitosis and are incorporated to daughter cell nucleoli, Exp. Cell Res., 221, 111, 10.1006/excr.1995.1358 Meier, 1994, NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteria, J. Cell Biol., 127, 1505, 10.1083/jcb.127.6.1505 Mélese, 1995, The nucleolus: An organelle formed by the act of building a ribosome, Curr. Opin. Cell Biol., 7, 319, 10.1016/0955-0674(95)80085-9 Michienzi, 2000, Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA, 97, 8955 Milkereit, 2001, Maturation and intranuclear transport of pre-ribosomes requires noc proteins, Cell, 105, 499, 10.1016/S0092-8674(01)00358-0 Mishra, 1997, Three small nucleolar RNAs that are involved in ribosomal RNA precursor processing, 94, 4972 Mitchell, 1999, A Box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end, Mol. Cell Biol., 19, 567, 10.1128/MCB.19.1.567 Mitchell, 1999, A telomerase component defective in the human disease dyskeratosis congenita, Nature (London), 402, 551, 10.1038/990141 Mo, 1999, Association of human DNA topoisomerase 11 alpha with mitotic chromosomes in mammalian cells is independent of its catalytic activity, Exp. Cell Res., 252, 50, 10.1006/excr.1999.4616 Mohaghegh, 2001, DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders, Hum. Mol. Genet., 10, 741, 10.1093/hmg/10.7.741 Morris, 1994, Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma, Science, 263, 1281, 10.1126/science.8122112 Mosgoeller, 1998, Ribosomal gene transcription is organized in foci within nucleolar components, Histochem. Cell. Biol., 109, 111, 10.1007/s004180050208 Mougey, 1993, The terminal balls characteristic of eukaryotic rRNA transcription units in chromatin spreads are rRNA processing complexes, Genes Dev., 7, 1609, 10.1101/gad.7.8.1609 Moy, 1999, Nuclear export of the small ribosomal subunit requires the Ran-GTPasc cycle and certain nucleoporins, Genes Deu, 13, 2118, 10.1101/gad.13.16.2118 Nagel, 2000, Substrate recognition by a eukaryotic RNase III: The doublestranded RNA-binding domain of Rntlp selectively binds RNA containing a 5′-AGNN-3′ tetraloop, RNA, 6, 1142, 10.1017/S1355838200000431 Narayanan, 1999, Role of the box C/D motif in localization of small nucleolar RNAs to coiled bodies and nucleoli, Mol. Biol. Cell, 10, 2131, 10.1091/mbc.10.7.2131 Narayanan, 1999, Nucleolar localization signals of box H/ACA small nucleolar RNAs, EMBO J., 18, 101, 10.1093/emboj/18.18.5120 Neff, 1999, The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells, Mol. Biol. Cell, 10, 665, 10.1091/mbc.10.3.665 Newman, 2000, Box C/D snoRNA-associated proteins: Two pairs of evolutionarily ancient proteins and possible links to replication and transcription, RNA, 6, 861, 10.1017/S1355838200992446 Nicol, 2000, The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase, Exp. Cell Res., 257, 272, 10.1006/excr.2000.4886 Nierras, 1997, Does Saccharomyces need an organized nucleolus?, Chromosoma, 105, 444 Oakes, 1998, Mutational analysis of the structure and localization of the nucleolus in the yeast Saccharomyces cerevisiae, J. Cell Biol., 143, 23, 10.1083/jcb.143.1.23 Ochs, 1983, Localization of nucleolar phosphoproteins B23 and C23 during mitosis, Exp. Cell. Res., 146, 139, 10.1016/0014-4827(83)90332-4 Ochs, 1985, Fibrillarin: A new protein of the nucleolus identified by autoimmune sera, Biol. Cell., 54, 123, 10.1111/j.1768-322X.1985.tb00387.x Ofengand, 1997, Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts, J. Mol. Biol., 265, 246, 10.1006/jmbi.1996.0737 Okuda, 2000, Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication, Cell, 103, 127, 10.1016/S0092-8674(00)00093-3 Okuwaki, 2001, Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone, FEBS Lett., 506, 272, 10.1016/S0014-5793(01)02939-8 Okuwaki, 2001, Identification of nucleophosminB23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins, J. Mol. Biol., 311, 41, 10.1006/jmbi.2001.4812 Olson, 1990, Vol. 2, 541 Olson, 1974, Phosphorylation of proteins of ribosomes and nucleolar preribosomal particles from Novikoff hepatoma ascites cells, J. Mol. Biol., 90, 161, 10.1016/0022-2836(74)90264-2 Olson, 1986, Preribosomal ribonucleoprotein particles are a major component of a nucleolar matrix fraction, Biochemistry, 25, 485, 10.1021/bi00350a031 Olson, 2000, The nucleolus: An old factory with unexpected capabilities, Trends Cell Biol., 10, 189, 10.1016/S0962-8924(00)01738-4 Orrick, 1973, Comparison of nucleolar proteins of normal rat liver and Novikoff hepatoma ascites cells by two-dimensional polyacrylamide gel electrophoresis, 70, 1316 Patterson, 1995, Reduced numatrin/ B23/nucleophosmin labeling in apoptotic Jurkat T lymphoblasts, J. Biol. Chem., 270, 9429, 10.1074/jbc.270.16.9429 Paule, 2000, Survey and summary: Transcription by RNA polymerases I and III, Nucleic Acids Res., 28, 1283, 10.1093/nar/28.6.1283 Peculis, 1992, Localization of nucleolar protein N038 in amphibian oocytes, J. Cell Biol., 116, 1, 10.1083/jcb.116.1.1 Peculis, 1998, The structure of the ITS2-proximal stem is required for pre-rRNA processing in yeast, RNA, 4, 1610, 10.1017/S1355838298981420 Pederson, 1998, Survey and summary. The plurifunctional nucleolus, Nucleic Acids Res., 17, 1871 Peter, 1990, Identification of major nucleolar proteins as candidate mitotic substrate of cdc2 kinase, Cell, 60, 791, 10.1016/0092-8674(90)90093-T Pfeifle, 1986, Characterization of nucleolarproteins as autoantigens using human antiimmune sera, Ann. Rheum. Dis., 45, 978, 10.1136/ard.45.12.978 Phair, 2000, High mobility of proteins in the mammalian cell nucleus, Nature (London), 404, 604, 10.1038/35007077 Phillips, 1998, The Nop60B gene of Drosophila encodes an essential nucleolar protein that functions in yeast, Mol. Gen. Genet., 260, 20, 10.1007/s004380050866 Pinol-Roma, 1999, Association of nonribosomal nucleolar proteins in ribonucleoprotein complexes during interphase and mitosis, Mol. Biol. Cell., 10, 77, 10.1091/mbc.10.1.77 Pintard, 2000, Spblp is a yeast nucleolar protein associated with Noplp and Nop58p that is able to bind S-adenosyl-L-methionine in vitro, Mol. Cell. Biol., 20, 1370, 10.1128/MCB.20.4.1370-1381.2000 Platani, 2000, In vivo analysis of Cajal body movement, separation, and joining in live human cells, J. Cell Biol., 151, 1561, 10.1083/jcb.151.7.1561 Pogacic, 2000, Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10, Mol. Cell. Biol., 20, 9028, 10.1128/MCB.20.23.9028-9040.2000 Pokrywka, 1995, Nuclear export pathways of tRNA and 40 S ribosomes include both common and specific intermediates, J. Biol. Chem., 270, 3619, 10.1074/jbc.270.8.3619 Politz, 2000, Signal recognition particle components in the nucleolus, 97, 55 Prestayko, 1974, Comparison of proteins of ribosomal subunits and nucleolar preribosomal particles from Novikoff hepatoma ascites cells by two dimensional polyacrylamide gel electrophoresis, Biochemistry, 13, 1945, 10.1021/bi00706a026 Ramakrishnan, 2001, Atomic structures at last: The ribosome in 2000, Curr. Opin. Stmct. Biol., 11, 144, 10.1016/S0959-440X(00)00184-6 Rasmussen, 1998, The putative nucleic acid helicase SenIp is required for formation and stability of termini and for maximal rates of synthesis and levels of accumulation of small nucleolar RNAs in Saccharomyces cerevisiae, Mol. Cell. Biol., 18, 6885, 10.1128/MCB.18.12.6885 Reeder, 1999, Regulation of RNA polymerase I transcription in yeast and vertebrates, Prog. Nucleic Acid Res. Mol. Biol., 62, 293, 10.1016/S0079-6603(08)60511-5 Rizos, 2000, Two arginine rich domains in the p 14ARF tumour suppressor mediate nucleolar localization, Oncogene, 19, 2978, 10.1038/sj.onc.1203629 Samarsky, 1999, A comprehensive database for the small nucleolar RNAs from Saccharomyces cerevisiae, Nucleic Acids Res., 27, 161, 10.1093/nar/27.1.161 Santoro, 2001, Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription, Mol. Cell, 8, 719, 10.1016/S1097-2765(01)00317-3 Savino, 1990, In vivo disruption of Xenopus U3 snRNA affects ribosomal RNA processing, EMBO J., 9, 2299, 10.1002/j.1460-2075.1990.tb07401.x Savino, 2001, Nucleolar assembly of the rRNA processing machinery in living cells, J. Cell Biol., 153, 1097, 10.1083/jcb.153.5.1097 Savkur, 1998, Preferential cleavage in pre-ribosomal RNA by protein B23 endoribonuclease, Nucleic Acids Res., 26, 4508, 10.1093/nar/26.19.4508 Scheer, 1999, Structure and function of the nucleolus, Curr. Opin. Cell Biol., 11, 385, 10.1016/S0955-0674(99)80054-4 Scheer, 1984, Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry, 81, 1431 Scheer, 1993, Structure, function and assembly of the nucleolus, Trends Cell Biol., 3, 236, 10.1016/0962-8924(93)90123-I Schmidt-Zachmann, 1988, DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli, Chromosoma (Berl.), 96, 417, 10.1007/BF00303035 Schmidt-Zachmann, 1987, A constitutive nucleolar protein identified as a member of the nucleoplasmin family, EMBO J., 6, 1881, 10.1002/j.1460-2075.1987.tb02447.x Schnapp, 1993, Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter, Mol. Cell. Biol., 13, 6723, 10.1128/MCB.13.11.6723 Schnapp, 1996, TFIIS binds to mouse RNA polymerase I and stimulates transcript elongation and hydrolytic cleavage of nascent rRNA, Mol. Gen. Genet., 252, 412, 10.1007/BF02173006 Schneiter, 1995, mRNA transport in yeast: Time to reinvestigate the functions of the nucleolus, Mol. Biol. Cell, 6, 357, 10.1091/mbc.6.4.357 Schultz, 1992, Topoisomerases and yeast rRNA transcription: Negative supercoiling stimulates initiation and topoisomerase activity is required for elongation, Genes Dev., 6, 1332, 10.1101/gad.6.7.1332 Shiratori, 1999, Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization, J. Cell Biol., 144, 1, 10.1083/jcb.144.1.1 Shore, 2000, The Sir2 protein family: A novel deacetylase for gene silencing and more, 97, 14030 Shou, 1999, Exit from mitosis is triggered by tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex, Cell, 97, 233, 10.1016/S0092-8674(00)80733-3 Sicard, 1998, The role of the Schizosaccharomyces pombe gar2 protein in nucleolar structure and function depends on the concerted action of its highly charged N terminus and its RNA-binding domains, Mol. Biol. Cell, 9, 2011, 10.1091/mbc.9.8.2011 Sipos, 1991, Nucleotin promotes secondary structure in ribosomal RNA, Biochem. Biophys. Res. Commun., 177, 673, 10.1016/0006-291X(91)91841-Y Sleeman, 1999, Newly assembled snRNPs associate first with coiled bodies then with speckles, suggesting a nuclear snRNP maturation pathway, Curr Biol., 9, 1, 10.1016/S0960-9822(99)80475-8 Snaar, 2000, Mutational analysis of fibrillarin and its mobility in living human cells, J. Cell Biol., 151, 653, 10.1083/jcb.151.3.653 Sollner-Webb, 1996, Ribosomal RNA processing in eukaryotes, 469 Spector, 1984, Silver staining, immunofluorescence, and immunoelectron microscopic localization of nucleolar phosphoproteins B23 and C23, Chromosoma, 90, 139, 10.1007/BF00292451 Srivastava, 1999, Molecular dissection of nucleolin's role in growth and cell proliferation: New insights, FASEB J., 13, 1911, 10.1096/fasebj.13.14.1911 Stade, 1997, Exportin 1 (Cgmlp) is an essential nuclear export factor, Cell, 90, 1041, 10.1016/S0092-8674(00)80370-0 Stage-Zimmerman, 2000, Factors affecting nuclear export of the 60S ribosomal subunit in vivo, Mol. Biol. Cell., 11, 3777, 10.1091/mbc.11.11.3777 Steitz, 1988, A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells, J. Cell Biol., 106, 545, 10.1083/jcb.106.3.545 Strohner, 2001, NoRC—a novel member of mammalian ISWI-containing chromatin remodeling machines, EMBO J., 20, 4892, 10.1093/emboj/20.17.4892 Sun, 2001, Cgr1p, a novel nucleolar protein encoded by Saccharomyces cerevisiae orf YGL0292w, Curr. Microbiol., 42, 65, 10.1007/s002840010180 Suzuki, 2001, Diverged nuclear localization of Werner helicase in human and mouse cells, Oncogene, 20, 2551, 10.1038/sj.onc.1204344 Szebeni, 1999, Nucleolar protein B23 has molecular chaperone activities, Protein Sci., 8, 905, 10.1110/ps.8.4.905 Szebeni, 1995, Interaction of nucleolar protein B23 with peptides related to nuclear localization signals, Biochemistry, 34, 8037, 10.1021/bi00025a009 Szebeni, 1997, Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin, Biochemistry, 36, 3941, 10.1021/bi9627931 Szekely, 2000, Werner protein recruits DNA polymerase to the nucleolus, 97, 11365 Takemura, 1994, Stimulation of calf thymus DNA polymerase alpha activity by nucleolar protein B23. Biochem, Biophys. Res. Commun., 199, 46, 10.1006/bbrc.1994.1191 Tanner, 2000, Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-0-acetyl-ADP-ribose, 97, 14178 Tawfic, 1995, Role of protein phosphorylation in post-translational regulation of protein B23 during programmed cell death in the prostate gland, J. Biol. Chem., 270, 21009, 10.1074/jbc.270.36.21009 Thiry, 1996 Thiry, 2000, Dynamics and three-dimensional localization of ribosomal RNA within the nucleolus, RNA, 6, 1750, 10.1017/S1355838200001564 Tokuyama, 2001, Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication, J. Biol. Chem., 276, 21529, 10.1074/jbc.M100014200 Tolerico, 1999, Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations, Genetics, 151, 57, 10.1093/genetics/151.1.57 Tollervey, 1997, Function and synthesis of small nucleolar RNAs, Curr Opin. Cell Biol., 9, 337, 10.1016/S0955-0674(97)80005-1 Tollervey, 1993, Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly, Cell, 72, 443, 10.1016/0092-8674(93)90120-F Tsutsui, 2001, Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum, J. Neurol., 431, 228 Tuteja, 1998, Nucleolin: A multifunctional major nucleolar phosphoprotein, Crit. Rev. Biochem. Mol. Biol., 33, 407, 10.1080/10409239891204260 Tuteja, 2001, A pea homologue of human DNA helicase I is localized within the dense fibrillar component of the nucleolus and stimulated by phosphorylation with CK2 and cdc2 protein kinases, Plant J., 25, 9, 10.1046/j.1365-313x.2001.00918.x Umekawa, 1993, Nucleolar protein B23: Bacterial expression, purification, oligomerization and secondary structure of two isoforms, Cell. Mol. Biol. Res., 39, 635 Umekawa, 2001, The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity, J. Biochem. (Tokyo), 130, 199, 10.1093/oxfordjournals.jbchem.a002973 Valdez, 1994, Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23, J. Biol. Chem., 269, 23776, 10.1016/S0021-9258(17)31583-1 Valentin, 1839, Repertorium Anat. Physiol., 4, 269 Vandelaer, 1998, The phosphoprotein pp135 is an essential constituent of the fibrillar components of nucleoli and of coiled bodies, Histochem. Cell Biol., 110, 169, 10.1007/s004180050278 Van Hoof, 2000, Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast, EMBO J., 19, 1357, 10.1093/emboj/19.6.1357 Vargas-Roig, 1998, Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy, Int. J. Cancer, 79, 468, 10.1002/(SICI)1097-0215(19981023)79:5<468::AID-IJC4>3.0.CO;2-Z Vaziri, 2001, hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase, Cell, 107, 149, 10.1016/S0092-8674(01)00527-X Verheggen, 1998, Presence of pre-rRNAs before activation of polymerase I transcription in the building process of nucleoli during early development of Xenopus laevis, J. Cell Biol., 142, 1167, 10.1083/jcb.142.5.1167 Verheggen, 2001, Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain, EMBO J., 20, 5480, 10.1093/emboj/20.19.5480 Visintin, 1999, Cfi 1 prevents premature exit from mitosis by anchoring Cdc 14 phosphatase in the nucleolus, Nature (London), 398, 818, 10.1038/19775 Voit, 1992, The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation, EMBO J., 11, 2211, 10.1002/j.1460-2075.1992.tb05280.x Voit, 1999, Phosphorylation by Gi-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF, EMBO J., 18, 1891, 10.1093/emboj/18.7.1891 Wachtler, 1984, On the fusion of nucleoli in interphase, Eur. J. Cell Biol., 34, 190 Wagner, 1835, Einige bemerkungen and fragen fiber das keimblaschen (vesicula germinativa), Müller's Arch. Anat. Physiol. U Wiss. Med., 268 Wai, 2000, Complete deletion of yeast chromosomal rDNA repeats and integration of a new rDNA repeat: Use of rDNA deletion strains for functional analysis of rDNA promoter elements in vivo, Nucleic Acids Res., 28, 3524, 10.1093/nar/28.18.3524 Wang, 1994, The nucleic acid binding activity of nucleolar protein B23.1 resides in its carboxy-terminal end, J. Biol. Chem., 269, 30994, 10.1016/S0021-9258(18)47380-2 Wang, 2000, Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution, EMBO J., 19, 317, 10.1093/emboj/19.3.317 Wang, 2001, Regulation of dna replication after heat shock by replication protein a-nucleolin interactions, J. Biol. Chem., 276, 20579, 10.1074/jbc.M100874200 Watkins, 1998, Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Garlp in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure, RNA, 4, 1549, 10.1017/S1355838298980761 Weinstein, 1999, Guided tours: From precursor snoRNA to functional snoRNP, Curr. Opin. Cell Biol., 11, 378, 10.1016/S0955-0674(99)80053-2 Weiserska-Gadek, 1992, Nucleolar proteins B23 and C23 as target antigens in chronic graft-versus-host disease, Blood, 79, 1081, 10.1182/blood.V79.4.1081.bloodjournal7941081 Wiederkehr, 1998, Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 188 rRNA maturation, RNA, 4, 1357, 10.1017/S1355838298980955 Wingfield, 1991, HIV-1 Rev expressed in recombinant E. coli: Purification, polymerization, and conformational properties, Biochemistry, 30, 7527, 10.1021/bi00244a023 Wolffe, 2001, Nuclear visions: Functional flexibility from structural instability, Cell, 104, 631 Wolin, 1999, The trials and travels of tRNA, Genes Dev., 13, 1, 10.1101/gad.13.1.1 Yamada, 1999, Nucleolar localization of the UL3 protein of herpes simplex virus type 2, J. Gen. Virol., 80, 2157, 10.1099/0022-1317-80-8-2157 Yang, 1994, Purification and characterization of nucleolin and its identification as a transcription repressor, Mol. Cell. Biol., 14, 6068, 10.1128/MCB.14.9.6068 Yang, 2000, Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp 140, Mol. Biol. Cell., 11, 567, 10.1091/mbc.11.2.567 Yankiwski, 2000, Nuclear structure in normal and Bloom syndrome cells, 97, 5214 Yu, 1997, Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group, Am. J. Hum. Genet., 60, 330 Yung, 1987, Identification and characterization of a hexameric form of nucleolar phosphoprotein B23, Biochim. Biophys. Acta, 925, 74, 10.1016/0304-4165(87)90149-8 Yung, 1985, Effects of actinomycin D analogs on nucleolar phosphoprotein B23 (37,000 daltons/pI 5.1), Biochem. Pharmacol., 34, 4059, 10.1016/0006-2952(85)90387-9 Yung, 1985, Translocation of nucleolar phosphoprotein B23 (37 kDa/ pI 5.1) induced by selective inhibitors of ribosome synthesis, Biochim. Biophys. Acta, 826, 167, 10.1016/0167-4781(85)90002-8 Yung, 1986, Effect of luzopeptins on protein B23 translocation and ribosomal RNA synthesis in HeLa cells, Cancer Res., 46, 922 Yung, 1990, Short exposure to actinomycin D induces “reversible” translocation of protein B23 as well as “reversible” inhibition of cell growth and RNA synthesis in HeLa cells, Cancer Res., 50, 5987 Zanchin, 1999, Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p, Mol. Cell. Biol., 19, 1518, 10.1128/MCB.19.2.1518 Zatsepina, 1997, Cell cycle-dependent translocations of a major nucleolar phosphoprotein, B23, and some characteristics of its variants, Eur. J. Cell Biol., 73, 58 Zatsepina, 1999, The nucleolar phosphoprotein B23 redistributes in part to the spindle poles during mitosis, J. Cell Sci., 112, 455, 10.1242/jcs.112.4.455 Zhai, 2000, Repression of RNA polymerase I transcription by the tumor suppressor p53, Mol. Cell. Biol., 20, 5930, 10.1128/MCB.20.16.5930-5938.2000 Zhang, 1999, Nucleolar localization of murine nuclear DNA helicase II (RNA helicase A), J. Cell Sci., 112, 2693, 10.1242/jcs.112.16.2693 Zhang, 2001, Control of p53 ubiquitination and nuclear export by MDM2 and ARF, Cell Growth Differ., 12, 175 Zirwes, 1997, Topogenesis of a nucleolar protein: Determination of molecular segments directing nucleolar association, Mol. Biol. Cell., 8, 231, 10.1091/mbc.8.2.231 Zirwes, 1997, Identification of a small, very acidic constitutive protein (N029) as a member of the nucleoplasmin family, 94, 11387 Zirwes, 2000, A novel helicase-type protein in the nucleolus: Protein NOH61, Mol. Biol. Cell, 11, 1153, 10.1091/mbc.11.4.1153 Zolotukhin, 1999, Nucleoporins Nup98 and Nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev, J. Virol., 73, 120, 10.1128/JVI.73.1.120-127.1999