Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Journal of Veterinary Internal Medicine - Tập 33 Số 3 - Trang 1434-1439 - 2019
Krystle L. Reagan1, Stanley L. Marks2, Patricia A. Pesavento3, Ann Della Maggiore1, Bing Zhu1, Amy M. Grooters4
1Veterinary Medical Teaching Hospital University of California Davis Davis California
2Department of Medicine and Epidemiology, School of Veterinary Medicine University of California Davis California
3Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California
4Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana

Tóm tắt

AbstractGastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti‐inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible.

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Journal of Veterinary Internal Medicine

Tập 33 Số 3

1434-1439

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