Atypical Amygdala Response to Fear Conditioning in Autism Spectrum Disorder

D. Nicholas Top Jr.1, Kevin G. Stephenson1, Christopher R. Doxey1, Michael J. Crowley2, C. Brock Kirwan1, Mikle South1
1Brigham Young University, Provo, Utah
2Yale Child Study Center, New Haven, Connecticut

Tài liệu tham khảo

2013 Buck, 2014, Psychiatric comorbidity and medication use in adults with autism spectrum disorder, J Autism Dev Disord, 44, 3063, 10.1007/s10803-014-2170-2 van Steensel, 2011, Anxiety disorders in children and adolescents with autistic spectrum disorders: A meta-analysis, Clin Child Fam Psychol Rev, 14, 302, 10.1007/s10567-011-0097-0 van Steensel, 2013, Psychiatric comorbidity in children with autism spectrum disorders: A comparison with children with ADHD, J Child Fam Stud, 22, 368, 10.1007/s10826-012-9587-z White, 2009, Anxiety in children and adolescents with autism spectrum disorders, Clin Psychol Rev, 29, 216, 10.1016/j.cpr.2009.01.003 Gotham, 2013, Exploring the relationship between anxiety and insistence on sameness in autism spectrum disorders, Autism Res, 6, 33, 10.1002/aur.1263 Rodgers, 2012, The relationship between anxiety and repetitive behaviours in autism spectrum disorder, J Autism Dev Disord, 42, 2404, 10.1007/s10803-012-1531-y Luke, 2012, Decision-making difficulties experienced by adults with autism spectrum conditions, Autism, 16, 612, 10.1177/1362361311415876 Conner, 2013, Parents’ state and trait anxiety: Relationships with anxiety severity and treatment response in adolescents with autism spectrum disorders, J Autism Dev Disord, 43, 1811, 10.1007/s10803-012-1728-0 White, 2014, Social-cognitive, physiological, and neural mechanisms underlying emotion regulation impairments: Understanding anxiety in autism spectrum disorder, Int J Dev Neurosci, 39, 22, 10.1016/j.ijdevneu.2014.05.012 Duvarci, 2014, Amygdala microcircuits controlling learned fear, Neuron, 82, 966, 10.1016/j.neuron.2014.04.042 Gilmartin, 2014, Prefrontal cortical regulation of fear learning, Trends Neurosci, 37, 455, 10.1016/j.tins.2014.05.004 VanElzakker, 2014, From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders, Neurobiol Learn Mem, 113, 3, 10.1016/j.nlm.2013.11.014 Feng, 2014, Memory consolidation of fear conditioning: Bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex, Soc Cogn Affect Neurosci, 9, 1730, 10.1093/scan/nst170 Milad, 2014, Neuroscience of fear extinction: Implications for assessment and treatment of fear-based and anxiety related disorders, Behav Res Ther, 62, 17, 10.1016/j.brat.2014.08.006 Sehlmeyer, 2009, Human fear conditioning and extinction in neuroimaging: A systematic review, PLoS One, 4, e5865, 10.1371/journal.pone.0005865 Finger, 2008, Dissociable roles of medial orbitofrontal cortex in human operant extinction learning, Neuroimage, 43, 748, 10.1016/j.neuroimage.2008.08.021 Schiller, 2008, From fear to safety and back: Reversal of fear in the human brain, J Neurosci, 28, 11517, 10.1523/JNEUROSCI.2265-08.2008 Loveland, 2008, Fronto-limbic functioning in children and adolescents with and without autism, Neuropsychologia, 46, 49, 10.1016/j.neuropsychologia.2007.08.017 South, 2012, Delayed reversal learning and association with repetitive behavior in autism spectrum disorders, Autism Res, 5, 398, 10.1002/aur.1255 Wigham, 2015, The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder, J Autism Dev Disord, 45, 943, 10.1007/s10803-014-2248-x Bernier, 2005, Individuals with autism spectrum disorder show normal responses to a fear potential startle paradigm, J Autism Dev Disord, 35, 575, 10.1007/s10803-005-0002-0 Sterling, 2013, Fear-potentiated startle response is unrelated to social or emotional functioning in adolescents with autism spectrum disorders, Autism Res, 6, 320, 10.1002/aur.1289 South, 2011, Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders, Autism Res, 4, 412, 10.1002/aur.221 Gaigg, 2007, Differential fear conditioning in Asperger’s syndrome: Implications for an amygdala theory of autism, Neuropsychologia, 45, 2125, 10.1016/j.neuropsychologia.2007.01.012 Lord, 2000, The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism, J Autism Dev Disord, 30, 205, 10.1023/A:1005592401947 Wechsler, 2011 Constantino, 2012 Spielberger, 1983 Meyer, 1990, Development and validation of the Penn State Worry Questionnaire, Behav Res Ther, 28, 487, 10.1016/0005-7967(90)90135-6 Leary, 1983, A brief version of the Fear of Negative Evaluation Scale, Pers Soc Psychol Bull, 371, 10.1177/0146167283093007 Carleton, 2007, Fearing the unknown: A short version of the Intolerance of Uncertainty Scale, J Anxiety Disord, 21, 105, 10.1016/j.janxdis.2006.03.014 Phelps, 2004, Extinction learning in humans: Role of the amygdala and vmPFC, Neuron, 43, 897, 10.1016/j.neuron.2004.08.042 Monk, 2003, A neuroimaging method for the study of threat in adolescents, Dev Psychobiol, 43, 359, 10.1002/dev.10146 Mazaika P.K. (2016): ArtRepair Software Center. Available at: http://cibsr.stanford.edu/tools/human-brain-project/artrepair-software.html. Fani, 2015, Fear-potentiated startle during extinction is associated with white matter microstructure and functional connectivity, Cortex, 64, 249, 10.1016/j.cortex.2014.11.006 Lindner, 2015, Fear-potentiated startle processing in humans: Parallel fMRI and orbicularis EMG assessment during cue conditioning and extinction, Int J Psychophysiol, 98, 535, 10.1016/j.ijpsycho.2015.02.025 Adams, 2012, Amygdala responses to averted vs direct gaze fear vary as a function of presentation speed, Soc Cogn Affect Neurosci, 7, 568, 10.1093/scan/nsr038 Ponz, 2010, Reduced amygdala activity during aversive conditioning in human narcolepsy, Ann Neurol, 67, 394 Cohn, 2013, Fear conditioning, persistence of disruptive behavior and psychopathic traits: An fMRI study, Transl Psychiatry, 3, e319, 10.1038/tp.2013.89 Mechias, 2010, A meta-analysis of instructed fear studies: Implications for conscious appraisal of threat, Neuroimage, 49, 1760, 10.1016/j.neuroimage.2009.09.040 Maldjian, 2004, Precentral gyrus discrepancy in electronic versions of the Talairach atlas, Neuroimage, 21, 450, 10.1016/j.neuroimage.2003.09.032 Maldjian, 2003, An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets, Neuroimage, 19, 1233, 10.1016/S1053-8119(03)00169-1 Tzourio-Mazoyer, 2002, Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain, Neuroimage, 15, 273, 10.1006/nimg.2001.0978 Brett M, Anton JL, Valabregue R, Poline JB: Region of interest analysis using an SPM toolbox [abstract]. Presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2–6, 2002, Sendai, Japan Brühl, 2014, Neuroimaging in social anxiety disorder-A meta-analytic review resulting in a new neurofunctional model, Neurosci Biobehav Rev, 47C, 260, 10.1016/j.neubiorev.2014.08.003 Etkin, 2007, Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia, Am J Psychiatry, 164, 1476, 10.1176/appi.ajp.2007.07030504 Davis, 2010, Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety, Neuropsychopharmacology, 35, 105, 10.1038/npp.2009.109 Paulus, 2006, An insular view of anxiety, Biol Psychiatry, 60, 383, 10.1016/j.biopsych.2006.03.042 Chamberlain, 2013, A potentiated startle study of uncertainty and contextual anxiety in adolescents diagnosed with autism spectrum disorder, Mol Autism, 4, 31, 10.1186/2040-2392-4-31 Lissek, 2014, Generalized anxiety disorder is associated with overgeneralization of classically conditioned fear, Biol Psychiatry, 75, 909, 10.1016/j.biopsych.2013.07.025 Eilam-Stock, 2014, Abnormal autonomic and associated brain activities during rest in autism spectrum disorder, Brain, 137, 153, 10.1093/brain/awt294 Dichter, 2012, Functional magnetic resonance imaging of autism spectrum disorders, Dialogues Clin Neurosci, 14, 319, 10.31887/DCNS.2012.14.3/gdichter Uljarevic, 2013, Recognition of emotions in autism: A formal meta-analysis, J Autism Dev Disord, 43, 1517, 10.1007/s10803-012-1695-5 Hadjikhani, 2009, Body expressions of emotion do not trigger fear contagion in autism spectrum disorder, Soc Cogn Affect Neurosci, 4, 70, 10.1093/scan/nsn038 Pelphrey, 2007, Perception of dynamic changes in facial affect and identity in autism, Soc Cogn Affect Neurosci, 2, 140, 10.1093/scan/nsm010 Schultz, 2005, Developmental deficits in social perception in autism: The role of the amygdala and fusiform face area, Int J Dev Neurosci, 23, 125, 10.1016/j.ijdevneu.2004.12.012 Dichter, 2012, Reward circuitry function in autism spectrum disorders, Soc Cogn Affect Neurosci, 7, 160, 10.1093/scan/nsq095 Di Martino, 2014, The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism, Mol Psychiatry, 19, 659, 10.1038/mp.2013.78 Birnie, 2011, The cold pressor task: Is it an ethically acceptable pain research method in children?, J Pediatr Psychol, 36, 1071, 10.1016/j.jaac.2012.11.007 Storch, 2013, The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: A randomized, controlled trial, J Am Acad Child Adolesc Psychiatry, 52, 132, 10.1016/j.jaac.2012.11.007 Wood, 2009, Cognitive behavioral therapy for anxiety in children with autism spectrum disorders: A randomized, controlled trial, J Child Psychol Psychiatry, 50, 224, 10.1111/j.1469-7610.2008.01948.x Sung, 2011, Effects of cognitive-behavioral therapy on anxiety in children with autism spectrum disorders: A randomized controlled trial, Child Psychiatry Hum Dev, 42, 634, 10.1007/s10578-011-0238-1