The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

Molecular Immunology - Tập 45 - Trang 3756-3766 - 2008
Jennifer A. Young1, Amy M. Becker1, Jennifer J. Medeiros1, Virginia S. Shapiro2, Andrew Wang1, J. David Farrar1, Timothy A. Quill3, Rob Hooft van Huijsduijnen4, Nicolai S.C. van Oers1,5
1Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States
3Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
4Merck-Serono Geneva Center for Research, Geneva, Switzerland
5Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, United States

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