Autoimmune myocarditis and dilated cardiomyopathy: focus on cardiac autoantibodies

Lupus - Tập 14 Số 9 - Trang 652-655 - 2005
Alida L.P. Caforio1, Luciano Daliento1, Annalisa Angelini2, Stefania Bottaro1, Annalisa Vinci1, Greta Dequal1, F. Tona1, Sabino Iliceto1, Gaetano Thiene2, William J. McKenna3
1Division of Cardiology, Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
2Cardiac Pathology, University of Padua, Padua, Italy
3The Heart Hospital, London, UK

Tóm tắt

Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expressed in the heart (organ-specific), others in heart and some skeletal muscle fibres (partially-heart specific) or in heart and skeletal muscle (muscle-specific). Distinct autoantibodies have different frequency in disease and normal controls. Different techniques detect one or more antibodies, thus they cannot be used interchangeably for screening. It is unknown whether the same patients produce more antibodies or different patient groups develop autoimmunity to distinct antigens. IgG antibodies, shown to be cardiac and disease-specific for myocarditis/DCM, can be used as autoimmune markers for identifying patients in whom immunosuppression may be beneficial and relatives at risk. Some autoantibodies may also have a functional role, but further work is needed.

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Lupus

Tập 14 Số 9

652-655

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