A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)

Bioorganic & Medicinal Chemistry Letters - Tập 20 - Trang 6721-6724 - 2010
Guyan Liang1, Yong Mi Choi-Sledeski2, Gregory Poli2, Xin Chen3, Patrick Shum2, Anne Minnich4, Qingping Wang5, Joseph Tsay4, Keith Sides4, Jennifer Cairns4, Gregory Stoklosa2, Thaddeus Nieduzak2, Zhicheng Zhao2, Jie Wang5, Roy J. Vaz1
1Drug Design, Chemical and Analytical Science, Sanofi-Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA
2Medicinal Chemistry, Internal Medicine, Sanofi-Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA
3Structural Biology, Chemical and Analytical Science, Sanofi-Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA
4In Vitro Pharmacology, Internal Medicine, Sanofi-Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA
5Drug Metabolism and Pharmacokinetics, Sanofi-Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA

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