Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

Gastroenterology - Tập 126 Số 3 - Trang 693-702 - 2004
Giovanni Barbara1, Vincenzo Stanghellini1, Roberto De Giorgio1, Cesare Cremon1, Graeme S. Cottrell2, Donatella Santini3, Gianandrea Pasquinelli3, Antonio Maria Morselli‐Labate1, Eileen F. Grady2, Nigel W. Bunnett2, Stephen M. Collins4, Roberto Corinaldesi1
1Department of Internal Medicine and Gastroenterology and CRBA, University of Bologna, Bologna, Italy.
2Departments of Surgery and Physiology, University of California San Francisco, San Francisco, California, USA
3Department of Pathology, University of Bologna, Bologna, Italy
4Division of Gastroenterology, McMaster University, Ontario, Canada.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Thompson, 1999, Functional bowel disorders and functional abdominal pain, Gut, 45, S43

Sandler, 1984, Symptom complaints and health care seeking behavior in subjects with bowel dysfunction, Gastroenterology, 87, 314, 10.1016/0016-5085(84)90706-6

Stanghellini, 2003, Motor function and dysfunction in functional dyspepsia and irritable bowel syndrome, 176

Camilleri, 2001, Management of the irritable bowel syndrome, Gastroenterology, 120, 652, 10.1053/gast.2001.21908

Barbara, 2002, A role for inflammation in irritable bowel syndrome?, Gut, 51, i41, 10.1136/gut.51.suppl_1.i41

Spiller, 2003, Postinfectious irritable bowel syndrome, Gastroenterology, 124, 1662, 10.1016/S0016-5085(03)00324-X

Chadwick, 2002, Activation of the mucosal immune system in irritable bowel syndrome, Gastroenterology, 122, 1778, 10.1053/gast.2002.33579

Weston, 1993, Terminal ileal mucosal mast cells in irritable bowel syndrome, Dig Dis Sci, 38, 1590, 10.1007/BF01303164

Tornblom, 2002, Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome, Gastroenterology, 123, 1972, 10.1053/gast.2002.37059

Gwee, 1996, Psychometric scores and persistence of irritable bowel after infectious diarrhea, Lancet, 347, 150, 10.1016/S0140-6736(96)90341-4

Neal, 1997, Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome, BMJ, 314, 779, 10.1136/bmj.314.7083.779

Isgar, 1983, Symptoms of irritable bowel syndrome in ulcerative colitis in remission, Gut, 24, 190, 10.1136/gut.24.3.190

O’Sullivan, 2000, Increased mast cells in the irritable bowel syndrome, Neurogastroenterol Motil, 12, 449, 10.1046/j.1365-2982.2000.00221.x

Stead, 1989, Mast cells are closely apposed to nerves in the human gastrointestinal mucosa, Gastroenterology, 97, 575, 10.1016/0016-5085(89)90627-6

Stead, 1987, Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves, Proc Natl Acad Sci U S A, 84, 2975, 10.1073/pnas.84.9.2975

Reed, 2003, Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons, J Physiol, 547, 531, 10.1113/jphysiol.2002.032011

Gao, 2002, Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine, Gastroenterology, 123, 1554, 10.1053/gast.2002.36581

Nozdrachev, 1999, Changes in afferent impulse activity of small intestine mesenteric nerves in response to antigen challenge, Neuroscience, 94, 1339, 10.1016/S0306-4522(99)00377-2

Bueno, 1997, Mediators and pharmacology of visceral sensitivity, Gastroenterology, 112, 1714, 10.1016/S0016-5085(97)70056-8

Castex, 1994, Role of 5-HT3 receptors and afferent fibers in the effects of mast cell degranulation on colonic motility in rats, Gastroenterology, 107, 976, 10.1016/0016-5085(94)90221-6

Metcalfe, 1997, Mast cells, Physiol Rev, 77, 1033, 10.1152/physrev.1997.77.4.1033

Macfarlane, 2001, Proteinase-activated receptors, Pharmacol Rev, 53, 245

Molino, 1997, Interactions of mast cell tryptase with thrombin receptors and PAR-2, J Biol Chem, 272, 4043, 10.1074/jbc.272.7.4043

Coelho, 2002, Proteinases and proteinase-activated receptor 2, Gastroenterology, 122, 1035, 10.1053/gast.2002.32387

Tamura, 1992, Effects of prolonged exposure to histamine on guinea pig intestinal neurons, Dig Dis Sci, 37, 1084, 10.1007/BF01300291

Fu, 1997, Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors, Am J Physiol, 273, H2726

Liu, 2003, Neuroimmune interactions in guinea pig stomach and small intestine, Am J Physiol Gastrointest Liver Physiol, 284, G154, 10.1152/ajpgi.00241.2002

Talley, 1989, A patient questionnaire to identify bowel disease, Ann Intern Med, 111, 671, 10.7326/0003-4819-111-8-671

Neri, 2000, Symptoms discriminate irritable bowel syndrome from organic gastrointestinal diseases and food allergy, Eur J Gastroenterol Hepatol, 12, 981, 10.1097/00042737-200012090-00003

Jensen, 1996, The use of multiple-item scales for pain intensity measurement in chronic pain patients, Pain, 67, 35, 10.1016/0304-3959(96)03078-3

Lee, 1988, Quantification of colonic lamina propria cells by means of a morphometric point-counting method, Gastroenterology, 94, 409, 10.1016/0016-5085(88)90430-1

Smith, 1985, Measurement of protein using bicinchoninic acid, Anal Biochem, 150, 76, 10.1016/0003-2697(85)90442-7

Raithel, 1999, Effect of substance P on histamine secretion from gut mucosa in inflammatory bowel disease, Scand J Gastroenterol, 34, 496, 10.1080/003655299750026236

Collins, 1996, The immunomodulation of enteric neuromuscular function, Gastroenterology, 111, 1683, 10.1016/S0016-5085(96)70034-3

Gwee, 1999, The role of psychological and biological factors in postinfective gut dysfunction, Gut, 44, 400, 10.1136/gut.44.3.400

Rao, 1987, Anorectal sensitivity and responses to rectal distention in patients with ulcerative colitis, Gastroenterology, 93, 1270, 10.1016/0016-5085(87)90255-1

Chang, 2000, Perceptual responses in patients with inflammatory and functional bowel disease, Gut, 47, 497, 10.1136/gut.47.4.497

Pockros, 1985, Golytely lavage versus a standard colonoscopy preparation. Effect on normal colonic mucosal histology, Gastroenterology, 88, 545, 10.1016/0016-5085(85)90519-0

Wood, 2002, Neuropathophysiology of irritable bowel syndrome, J Clin Gastroenterol, 35, S11, 10.1097/00004836-200207001-00004

Rao, 1988, Symptoms and stool patterns in patients with ulcerative colitis, Gut, 29, 342, 10.1136/gut.29.3.342

Schuurs, 1990, Effects of gender and sex steroids on the immune response, J Steroid Biochem, 35, 157, 10.1016/0022-4731(90)90270-3

Bradesi, 2001, Effect of ovarian hormones on intestinal mast cell reactivity to substance P, Life Sci, 68, 1047, 10.1016/S0024-3205(00)01008-0

Wilhelm, 2000, Gonadal steroids regulate the number and activational state of mast cells in the medial habenula, Endocrinology, 141, 1178, 10.1210/en.141.3.1178

Chang, 2002, Gender differences in irritable bowel syndrome, Gastroenterology, 123, 1686, 10.1053/gast.2002.36603

Coelho, 1998, Mast cell degranulation induces delayed rectal allodynia in rats, Dig Dis Sci, 43, 727, 10.1023/A:1018853728251

Vergnolle, 2000, Review article, Aliment Pharmacol Ther, 14, 257, 10.1046/j.1365-2036.2000.00690.x

Vergnolle, 2001, Proteinase-activated receptor-2 and hyperalgesia, Nat Med, 7, 821, 10.1038/89945

Pearce, 1982, Mucosal mast cells. II. Effects of anti-allergic compounds on histamine secretion by isolated intestinal mast cells, J Immunol, 128, 2481, 10.4049/jimmunol.128.6.2481

Kashiba, 1999, Gene expression of histamine H1 receptor in guinea pig primary sensory neurons, Brain Res Mol Brain Res, 66, 24, 10.1016/S0169-328X(98)00346-5

Soter, 1979, Oral disodium cromoglycate in the treatment of systemic mastocytosis, N Engl J Med, 301, 465, 10.1056/NEJM197908303010903

Stefanini, 1995, Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients, Scand J Gastroenterol, 30, 535, 10.3109/00365529509089786

Lembo, 1999, Symptoms and visceral perception in patients with pain-predominant irritable bowel syndrome, Am J Gastroenterol, 94, 1320, 10.1111/j.1572-0241.1999.01009.x

Smout, 2000, Potential pitfalls in the differential diagnosis of irritable bowel syndrome, Digestion, 61, 247, 10.1159/000007765

Yu, 2001, Role of mast cells in intestinal mucosal function, Immunol Rev, 179, 61, 10.1034/j.1600-065X.2001.790107.x