Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health

Springer Science and Business Media LLC - Tập 56 - Trang 1012-1020 - 2013
J. Henson1,2, T. Yates2,3, S. J. H. Biddle4,5, C. L. Edwardson2,6, K. Khunti2,3, E. G. Wilmot3, L. J. Gray7, T. Gorely8, M. A. Nimmo4,5, M. J. Davies2,3
1Department of Cardiovascular Sciences, University of Leicester, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK
2National Institute for Health Research Leicester–Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester and University of Leicester, Leicester, UK
3Diabetes Research Unit, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK
4National Institute for Health Research Leicester–Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Loughborough University, Loughborough, UK
5School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
6University Hospitals of Leicester, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK
7Department of Health Sciences, University of Leicester Leicester UK
8School of Sport, University of Stirling, Stirling, UK

Tóm tắt

The study aimed to examine the associations between objectively measured sedentary time, breaks in sedentary time, moderate-to-vigorous physical activity (MVPA) and total physical activity with markers of cardiometabolic health in a population with known risk factors for type 2 diabetes mellitus. This study reports data from two ongoing diabetes prevention programmes. Participants with known risk factors were recruited from primary care practices located within the East Midlands, UK, over the period 2010–2011. ActiGraph GT3X accelerometers (15 s epochs) were used to assess sedentary time (<25 counts per 15 s), MVPA (≥488 counts per 15 s) and total physical activity (total counts). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Linear regression examined the independent association of sedentary time, breaks in sedentary time, MVPA and total physical activity with markers of cardiometabolic health. The sample comprised 878 participants; 153 from Project STAND (Sedentary Time And Diabetes) (age 32.9 ± 5.6 years, 28.8% male) and 725 from Walking Away from Diabetes (age 63.7 ± 7.8 years, 64.8% male). Following adjustment for various covariates, including MVPA and BMI, there were detrimental linear associations of sedentary time with 2 h plasma glucose (standardised beta coefficient) (β = 0.220, p < 0.001), triacylglycerol (β = 0.206, p = 0.001) and HDL-cholesterol (β = −0.123, p = 0.029). Breaks in sedentary time, total physical activity and MVPA were significantly inversely associated with measures of adiposity, but not with any other cardiometabolic variables after adjustment for sedentary time and BMI. In adults at high risk of type 2 diabetes mellitus, time spent sedentary is strongly and adversely associated with cardiometabolic health and may be a more important indicator of poor health than MVPA.

Tài liệu tham khảo

Pate RR, O'Neill JR, Lobelo F (2008) The evolving definition of “sedentary”. Exerc Sport Sci Rev 36:173–178 Tremblay MS, Colley RC, Saunders TJ, Healy GN, Owen N (2010) Physiological and health implications of a sedentary lifestyle. Appl Physiol Nutr Metab 35:725–740 Sedentary Behaviour Research Network (2012) Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”. Appl Physiol Nutr Metab 37:540–542 Healy GN, Matthews CE, Dunstan DW, Winkler EA, Owen N (2011) Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06. Eur Heart J 32:590–597 Healy GN, Wijndaele K, Dunstan DW et al (2008) Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care 31:369–371 Hu FB (2003) Sedentary lifestyle and risk of obesity and type 2 diabetes. Lipids 38:103–108 Katzmarzyk PT, Church TS, Craig CL, Bouchard C (2009) Sitting time and mortality from all causes, cardiovascular disease, and cancer. Med Sci Sports Exerc 41:998–1005 Healy GN, Dunstan DW, Salmon J et al (2008) Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care 31:661–666 Thorp AA, Owen N, Neuhaus M, Dunstan DW (2011) Sedentary behaviors and subsequent health outcomes in adults a systematic review of longitudinal studies, 1996–2011. Am J Prev Med 41:207–215 Wilmot EG, Edwardson CL, Achana FA et al (2012) Sedentary time in adults and the association with diabetes, cardiovascular disease and death: Systematic review and meta-analysis. Diabetologia 55:2895–2905 Sugiyama T, Healy GN, Dunstan DW, Salmon J, Owen N (2008) Is television viewing time a marker of a broader pattern of sedentary behavior? Ann Behav Med 35:245–250 Besson H, Brage S, Jakes RW, Ekelund U, Wareham NJ (2010) Estimating physical activity energy expenditure, sedentary time, and physical activity intensity by self-report in adults. Am J Clin Nutr 91:106–114 Rikli RE (2000) Reliability, validity, and methodological issues in assessing physical activity in older adults. Res Q Exerc Sport 71:S89–S96 Healy GN, Dunstan DW, Salmon J et al (2007) Objectively measured light-intensity physical activity is independently associated with 2-h plasma glucose. Diabetes Care 30:1384–1389 Bankoski A, Harris TB, McClain JJ et al (2011) Sedentary activity associated with metabolic syndrome independent of physical activity. Diabetes Care 34:497–503 Chatterton H, Younger T, Fischer A, Khunti K, Programme Development Group (2012) Risk identification and interventions to prevent type 2 diabetes in adults at high risk: summary of NICE guidance. BMJ 345:e4624 Ceriello A, Colagiuri S (2008) International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations. Diabet Med 25:1151–1156 Paulweber B, Valensi P, Lindstrom J et al (2010) A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res 42(Suppl 1):S3–S36 Yates T, Davies MJ, Henson J et al (2012) Walking away from type 2 diabetes: trial protocol of a cluster randomized controlled trial evaluating a structured education programme in those at high risk of developing type 2 diabetes. BMC Fam Pract 13:46 Wilmot EG, Davies MJ, Edwardson CL et al (2011) Rationale and study design for a randomised controlled trial to reduce sedentary time in adults at risk of type 2 diabetes mellitus: project stand (Sedentary Time ANd Diabetes). BMC Publ Health 11:908 Gray LJ, Davies MJ, Hiles S et al (2012) Detection of impaired glucose regulation and/or type 2 diabetes mellitus, using primary care electronic data, in a multiethnic UK community setting. Diabetologia 55:959–966 World Health Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. Available from http://www.who.int/diabetes/publications/diagnosis_diabetes2006/en/index.html, accessed 13 December 2011 The English Indices of Deprivation: Summary (2007). Available from https://www.gov.uk/government/organisations/department-for-communities-and-local-government/series/english-indices-of-deprivation, accessed 11 January, 2012 Freedson PS, Melanson E, Sirard J (1998) Calibration of the Computer Science and Applications, Inc. accelerometer. Med Sci Sports Exerc 30:777–781 Trost SG, McIver KL, Pate RR (2005) Conducting accelerometer-based activity assessments in field-based research. Med Sci Sports Exerc 37:S531–S543 Dunstan DW, Salmon J, Healy GN et al (2007) Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes. Diabetes Care 30:516–522 Healy GN, Dunstan DW, Salmon J, Shaw JE, Zimmet PZ, Owen N (2008) Television time and continuous metabolic risk in physically active adults. Med Sci Sports Exerc 40:639–645 Ford ES, Schulze MB, Kroger J, Pischon T, Bergmann MM, Boeing H (2010) Television watching and incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. J Diabetes 2:23–27 Edwardson CL, Gorely T, Davies MJ et al (2012) Association of sedentary behaviour with metabolic syndrome: a meta-analysis. PLoS One 7:e34916 Ekelund U, Griffin DJ, Wareham NJ (2007) Physical activity and metabolic risk in individuals with a family history of type 2 diabetes. Diabetes Care 30:337–342 Ekelund U, Brage S, Griffin SJ, Wareham NJ, ProActive UK Research Group (2009) Objectively measured moderate- and vigorous-intensity physical activity but not sedentary time predicts insulin resistance in high-risk individuals. Diabetes Care 32:1081–1086 Cooper AR, Sebire S, Montgomery AA et al (2012) Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes. Diabetologia 55:589–599 Swartz AM, Squires L, Strath SJ (2011) Energy expenditure of interruptions to sedentary behavior. Int J Behav Nutr Phys Act 8:69 Balkau B, Mhamdi L, Oppert JM et al (2008) Physical activity and insulin sensitivity: the RISC study. Diabetes 57:2613–2618 Faerch K, Borch-Johnsen K, Holst JJ, Vaag A (2009) Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes? Diabetologia 52:1714–1723 Hamilton MT, Hamilton DG, Zderic TW (2007) Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 56:2655–2667 Mead JR, Irvine SA, Ramji DP (2002) Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med (Berl) 80:753–769 Hamilton MT, Hamilton DG, Zderic TW (2004) Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulation. Exerc Sport Sci Rev 32:161–166 Dunstan DW, Kingwell BA, Larsen R et al (2012) Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care 35:976–983 World Health Organization (2007) Global recommendations on physical activity for health. Available from http://whqlibdoc.who.int/publications/2010/9789241599979_eng.pdf, accessed 7 February 2012