Verso la personalizzazione del trattamento con FSH nell’infertilità maschile
Tóm tắt
L’infertilità maschile idiopatica rimane ad oggi una sfida terapeutica. I dati relativi al miglioramento della qualità spermatica dopo terapia con gonadotropine sono ancora controversi, nonostante il noto ruolo dell’ormone follicolo-stimolante (FSH) nella spermatogenesi. La ricerca scientifica si sta sempre più focalizzando su possibili fattori predittivi di risposta e schemi di trattamento efficaci, al fine di ottenere terapie personalizzate.
Tài liệu tham khảo
Valenti D, La Vignera S, Condorelli RA et al. (2013) Follicle-stimulating hormone treatment in normogonadotropic infertile men. Nat Rev Urol 10(1):55–62
Casamonti E, Vinci S, Serra E et al. (2014) Short-term FSH treatment and sperm maturation: a prospective study in idiopathic infertile men. Andrology 5(3):414–422
Gulino G, Stefanucci M, Antonucci M et al. (2014) Male infertility: non-surgical therapy. Urologia 81(3):148–153
Busch AS, Kliesch S, Tuttelmann F, Gromoll J (2015) FSHB \(-211\mbox{G}>\mbox{T}\) stratification for follicle-stimulating hormone treatment of male infertility patients: making the case for a pharmacogenetic approach in genetic functional secondary hypogonadism. Andrology 3(6):1050–1053
Huhtaniemi I (2015) A short evolutionary history of FSH-stimulated spermatogenesis. Hormones (Athens) 14(4):468–478
Dabaja AA, Schlegel PN (2014) Medical treatment of male infertility. Transl Androl Urol 3(1):9–16
Lledo B, Dapena P, Ortiz JA et al. (2016) Clinical efficacy of recombinant versus highly purified follicle-stimulating hormone according to follicle-stimulating hormone receptor genotype. Pharmacogenet Genomics 26(6):288–293
Orvieto R, Seifer DB (2016) Biosimilar FSH preparations- are they identical twins or just siblings? Reprod Biol Endocrinol 14:32
Santi D, Granata AR, Simoni M (2015) FSH treatment of male idiopathic infertility improves pregnancy rate: a meta-analysis. Endocr Connect 4(3):R46–R58
Attia AM, Abou-Setta AM, Al-Inany HG (2013) Gonadotrophins for idiopathic male factor subfertility. Cochrane Database Syst Rev 4(8):CD005071
Simoni M, Santi D, Negri L et al. (2016) Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study. Hum Reprod 31(9):1960–1969
Tuttelmann F, Laan M, Grigorova M et al. (2012) Combined effects of the variants FSHB \(-211\mbox{G}>\mbox{T}\) and FSHR 2039A>G on male reproductive parameters. J Clin Endocrinol Metab 97(10):3639–3647