Neutrophils, from Marrow to Microbes

Abram, 2009, Leukocyte adhesion deficiency syndrome: A controversy solved, Immunol. Cell Biol., 87, 440, 10.1038/icb.2009.32 Abram, 2009, The ins and outs of leukocyte integrin signaling, Annu. Rev. Immunol., 27, 339, 10.1146/annurev.immunol.021908.132554 Alcaide, 2009, Neutrophil recruitment under shear flow: It's all about endothelial cell rings and gaps, Microcirculation, 16, 43, 10.1080/10739680802273892 Allingham, 2007, ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration, J. Immunol., 179, 4053, 10.4049/jimmunol.179.6.4053 Alvarez, 2008, The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling, Mol. Immunol., 45, 253, 10.1016/j.molimm.2007.05.006 Anthis, 2009, The structure of an integrin/talin complex reveals the basis of inside-out signal transduction, EMBO J., 28, 3623, 10.1038/emboj.2009.287 Arita, 2007, Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation, J. Immunol., 178, 3912, 10.4049/jimmunol.178.6.3912 Arnljots, 1998, Timing, targeting and sorting of azurophil granule proteins in human myeloid cells, Leukemia, 12, 1789, 10.1038/sj.leu.2401202 Barreiro, 2009, Molecular basis of leukocyte-endothelium interactions during the inflammatory response, Rev. Esp. Cardiol., 62, 552, 10.1016/S0300-8932(09)71035-8 Barreiro, 2002, Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes, J. Cell Biol., 157, 1233, 10.1083/jcb.200112126 Barreiro, 2008, Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms, J. Cell Biol., 183, 527, 10.1083/jcb.200805076 Bayat, 2010, Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1, J. Immunol., 184, 3889, 10.4049/jimmunol.0903136 Bazzoni, 2009, Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals, Proc. Natl. Acad. Sci. USA, 106, 5282, 10.1073/pnas.0810909106 Bianchi, 2009, Restoration of NET formation by gene therapy in CGD controls aspergillosis, Blood, 114, 2619, 10.1182/blood-2009-05-221606 Bixel, 2007, A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo, Blood, 109, 5327, 10.1182/blood-2006-08-043109 Bixel, 2010, CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis, Blood, 116, 1172, 10.1182/blood-2009-12-256388 Bjerregaard, 2003, The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow, Blood, 101, 4322, 10.1182/blood-2002-03-0835 Borregaard, 1997, Granules of the human neutrophilic polymorphonuclear leukocyte, Blood, 89, 3503, 10.1182/blood.V89.10.3503 Borregaard, 1984, Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein, J. Biol. Chem., 259, 47, 10.1016/S0021-9258(17)43619-2 Borregaard, 1983, Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: Translocation during activation, J. Cell Biol., 97, 52, 10.1083/jcb.97.1.52 Borregaard, 1987, Chemoattractant-regulated mobilization of a novel intracellular compartment in human neutrophils, Science, 237, 1204, 10.1126/science.3629236 Borregaard, 1992, Stimulus-dependent secretion of plasma proteins from human neutrophils, J. Clin. Invest., 90, 86, 10.1172/JCI115860 Borregaard, 1993, Granules and vesicles of human neutrophils. The role of endomembranes as source of plasma membrane proteins, Eur. J. Haematol., 51, 318, 10.1111/j.1600-0609.1993.tb01615.x Borregaard, 1994, Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators, J. Leukoc. Biol., 56, 80, 10.1002/jlb.56.1.80 Borregaard, 1995, Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation, Blood, 85, 812, 10.1182/blood.V85.3.812.bloodjournal853812 Borregaard, 2007, Neutrophil granules: A library of innate immunity proteins, Trends Immunol., 28, 340, 10.1016/j.it.2007.06.002 Bouchon, 2000, Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes, J. Immunol., 164, 4991, 10.4049/jimmunol.164.10.4991 Bouchon, 2001, TREM-1 amplifies inflammation and is a crucial mediator of septic shock, Nature, 410, 1103, 10.1038/35074114 Brinkmann, 2007, Beneficial suicide: Why neutrophils die to make NETs, Nat. Rev. Microbiol., 5, 577, 10.1038/nrmicro1710 Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385 Bruehl, 1997, Leukocyte activation induces surface redistribution of P-selectin glycoprotein ligand-1, J. Leukoc. Biol., 61, 489, 10.1002/jlb.61.4.489 Bunting, 2002, Leukocyte adhesion deficiency syndromes: Adhesion and tethering defects involving beta 2 integrins and selectin ligands, Curr. Opin. Hematol., 9, 30, 10.1097/00062752-200201000-00006 Buscher, 2010, The transmembrane domains of L-selectin and CD44 regulate receptor cell surface positioning and leukocyte adhesion under flow, J. Biol. Chem., 285, 13490, 10.1074/jbc.M110.102640 Carman, 2009, Mechanisms for transcellular diapedesis: Probing and pathfinding by ‘invadosome-like protrusions’, J. Cell Sci., 122, 3025, 10.1242/jcs.047522 Carman, 2004, A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them, J. Cell Biol., 167, 377, 10.1083/jcb.200404129 Carman, 2007, Transcellular diapedesis is initiated by invasive podosomes, Immunity, 26, 784, 10.1016/j.immuni.2007.04.015 Cash, 2010, Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner, J. Immunol., 184, 5315, 10.4049/jimmunol.0903378 Celli, 2006, Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis, J. Immunol., 177, 4113, 10.4049/jimmunol.177.6.4113 Cheng, 2010, Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules, J. Immunol., 185, 1238, 10.4049/jimmunol.0904104 Christopher, 2009, Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization, Blood, 114, 1331, 10.1182/blood-2008-10-184754 Chumakov, 2007, Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway, Blood, 109, 4209, 10.1182/blood-2005-09-031963 Corada, 2005, Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury, Proc. Natl. Acad. Sci. USA, 102, 10634, 10.1073/pnas.0500147102 Croker, 2004, SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis, Immunity, 20, 153, 10.1016/S1074-7613(04)00022-6 D'Alo', 2003, The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells, Blood, 102, 3163, 10.1182/blood-2003-02-0479 Daëron, 2008, Immunoreceptor tyrosine-based inhibition motifs: A quest in the past and future, Immunol. Rev., 224, 11, 10.1111/j.1600-065X.2008.00666.x Dahl, 2003, Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor, Nat. Immunol., 4, 1029, 10.1038/ni973 Dale, 2000, Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia, Blood, 96, 2317, 10.1182/blood.V96.7.2317 Dangerfield, 2002, PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane, J. Exp. Med., 196, 1201, 10.1084/jem.20020324 Deban, 2010, Regulation of leukocyte recruitment by the long pentraxin PTX3, Nat. Immunol., 11, 328, 10.1038/ni.1854 Di Gennaro, 2009, Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin), FASEB J., 23, 1750, 10.1096/fj.08-121277 Ducker, 1992, Subcellular localization of CD66, CD67, and NCA in human neutrophils, J. Leukoc. Biol., 52, 11, 10.1002/jlb.52.1.11 Dufour, 2008, CD99 is essential for leukocyte diapedesis in vivo, Cell Commun. Adhes., 15, 351, 10.1080/15419060802442191 Dufton, 2010, Anti-inflammatory role of the murine formyl-peptide receptor 2: Ligand-specific effects on leukocyte responses and experimental inflammation, J. Immunol., 184, 2611, 10.4049/jimmunol.0903526 Eash, 2009, CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions, Blood, 113, 4711, 10.1182/blood-2008-09-177287 Eash, 2010, CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow, J. Clin. Invest., 120, 10.1172/JCI41649 El-Benna, 2009, p47phox, the phagocyte NADPH oxidase/NOX2 organizer: Structure, phosphorylation and implication in diseases, Exp. Mol. Med., 41, 217, 10.3858/emm.2009.41.4.058 Engelhardt, 2008, Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines, J. Neurol. Sci., 274, 23, 10.1016/j.jns.2008.05.019 Evans, 2009, Integrins in immunity, J. Cell Sci., 122, 215, 10.1242/jcs.019117 Faurschou, 2002, Defensin-rich granules of human neutrophils: Characterization of secretory properties, Biochim. Biophys. Acta, 1591, 29, 10.1016/S0167-4889(02)00243-4 Fazi, 2005, A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis, Cell, 123, 819, 10.1016/j.cell.2005.09.023 Fernandez-Borja, 2010, The regulation of leucocyte transendothelial migration by endothelial signalling events, Cardiovasc. Res., 86, 202, 10.1093/cvr/cvq003 Flannagan, 2009, Antimicrobial mechanisms of phagocytes and bacterial evasion strategies, Nat. Rev. Microbiol., 7, 355, 10.1038/nrmicro2128 Ford, 2009, TREM and TREM-like receptors in inflammation and disease, Curr. Opin. Immunol., 21, 38, 10.1016/j.coi.2009.01.009 Fuchs, 2007, Novel cell death program leads to neutrophil extracellular traps, J. Cell Biol., 176, 231, 10.1083/jcb.200606027 Fuchs, 2010, Extracellular DNA traps promote thrombosis, Proc. Natl. Acad. Sci. USA., 107, 14390, 10.1073/pnas.1005743107 Gery, 2004, C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis, Blood, 103, 828, 10.1182/blood-2003-01-0159 Gombart, 2001, Neutrophil-specific granule deficiency: Homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein—epsilon, Blood, 97, 2561, 10.1182/blood.V97.9.2561 Grassinger, 2009, Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins, Blood, 114, 49, 10.1182/blood-2009-01-197988 Gupta, 2010, Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death, FEBS Lett., 584, 3193, 10.1016/j.febslet.2010.06.006 Hakkim, 2010, Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis, Proc. Natl. Acad. Sci. USA, 107, 9813, 10.1073/pnas.0909927107 Hernandez, 2003, Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease, Nat. Genet., 34, 70, 10.1038/ng1149 Hidalgo, 2007, Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44, Immunity, 26, 477, 10.1016/j.immuni.2007.03.011 Hirai, 2006, C/EBPbeta is required for ‘emergency’ granulopoiesis, Nat. Immunol., 7, 732, 10.1038/ni1354 Hock, 2003, Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation, Immunity, 18, 109, 10.1016/S1074-7613(02)00501-0 Hock, 2004, Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells, Nature, 431, 1002, 10.1038/nature02994 Holland, 2010, Chronic granulomatous disease, Clin. Rev. Allergy Immunol., 38, 3, 10.1007/s12016-009-8136-z Horman, 2009, Gfi1 integrates progenitor versus granulocytic transcriptional programming, Blood, 113, 5466, 10.1182/blood-2008-09-179747 Ishida, 2010, Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis, Inflamm. Bowel Dis., 16, 87, 10.1002/ibd.21029 Iwasaki, 2005, Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation, Blood, 106, 1590, 10.1182/blood-2005-03-0860 Jacobsen, 2007, Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils, Blood, 109, 3084, 10.1182/blood-2006-06-032599 Jaillon, 2007, The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps, J. Exp. Med., 204, 793, 10.1084/jem.20061301 Johansson, 2001, Alpha-1-antitrypsin is present in the specific granules of human eosinophilic granulocytes, Clin. Exp. Allergy, 31, 379, 10.1046/j.1365-2222.2001.01017.x Johnnidis, 2008, Regulation of progenitor cell proliferation and granulocyte function by microRNA-223, Nature, 451, 1125, 10.1038/nature06607 Kang, 2001, Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils, J. Biol. Chem., 276, 21960, 10.1074/jbc.M007997200 Karsunky, 2002, Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1, Nat. Genet., 30, 295, 10.1038/ng831 Kaur, 2010, Identification of chemerin receptor (ChemR23) in human endothelial cells: Chemerin-induced endothelial angiogenesis, Biochem. Biophys. Res. Commun., 391, 1762, 10.1016/j.bbrc.2009.12.150 Khandoga, 2009, Leukocyte transmigration in inflamed liver: A role for endothelial cell-selective adhesion molecule, J. Hepatol., 50, 755, 10.1016/j.jhep.2008.11.027 Khanna-Gupta, 2007, Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene, Blood, 109, 4181, 10.1182/blood-2005-05-022004 Kjeldsen, 1992, Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules, Biochem. J., 287, 603, 10.1042/bj2870603 Kjeldsen, 1993, Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: Identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation, Blood, 82, 3183, 10.1182/blood.V82.10.3183.bloodjournal82103183 Klausen, 2004, End-stage differentiation of neutrophil granulocytes in vivo is accompanied by up-regulation of p27kip1 and down-regulation of CDK2, CDK4, and CDK6, J. Leukoc. Biol., 75, 569, 10.1189/jlb.1003474 Klein, 2007, HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease), Nat. Genet., 39, 86, 10.1038/ng1940 Koenen, 2009, Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases, Blood, 113, 4799, 10.1182/blood-2008-04-152330 Kolaczkowska, 2009, Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis, J. Leukoc. Biol., 85, 374, 10.1189/jlb.0808460 Kubes, 1991, Nitric oxide: An endogenous modulator of leukocyte adhesion, Proc. Natl. Acad. Sci. USA, 88, 4651, 10.1073/pnas.88.11.4651 Kuijpers, 2009, LAD-1/variant syndrome is caused by mutations in FERMT3, Blood, 113, 4740, 10.1182/blood-2008-10-182154 Kuwano, 2010, Rolling on E- or P-selectin induces the extended, but not high affinity conformation of LFA-1 in neutrophils, Blood, 116, 617, 10.1182/blood-2010-01-266122 Lapidot, 2002, The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice, Leukemia, 16, 1992, 10.1038/sj.leu.2402684 Lapinet, 2000, Infect. Immun., 68, 6917, 10.1128/IAI.68.12.6917-6923.2000 Laslo, 2006, Multilineage transcriptional priming and determination of alternate hematopoietic cell fates, Cell, 126, 755, 10.1016/j.cell.2006.06.052 Le Cabec, 1996, Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells, Proc. Natl. Acad. Sci. USA, 93, 6454, 10.1073/pnas.93.13.6454 Lekstrom-Himes, 1999, CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge, Blood, 93, 3096, 10.1182/blood.V93.9.3096 Ley, 2006, IL-17A-producing neutrophil-regulatory Tn lymphocytes, Immunol. Res., 34, 229, 10.1385/IR:34:3:229 Ley, 2007, Getting to the site of inflammation: The leukocyte adhesion cascade updated, Nat. Rev. Immunol., 7, 678, 10.1038/nri2156 Li, 2010, PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps, J. Exp. Med., 207, 1853, 10.1084/jem.20100239 Lieschke, 1994, Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization, Blood, 84, 1737, 10.1182/blood.V84.6.1737.1737 Lollike, 1995, Lysozyme in human neutrophils and plasma. A parameter of myelopoietic activity, Leukemia, 9, 159 Lominadze, 2005, Proteomic analysis of human neutrophil granules, Mol. Cell. Proteomics, 4, 1503, 10.1074/mcp.M500143-MCP200 Lühn, 2001, The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter, Nat. Genet., 28, 69, 10.1038/ng0501-69 Maderna, 2009, Lipoxins: Resolutionary road, Br. J. Pharmacol., 158, 947, 10.1111/j.1476-5381.2009.00386.x Maderna, 2010, FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis, FASEB J., 24, 4240, 10.1096/fj.10-159913 Mambole, 2010, Human neutrophil integrin alpha9beta1: Up-regulation by cell activation and synergy with beta2 integrins during adhesion to endothelium under flow, J. Leukoc. Biol., 88, 321, 10.1189/jlb.1009704 Matute, 2009, A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity, Blood, 114, 3309, 10.1182/blood-2009-07-231498 McCormick, 2010, NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigates, Microbes. Infect., 12, 928, 10.1016/j.micinf.2010.06.009 McDowall, 2003, A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins, J. Clin. Invest., 111, 51, 10.1172/JCI200314076 McDowall, 2010, Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro, Blood, 115, 4834, 10.1182/blood-2009-08-238709 Metzler, 2010, Myeloperoxidase is required for neutrophil extracellular trap formation: Implications for innate immunity, Blood Middleton, 2002, Leukocyte extravasation: Chemokine transport and presentation by the endothelium, Blood, 100, 3853, 10.1182/blood.V100.12.3853 Morosetti, 1997, A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation, Blood, 90, 2591, 10.1182/blood.V90.7.2591 Moser, 2008, Kindlin-3 is essential for integrin activation and platelet aggregation, Nat. Med., 14, 325, 10.1038/nm1722 Moser, 2009, Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells, Nat. Med., 15, 300, 10.1038/nm.1921 Moser, 2009, The tail of integrins, talin, and kindlins, Science, 324, 895, 10.1126/science.1163865 Mueller, 2010, Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways, Blood, 115, 3118, 10.1182/blood-2009-11-254185 Murthy, 1993, In vitro candidastatic properties of the human neutrophil calprotectin complex, J. Immunol., 151, 6291, 10.4049/jimmunol.151.11.6291 Nakashima, 2002, Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes, J. Biol. Chem., 277, 49562, 10.1074/jbc.M208795200 Nauseef, 2007, How human neutrophils kill and degrade microbes: An integrated view, Immunol. Rev., 219, 88, 10.1111/j.1600-065X.2007.00550.x Nerlov, 1998, PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors, Genes Dev., 12, 2403, 10.1101/gad.12.15.2403 Oh, 2007, RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: Functional implication for the leukocyte adhesion and transmigration, Mol. Biol. Cell, 18, 2322, 10.1091/mbc.E06-08-0744 Ohira, 2010, Resolvin E1 receptor activation signals phosphorylation and phagocytosis, J. Biol. Chem., 285, 3451, 10.1074/jbc.M109.044131 Papayannopoulos, 2010, Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps, J. Cell Biol., 191, 677, 10.1083/jcb.201006052 Patel, 2010, Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation, Nitric Oxide, 22, 226, 10.1016/j.niox.2010.01.001 Person, 2003, Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2, Nat. Genet., 34, 308, 10.1038/ng1170 Petri, 2008, The physiology of leukocyte recruitment: An in vivo perspective, J. Immunol., 180, 6439, 10.4049/jimmunol.180.10.6439 Phillips, 1995, Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2, J. Clin. Invest., 96, 2898, 10.1172/JCI118361 Phillipson, 2006, Intraluminal crawling of neutrophils to emigration sites: A molecularly distinct process from adhesion in the recruitment cascade, J. Exp. Med., 203, 2569, 10.1084/jem.20060925 Phillipson, 2008, Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration, PLoS. One, 3, e1649, 10.1371/journal.pone.0001649 Phillipson, 2009, Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature, J. Immunol., 182, 6870, 10.4049/jimmunol.0803414 Pospieszalska, 2009, Dynamics of microvillus extension and tether formation in rolling leukocytes, Cell Mol. Bioeng., 2, 207, 10.1007/s12195-009-0063-9 Pulikkan, 2010, Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia, Blood, 115, 1768, 10.1182/blood-2009-08-240101 Qian, 2006, Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins, Blood, 107, 3503, 10.1182/blood-2005-10-3932 Qian, 2007, Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells, Blood, 110, 2399, 10.1182/blood-2006-10-051276 Radomska, 1998, CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors, Mol. Cell. Biol., 18, 4301, 10.1128/MCB.18.7.4301 Reddy, 2002, Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: Possible role in lineage commitment decisions, Blood, 100, 483, 10.1182/blood.V100.2.483 Robinson, 2008, Reactive oxygen species in phagocytic leukocytes, Histochem. Cell Biol., 130, 281, 10.1007/s00418-008-0461-4 Robinson, 2009, Phagocytic leukocytes and reactive oxygen species, Histochem. Cell Biol., 131, 465, 10.1007/s00418-009-0565-5 Rørvig, 2009, Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP, J. Leukoc. Biol., 86, 1439, 10.1189/jlb.1008606 Rowe, 2008, Breaching the basement membrane: Who, when and how?, Trends Cell Biol., 18, 560, 10.1016/j.tcb.2008.08.007 Sachs, 2007, The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31), J. Biol. Chem., 282, 23603, 10.1074/jbc.M701120200 Salipante, 2009, Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase, Mol. Cell. Biol., 29, 4394, 10.1128/MCB.00596-09 Sasawatari, 2010, The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking, Immunity, 32, 200, 10.1016/j.immuni.2010.01.012 Sato, 1992, A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites, J. Cell Sci., 103, 131, 10.1242/jcs.103.1.131 Scapini, 2000, The neutrophil as a cellular source of chemokines, Immunol. Rev., 177, 195, 10.1034/j.1600-065X.2000.17706.x Scapini, 2005, Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: Implications for inflammatory diseases, Blood, 105, 830, 10.1182/blood-2004-02-0564 Scapini, 2008, Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils, Immunol. Lett., 116, 1, 10.1016/j.imlet.2007.11.009 Scheiermann, 2010, Neutrophil microdomains: Linking heterocellular interactions with vascular injury, Curr. Opin. Hematol., 17, 25, 10.1097/MOH.0b013e328333d2a3 Schreiber, 2009, The integrin alpha9beta1 on hematopoietic stem and progenitor cells: Involvement in cell adhesion, proliferation and differentiation, Haematologica, 94, 1493, 10.3324/haematol.2009.006072 Schwab, 2007, Resolvin E1 and protectin D1 activate inflammation-resolution programmes, Nature, 447, 869, 10.1038/nature05877 Schwarzenberger, 2000, Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis, J. Immunol., 164, 4783, 10.4049/jimmunol.164.9.4783 Sengeløv, 1993, Control of exocytosis in early neutrophil activation, J. Immunol., 150, 1535, 10.4049/jimmunol.150.4.1535 Sengeløv, 1994, Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils, J. Immunol., 153, 804, 10.4049/jimmunol.153.2.804 Sengeløv, 1995, Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils, J. Immunol., 154, 4157, 10.4049/jimmunol.154.8.4157 Serhan, 2009, Systems approach to inflammation resolution: Identification of novel anti-inflammatory and pro-resolving mediators, J. Thromb. Haemost., 7, 44, 10.1111/j.1538-7836.2009.03396.x Serhan, 2008, Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators, Nat. Rev. Immunol., 8, 349, 10.1038/nri2294 Skokowa, 2006, LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia, Nat. Med., 12, 1191, 10.1038/nm1474 Skubitz, 2008, Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells, J. Transl. Med., 6, 78, 10.1186/1479-5876-6-78 Somers, 2000, Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1, Cell, 103, 467, 10.1016/S0092-8674(00)00138-0 Sørensen, 1999, The human antibacterial cathelicidin, hCAP-18, is bound to lipoproteins in plasma, J. Biol. Chem., 274, 22445, 10.1074/jbc.274.32.22445 Sørensen, 2001, Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3, Blood, 97, 3951, 10.1182/blood.V97.12.3951 Spite, 2009, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis, Nature, 461, 1287, 10.1038/nature08541 Stamatovic, 2003, Potential role of MCP-1 in endothelial cell tight junction ‘opening’: Signaling via Rho and Rho kinase, J. Cell Sci., 116, 4615, 10.1242/jcs.00755 Stark, 2005, Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17, Immunity, 22, 285, 10.1016/j.immuni.2005.01.011 Steegmaier, 1997, The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface, J. Cell Sci., 110, 687, 10.1242/jcs.110.6.687 Steevels, 2010, Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes, J. Immunol., 184, 4741, 10.4049/jimmunol.0902039 Svensson, 2009, Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation, Nat. Med., 15, 306, 10.1038/nm.1931 Taooka, 1999, The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1, J. Cell Biol., 145, 413, 10.1083/jcb.145.2.413 Tessarz, 2008, The TREM-1/DAP12 pathway, Immunol. Lett., 116, 111, 10.1016/j.imlet.2007.11.021 Theilgaard-Mönch, 2004, The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing, J. Immunol., 172, 7684, 10.4049/jimmunol.172.12.7684 Theilgaard-Mönch, 2005, The transcriptional program of terminal granulocytic differentiation, Blood, 105, 1785, 10.1182/blood-2004-08-3346 Theilgaard-Mönch, 2005, Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils, J. Leukoc. Biol., 78, 462, 10.1189/jlb.0105042 Theilgaard-Mönch, 2006, Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation, Blood, 108, 353, 10.1182/blood-2005-09-3890 Theilgaard-Mönch, 2006, Systems biology of neutrophil differentiation and immune response, Curr. Opin. Immunol., 18, 54, 10.1016/j.coi.2005.11.010 Tsukita, 1997, ERM (ezrin/radixin/moesin) family: From cytoskeleton to signal transduction, Curr. Opin. Cell Biol., 9, 70, 10.1016/S0955-0674(97)80154-8 Tsukita, 1999, Cortical actin organization: Lessons from ERM (ezrin/radixin/moesin) proteins, J. Biol. Chem., 274, 34507, 10.1074/jbc.274.49.34507 Udby, 2002, Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils, J. Leukoc. Biol., 72, 462, 10.1189/jlb.72.3.462 Urban, 2009, Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans, PLoS Pathog., 5, e1000639, 10.1371/journal.ppat.1000639 van Buul, 2008, Endothelial signalling by Ig-like cell adhesion molecules, Transfus. Clin. Biol., 15, 3, 10.1016/j.tracli.2008.04.002 van Buul, 2005, Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation, J. Biol. Chem., 280, 21129, 10.1074/jbc.M500898200 van Buul, 2007, RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration, J. Cell Biol., 178, 1279, 10.1083/jcb.200612053 van Buul, 2010, Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium, PLoS ONE, 5, e11336, 10.1371/journal.pone.0011336 van Buul, 2010, ICAM-1 clustering on endothelial cells recruits VCAM-1, J. Biomed. Biotechnol., 2010, 120328, 10.1155/2010/120328 Van Keymeulen, 2006, To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front, J. Cell Biol., 174, 437, 10.1083/jcb.200604113 Velu, 2009, Gfi1 regulates miR-21 and miR-196b to control myelopoiesis, Blood, 113, 4720, 10.1182/blood-2008-11-190215 Vestweber, 2007, Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium, Immunol. Rev., 218, 178, 10.1111/j.1600-065X.2007.00533.x von Vietinghoff, 2009, IL-17A controls IL-17F production and maintains blood neutrophil counts in mice, J. Immunol., 183, 865, 10.4049/jimmunol.0804080 Wang, 2004, Human PAD4 regulates histone arginine methylation levels via demethylimination, Science, 306, 279, 10.1126/science.1101400 Wang, 2009, NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production, J. Immunol., 182, 5757, 10.4049/jimmunol.0803861 Wegmann, 2006, ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability, J. Exp. Med., 203, 1671, 10.1084/jem.20060565 Williams, 2010, A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration, J. Immunol., 185, 3057, 10.4049/jimmunol.1000119 Winkler, 2010, Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches, Blood, 116, 375, 10.1182/blood-2009-07-233437 Wojcikiewicz, 2009, LFA-1 binding destabilizes the JAM-A homophilic interaction during leukocyte transmigration, Biophys. J., 96, 285, 10.1529/biophysj.108.135491 Woodfin, 2009, Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1, Blood, 113, 6246, 10.1182/blood-2008-11-188375 Woodfin, 2010, Recent developments and complexities in neutrophil transmigration, Curr. Opin. Hematol., 17, 9, 10.1097/MOH.0b013e3283333930 Xu, 2003, Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils, Cell, 114, 201, 10.1016/S0092-8674(03)00555-5 Yago, 2010, E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling, Blood, 116, 485, 10.1182/blood-2009-12-259556 Yamanaka, 1997, Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice, Proc. Natl. Acad. Sci. USA, 94, 13187, 10.1073/pnas.94.24.13187 Yamanaka, 1997, CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing, Proc. Natl. Acad. Sci. USA, 94, 6462, 10.1073/pnas.94.12.6462 Yang, 2006, Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration, J. Immunol., 177, 6440, 10.4049/jimmunol.177.9.6440 Yang, 2006, Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro, Circ. Res., 98, 394, 10.1161/01.RES.0000201958.59020.1a Yost, 2009, Impaired neutrophil extracellular trap (NET) formation: A novel innate immune deficiency of human neonates, Blood, 113, 6419, 10.1182/blood-2008-07-171629 Yousefi, 2009, Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps, Cell Death Differ., 16, 1438, 10.1038/cdd.2009.96 Zabel, 2005, Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades, J. Biol. Chem., 280, 34661, 10.1074/jbc.M504868200 Zabel, 2006, Chemoattractants, extracellular proteases, and the integrated host defense response, Exp. Hematol., 34, 1021, 10.1016/j.exphem.2006.05.003 Zarbock, 2009, Neutrophil adhesion and activation under flow, Microcirculation, 16, 31, 10.1080/10739680802350104 Zarbock, 2009, New insights into leukocyte recruitment by intravital microscopy, Curr. Top. Microbiol. Immunol., 334, 129 Zarbock, 2007, Galphai2 is required for chemokine-induced neutrophil arrest, Blood, 110, 3773, 10.1182/blood-2007-06-094565 Zarbock, 2008, PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling, J. Exp. Med., 205, 2339, 10.1084/jem.20072660 Zarebski, 2008, Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1, Immunity, 28, 370, 10.1016/j.immuni.2007.12.020 Zhang, 1997, Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice, Proc. Natl. Acad. Sci. USA, 94, 569, 10.1073/pnas.94.2.569