TGF-β Tumor Suppression through a Lethal EMT

Cell - Tập 164 - Trang 1015-1030 - 2016
Charles J. David1, Yun-Han Huang, Mo Chen2, Jie Su1, Yilong Zou, Nabeel Bardeesy3, Christine A. Iacobuzio-Donahue4, Joan Massagué5
1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
2The Rockefeller University, New York, NY 10065, USA
3Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
5Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

Tài liệu tham khảo

Aguirre, 2003, Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma, Genes Dev., 17, 3112, 10.1101/gad.1158703 Bardeesy, 2006, Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer, Genes Dev., 20, 3130, 10.1101/gad.1478706 Bialkowska, 2014, A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α), J. Biol. Chem., 289, 5997, 10.1074/jbc.M113.508549 Boj, 2015, Organoid models of human and mouse ductal pancreatic cancer, Cell, 160, 324, 10.1016/j.cell.2014.12.021 Burk, 2008, A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells, EMBO Rep., 9, 582, 10.1038/embor.2008.74 Campos, 2015, Colorectal cancer risk in hamartomatous polyposis syndromes, World J. Gastrointest. Surg., 7, 25, 10.4240/wjgs.v7.i3.25 Chen, 1998, Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway, Oncogene, 17, 1959, 10.1038/sj.onc.1202111 Chia, 2015, Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development, Gut, 64, 707, 10.1136/gutjnl-2013-306596 Cicchini, 2006, Snail controls differentiation of hepatocytes by repressing HNF4alpha expression, J. Cell. Physiol., 209, 230, 10.1002/jcp.20730 DaCosta Byfield, 2004, SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7, Mol. Pharmacol., 65, 744, 10.1124/mol.65.3.744 Doulatov, 2013, Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors, Cell Stem Cell, 13, 459, 10.1016/j.stem.2013.09.002 Duda, 2003, Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells, Oncogene, 22, 6857, 10.1038/sj.onc.1206751 2012, An integrated encyclopedia of DNA elements in the human genome, Nature, 489, 57, 10.1038/nature11247 Fellmann, 2013, An optimized microRNA backbone for effective single-copy RNAi, Cell Rep., 5, 1704, 10.1016/j.celrep.2013.11.020 Friess, 1993, Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival, Gastroenterology, 105, 1846, 10.1016/0016-5085(93)91084-U Gaarenstroom, 2014, TGF-β signaling to chromatin: how Smads regulate transcription during self-renewal and differentiation, Semin. Cell Dev. Biol., 32, 107, 10.1016/j.semcdb.2014.01.009 Gal, 2008, Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis, Oncogene, 27, 1218, 10.1038/sj.onc.1210741 Garraway, 2006, Lineage dependency and lineage-survival oncogenes in human cancer, Nat. Rev. Cancer, 6, 593, 10.1038/nrc1947 Ghaleb, 2005, Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation, Cell Res., 15, 92, 10.1038/sj.cr.7290271 Goggins, 1998, Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas, Cancer Res., 58, 5329 Guasch, 2007, Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia, Cancer Cell, 12, 313, 10.1016/j.ccr.2007.08.020 Hahn, 1996, DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1, Science, 271, 350, 10.1126/science.271.5247.350 Heldin, 2012, Regulation of EMT by TGFβ in cancer, FEBS Lett., 586, 1959, 10.1016/j.febslet.2012.02.037 Hingorani, 2003, Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse, Cancer Cell, 4, 437, 10.1016/S1535-6108(03)00309-X Hingorani, 2005, Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice, Cancer Cell, 7, 469, 10.1016/j.ccr.2005.04.023 Horiguchi, 2009, Role of Ras signaling in the induction of snail by transforming growth factor-beta, J. Biol. Chem., 284, 245, 10.1074/jbc.M804777200 Howe, 1998, Mutations in the SMAD4/DPC4 gene in juvenile polyposis, Science, 280, 1086, 10.1126/science.280.5366.1086 Iacobuzio-Donahue, 2009, DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer, J. Clin. Oncol., 27, 1806, 10.1200/JCO.2008.17.7188 Ikushima, 2009, Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors, Cell Stem Cell, 5, 504, 10.1016/j.stem.2009.08.018 Kane, 2014, Sarcomatoid (spindle cell) carcinoma of the pancreas: A case report and review of the literature, Oncol. Lett., 7, 245, 10.3892/ol.2013.1683 Kim, 2000, Activin receptor patterning of foregut organogenesis, Genes Dev., 14, 1866, 10.1101/gad.14.15.1866 Konturek, 1998, Comparison of epidermal growth factor and transforming growth factor-beta1 expression in hormone-induced acute pancreatitis in rats, Digestion, 59, 110, 10.1159/000007483 Lee, 2013, Transcriptional regulation and its misregulation in disease, Cell, 152, 1237, 10.1016/j.cell.2013.02.014 Li, 2010, Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels, Cancer Res., 70, 5226, 10.1158/0008-5472.CAN-09-4227 Lonardo, 2011, Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy, Cell Stem Cell, 9, 433, 10.1016/j.stem.2011.10.001 Massagué, 2008, TGFbeta in Cancer, Cell, 134, 215, 10.1016/j.cell.2008.07.001 Massagué, 2012, TGFβ signalling in context, Nat. Rev. Mol. Cell Biol., 13, 616, 10.1038/nrm3434 Morris, 2010, Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice, J. Clin. Invest., 120, 508, 10.1172/JCI40045 Nakaya, 2014, KLF5 regulates the integrity and oncogenicity of intestinal stem cells, Cancer Res., 74, 2882, 10.1158/0008-5472.CAN-13-2574 Nandan, 2015, Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells, Stem Cell Res. (Amst.), 14, 10, 10.1016/j.scr.2014.10.008 Ohnishi, 2000, Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5, Dev. Dyn., 217, 421, 10.1002/(SICI)1097-0177(200004)217:4<421::AID-DVDY9>3.0.CO;2-1 Oshimori, 2012, The harmonies played by TGF-β in stem cell biology, Cell Stem Cell, 11, 751, 10.1016/j.stem.2012.11.001 Oshimori, 2015, TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma, Cell, 160, 963, 10.1016/j.cell.2015.01.043 Peinado, 2003, Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions, J. Biol. Chem., 278, 21113, 10.1074/jbc.M211304200 Piñon, 2008, Bim and Bmf in tissue homeostasis and malignant disease, Oncogene, 27, S41, 10.1038/onc.2009.42 Ramachandra, 2002, Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis, Cancer Res., 62, 6045 Rhim, 2012, EMT and dissemination precede pancreatic tumor formation, Cell, 148, 349, 10.1016/j.cell.2011.11.025 Saborowski, 2014, A modular and flexible ESC-based mouse model of pancreatic cancer, Genes Dev., 28, 85, 10.1101/gad.232082.113 Stepanenko, 2013, Antagonistic functional duality of cancer genes, Gene, 529, 199, 10.1016/j.gene.2013.07.047 Thiery, 2009, Epithelial-mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007 Tiwari, 2013, Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8), PLoS ONE, 8, e57329, 10.1371/journal.pone.0057329 Tiwari, 2013, Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming, Cancer Cell, 23, 768, 10.1016/j.ccr.2013.04.020 Valastyan, 2011, Tumor metastasis: molecular insights and evolving paradigms, Cell, 147, 275, 10.1016/j.cell.2011.09.024 Vervoort, 2013, The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?, Oncogene, 32, 3397, 10.1038/onc.2012.506 Vincent, 2009, A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition, Nat. Cell Biol., 11, 943, 10.1038/ncb1905 Wagner, 1999, Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer, Pancreas, 19, 370, 10.1097/00006676-199911000-00008 Whyte, 2013, Master transcription factors and mediator establish super-enhancers at key cell identity genes, Cell, 153, 307, 10.1016/j.cell.2013.03.035 Wiater, 2012, Roles of activin family in pancreatic development and homeostasis, Mol. Cell. Endocrinol., 359, 23, 10.1016/j.mce.2012.02.015 Wilson, 2005, The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas, Diabetes, 54, 3402, 10.2337/diabetes.54.12.3402 Zhang, 2013, KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells, Mol. Cell. Biol., 33, 4919, 10.1128/MCB.00787-13 Zhang, 2013, Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia, Cancer Cell, 24, 575, 10.1016/j.ccr.2013.09.018 Zheng, 2015, Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer, Nature, 527, 525, 10.1038/nature16064 Zuber, 2011, RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia, Nature, 478, 524, 10.1038/nature10334