Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: Identification of a lead for anti-inflammatory drug

Cavaillon, 2009 Izraely, 2012 Murray, 1990 Kujubu, 1991, The Journal of Biological Chemistry, 266, 12866, 10.1016/S0021-9258(18)98774-0 Xie, 1991, Proceedings of the National Academy of Sciences of the United States of America, 88, 2692, 10.1073/pnas.88.7.2692 Vane, 1971, Nature New Biology, 231, 232, 10.1038/newbio231232a0 Smith, 1996, Journal of Biological Chemistry, 271, 33157, 10.1074/jbc.271.52.33157 Everts, 2000, Clinical Rheumatology, 19, 331, 10.1007/s100670070024 Food and Drug Administration, News Release, September 30, 2004. Food and Drug Administration, News Release, April 7, 2005. Zhang, 2010 Jachak, 2006, Current Medicinal Chemistry, 13, 659, 10.2174/092986706776055698 Hart, 1963, British Medical Journal, 5363, 965, 10.1136/bmj.2.5363.965 Penning, 1997, Journal of Medicinal Chemistry, 40, 1347, 10.1021/jm960803q Meunier, 2008, Accounts of Chemical Research, 41, 69, 10.1021/ar7000843 Mehta, 2002, Chemical Society Reviews, 31, 324, 10.1039/b204748a Singh, 2010, European Journal of Medicinal Chemistry, 45, 4968, 10.1016/j.ejmech.2010.08.004 COX Inhibitor Screening Assay kit, Item No. 560131. Cayman Chemical Co. Lipoxygenase Inhibitor Screening Assay Kit, Item No. 760700. Cayman Chemicals Co. Rodrigues, 2004, Medicinal Chemistry Reviews, 1, 73 Chi, 2001, Biochemical Pharmacology, 61, 1195, 10.1016/S0006-2952(01)00597-4 Meade, 1993, Journal of Biological Chemistry, 268, 6610, 10.1016/S0021-9258(18)53294-4 Lipsky, 1997, Journal of Rheumatology, 24, 9 ArgusLab 4.0.1, M. A. Thompson, Planaria Software LLC, Seattle, WA 98155. Kurumbail, 1996, Nature, 384, 644, 10.1038/384644a0 Selinsky, 2001, Biochemistry, 40, 5172, 10.1021/bi010045s Zhang, 2003, Analytical Chemistry, 75, 3010, 10.1021/ac034089d Loo, 1997, Mass Spectrometry Reviews, 16, 1, 10.1002/(SICI)1098-2787(1997)16:1<1::AID-MAS1>3.0.CO;2-L Pacholarz, 2012, Chemical Society Reviews, 41, 4335, 10.1039/c2cs35035a Robinson, 1996, Journal of the American Chemical Society, 118, 8646, 10.1021/ja960211x Loo, 1997, Journal of the American Society for Mass Spectrometry, 8, 234, 10.1016/S1044-0305(96)00238-3 Watson, 2007 Loo, 2009 Sakurada, 2003, Pharmacology Biochemistry and Behavior, 75, 115, 10.1016/S0091-3057(03)00066-2 Singh, 2012, Journal of Medicinal Chemistry, 55, 6381, 10.1021/jm300644g Chirumbolo, 2010, Inflammation & Allergy – Drug Targets, 9, 263, 10.2174/187152810793358741 Lipinski Values Were Calculated Using Molinspiration, www.molinspiration.com.