Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors

Bioorganic & Medicinal Chemistry Letters - Tập 14 - Trang 859-863 - 2004
Wallace T. Ashton1, Hong Dong1, Rosemary M. Sisco1, George A. Doss2, Barbara Leiting3, Reshma A. Patel3, Joseph K. Wu3, Frank Marsilio3, Nancy A. Thornberry3, Ann E. Weber1
1Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA
2Department of Preclinical Drug Metabolism, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA
3Department of Metabolic Disorders, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA

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