Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons
Tài liệu tham khảo
Okita, 2011, A more efficient method to generate integration-free human iPS cells, Nat Methods, 8, 409, 10.1038/nmeth.1591
Takahashi, 2007, Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell., 131, 861, 10.1016/j.cell.2007.11.019
Akiyama, 2016, Genotype-phenotype relationships in familial amyotrophic lateral sclerosis with FUS/TLS mutations in Japan, Muscle Nerve, 54, 398, 10.1002/mus.25061
Ichiyanagi, 2016, Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells, Stem Cell Rep., 6, 496, 10.1016/j.stemcr.2016.02.011
Fujimori, 2018, Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent, Nat Med, 24, 1579, 10.1038/s41591-018-0140-5
Egawa, 2012, Drug screening for ALS using patient-specific induced pluripotent stem cells, Sci Transl Med, 4, 145ra04, 10.1126/scitranslmed.3004052
Kanegae, 1995, Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase, Nucleic Acids Res, 23, 3816, 10.1093/nar/23.19.3816
Niwa, 1991, Efficient selection for high-expression transfectants with a novel eukaryotic vector, Gene., 108, 193, 10.1016/0378-1119(91)90434-D
Nakano, 2010, Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation, Development, 137, 1689, 10.1242/dev.047464
Nusslein-Volhard CaD, 2002
Kawada, 2017, Generation of a motor nerve Organoid with human stem cell-derived neurons, Stem cell Rep., 9, 1441, 10.1016/j.stemcr.2017.09.021
Shimojo, 2015, Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells, Mol Brain, 8, 79, 10.1186/s13041-015-0172-4
Nagai, 2002, A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications, Nat Biotechnol, 20, 87, 10.1038/nbt0102-87
Taylor, 2005, A microfluidic culture platform for CNS axonal injury, regeneration and transport, Nat Methods, 2, 599, 10.1038/nmeth777
Spillane, 2014, Involvement of Rho-family GTPases in axon branching, Small GTPases, 5, e27974, 10.4161/sgtp.27974
Bourne, 2008, Balancing structure and function at hippocampal dendritic spines, Annu Rev Neurosci, 31, 47, 10.1146/annurev.neuro.31.060407.125646
Trapnell, 2009, TopHat: discovering splice junctions with RNA-Seq, Bioinformatics (Oxford, England), 25, 1105, 10.1093/bioinformatics/btp120
Trapnell, 2013, Differential analysis of gene regulation at transcript resolution with RNA-seq, Nat Biotechnol, 31, 46, 10.1038/nbt.2450
Briese, 2016, Whole transcriptome profiling reveals the RNA content of motor axons, Nucleic Acids Res, 44, e33, 10.1093/nar/gkv1027
Brooks, 2000, El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis other Motor Neuron Disorders, 1, 293, 10.1080/146608200300079536
Taylor, 2016, Decoding ALS: from genes to mechanism, Nature., 539, 197, 10.1038/nature20413
Suzuki, 2010, FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion, J Hum Genet, 55, 252, 10.1038/jhg.2010.16
Nishiyama, 2017, Comprehensive targeted next-generation sequencing in Japanese familial amyotrophic lateral sclerosis, Neurobiol Aging, 53, e191
Shiihashi, 2016, Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice, Brain, 139, 2380, 10.1093/brain/aww161
Fischer, 2004, Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man, Exp Neurol, 185, 232, 10.1016/j.expneurol.2003.10.004
Roy, 2005, Axonal transport defects: a common theme in neurodegenerative diseases, Acta Neuropathol, 109, 5, 10.1007/s00401-004-0952-x
Armstrong, 2013, Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS, Hum Mol Genet, 22, 4282, 10.1093/hmg/ddt278
Naumann, 2018, Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation, Nat Commun, 9, 335, 10.1038/s41467-017-02299-1
Tian, 2016, Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging, Nat Commun, 7, 10.1038/ncomms13283
Lopez-Erauskin, 2018, ALS/FTD-linked mutation in FUS suppresses intra-axonal protein synthesis and drives disease without nuclear loss-of-function of FUS, Neuron., 100, 816, 10.1016/j.neuron.2018.09.044
Sharma, 2016, ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function, Nat Commun, 7, 10.1038/ncomms10465
So, 2017, Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice, Hum Mol Genet, 27, 463, 10.1093/hmg/ddx415
Groen, 2013, ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN, Hum Mol Genet, 22, 3690, 10.1093/hmg/ddt222
Kabashi, 2011, FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis, PLoS Genet, 7, e1002214, 10.1371/journal.pgen.1002214
Guo, 2017, HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients, Nat Commun, 8, 861, 10.1038/s41467-017-00911-y
Jung, 2012, Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair, Nat. Rev. Neurosci., 13, 308, 10.1038/nrn3210
Maciel, 2018, The human motor neuron axonal transcriptome is enriched for transcripts related to mitochondrial function and microtubule-based axonal transport, Exp Neurol, 307, 155, 10.1016/j.expneurol.2018.06.008
Rotem, 2017, ALS along the axons - expression of coding and noncoding RNA differs in axons of ALS models, Sci. Rep., 7, 44500, 10.1038/srep44500
Nijssen, 2018, Axon-Seq decodes the motor axon transcriptome and its modulation in response to ALS, Stem Cell Rep., 11, 1565, 10.1016/j.stemcr.2018.11.005
Schoen, 2015, Super-resolution microscopy reveals presynaptic localization of the ALS/FTD related protein FUS in hippocampal neurons, Front Cell Neurosci, 9, 496
Takahashi, 2006, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell., 126, 663, 10.1016/j.cell.2006.07.024
Joung, 2013, TALENs: a widely applicable technology for targeted genome editing, Nat Rev Mol Cell Biol, 14, 49, 10.1038/nrm3486
Fujimori, 2017, Escape from Pluripotency via inhibition of TGF-beta/BMP and activation of Wnt Signaling accelerates differentiation and aging in hPSC progeny cells, Stem Cell Rep., 9, 1675, 10.1016/j.stemcr.2017.09.024
Dormann, 2010, ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import, EMBO J., 29, 2841, 10.1038/emboj.2010.143
Bentmann, 2012, Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43), J Biol Chem, 287, 23079, 10.1074/jbc.M111.328757
Davis-Dusenbery, 2014, How to make spinal motor neurons, Development, 141, 491, 10.1242/dev.097410
Patani, 2016, Generating diverse spinal motor neuron subtypes from human pluripotent stem cells, Stem Cells Int., 2016, 10.1155/2016/1036974
Warde-Farley, 2010, The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function, Nucl. Acids Res., 38, W214, 10.1093/nar/gkq537
Choi, 2017, An in vitro technique to identify the RNA binding-site sequences for RNA-binding proteins, BioTechniques., 63, 28, 10.2144/000114567
Aikawa, 2008, Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1, Nat Biotechnol, 26, 817, 10.1038/nbt1412
Suzuki, 2012, FUS/TLS-immunoreactive neuronal and glial cell inclusions increase with disease duration in familial amyotrophic lateral sclerosis with an R521C FUS/TLS mutation, J Neuropathol Exp Neurol, 71, 779, 10.1097/NEN.0b013e318264f164
Okano, 2014, 7, 22
Lo Bello, 2017, ALS-related mutant FUS protein is Mislocalized to cytoplasm and is recruited into stress granules of fibroblasts from asymptomatic FUS P525L mutation carriers, Neurodegener Dis, 17, 292, 10.1159/000480085
Martineau, 2018, Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS, eLife, 7, 10.7554/eLife.41973
Pereno, 2011, Kainic acid-induced early genes activation and neuronal death in the medial extended amygdala of rats, Exp. Toxicol. Pathol., 63, 291, 10.1016/j.etp.2010.02.001
Cahill, 2018, The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling, Mol Psychiatry, 23, 1474, 10.1038/mp.2017.116
Lafragette, 2017, Reduction of cocaine-induced Locomotor effects by enriched environment is associated with cell-specific accumulation of DeltaFosB in striatal and cortical subregions, Int J Neuropsychopharmacol, 20, 237
Anastasiadou, 2016, The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration, Exp Neurol, 279, 243, 10.1016/j.expneurol.2016.03.012
Grueter, 2013, FosB differentially modulates nucleus accumbens direct and indirect pathway function, Proc Natl Acad Sci U S A, 110, 1923, 10.1073/pnas.1221742110
Bhinge, 2017, Genetic correction of SOD1 mutant iPSCs reveals ERK and JNK activated AP1 as a driver of neurodegeneration in amyotrophic lateral sclerosis, Stem Cell Rep., 8, 856, 10.1016/j.stemcr.2017.02.019
Le Pichon, 2017, Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease, Sci Transl Med, 9, 10.1126/scitranslmed.aag0394
Qiu, 2014, ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects, J Clin Invest, 124, 981, 10.1172/JCI72723
Kim, 2018, Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration, Proc Natl Acad Sci U S A, 115, E390, 10.1073/pnas.1717230115
De Santis, 2017, FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis, Stem cell Rep., 9, 1450, 10.1016/j.stemcr.2017.09.004
Kuntz, 2000, Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis, Exp Neurol, 165, 184, 10.1006/exnr.2000.7464
Huang, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protoc, 4, 44, 10.1038/nprot.2008.211
Huang, 2009, Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res, 37, 1, 10.1093/nar/gkn923
