Emerging pyroptosis-engineered nanobiotechnologies regulate cancers and inflammatory diseases: A double-edged sword

Matter - Tập 5 - Trang 3740-3774 - 2022
Yan Zhang1, Chao Fang1,2, Wei Zhang3, Kun Zhang1,2,3
1Central Laboratory, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Tongji University, No. 301 Yan-chang-zhong Road, Shanghai 200072, P. R. China
2National Center for International Research of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, No. 22 Shuangyong Road 22, Nanning, Guangxi 530021, P. R. China
3Department of Radiology, Liuzhou People’s Hospital, Guangxi Medical University, No. 8 Wenchang Road, Liuzhou, Guangxi 545006, P. R. China

Tài liệu tham khảo

Silva, 2010, Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism, J. Leukoc. Biol., 88, 885, 10.1189/jlb.0410205 Galluzzi, 2018, Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018, Cell Death Differ., 25, 486, 10.1038/s41418-017-0012-4 Friedlander, 1986, Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process, J. Biol. Chem., 261, 7123, 10.1016/S0021-9258(17)38364-3 D'Souza, 2001, Dismantling the cryptococcus coat, Trends Microbiol., 9, 112, 10.1016/S0966-842X(00)01945-4 Kerr, 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer, 26, 239, 10.1038/bjc.1972.33 Zhang, 2018, Plasma membrane changes during programmed cell deaths, Cell Res., 28, 9, 10.1038/cr.2017.133 Shen, 2018, NLRP3: a promising therapeutic target for autoimmune diseases, Autoimmun. Rev., 17, 694, 10.1016/j.autrev.2018.01.020 Pezuk, 2019, Pyroptosis in combinatorial treatment to improve cancer patients' outcome, is that what we want?, Ebiomedicine, 41, 17, 10.1016/j.ebiom.2019.03.007 Fang, 2019, Radiofrequency-sensitive longitudinal relaxation tuning strategy enabling the visualization of radiofrequency ablation intensified by magnetic composite, ACS Appl. Mater. Inter., 11, 11251, 10.1021/acsami.9b02401 Kong, 2022, Abundance and metabolism disruptions of intratumoral microbiota by chemical and physical actions unfreeze tumor treatment resistance, Adv. Sci., 9, 2105523, 10.1002/advs.202105523 Zhang, 2019, Quantum yield-engineered biocompatible probes illuminate lung tumor based on viscosity confinement-mediated antiaggregation, Adv. Funct. Mater., 29, 1905124, 10.1002/adfm.201905124 Yin, 2022, Acute silica exposure triggers pulmonary inflammation through macrophage pyroptosis: an experimental simulation, Front. Immunol., 13, 874459, 10.3389/fimmu.2022.874459 Wu, 2022, Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy, Bioact. Mater., 13, 223 Li, 2021, Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes, Nano Today, 37, 101061, 10.1016/j.nantod.2020.101061 Lu, 2016, CdSe/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation, Biomaterials, 90, 27, 10.1016/j.biomaterials.2016.03.003 Jia, 2021, {BiW8O30} exerts antitumor effect by triggering pyroptosis and upregulating reactive oxygen species, Angew. Chem. Int. Ed. Engl., 60, 21449, 10.1002/anie.202107265 Katifelis, 2022, Ag/Au bimetallic nanoparticles trigger different cell death pathways and affect damage associated molecular pattern release in human cell lines, Cancers (Basel), 14, 1546, 10.3390/cancers14061546 Jiang, 2022, Tetrahedral framework nucleic acids inhibit skin fibrosis via the pyroptosis pathway, ACS Appl. Mater. Inter., 14, 15069, 10.1021/acsami.2c02877 Wei, 2021, Engineered biomimetic nanoplatform protects the myocardium against ischemia/reperfusion injury by inhibiting pyroptosis, ACS Appl. Mater. Inter., 13, 33756, 10.1021/acsami.1c03421 Wu, 2021, Cell death mediated by the pyroptosis pathway with the aid of nanotechnology: prospects for cancer therapy, Angew. Chem. Int. Ed. Engl., 60, 8018, 10.1002/anie.202010281 Rao, 2022, Pyroptosis in inflammatory diseases and cancer, Theranostics, 12, 4310, 10.7150/thno.71086 Zheng, 2020, Mechanisms and therapeutic regulation of pyroptosis in inflammatory diseases and cancer, Int. J. Mol. Sci., 21, E1456, 10.3390/ijms21041456 Ploetz, 2020, Metal-organic framework nanoparticles induce pyroptosis in cells controlled by the extracellular pH, Adv. Mater., 32, 1907267, 10.1002/adma.201907267 Xia, 2022, Hydroxyapatite nanoparticles promote mitochondrial-based pyroptosis via activating calcium homeostasis and redox imbalance in vascular smooth muscle cells, Nanotechnology, 33, 275101, 10.1088/1361-6528/ac61ca Ding, 2021, Biodegradable upconversion nanoparticles induce pyroptosis for cancer immunotherapy, Nano Lett., 21, 8281, 10.1021/acs.nanolett.1c02790 Gao, 2020, Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma, Nat. Biomed. Eng., 4, 743, 10.1038/s41551-020-0583-0 Wu, 2022, Biomimetic nanocarriers guide extracellular ATP homeostasis to remodel energy metabolism for activating innate and adaptive immunity system, Adv. Sci., 9, 2105376, 10.1002/advs.202105376 Zhao, 2020, Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy, Biomaterials, 254, 120142, 10.1016/j.biomaterials.2020.120142 Wu, 2021, Activation of pyroptosis by membrane-anchoring AIE photosensitizer design: new prospect for photodynamic cancer cell ablation, Angew. Chem. Int. Ed. Engl., 60, 9093, 10.1002/anie.202016399 Zhou, 2021, Inspired heat shock protein alleviating prodrug enforces immunogenic photodynamic therapy by eliciting pyroptosis, Nano Res., 15, 3398, 10.1007/s12274-021-3946-2 Yu, 2022, Biomimetic metal-organic framework nanoparticles for synergistic combining of SDT-chemotherapy induce pyroptosis in gastric cancer, Front. Bioeng. Biotechnol., 10, 796820, 10.3389/fbioe.2022.796820 Broz, 2020, The gasdermins, a protein family executing cell death and inflammation, Nat. Rev. Immunol., 20, 143, 10.1038/s41577-019-0228-2 Chen, 2018, Gasdermin family: a promising therapeutic target for stroke, Transl. Stroke Res., 9, 555, 10.1007/s12975-018-0666-3 Yang, 2018, Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor, Proc. Natl. Acad. Sci. USA, 115, 6792, 10.1073/pnas.1800562115 Kuang, 2017, Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis, Proc. Natl. Acad. Sci. USA, 114, 10642, 10.1073/pnas.1708194114 Liu, 2019, Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization, Immunity, 51, 43, 10.1016/j.immuni.2019.04.017 Ding, 2016, Pore-forming activity and structural autoinhibition of the gasdermin family, Nature, 535, 111, 10.1038/nature18590 Xia, 2019, The role of pyroptosis in cancer: pro-cancer or pro-"host"?, Cell Death Dis., 10, 650, 10.1038/s41419-019-1883-8 Liston, 2017, Homeostasis-altering molecular processes as mechanisms of inflammasome activation, Nat. Rev. Immunol., 17, 208, 10.1038/nri.2016.151 Amarante-Mendes, 2018, Pattern recognition receptors and the host cell death molecular machinery, Front. Immunol., 9, 2379, 10.3389/fimmu.2018.02379 Lamkanfi, 2011, Emerging inflammasome effector mechanisms, Nat. Rev. Immunol., 11, 213, 10.1038/nri2936 Aachoui, 2013, Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection, Curr. Opin. Microbiol., 16, 319, 10.1016/j.mib.2013.04.004 Sborgi, 2016, GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death, EMBO J., 35, 1766, 10.15252/embj.201694696 Shi, 2015, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death, Nature, 526, 660, 10.1038/nature15514 Liu, 2016, Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores, Nature, 535, 153, 10.1038/nature18629 Shi, 2014, Inflammatory caspases are innate immune receptors for intracellular LPS, Nature, 514, 187, 10.1038/nature13683 Rühl, 2015, Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux, Eur. J. Immunol., 45, 2927, 10.1002/eji.201545772 Shi, 2017, Pyroptosis: gasdermin-mediated programmed necrotic cell death, Trends Biochem. Sci., 42, 245, 10.1016/j.tibs.2016.10.004 Wang, 2017, Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin, Nature, 547, 99, 10.1038/nature22393 Rogers, 2017, Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death, Nat. Commun., 8, 14128, 10.1038/ncomms14128 Hou, 2020, PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis, Nat. Cell Biol., 22, 1396, 10.1038/s41556-020-00599-1 Liu, 2020, Gasdermin E-mediated target cell pyroptosis by CAR-T cells triggers cytokine release syndrome, Sci. Immunol., 5, eaax7969, 10.1126/sciimmunol.aax7969 Zhang, 2020, Gasdermin E suppresses tumour growth by activating anti-tumour immunity, Nature, 579, 415, 10.1038/s41586-020-2071-9 Zhou, 2020, Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells, Science, 368, eaaz7548, 10.1126/science.aaz7548 Reisetter, 2011, Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles, J. Biol. Chem., 286, 21844, 10.1074/jbc.M111.238519 Yin, 2021, Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma, Nano Today, 36, 101009, 10.1016/j.nantod.2020.101009 Luo, 2021, Switching reactive oxygen species into reactive nitrogen species by photocleaved O2 -released nanoplatforms favors hypoxic tumor repression, Adv. Sci., 8, 2101065, 10.1002/advs.202101065 Zhang, 2018, Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis, Nanoscale, 10, 9141, 10.1039/C8NR00554K Chen, 2022, Pyroptosis activation by photodynamic-boosted nanocatalytic medicine favors malignancy recession, Chem. Eng. J., 441, 136030, 10.1016/j.cej.2022.136030 Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663 Katifelis, 2018, Ag/Au bimetallic nanoparticles induce apoptosis in human cancer cell lines via P53, CASPASE-3 and BAX/BCL-2 pathways, Artif. Cells Nanomed. Biotechnol., 46, S389, 10.1080/21691401.2018.1495645 Zhao, 2020, Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics, Theranostics, 10, 6278, 10.7150/thno.42564 Mirshafiee, 2018, Toxicological profiling of metal oxide nanoparticles in liver context reveals pyroptosis in Kupffer cells and macrophages versus apoptosis in hepatocytes, ACS Nano, 12, 3836, 10.1021/acsnano.8b01086 Rookyard, 2021, A global profile of reversible and irreversible cysteine redox post-translational modifications during myocardial ischemia/reperfusion injury and antioxidant intervention, Antioxid. Redox Signal., 34, 11, 10.1089/ars.2019.7765 Cadenas, 2018, ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection, Free Radic. Biol. Med., 117, 76, 10.1016/j.freeradbiomed.2018.01.024 Del Re, 2019, Fundamental mechanisms of regulated cell death and implications for heart disease, Physiol. Rev., 99, 1765, 10.1152/physrev.00022.2018 Cho, 2020, 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/beta-catenin pathway activation, Nat. Commun., 11, 5321, 10.1038/s41467-020-19173-2 Bijnsdorp, 2010, Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells, Int. J. Cancer, 126, 2457, 10.1002/ijc.24943 Guler, 2018, Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels, Bratisl. Lek. Listy, 119, 692 Balahura, 2021, Cellulose nanofiber-based hydrogels embedding 5-FU promote pyroptosis activation in breast cancer cells and support human adipose-derived stem cell proliferation, opening new perspectives for breast tissue engineering, Pharmaceutics, 13, 1189, 10.3390/pharmaceutics13081189 Bertheau, 2008, TP53 status and response to chemotherapy in breast cancer, Pathobiology., 75, 132, 10.1159/000123851 Cao, 2021, Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity, Signal. Transduct. Target. Ther., 6, 426, 10.1038/s41392-021-00830-x Yang, 2022, Urine-microenvironment-initiated composite hydrogel patch reconfiguration propels scarless memory repair and reinvigoration of the urethra, Adv. Mater., 34, 2109522, 10.1002/adma.202109522 Zhang, 2019, Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence, Nat. Commun., 10, 5380, 10.1038/s41467-019-13115-3 Hu, 2019, Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment, Signal. Transduct. Target. Ther., 4, 28, 10.1038/s41392-019-0062-9 Lamkanfi, 2014, Mechanisms and functions of inflammasomes, Cell, 157, 1013, 10.1016/j.cell.2014.04.007 Zhang, 2020, Smart oral administration of polydopamine-coated nanodrugs for efficient attenuation of radiation-induced gastrointestinal syndrome, Adv. Healthc. Mater., 9, 1901778, 10.1002/adhm.201901778 Lee, 2022, Strategies of perturbing ion homeostasis for cancer therapy, Adv. Ther., 5, 2100189, 10.1002/adtp.202100189 Cao, 2019, Lanthanide-doped nanoparticles with upconversion and downshifting near-infrared luminescence for bioimaging, Inorg. Chem., 58, 9351, 10.1021/acs.inorgchem.9b01071 Dibaba, 2019, Recent progress of energy transfer and luminescence intensity boosting mechanism in Nd3+-sensitized upconversion nanoparticles, J. Rare Earths, 37, 791, 10.1016/j.jre.2019.02.001 Zhu, 2019, Recent progress of rare-earth doped upconversion nanoparticles: synthesis, optimization, and applications, Adv. Sci., 6, 1901358, 10.1002/advs.201901358 Escudero, 2017, Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications, Nanophotonics, 6, 881, 10.1515/nanoph-2017-0007 Wu, 2017, Metal-organic framework (MOF)-based drug/cargo delivery and cancer therapy, Adv. Mater., 29, 1606134, 10.1002/adma.201606134 Wang, 2017, Metal-organic frameworks for biosensing and bioimaging applications, Coord. Chem. Rev., 349, 139, 10.1016/j.ccr.2017.08.015 Goldberg, 2007, Epigenetics: a landscape takes shape, Cell, 128, 635, 10.1016/j.cell.2007.02.006 Hogg, 2020, Targeting the epigenetic regulation of antitumour immunity, Nat. Rev. Drug Discov., 19, 776, 10.1038/s41573-020-0077-5 Li, 2017, Increased IFN gamma(+) T cells are responsible for the clinical responses of low-dose DNA-demethylating agent decitabine antitumor therapy, Clin. Cancer Res., 23, 6031, 10.1158/1078-0432.CCR-17-1201 Fan, 2019, Epigenetics-based tumor cells pyroptosis for enhancing the immunological effect of chemotherapeutic nanocarriers, Nano Lett., 19, 8049, 10.1021/acs.nanolett.9b03245 Xie, 2021, Combination of DNA demethylation and chemotherapy to trigger cell pyroptosis for inhalation treatment of lung cancer, Nanoscale, 13, 18608, 10.1039/D1NR05001J Beavis, 2012, CD73: a potent suppressor of antitumor immune responses, Trends Immunol., 33, 231, 10.1016/j.it.2012.02.009 Ma, 2017, Blockade of adenosine A2A receptor enhances CD8(+) T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma, Mol. Cancer, 16, 99, 10.1186/s12943-017-0665-0 Mandapathil, 2009, Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer, Clin. Cancer Res., 15, 6348, 10.1158/1078-0432.CCR-09-1143 Wang, 2011, CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice, J. Clin. Invest., 121, 2371, 10.1172/JCI45559 Xiong, 2021, Inspired epigenetic modulation synergy with adenosine inhibition elicits pyroptosis and potentiates cancer immunotherapy, Adv. Funct. Mater., 31, 2100007, 10.1002/adfm.202100007 Dinarello, 2018, Overview of the IL-1 family in innate inflammation and acquired immunity, Immunol. Rev., 281, 8, 10.1111/imr.12621 Joosten, 2013, Interleukin-1beta in innate inflammation, autophagy and immunity, Semin. Immunol., 25, 416, 10.1016/j.smim.2013.10.018 Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat. Immunol., 8, 950, 10.1038/ni1497 Kursunel, 2016, The untold story of IFN-gamma in cancer biology, Cytokine Growth Factor Rev., 31, 73, 10.1016/j.cytogfr.2016.07.005 Mantovani, 2019, Interleukin-1 and related cytokines in the regulation of inflammation and immunity, Immunity, 50, 778, 10.1016/j.immuni.2019.03.012 Zhao, 2014, IFN-gamma mediates graft-versus-breast cancer effects via enhancing cytotoxic T lymphocyte activity, Exp. Ther. Med., 8, 347, 10.3892/etm.2014.1760 Senju, 2018, Effect of IL-18 on the expansion and phenotype of human natural killer cells: application to cancer immunotherapy, Int. J. Biol. Sci., 14, 331, 10.7150/ijbs.22809 Volchuk, 2020, Indirect regulation of HMGB1 release by gasdermin D, Nat. Commun., 11, 4561, 10.1038/s41467-020-18443-3 Yang, 2015, High mobility group box protein 1 (HMGB1): the prototypical endogenous danger molecule, Mol. Med., 21, S6, 10.2119/molmed.2015.00087 Yang, 2010, A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release, Proc. Natl. Acad. Sci. USA, 107, 11942, 10.1073/pnas.1003893107 Klune, 2008, HMGB1: endogenous danger signaling, Mol. Med., 14, 476, 10.2119/2008-00034.Klune Wang, 2020, A bioorthogonal system reveals antitumour immune function of pyroptosis, Nature, 579, 421, 10.1038/s41586-020-2079-1 Chaudhary, 2016, Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting, Vaccines, 4, 28, 10.3390/vaccines4030028 Manjili, 2016, Role of Tregs in cancer dormancy or recurrence, Immunol. Invest., 45, 759, 10.1080/08820139.2016.1194428 Hiller, 2018, Perioperative events influence cancer recurrence risk after surgery, Nat. Rev. Clin. Oncol., 15, 205, 10.1038/nrclinonc.2017.194 Predina, 2013, Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery, Proc. Natl. Acad. Sci. USA, 110, E415, 10.1073/pnas.1211850110 Zhao, 2020, Implantable bioresponsive nanoarray enhances postsurgical immunotherapy by activating pyroptosis and remodeling tumor microenvironment, Adv. Funct. Mater., 30, 2005747, 10.1002/adfm.202005747 Paterson, 2010, Listeria and Salmonella bacterial vectors of tumor-associated antigens for cancer immunotherapy, Semin. Immunol., 22, 183, 10.1016/j.smim.2010.02.002 Liu, 2022, Intravenous delivery of living Listeria monocytogenes elicits gasdmermin-dependent tumor pyroptosis and motivates anti-tumor immune response, ACS Nano, 16, 4102, 10.1021/acsnano.1c09818 Han, 2021, Advances in nanomaterial-mediated photothermal cancer therapies: toward clinical applications, Biomedicines, 9, 305, 10.3390/biomedicines9030305 Liu, 2021, Photodynamic immunotherapy of cancers based on nanotechnology: recent advances and future challenges, J. Nanobiotechnol., 19, 160, 10.1186/s12951-021-00903-7 Chen, 2022, A pyroptosis nanotuner for cancer therapy, Nat. Nanotechnol., 17, 788, 10.1038/s41565-022-01125-0 Zhang, 2021, Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis, J. Nanobiotechnol., 19, 161, 10.1186/s12951-021-00897-2 Guan, 2020, Tumor metabolism-engineered composite nanoplatforms potentiate sonodynamic therapy via reshaping tumor microenvironment and facilitating electron-hole pairs' separation, Adv. Funct. Mater., 30, 2000326, 10.1002/adfm.202000326 Lei, 2022, Structure inversion-bridged sequential amino acid metabolism disturbance potentiates photodynamic-evoked immunotherapy, Adv. Funct. Mater., 32, 2103394, 10.1002/adfm.202103394 Mei, 2021, Fluorocarbon-driven photosensitizer assembly decodes energy conversion pathway for suppressing breast tumor, Nano Today, 41, 101305, 10.1016/j.nantod.2021.101305 Zhang, 2022, Biomimetic radiosensitizers unlock radiogenetics for local interstitial radiotherapy to activate systematic immune responses and resist tumor metastasis, J. Nanobiotechnol., 20, 103, 10.1186/s12951-022-01324-w Qian, 2016, Micro/nanoparticle-augmented sonodynamic therapy (SDT): breaking the depth shallow of photoactivation, Adv. Mater., 28, 8097, 10.1002/adma.201602012 Tang, 2019, Chemodynamic therapy: tumour microenvironment-mediated fenton and fenton-like reactions, Angew. Chem. Int. Ed. Engl., 58, 946, 10.1002/anie.201805664 Xu, 2021, Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF, Nanoscale Horiz., 6, 348, 10.1039/D0NH00674B Nash, 2021, Nanoscale metal-organic layer isolates phthalocyanines for efficient mitochondria-targeted photodynamic therapy, J. Am. Chem. Soc., 143, 2194, 10.1021/jacs.0c12330 Zhang, 2022, Engineering multienzyme-mimicking covalent organic frameworks as pyroptosis inducers for boosting antitumor immunity, Adv. Mater., 34, 2108174, 10.1002/adma.202108174 Hou, 2022, Physical & chemical microwave ablation (MWA) enabled by nonionic MWA nanosensitizers repress incomplete MWA-arised liver tumor recurrence, ACS Nano, 16, 5704, 10.1021/acsnano.1c10714 Nadeem, 2021, A virus-spike tumor-activatable pyroptotic agent, Small, 17, 2006599, 10.1002/smll.202006599 Pavlova, 2016, The emerging hallmarks of cancer metabolism, Cell Metab., 23, 27, 10.1016/j.cmet.2015.12.006 Hay, 2016, Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?, Nat. Rev. Cancer, 16, 635, 10.1038/nrc.2016.77 Li, 2020, Self-boosting catalytic nanoreactors integrated with triggerable crosslinking membrane networks for initiation of immunogenic cell death by pyroptosis, Angew. Chem. Int. Ed. Engl., 59, 13526, 10.1002/anie.202004180 Holmström, 2014, Cellular mechanisms and physiological consequences of redox-dependent signalling, Nat. Rev. Mol. Cell Biol., 15, 411, 10.1038/nrm3801 Wang, 2022, Oligomycin A induces apoptosis-to-pyroptosis switch against melanoma with sensitized immunotherapy, Adv. Funct. Mater., 32, 2106332, 10.1002/adfm.202106332 Ji, 2022, Modulation of mitochondrial electron transport chain by pyroptosis nanoagonists for photoresponsive tumor destruction, Nano Today, 44, 101511, 10.1016/j.nantod.2022.101511 Dong, 2017, Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity, Oncoimmunology, 6, 1282589, 10.1080/2162402X.2017.1282589 Jin, 2017, Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway, Biomaterials, 113, 93, 10.1016/j.biomaterials.2016.10.036 Ma, 2016, Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles, Cell Res., 26, 713, 10.1038/cr.2016.53 Ma, 2018, Mechanisms by which dendritic cells present tumor microparticle antigens to CD8(+) T cells, Cancer Immunol. Res., 6, 1057, 10.1158/2326-6066.CIR-17-0716 Wang, 2014, Recent advances in small molecule prodrugs for cancer therapy, Anti Cancer Agents Med. Chem., 14, 418, 10.2174/18715206113139990317 Karmakar, 2020, N-GSDMD trafficking to neutrophil organelles facilitates IL-1 beta release independently of plasma membrane pores and pyroptosis, Nat. Commun., 11, 2212, 10.1038/s41467-020-16043-9 Wang, 2021, An NIR-fluorophore-based theranostic for selective initiation of tumor pyroptosis-induced immunotherapy, Small, 17, 2102610, 10.1002/smll.202102610 Xiao, 2021, Microenvironment-responsive prodrug-induced pyroptosis boosts cancer immunotherapy, Adv. Sci., 8, 2101840, 10.1002/advs.202101840 Hamblin, 2019, Photobiomodulation for traumatic brain injury and stroke, J. Neurosci. Res., 97, 373 Naeser, 2020, Increased functional connectivity within intrinsic neural networks in chronic stroke following treatment with red/near-infrared transcranial photobiomodulation: case series with improved naming in aphasia, Photobiomodul. Photomed. Laser Surg., 38, 115 Kim, 2020, AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice, Brain Behav. Immun., 87, 765, 10.1016/j.bbi.2020.03.011 Kim, 2022, Benefits of a skull-interfaced flexible and implantable multilight emitting diode array for photobiomodulation in ischemic stroke, Adv. Sci., 9, 2104629, 10.1002/advs.202104629 Wang, 2020, Structure and activity of nanozymes: inspirations for de novo design of nanozymes, Mater. Today, 41, 81, 10.1016/j.mattod.2020.08.020 Ma, 2022, Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration, Adv. Mater., 34, 2106723, 10.1002/adma.202106723 Gotts, 2016, Sepsis: pathophysiology and clinical management, Br. Med. J., 353, i1585, 10.1136/bmj.i1585 Rubio, 2019, Current gaps in sepsis immunology: new opportunities for translational research, Lancet Infect. Dis., 19, E422, 10.1016/S1473-3099(19)30567-5 Chen, 2022, Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis, ACS Nano, 16, 2429, 10.1021/acsnano.1c08913 Evavold, 2021, Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway, Cell, 184, 4495, 10.1016/j.cell.2021.06.028 Ou, 2021, Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases, Acta Pharmacol. Sin., 42, 1913, 10.1038/s41401-021-00770-w Kim, 2016, Synergistic nanomedicine by combined gene and photothermal therapy, Adv. Drug Deliv. Rev., 98, 99, 10.1016/j.addr.2015.12.018 Majzoub, 2016, Cationic liposome-nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing, Philos. Trans. A. Math. Phys. Eng. Sci., 374, 20150129 Wong, 2017, Will nanotechnology bring new hope for gene delivery?, Trends Biotechnol., 35, 434, 10.1016/j.tibtech.2016.12.009 Noble, 2014, Ligand-targeted liposome design: challenges and fundamental considerations, Trends Biotechnol., 32, 32, 10.1016/j.tibtech.2013.09.007 van der Meel, 2013, Ligand-targeted particulate nanomedicines undergoing clinical evaluation: current status, Adv. Drug Deliv. Rev., 65, 1284, 10.1016/j.addr.2013.08.012 Wang, 2015, Delivery of oligonucleotides with lipid nanoparticles, Adv. Drug Deliv. Rev., 87, 68, 10.1016/j.addr.2015.02.007 Luan, 2020, GSDMD membrane pore is critical for IL-1 beta release and antagonizing IL-1 beta by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis, Biomaterials, 227, 119570, 10.1016/j.biomaterials.2019.119570 Phinney, 2017, Concise review: MSC-derived exosomes for cell-free therapy, Stem Cells, 35, 851, 10.1002/stem.2575 Le Maitre, 2006, Human disc degeneration is associated with increased MMP 7 expression, Biotech. Histochem., 81, 125, 10.1080/10520290601005298 Le Maitre, 2007, Matrix synthesis and degradation in human intervertebral disc degeneration, Biochem. Soc. Trans., 35, 652, 10.1042/BST0350652 Song, 2017, Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells, J. Cell. Mol. Med., 21, 1373, 10.1111/jcmm.13067 Alcaraz, 2020, Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases, Cells, 9, 98, 10.3390/cells9010098 Liao, 2021, Engineering extracellular vesicles restore the impaired cellular uptake and attenuate intervertebral disc degeneration, ACS Nano, 15, 14709, 10.1021/acsnano.1c04514 Xing, 2021, Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration, J. Nanobiotechnology, 19, 264, 10.1186/s12951-021-00991-5 Niu, 2017, Caspase-1 cleaves PPAR gamma for potentiating the pro-tumor action of TAMs, Nat. Commun., 8, 766, 10.1038/s41467-017-00523-6 van Deventer, 2010, The inflammasome component Nlrp3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells, Cancer Res., 70, 10161, 10.1158/0008-5472.CAN-10-1921 Zhen, 2019, NLRP3 inflammasome and inflammatory bowel disease, Front. Immunol., 10, 276, 10.3389/fimmu.2019.00276 Chow, 2012, NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases, Cancer Res., 72, 5721, 10.1158/0008-5472.CAN-12-0509 Dupaul-Chicoine, 2015, The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity, Immunity, 43, 751, 10.1016/j.immuni.2015.08.013 Kolb, 2016, Obesity-associated NLRC4 inflammasome activation drives breast cancer progression, Nat. Commun., 7, 13007, 10.1038/ncomms13007 Bunt, 2007, Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression, Cancer Res., 67, 10019, 10.1158/0008-5472.CAN-07-2354 Bruchard, 2013, Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth, Nat. Med., 19, 57, 10.1038/nm.2999 Zhang, 2018, Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment, Hepatology, 67, 1872, 10.1002/hep.29681 Lu, 2021, Strategies to package recombinant Adeno-associated virus expressing the N-terminal gasdermin domain for tumor treatment, Nat. Commun., 12, 7155, 10.1038/s41467-021-27407-0 Wu, 2021, Delivery of ultrasmall nanoparticles to the cytosolic compartment of pyroptotic J774A.1 macrophages via GSDMD(Nterm) membrane pores, ACS Appl. Mater. Inter., 13, 50823, 10.1021/acsami.1c17382