Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins
Tài liệu tham khảo
Bertout, 2008, The impact of O 2 availability on human cancer, Nat. Rev. Canc., 8, 967, 10.1038/nrc2540
Janssen, 2005, Hypoxia in head and neck cancer: how much, how important?, Head Neck, 27, 622, 10.1002/hed.20223
Zeng, 2010, Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells, PLOS One, 5, 10.1371/journal.pone.0010966
House, 1956, On respiratory impairment in cancer cells, Science, 124, 267, 10.1126/science.124.3215.267
Kumareswaran, 2012, Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability, J. Cell Sci., 125, 189, 10.1242/jcs.092262
Teicher, 1995, Angiogenesis and cancer metastases: therapeutic approaches, Crit. Rev. Oncol.-Hematol., 20, 9, 10.1016/1040-8428(94)00142-G
Keith, 2007, Hypoxia-inducible factors, stem cells, and cancer, Cell, 129, 465, 10.1016/j.cell.2007.04.019
Walsh, 2014, The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities, Antioxidants Redox Signal., 21, 1516, 10.1089/ars.2013.5378
Ai, 2015, Tumor hypoxia drives immune suppression and immunotherapy resistance, J. Immunother. Canc., 3, P392, 10.1186/2051-1426-3-S2-P392
Kizaka‐Kondoh, 2009, Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia, Canc. Sci., 100, 1366, 10.1111/j.1349-7006.2009.01195.x
Overgaard, 1989, Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study, Int. J. Radiat. Oncol. Biol. Phys., 16, 1065, 10.1016/0360-3016(89)90917-6
Lee, 1995, Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas, Int. J. Radiat. Oncol. Biol. Phys., 32, 567, 10.1016/0360-3016(95)00150-W
Rajendran, 2003, [18 F] FMISO and [18 F] FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression, Eur. J. Nucl. Med. Mol. Imag., 30, 695, 10.1007/s00259-002-1096-7
Mortensen, 2012, FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial, Radiother. Oncol., 105, 14, 10.1016/j.radonc.2012.09.015
Varia, 1998, Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma, Gynecol. Oncol., 71, 270, 10.1006/gyno.1998.5163
Evans, 2000, Detection of hypoxia in human squamous cell carcinoma by EF5 binding, Canc. Res., 60, 2018
Kumar, 2002, Microwave-assisted (radio) halogenation of nitroimidazole-based hypoxia markers, Appl. Radiat. Isot., 57, 697, 10.1016/S0969-8043(02)00185-9
Mannan, 1991, arabinofuranosyl)-2-thtroimidazole, J. Nucl. Med., 32, 1764
Koch, 1979, Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions, Br. J. Canc., 39, 321, 10.1038/bjc.1979.56
Pathan, 2015, FunRich: an open access standalone functional enrichment and interaction network analysis tool, Proteomics, 15, 2597, 10.1002/pmic.201400515
Mi, 2019, Panther version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools, Nucleic Acids Res., 47, D419, 10.1093/nar/gky1038
Kramer, 2014, Causal analysis approaches in ingenuity pathway analysis, Bioinformatics, 30, 523, 10.1093/bioinformatics/btt703
Mowery, 2018, Characterization of novel primary mouse models of HPV-negative squamous cell carcinoma of the oral cavity
Dubois, 2011, Preclinical evaluation and validation of [18F] HX4, a promising hypoxia marker for PET imaging, Proc. Natl. Acad. Sci. Unit. States Am., 108, 14620, 10.1073/pnas.1102526108
Otsu, 1979, A threshold selection method from gray-level histograms, IEEE Trans. Syst. Man Cybernet., 9, 62, 10.1109/TSMC.1979.4310076
Feoktistova, 2016, Crystal violet assay for determining viability of cultured cells, Cold Spring Harb. Protoc., April 1, 10.1101/pdb.prot087379
Wislocki, 1984, Drug residue formation from ronidazole, a 5-nitroimidazole. V. Cysteine adducts formed upon reduction of ronidazole by dithionite or rat liver enzymes in the presence of cysteine, Chem. Biol. Interact., 49, 13, 10.1016/0009-2797(84)90049-8
Brotzel, 2007, Nucleophilicities of amino acids and peptides, Org. Biomol. Chem., 5, 3814, 10.1039/b713778h
Millar, 2007, ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment, Free Radic. Biol. Med., 42, 1165, 10.1016/j.freeradbiomed.2007.01.015
Yaromina, 2006, Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies, Radiother. Oncol., 81, 122, 10.1016/j.radonc.2006.08.010
Hirata, 2017, Tumor microenvironment and differential responses to therapy, Cold Spring Harb. Perspect. Med., 7, a026781, 10.1101/cshperspect.a026781
Overgaard, 1998, A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85, Radiother. Oncol., 46, 135, 10.1016/S0167-8140(97)00220-X
Overgaard, 1994, Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors, Oncol. Res., 6, 509
Varghese, 1980, Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole, Canc. Res., 40, 2165
Edwards, 2013, Reduction of nitroimidazoles in vitro and DNA damage, 53
Zahoor, 1987, Dna damage induced by reduced nitroimidazole drugs, Biochem. Pharmacol., 36, 3299, 10.1016/0006-2952(87)90648-4
Jenner, 1988, Enhancement of Dna damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131, Biochem. Pharmacol., 37, 3837, 10.1016/0006-2952(88)90064-0
Leitsch, 2007, Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase, PLoS Biol., 5, 10.1371/journal.pbio.0050211
Leitsch, 2009, Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance, Mol. Microbiol., 72, 518, 10.1111/j.1365-2958.2009.06675.x
Leitsch, 2012, Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia, Int. J. Parasitol.: Drugs Drug Resist., 2, 166
Lauwaet, 2020, Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis, PLoS Neglected Trop. Dis., 14, 10.1371/journal.pntd.0008224
Baird, 2006, Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1, J. Biol. Chem., 281, 38675, 10.1074/jbc.M608013200
Jain, 2014, Differential hypoxic tolerance is mediated by activation of heat shock response and nitric oxide pathway, Cell Stress Chaperones, 19, 801, 10.1007/s12192-014-0504-9
Nagao, 2019, HIF-1-dependent reprogramming of glucose metabolic pathway of cancer cells and its therapeutic significance, Int. J. Mol. Sci., 20, 238, 10.3390/ijms20020238
Pelicano, 2006, Glycolysis inhibition for anticancer treatment, Oncogene, 25, 4633, 10.1038/sj.onc.1209597
Yamaji, 2003, Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger, Biochim. Biophys. Acta Mol. Cell Res., 1593, 269, 10.1016/S0167-4889(02)00397-X
Higashimura, 2011, Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells, Arch. Biochem. Biophys., 509, 1, 10.1016/j.abb.2011.02.011
Said, 2007, GAPDH is not regulated in human glioblastoma under hypoxic conditions, BMC Mol. Biol., 8, 55, 10.1186/1471-2199-8-55
Ganapathy-Kanniappan, 2013, Tumor glycolysis as a target for cancer therapy: progress and prospects, Mol. Canc., 12, 152, 10.1186/1476-4598-12-152
Tristan, 2011, The diverse functions of GAPDH: views from different subcellular compartments, Cell. Signal., 23, 317, 10.1016/j.cellsig.2010.08.003
Manjunatha, 2009, The mechanism of action of PA-824: novel insights from transcriptional profiling, Commun. Integr. Biol., 2, 215, 10.4161/cib.2.3.7926
Knight, 1996, Inhibition of glyceraldehyde-3-phosphate dehydrogenase in post-ischaemic myocardium, Cardiovasc. Res., 32, 1016, 10.1016/S0008-6363(96)00137-X
Hildebrandt, 2015, Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?, Biol. Chem., 396, 523, 10.1515/hsz-2014-0295
Nakajima, 2007, The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death, J. Biol. Chem., 282, 26562, 10.1074/jbc.M704199200
Kubo, 2016, Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death, Nitric Oxide, 53, 13, 10.1016/j.niox.2015.12.005
Bone, 2000, In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, α-chlorohydrin and 1-chloro-3-hydroxypropanone, Int. J. Androl., 23, 284, 10.1046/j.1365-2605.2000.00243.x
Marcus, 2016, The drug ornidazole inhibits photosynthesis in a different mechanism described for protozoa and anaerobic bacteria, Biochem. J., 473, 4413, 10.1042/BCJ20160433
Phadke, 2009, Glyceraldehyde 3-phosphate dehydrogenase depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines, J. Pharmacol. Exp. Therapeut., 331, 77, 10.1124/jpet.109.155671
Chatterjee, 2018, The multifaceted role of glutathione S-transferases in cancer, Canc. Lett., 433, 33, 10.1016/j.canlet.2018.06.028
Townsend, 2003, The role of glutathione-S-transferase in anti-cancer drug resistance, Oncogene, 22, 7369, 10.1038/sj.onc.1206940
Tew, 1994, Glutathione-associated enzymes in anticancer drug resistance, Canc. Res., 54, 4313
Fletcher, 2015, Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism, Am. J. Physiol. Lung Cell Mol. Physiol., 308, L1274, 10.1152/ajplung.00220.2014
O'dwyer, 1993, Phase I/pharmacokinetic/biochemical study of the nitroimadazole hypoxic cell sensitiser SR2508 (etanidazole) in combination with cyclophosphamide, Br. J. Canc., 68, 756, 10.1038/bjc.1993.424
Kumar, 1986, Inhibition of glutathione peroxidase and glutathione transferase in mouse liver by misonidazole, Biochem. Pharmacol., 35, 3143, 10.1016/0006-2952(86)90399-0
Hanschmann, 2013, Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling, Antioxidants Redox Signal., 19, 1539, 10.1089/ars.2012.4599
Kim, 2007, Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology, Canc. Res., 67, 546, 10.1158/0008-5472.CAN-06-2401
Ding, 2017, Peroxiredoxin 1–an antioxidant enzyme in cancer, J. Cell Mol. Med., 21, 193, 10.1111/jcmm.12955
Zhang, 2014, Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-κB in oral cancer, PLOS One, 9
Reischl, 2007, Imaging of tumor hypoxia with [124i] IAZA in comparison with [18F] FMISO and [18F] FAZA–first small animal PET results, J. Pharm. Pharmaceut. Sci., 10, 203
Tercel, 2011, Agents and methods for detection and/or imaging of hypoxia, Google Patents
Hou, 2016, A novel click chemistry-based method to detect hypoxic tumour cells and characterise their gene expression, Researchspace@ Auckland
Vaupel, 2007, Detection and characterization of tumor hypoxia using pO2 histography, Antioxidants Redox Signal., 9, 1221, 10.1089/ars.2007.1628