The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate

Madison, 1999, Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic, Microbiol Mol Biol Rev, 63, 21, 10.1128/MMBR.63.1.21-53.1999 Steinbuchel, 1995, Diversity of bacterial polyhydroxyalkanoic acids, FEMS Microbiol Lett, 128, 219, 10.1016/0378-1097(95)00125-O Brandl, 1988, Pseudomonas oleovorans as a source of poly(β-hydroxyalkanoates) for potential applications as biodegradable polyesters, Appl Environ Microbiol, 54, 1977, 10.1128/aem.54.8.1977-1982.1988 Chen, 2009, A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry, Chem Soc Rev, 38, 2434, 10.1039/b812677c Chen, 2005, The application of polyhydroxyalkanoates as tissue engineering materials, Biomaterials, 26, 6565, 10.1016/j.biomaterials.2005.04.036 Gao, 2011, The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides, Biomaterials, 32, 3899, 10.1016/j.biomaterials.2011.02.013 McPhee, 2005, Function and therapeutic potential of host defence peptides, J Pept Sci, 11, 677, 10.1002/psc.704 Zasloff, 2002, Antimicrobial peptides of multicellular organisms, Nature, 415, 389, 10.1038/415389a Mader, 2006, Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment, Expert Opin Investig Drugs, 15, 933, 10.1517/13543784.15.8.933 Powers, 2003, The relationship between peptide structure and antibacterial activity, Peptides, 24, 1681, 10.1016/j.peptides.2003.08.023 Schweizer, 2009, Cationic amphiphilic peptides with cancer-selective toxicity, Eur J Pharmacol, 625, 190, 10.1016/j.ejphar.2009.08.043 Shai, 1999, Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by [alpha]-helical antimicrobial and cell non-selective membrane-lytic peptides, Biochim Biophys Acta – Biomembranes, 1462, 55, 10.1016/S0005-2736(99)00200-X Shin, 2001, Antibacterial, antitumor and hemolytic activities of a-helical antibiotic peptide, P18 and it's analogs, J Pept Res, 58, 504, 10.1034/j.1399-3011.2001.00934.x Zasloff, 1987, Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor, Proc Natl Acad Sci U S A, 84, 5449, 10.1073/pnas.84.15.5449 Hancock, 2006, Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies, Nat Biotechnol, 24, 1551, 10.1038/nbt1267 Kuznetsova, 2006, Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents, Bioorg Med Chem Lett, 16, 974, 10.1016/j.bmcl.2005.10.089 Ward, 2005, Accumulation of polyhydroxyalkanoate from styrene and phenylacetic acid by Pseudomonas putida CA-3, Appl Environ Microbiol, 71, 2046, 10.1128/AEM.71.4.2046-2052.2005 Elbahloul, 2009, Large-scale production of poly(3-hydroxyoctanoic acid) by Pseudomonas putida GPo1 and a simplified downstream process, Appl Environ Microbiol, 75, 643, 10.1128/AEM.01869-08 Lee, 1995, Gas chromatography–mass spectrometric analysis and its application to a screening procedure for novel bacterial polyhydroxyalkanoic acids containing long chain saturated and unsaturated monomers, J Ferment Bioeng, 80, 408, 10.1016/0922-338X(95)94214-C Ruth, 2007, Efficient production of (R)-3-hydroxycarboxylic acids by biotechnological conversion of polyhydroxyalkanoates and their purification, Biomacromolecules, 8, 279, 10.1021/bm060585a Merrifield, 1986, Solid phase synthesis, Science, 232, 341, 10.1126/science.3961484 Falchi, 2000, 4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM): a valuable alternative to PyBOP for solid phase peptide synthesis, Synlett, 2, 275, 10.1055/s-2000-6490 Kaiser, 1970, Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides, Anal Biochem, 34, 595, 10.1016/0003-2697(70)90146-6 Hsu, 1999, Melanoma: the Wistar (WM) melanoma cell lines, 259 Hansen, 1989, Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill, J Immunol Methods, 119, 203, 10.1016/0022-1759(89)90397-9 Pegram, 2004, Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer, J Natl Cancer Inst, 96, 739, 10.1093/jnci/djh131 Oleinick, 2002, The role of apoptosis in response to photodynamic therapy: what, where, why, and how, Photochem Photobiol Sci, 1, 1, 10.1039/b108586g Shin, 1999, Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptides, J Pept Res, 53, 82, 10.1111/j.1399-3011.1999.tb01620.x Oh, 1999, NMR structural characterization of cecropin A(1–8) – magainin 2(1–12) and cecropin A(1–8) – melittin(1–12) hybrid peptides, J Pept Res, 53, 578, 10.1034/j.1399-3011.1999.00067.x Hwang, 1998, Structure–function relationships of antimicrobial peptides, Biochem Cell Biol, 76, 235, 10.1139/o98-026 de Kroon, 1997, Phospholipid composition of highly purified mitochondrial outer membrane of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane?, Biochim Biophys Acta, 1325, 108, 10.1016/S0005-2736(96)00240-4 Parlo, 1984, Enhanced rate of citrate export from cholesterol-rich hepatoma mitochondria. The truncated Krebs cycle and other metabolic ramifications of mitochondrial membrane cholesterol, J Biol Chem, 259, 9997, 10.1016/S0021-9258(18)90917-8 Villa, 2004, Mitochondria in tumor cells studied by laser scanning confocal microscopy, J Biomed Opt, 9, 385, 10.1117/1.1646414 Eliassen, 2006, The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo, Int J Cancer, 119, 493, 10.1002/ijc.21886 Tang, 2010, Anticancer mechanism of peptide P18 in human leukemia K562 cells, Org Biomol Chem, 8, 984, 10.1039/b920762g Kroemer, 1998, The mitochondrial death/life regulator in apoptosis and necrosis, Anu Rev Physiol, 60, 619, 10.1146/annurev.physiol.60.1.619 Slee, 1999, Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner, J Cell Biol, 144, 281, 10.1083/jcb.144.2.281 Mader, 2007, Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria, Exp Cell Res, 313, 2634, 10.1016/j.yexcr.2007.05.015 Mader, 2005, Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines, Mol Cancer Ther, 4, 612, 10.1158/1535-7163.MCT-04-0077 Hui, 2002, The combined effects of antibacterial peptide cecropin A and anti-cancer agents on leukemia cells, Anticancer Res, 22, 2811 Ohsaki, 1992, Antitumor activity of magainin analogues against human lung cancer cell lines, Cancer Res, 52, 3534