Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study

Ahmed, 1995, Synthesis and biological evaluation of imidazole based compounds as cytochrome P450 inhibitors, Drug Des. Discov., 13, 27 Amacher, 1997, Hepatic microsomal enzyme induction, β-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat, Toxicol. Appl. Pharmacol., 142, 143, 10.1006/taap.1996.8007 Borg, 1994, Androgens in teleosts fishes, Comp. Biochem. Physiol., 109C, 219 Bradford, 1976, A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Corcoran, 2010, Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish, Crit. Rev. Toxicol., 40, 287, 10.3109/10408440903373590 Daughton, 1999, Pharmaceuticals and personal care products in the environment: agents of subtle change?, Environ. Health Perspect., 107, 907, 10.1289/ehp.99107s6907 Devlin, 2002, Sex determination and sex differentiation in fish: an overview of genetic, physiological and environmental influences, Aquaculture, 208, 191, 10.1016/S0044-8486(02)00057-1 Fent, 2006, Ecotoxicology of human pharmaceuticals, Aquat. Toxicol., 76, 122, 10.1016/j.aquatox.2005.09.009 Fernandes, 2007, Mitochondrial metabolism of 17α-hydroxyprogesterone in male sea bass (Dicentrarchus labrax): a potential target for endocrine disruptors, Aquat. Toxicol., 85, 258, 10.1016/j.aquatox.2007.09.010 Foran, 2004, Reproductive assessment of Japanese medaka (Oryzias latipes) following a four-week fluoxetine (SSRI) exposure, Arch. Environ. Contam. Toxicol., 46, 511, 10.1007/s00244-003-3042-5 Han, 2010, Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzian latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa, Aquat. Toxicol., 98, 256, 10.1016/j.aquatox.2010.02.013 Hemeryck, 2002, Selective serotonin reuptake inhibitors and cytochrome P450 mediated drug–drug interactions: an update, Current Drug Metab., 3, 13, 10.2174/1389200023338017 Kime, 1993, “Classical” and “non-classical” reproductive steroids in fish, Rev. Fish Biol. Fisher., 3, 160, 10.1007/BF00045230 Laville, 2004, Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes, Toxicology, 196, 41, 10.1016/j.tox.2003.11.002 Lister, 2009, Inhibition of egg production in zebra fish by fluoxetine and municipal effluents: a mechanistic evaluation, Aquat. Toxicol., 95, 320, 10.1016/j.aquatox.2009.04.011 Liu, 2000, Expression of cytochrome P45011β (11β-hydroxylase) gene during gonadal sex differentiation and spermatogenesis in rainbow trout, Oncorhynchus mykiss, J. Steroid Biochem. Mol. Biol., 75, 291, 10.1016/S0960-0760(00)00186-2 Mennigen, 2010, Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus, Aquat. Toxicol., 100, 354, 10.1016/j.aquatox.2010.08.016 Monteiro, 2000, Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.). Aquat, Toxicol, 48, 549 Nakamura, 2008, The effects of pH on fluoxetine on Japanese medaka (Oryzias latipes): acute toxicity in fish larvae and bioaccumulation in juvenile fish, Chemosphere, 70, 865, 10.1016/j.chemosphere.2007.06.089 Paterson, 2008, Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes), Chemosphere, 74, 125, 10.1016/j.chemosphere.2008.08.022 Pelkonen, 2008, Inhibition and induction of human cytochrome P450 enzymes: current status, Arch. Toxicol., 82, 667, 10.1007/s00204-008-0332-8 Schnell, 2009, The interference of nitro- and polycyclic musks with endogenous and xenobiotic metabolizing enzymes in carp: an in vitro study, Environ. Sci. Technol., 43, 9458, 10.1021/es902128x Tang, 2003, The metabolism of diclofenac-enzymology and toxicology perspectives, Curr Drug Metab., 11, 319, 10.2174/1389200033489398 Thibaut, 2006, The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: an in vitro study, Environ. Sci. Technol., 40, 5154, 10.1021/es0607483 Weber, 1991, Effect of ketoconazole on human ovarian C17, 20-desmolase and aromatase, J. Steroid. Biochem. Mol. Biol., 38, 213, 10.1016/0960-0760(91)90128-R