Is PCOS an inflammatory process?

Ross, 1999, Atherosclerosis–an inflammatory disease, N Engl J Med, 340, 115, 10.1056/NEJM199901143400207 Carmina, 2007, Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance, J Clin Endocrinol Metab, 92, 2500, 10.1210/jc.2006-2725 Wildman, 2011, Body size phenotypes and inflammation in the Women’s Health Initiative Observational Study, Obesity (Silver Spring), 19, 1482, 10.1038/oby.2010.332 Castell, 1989, Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes, FEBS Lett, 242, 237, 10.1016/0014-5793(89)80476-4 Han, 2004, C-reactive protein promotes monocyte chemoattractant protein-1–mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes, Circulation, 109, 2566, 10.1161/01.CIR.0000131160.94926.6E Venugopal, 2005, Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role, Curr Opin Nephrol Hypertens, 14, 33, 10.1097/00041552-200501000-00006 Ridker, 2003, C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women, Circulation, 107, 391, 10.1161/01.CIR.0000055014.62083.05 Ridker, 2003, C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women, Circulation, 107, 391, 10.1161/01.CIR.0000055014.62083.05 Kelly, 2001, Low grade chronic inflammation in women with polycystic ovarian syndrome, J Clin Endocrinol Metab, 86, 2453, 10.1210/jcem.86.6.7580 Zawdaki, 1992, Diagnostic criteria for polycystic ovary syndrome: towards a rational approach, 377 2004, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome, Fertil Steril, 81, 19, 10.1016/j.fertnstert.2003.10.004 Escobar-Morreale, 2011, Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis, Fertil Steril, 95, 10.1016/j.fertnstert.2010.11.036 Ridker, 2007, C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus, J Am Coll Cardiol, 49, 2129, 10.1016/j.jacc.2007.02.052 Zirlik, 2007, Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study, Arterioscler Thromb Vasc Biol, 27, 2043, 10.1161/ATVBAHA.107.149484 Furtado, 2009, Interleukin-18: an independent predictor of cardiovascular events in patients with acute coronary syndrome after 6 months of follow-up, Coron Artery Dis, 20, 327, 10.1097/MCA.0b013e32832e5c73 Niu, 2009, Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications, Clin Sci (Lond), 117, 95, 10.1042/CS20080581 de Jager, 2008, CCL3 (MIP-1 alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events, J Mol Cell Cardiol, 45, 446, 10.1016/j.yjmcc.2008.06.003 Escobar-Morreale, 2004, Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity, J Clin Endocrinol Metab, 89, 806, 10.1210/jc.2003-031365 Zhang, 2006, Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome, Endocrine, 29, 419, 10.1385/ENDO:29:3:419 Kaya, 2010, Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors, Fertil Steril, 93, 1200, 10.1016/j.fertnstert.2008.10.070 Yang, 2011, Is interleukin-18 associated with polycystic ovary syndrome?, Reprod Biol Endocrinol, 9, 7, 10.1186/1477-7827-9-7 Gonzalez, 2009, Evidence of proatherogenic inflammation in polycystic ovary syndrome, Metabolism, 58, 954, 10.1016/j.metabol.2009.02.022 Glintborg, 2009, Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment, Clin Endocrinol, 71, 652, 10.1111/j.1365-2265.2009.03523.x Hu, 2011, Elevated C-reactive protein and monocyte chemoattractant protein-1 in patients with polycystic ovary syndrome, Eur J Obstet Gynecol Reprod Biol, 157, 53, 10.1016/j.ejogrb.2011.03.015 Hasegawa, 2002, WBC count, atherosclerosis and coronary risk factors, J Atheroscler Thromb, 9, 219, 10.5551/jat.9.219 Brown, 2001, White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort, J Clin Epidemiol, 54, 316, 10.1016/S0895-4356(00)00296-1 Orio, 2005, The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome, J Clin Endocrinol Metab, 90, 2, 10.1210/jc.2004-0628 Kebapcilar, 2009, High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome, Arch Gynecol Obstet, 280, 187, 10.1007/s00404-008-0884-0 Ruan, 2009, Study on chronic low-grade inflammation and influential factors of polycystic ovary syndrome, Med Princ Pract, 18, 118, 10.1159/000189809 Herlihy, 2011, Polycystic ovary syndrome and the peripheral blood white cell count, J Obstet Gynaecol, 31, 242, 10.3109/01443615.2011.553693 Hulsmans, 2010, The vicious circle between oxidative stress and inflammation in atherosclerosis, J Cell Mol Med, 14, 70, 10.1111/j.1582-4934.2009.00978.x Sabuncu, 2001, Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease, Clin Biochem, 34, 407, 10.1016/S0009-9120(01)00245-4 Kuscu, 2009, Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome, Acta Obstet Gynecol Scand, 88, 612, 10.1080/00016340902859315 Fenkci, 2003, Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease, Fertil Steril, 80, 123, 10.1016/S0015-0282(03)00571-5 Dinger, 2005, DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome, Scand J Clin Lab Invest, 65, 721, 10.1080/00365510500375263 Insenser, 2010, Proteomic analysis of plasma in the polycystic ovary syndrome identifies novel markers involved in iron metabolism, acute-phase response, and inflammation, J Clin Endocrinol Metab, 95, 3863, 10.1210/jc.2010-0220 Gonzalez, 2006, Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome, J Clin Endocrinol Metab, 91, 336, 10.1210/jc.2005-1696 Barlovic, 2010, Cardiovascular disease: what’s all the AGE/RAGE about?, Cardiovasc Hematol Disord Drug Targets, 10, 7, 10.2174/187152910790780050 Diamanti-Kandarakis, 2008, Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS), Clin Endocrinol, 69, 634, 10.1111/j.1365-2265.2008.03247.x Diamanti-Kandarakis, 2009, Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome, Eur J Endocrinol, 160, 847, 10.1530/EJE-08-0510 Schulz, 2011, Oxidative stress and endothelial dysfunction in hypertension, Hypertens Res, 34, 665, 10.1038/hr.2011.39 Paradisi, 2001, Polycystic ovary syndrome is associated with endothelial dysfunction, Circulation, 103, 1410, 10.1161/01.CIR.103.10.1410 Orio, 2004, Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome, J Clin Endocrinol Metab, 89, 4588, 10.1210/jc.2003-031867 Tarkun, 2004, Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation, J Clin Endocrinol Metab, 89, 5592, 10.1210/jc.2004-0751 Diamanti-Kandarakis, 2005, Metformin administration improves endothelial function in women with polycystic ovary syndrome, Eur J Endocrinol, 152, 749, 10.1530/eje.1.01910 Carmina, 2006, Endothelial dysfunction in PCOS: role of obesity and adipose hormones, Am J Med, 119, 356.e1, 10.1016/j.amjmed.2005.10.059 Nasiek, 2004, Plasma concentration of soluble intercellular adhesion molecule-1 in women with polycystic ovary syndrome, Gynecol Endocrinol, 19, 208, 10.1080/09513590400014313 Diamanti-Kandarakis, 2006, Inflammatory and endothelial markers in women with polycystic ovary syndrome, Eur J Clin Invest, 36, 691, 10.1111/j.1365-2362.2006.01712.x Moran, 2009, A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome, Clin Sci, 116, 761, 10.1042/CS20080218 Mayr, 2000, Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis, Circulation, 102, 833, 10.1161/01.CIR.102.8.833 Saikku, 1988, Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction, Lancet, 2, 983, 10.1016/S0140-6736(88)90741-6 Ohnishi, 2008, Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus, Metabolism, 57, 1760, 10.1016/j.metabol.2008.08.001 Pellicano, 2003, Helicobacter pylori seropositivity in patients with unstable angina, J Cardiovasc Surg, 44, 605 Xu, 2011, Prospective association of periodontal disease with cardiovascular and all-cause mortality: NHANES III follow-up study, Atherosclerosis, 218, 536, 10.1016/j.atherosclerosis.2011.07.091 Morin-Papunen, 2009, Chlamydia antibodies and self-reported symptoms of oligoamenorrhea and hirsutism: A new etiologic factor in polycystic ovary syndrome?, Fertil Steril, 94, 1799, 10.1016/j.fertnstert.2009.10.021 Yavasoglu, 2009, A novel association between polycystic ovary syndrome and Helicobacter pylori, Am J Med Sci, 338, 174, 10.1097/MAJ.0b013e3181a63c8a Dursun, 2011, Periodontal disease in polycystic ovary syndrome, Fertil Steril, 95, 320, 10.1016/j.fertnstert.2010.07.1052 Tarkun, 2006, association between circulating tumor necrosis factor-alpha, interleukin-6, and insulin resistance in normal-weight women with polycystic ovary syndrome, Metab Syndr Relat Disord, 4, 122, 10.1089/met.2006.4.122 Vgontzas, 2006, Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea, Metabolism, 55, 1076, 10.1016/j.metabol.2006.04.002 Samy, 2009, Clinical significance of inflammatory markers in polycystic ovary syndrome: their relationship to insulin resistance and body mass index, Dis Markers, 26, 163, 10.1155/2009/465203 Toulis, 2009, Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis, Hum Reprod Update, 15, 297, 10.1093/humupd/dmp006 Tosi, 2009, Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome, Eur J Endocrinol, 161, 737, 10.1530/EJE-09-0379 Ridker, 2007, C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus, J Am Coll Cardiol, 49, 2129, 10.1016/j.jacc.2007.02.052 Taylor, 2011, Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome, Hum Reprod, 26, 2226, 10.1093/humrep/der101 Lin, 2011, Imaging of subclinical atherosclerosis: questions and answers, Curr Probl Diagn Radiol, 40, 116, 10.1067/j.cpradiol.2010.02.003 Shroff, 2007, Young obese women with polycystic ovary syndrome have evidence of early coronary atherosclerosis, Clin Endocrinol Metab, 92, 4609, 10.1210/jc.2007-1343 Chang, 2011, Polycystic ovarian syndrome and subclinical atherosclerosis among women of reproductive age in the Dallas heart study, Clin Endocrinol, 74, 89, 10.1111/j.1365-2265.2010.03907.x Lecke, 2011, Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome, Fertil Steril, 95, 2044, 10.1016/j.fertnstert.2011.02.041