A new model for retinal lesion detection of diabetic retinopathy using hierarchical self-organizing maps

Springer Science and Business Media LLC - Tập 3 - Trang 93-101 - 2019
Hossein Ghayoumi Zadeh1,2, Hamidreza Jamshidi3, Ali Fayazi1,2, Mohammad Hossein Gholizadeh1, Cyrus Ahmadi Toussi4,5, Mostafa Danaeian1,2
1Department of Electrical Engineering, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
2Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3Department of Electrical Engineering, Islamic Azad University Kermanshah Branch, Kermanshah, Iran
4Biomedical Engineering, Hakim Sabzevari University, Sabzevar, Iran
5Department of Chemistry, Dalhousie University, Halifax, Canada

Tóm tắt

Diabetes is a disease that impairs blood flow throughout the body. In this disease, the retinal blood vessels may leak and cause retinal swelling known as edema. The person’s sight might be affected if this swelling happens in the central vision area of retina, the macula. In this paper, we proposed a classification system, including a novel combination of Self-Organizing Maps (SOM) for detecting retinal lesions. The proposed system consists of a fast pre-processing step followed by lesion feature extraction and, finally, a detailed classification model. In the pre-processing stage, the system is divided into the three procedures of initial target lesion extraction, optical disk extraction, and eventually extracting retinal blood vessels from the retina. The second step is a combination of multiple features such as morphology, color, intensity, and moments. The classifier is a model of Hierarchical Self-Organizing Maps (HSOM), which aims to increase the accuracy and speed of classifying the lesions while considering the high amount of data in extracting the features. The overall accuracy and sensitivity of the proposed method according to the MESSIDOR database is 97.87% and 98.51%, respectively. The results show that the proposed model can detect and classify the Lesions in HDR images accurately.

Tài liệu tham khảo

Gudla, S., Tenneti, D., Pande, M., Tipparaju, S.M.: Diabetic retinopathy: pathogenesis, treatment, and complications. Drug delivery for the retina and posterior segment disease, pp. 83–94. Springer, Berlin (2018) Harrison, W.W., Bearse, M.A., Ng, J.S., Jewell, N.P., Barez, S., Burger, D., et al.: Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest. Ophthalmol. Vis. Sci. 52(2), 772–777 (2011) Group ETDRSR: Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics: ETDRS report number 7. Ophthalmology 98(5), 741–756 (1991) Qiu, C., Cotch, M.F., Sigurdsson, S., Garcia, M., Klein, R., Jonasson, F., et al.: Retinal and cerebral microvascular signs and diabetes the age, gene/environment susceptibility-reykjavik study. Diabetes 57(6), 1645–1650 (2008) Ege, B.M., Hejlesen, O.K., Larsen, O.V., Møller, K., Jennings, B., Kerr, D., et al.: screening for diabetic retinopathy using computer based image analysis and statistical classification. Comput. Methods Programs Biomed. 62(3), 165–175 (2000) Vallabha, D., Dorairaj, R., Namuduri, K., Thompson, H.: Automated detection and classification of vascular abnormalities in diabetic retinopathy. In: Conference Record of the Thirty-Eighth Asilomar Conference on Signals, Systems and Computer. IEEE, Pacific Grove, CA (2004) Ravishankar, S., Jain, A., Mittal, A.: Automated feature extraction for early detection of diabetic retinopathy in fundus images. In: 2009 IEEE Conference on Computer Vision and Pattern Recognition, pp. 210–217. IEEE Akram, M.U., Khalid, S., Tariq, A., Khan, S.A., Azam, F.: Detection and classification of retinal lesions for grading of diabetic retinopathy. Comput. Biol. Med. 45, 161–171 (2014) Zhang, Y., Bu, W., Su, C., Wang, L., Xu, H.: Intrusion detection method based on improved growing hierarchical self-organizing map. Trans. Tianjin Univ. 22(4), 334–338 (2016) MESSIDOR.: https://messidor.crihan.fr/index-en.php. Accessed 2016 Tyo, J.S., Konsolakis, A., Diersen, D.I., Olsen, R.C.: Principal-components-based display strategy for spectral imagery. IEEE Trans. Geosci. Remote Sens. 41(3), 708–718 (2003) Zhang, Y., Wu, X., Lu, S., Wang, H., Phillips, P., Wang, S.: Smart detection on abnormal breasts in digital mammography based on contrast-limited adaptive histogram equalization and chaotic adaptive real-coded biogeography-based optimization. Simulation. 92(9), 873–885 (2016) Zhang, Y., Ji, T., Li, M., Wu, Q.: Identification of power disturbances using generalized morphological open-closing and close-opening undecimated wavelet. IEEE Trans. Ind. Electron. 63(4), 2330–2339 (2016) Walter, T., Klein, J.-C., Massin, P., Erginay, A.: A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina. IEEE Trans. Med. Imaging 21(10), 1236–1243 (2002) Cao, G., Zhao, Y., Ni, R., Yu, L., Tian, H., editors.: Forensic detection of median filtering in digital images. In”Multimedia and Expo (ICME), 2010 IEEE International Conference on; 2010: IEEE Kawadiwale, R.B/, Mane, V.M., editors.: Evaluation of algorithms for segmentation of retinal blood vessels. In: Pervasive Computing (ICPC), 2015 International Conference on; 2015: IEEE Osareh, A., Mirmehdi, M., Thomas, B., Markham, R.: Automated identification of diabetic retinal exudates in digital color images. Br. J. Ophthalmol. 87(10), 1220–1223 (2003) Carter, J.V., Pan, J., Rai, S.N., Galandiuk, S.: ROC-ing along: evaluation and interpretation of receiver operating characteristic curves. Surgery. 159(6), 1638–1645 (2016)