How and how fast does pain lead to disability? A multilevel mediation analysis on structural, temporal and biopsychosocial pathways in patients with chronic nonspecific low back pain

Allegri, 2016, Mechanisms of low back pain: a guide for diagnosis and therapy, F1000Research, 5, 10.12688/f1000research.8105.2 Booth, 2000, Assessment of physical activity: an international perspective, Res. Q. Exerc. Sport, 71, 114, 10.1080/02701367.2000.11082794 Costa, 2011, Self-efficacy is more important than fear of movement in mediating the relationship between pain and disability in chronic low back pain, Eur. J. Pain (London, England), 15, 213, 10.1016/j.ejpain.2010.06.014 Crighton, 2014, Can brief measures effectively screen for pain and somatic malingering? Examination of the modified somatic perception questionnaire and pain disability index, Spine J. : Off. J. North Am. Spine Soc., 14, 2042, 10.1016/j.spinee.2014.04.012 Dillmann, 1994, Behinderungseinschätzung bei chronischen Schmerzpatienten, Schmerz (Berlin, Germany), 8, 100, 10.1007/BF02530415 Gay, 2015, Investigating dynamic pain sensitivity in the context of the fear-avoidance model, Eur. J. Pain (London, England), 19, 48, 10.1002/ejp.519 Gelfand, 2009, Mediation analysis: a retrospective snapshot of practice and more recent directions, J. Gen. Psychol., 136, 153, 10.3200/GENP.136.2.153-178 Gheldof, 2006, Pain and pain-related fear are associated with functional and social disability in an occupational setting: evidence of mediation by pain-related fear, Eur. J. Pain (London, England), 10, 513, 10.1016/j.ejpain.2005.07.005 Hall, 2011, Symptoms of depression and stress mediate the effect of pain on disability, Pain, 152, 1044, 10.1016/j.pain.2011.01.014 Hawker, 2011, Arthritis Care Res., 63, S240, 10.1002/acr.20543 Hayes, 2019, Conditional process analysis: concepts, computation, and advances in the modeling of the contingencies of mechanisms, Am. Behav. Sci., 28 Kori, 1990, Kinesiophobia: a new view of chronic pain behavior, Pain Manag., 3, 35 Lee, 2015, How does pain lead to disability? A systematic review and meta-analysis of mediation studies in people with back and neck pain, Pain, 156, 988, 10.1097/j.pain.0000000000000146 Lee, 2016, Causal mechanisms in the clinical course and treatment of back pain. Best practice & research, Clin. Rheumatol., 30, 1074 Linton, 2018, Understanding the etiology of chronic pain from a psychological perspective, Phys. Ther., 98, 315, 10.1093/ptj/pzy027 Linton, 2011, Impact of psychological factors in the experience of pain, Phys. Ther., 91, 700, 10.2522/ptj.20100330 Löwe, 2004, Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9), J. Affect. Disord., 81, 61, 10.1016/S0165-0327(03)00198-8 MacKinnon, 2007, Mediation analysis, Annu. Rev. Psychol., 58, 593, 10.1146/annurev.psych.58.110405.085542 Morley, 2015, Well, I wouldn't start from here, Pain, 156, 986, 10.1097/j.pain.0000000000000183 Noll, 2016, Back pain prevalence and its associated factors in Brazilian athletes from public high schools: a cross-sectional study, PloS One, 11, 10.1371/journal.pone.0150542 Pincus, 2013, Twenty-five years with the biopsychosocial model of low back pain-is it time to celebrate? A report from the twelfth international forum for primary care research on low back pain, Spine, 38, 2118, 10.1097/BRS.0b013e3182a8c5d6 Sachs, 2003 1999, 101 Seekatz, 2013, Depressivität als Mediator im Angst-Vermeidungs-Modell : eine pfadanalytische Untersuchung an Patienten mit chronischen Rückenschmerzen, Schmerz (Berlin, Germany), 27, 612, 10.1007/s00482-013-1376-0 Serlin, 1995, When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function, Pain, 61, 277, 10.1016/0304-3959(94)00178-H Tait, 1990, The pain disability index: psychometric properties, Pain, 40, 171, 10.1016/0304-3959(90)90068-O Woo, 2010, Depression and anxiety in pain, Reviews in Pain, 4, 8, 10.1177/204946371000400103 2013, World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects, J. Am. Med. Assoc., 310, 2191, 10.1001/jama.2013.281053