Healthy centenarians show high levels of circulating interleukin-22 (IL-22)

Aujla, 2009, IL-22: a critical mediator in mucosal host defense, J. Mol. Med., 87, 451, 10.1007/s00109-009-0448-1

Caruso, 2004, Aging, longevity, inflammation, and cancer, Ann. N.Y. Acad. Sci., 1028, 1, 10.1196/annals.1322.001

De Martinis, 2005, Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity, FEBS Lett., 579, 2035, 10.1016/j.febslet.2005.02.055

Ershler, 2000, Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty, Annu. Rev. Med., 51, 245, 10.1146/annurev.med.51.1.245

Franceschi, 2000, Do men and women follow different trajectories to reach extreme longevity?, Aging Clin. Exp. Res., 12, 77, 10.1007/BF03339894

Franceschi, 2007, Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans, Mech. Ageing Dev., 128, 92, 10.1016/j.mad.2006.11.016

Frayling, 2007, An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people, J. Gerontol. A: Biol. Sci. Med. Sci., 62, 73, 10.1093/gerona/62.1.73

Gangemi, 2003, Increased circulating interleu-kin-18 levels in centenarians with signs of vascular disease: another paradox of longevity?, Exp. Gerontol., 38, 669, 10.1016/S0531-5565(03)00061-5

Gangemi, 2005, Age-related modifications in circulating IL-15 levels in humans, Mediators Inflamm., 31, 245, 10.1155/MI.2005.245

Gangemi, 2010, Is interleukin-22 a possible indicator of chronic heart failure's progression?, Arch. Gerontol. Geriatr., 50, 311, 10.1016/j.archger.2009.05.003

Giuliani, 2001, Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes, Exp. Gerontol., 36, 547, 10.1016/S0531-5565(00)00220-5

Passeri, 2008, Italian Multicentric Study on Centenarians (IMUSCE). Calcium metabolism and vitamin D in the extreme longevity, Exp. Gerontol., 43, 79, 10.1016/j.exger.2007.06.013

Sanjabi, 2009, Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity, Curr. Opin. Pharmacol., 9, 447, 10.1016/j.coph.2009.04.008

Witte, 2010, Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection, Cytokine Growth Factor Rev., 21, 365, 10.1016/j.cytogfr.2010.08.002

Wolk, 2010, Biology of interleukin-22, Semin. Immunopathol., 32, 17, 10.1007/s00281-009-0188-x