Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives

BioMed Research International - Tập 2015 - Trang 1-16 - 2015
Christiana M. Neophytou1, Andreas I. Constantinou1
1Department of Biological Sciences, Faculty of Pure and Applied Sciences, University of Cyprus, 1678 Nicosia, Cyprus

Tóm tắt

Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E delivery. Furthermore, several drug delivery systems that incorporate Vitamin E isoforms have been synthesized in order to increase the bioavailability of chemotherapeutic agents or to provide a synergistic effect. D-alpha-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) is a synthetic derivative of natural alpha-tocopherol which is gaining increasing interest in the development of drug delivery systems and has also shown promising anticancer effect as a single agent. This review provides a summary of the properties and anticancer effects of the most potent Vitamin E isoforms and an overview of the various formulations developed to improve their efficacy, with an emphasis on the use of TPGS in drug delivery approaches.

Từ khóa


Tài liệu tham khảo

10.1016/j.freeradbiomed.2007.03.024

10.1016/j.freeradbiomed.2014.03.035

10.1161/01.str.0000181082.70763.22

10.1002/ijc.23689

10.1002/bdd.1790

10.1111/j.2042-7158.2003.tb02433.x

10.1124/dmd.109.031567

10.1208/s12248-013-9481-7

10.1007/BF02522884

10.1002/mnfr.200500267

10.1038/sj.bjc.6601360

10.1172/JCI111883

1992, The Journal of Lipid Research, 33, 1171, 10.1016/S0022-2275(20)40769-2

10.1007/s11745-001-0666-z

2006, American Journal of Clinical Nutrition, 84, 835, 10.1093/ajcn/84.4.835

10.1211/0022357011775208

1996, International Journal for Vitamin and Nutrition Research, 66, 217

10.1016/j.freeradbiomed.2005.06.013

1988, Bulletin of Experimental Biology and Medicine, 105, 667, 10.1007/BF00841526

1986, Biulleten' Eksperimental'noĭ Biologii i Meditsiny, 102, 689

10.1016/j.jnutbio.2004.02.006

1984, The American Journal of Clinical Nutrition, 40, 747, 10.1093/ajcn/40.4.747

1985, Journal of Nutrition, 115, 1673, 10.1093/jn/115.12.1673

10.1165/ajrcmb.27.1.4774

10.1046/j.1471-4159.2001.00100.x

10.1016/S0891-5849(99)00139-2

2002, Journal of Nutrition, 132, 443, 10.1093/jn/132.3.443

2000, Journal of Lipid Research, 41, 2009, 10.1016/S0022-2275(20)32362-2

10.1194/jlr.m500143-jlr200

10.1046/j.1365-2443.2003.00676.x

10.1111/j.1749-6632.1989.tb14910.x

10.1016/0005-2760(84)90253-4

10.1196/annals.1331.034

10.1194/jlr.m015560

10.1016/j.bbadis.2011.11.009

10.3109/10715769109088952

10.2174/0929867043365332

10.1016/j.freeradbiomed.2003.10.009

1989, European Journal of Clinical Nutrition, 43, 49

10.1007/bf00054161

10.1093/jnci/90.6.440

10.1158/1055-9965.epi-06-1071

10.1097/01.ju.0000107220.64675.74

2002, Clinical Cancer Research, 8, 863

10.1186/1743-7075-11-52

2005, Experimental Biology and Medicine, 230, 235, 10.1177/153537020523000402

10.1074/jbc.m610028200

10.1016/j.jnutbio.2005.11.001

10.1158/0008-5472.can-11-3103

10.1186/bcr2801

10.1038/sj.bjc.6606019

10.1158/0008-5472.can-03-2327

2003, Molecular Cancer Therapeutics, 2, 437

10.1016/j.mito.2012.07.112

10.1096/fj.00-0251com

10.1371/journal.pone.0011865

10.1046/j.1432-1033.2003.03394.x

10.1016/s1357-2725(02)00272-8

2004, Cellular and Molecular Life Sciences, 61, 1520

10.1016/j.mam.2007.02.003

2011, Free Radical Biology & Medicine, 50, 1546, 10.1016/j.freeradbiomed.2011.02.032

10.1073/pnas.0931245100

10.1179/1351000213y.0000000064

10.1089/ars.2013.5594

10.1016/j.jconrel.2012.05.031

1986, Cancer Research, 46, 6387

10.1007/978-1-60761-609-2_3

10.1002/ijc.21171

10.1016/j.taap.2009.01.027

10.1007/s00280-004-0817-y

10.1016/j.biomaterials.2005.05.042

10.1007/s11095-006-9132-0

10.1016/s0168-3659(99)00248-5

10.1016/j.ijpharm.2011.12.004

10.3109/03639045.2014.935390

10.1002/adhm.201200431

10.1016/j.jconrel.2014.12.029

10.1016/j.jconrel.2009.08.017

10.1016/j.jconrel.2011.04.015

10.1016/j.biopha.2009.09.018

2010, Anticancer Research, 30, 429

10.1007/s11745-007-3102-0

10.1146/annurev-physchem-032210-103436

10.1016/j.ejps.2012.12.011

10.3109/10717544.2014.966925

10.1016/j.ejpb.2014.04.016

2012, Biomaterials, 33, 4889, 10.1016/j.biomaterials.2012.03.046

10.1016/j.ejps.2013.02.006

1994, The American Journal of Clinical Nutrition, 59, 1270, 10.1093/ajcn/59.6.1270

1993, Gastroenterology, 104, 1727, 10.1016/0016-5085(93)90652-S

10.1016/s0022-3476(87)80196-8

10.1007/s11095-005-9262-9

10.1016/j.ejps.2005.04.003

10.1021/jf60210a002

2007, EFSA Journal

1988, The American Journal of Clinical Nutrition, 48, 605, 10.1093/ajcn/48.3.605

10.1016/s0168-3659(02)00025-1

10.1002/bit.21924

10.1023/a:1015000503629

10.1016/j.ijpharm.2005.08.026

10.2217/17435889.1.3.297

10.1016/j.biomaterials.2005.11.008

10.1016/j.actbio.2011.06.015

2005

10.1016/j.jconrel.2005.05.014

10.1080/01635581.2012.630167

10.1016/j.bcp.2014.02.003

10.1016/j.ejpb.2011.11.016

10.1023/A:1018939006780

10.1016/S0009-9236(96)80007-5

10.1002/jps.20553

10.1021/mp060121r

10.1016/j.ejpb.2010.06.008

10.1016/j.jconrel.2005.11.005

10.1016/j.ejpb.2010.12.033

10.1016/j.jconrel.2011.03.017

10.1016/j.actbio.2014.12.001

10.1517/17425247.2014.951634

10.1016/j.biomaterials.2014.01.003

10.1016/j.ijpharm.2011.09.045

10.1016/j.biomaterials.2014.11.008

10.1016/j.ijpharm.2012.08.038

2015, Chemical and Pharmaceutical Bulletin, 63, 68, 10.1248/cpb.c14-00423

10.1016/j.colsurfb.2014.10.007

10.1016/j.colsurfb.2014.06.059

10.1016/j.ejpb.2014.09.013

10.1016/j.biomaterials.2011.02.022

10.1021/bc400326y

10.2147/ijn.s73971

10.1158/2159-8290.CD-11-0348

10.1038/nrn2685