Mefenamic acid taste-masked oral disintegrating tablets with enhanced solubility via molecular interaction produced by hot melt extrusion technology

Chaudhary, 2013, Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design, Bull. Fac. Pharm. Cairo Univ., 51, 193, 10.1016/j.bfopcu.2013.05.002 Hearnden, 2012, New developments and opportunities in oral mucosal drug delivery for local and systemic disease, Adv. Drug Deliv. Rev., 64, 16, 10.1016/j.addr.2011.02.008 Park, 2013, Drug release-modulating mechanism of hydrophilic hydroxypropylmethylcellulose matrix tablets: distribution of atoms and carrier and texture analysis, Curr. Drug Deliv., 10, 732, 10.2174/156720181006131125155652 Sattar, 2014, Oral transmucosal drug delivery–current status and future prospects, Int. J. Pharm., 471, 498, 10.1016/j.ijpharm.2014.05.043 Abdelbary, 2005, Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration, Int. J. Pharm., 292, 29, 10.1016/j.ijpharm.2004.08.019 Huang, 2012, Comparative fasting bioavailability of dispersible and conventional tablets of risperidone: a single-dose, randomized-sequence, open-label, two-period crossover study in healthy male Chinese volunteers, Clin. Ther., 34, 1432, 10.1016/j.clinthera.2012.04.027 Narmada, 2009, Formulation, evaluation and optimization of fast dissolving tablets containing amlodipine besylate by sublimation method, ARS Pharm., 50, 129 Kim, 2013, In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex, Int. J. Pharm., 455, 31, 10.1016/j.ijpharm.2013.07.072 Liu, 2013, Use of polymer combinations in the preparation of solid dispersions of a thermally unstable drug by hot-melt extrusion, Acta Pharm. Sin. B, 3, 263, 10.1016/j.apsb.2013.06.007 Shah, 2013, Melt extrusion with poorly soluble drugs, Int. J. Pharm., 453, 233, 10.1016/j.ijpharm.2012.11.001 Tran, 2013, Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion, Int. J. Pharm., 450, 79, 10.1016/j.ijpharm.2013.04.022 Vo, 2013, Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs, Eur. J. Pharm. Biopharm., 85, 799, 10.1016/j.ejpb.2013.09.007 Crowley, 2007, Pharmaceutical applications of hot-melt extrusion: part I, Drug Dev. Ind. Pharm., 33, 909, 10.1080/03639040701498759 Vemula, 2010, Solubility enhancement techniques, Int. J. Pharm. Sci. Rev. Res., 5, 41 Khan, 2014, Enhanced dissolution and bioavailability of grapefruit flavonoid naringenin by solid dispersion utilizing fourth generation carrier, Drug Dev. Ind. Pharm., 1, 10.3109/03639045.2014.902466 Madana, 2012, Hot melt extrusion and its pharmaceutical applications, Asian J. Pharmacol., 7, 123 Mohammed, 2012, Klucel™ EF and ELF polymers for immediate-release oral dosage forms prepared by melt extrusion technology, AAPS PharmSciTech, 13, 1158, 10.1208/s12249-012-9834-z Park, 2013, New investigation of distribution imaging and content uniformity of very low dose drugs using hot-melt extrusion method, Int. J. Pharm., 458, 245, 10.1016/j.ijpharm.2013.10.027 Reintjes, 2011, 2011 Maniruzzaman, 2012, Taste masking of paracetamol by hot-melt extrusion: an in vitro and in vivo evaluation, Eur. J. Pharm. Biopharm., 80, 433, 10.1016/j.ejpb.2011.10.019 Zeinolabedini Hezave, 2012, Measurement and modeling of mefenamic acid solubility in supercritical carbon dioxide, Fluid Phase Equilibria, 313, 140, 10.1016/j.fluid.2011.09.031 Adam, 2000, Some physicochemical properties of mefenamic acid, Drug Dev. Ind. Pharm., 26, 477, 10.1081/DDC-100101258 Dixit, 2011, Enhancing solubility and dissolution of mefenamic acid by freeze drying, Bio Phys., 39, 5026 Kojima, 2012, Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT® EPO, Pharm. Res., 29, 2777, 10.1007/s11095-011-0655-7 Sultana, 2012, RP-HPLC method for the simultaneous determination of lisinopril and NSAIDs in API, pharmaceutical formulations and human serum, Am. J. Anal. Chem., 3, 147, 10.4236/ajac.2012.32021 Kim, 2012, Investigation of an active film coating to prepare new fixed-dose combination tablets for treatment of diabetes, Int. J. Pharm., 427, 201, 10.1016/j.ijpharm.2012.01.057 Deng, 2013, Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion, Drug Dev. Ind. Pharm., 39, 290, 10.3109/03639045.2012.679280 Repka, 2012, Melt extrusion: process to product, Expert Opin. Drug Deliv., 9, 105, 10.1517/17425247.2012.642365 Sarode, 2013, Hot melt extrusion (HME) for amorphous solid dispersions: predictive tools for processing and impact of drug–polymer interactions on supersaturation, Eur. J. Pharm. Sci., 48, 371, 10.1016/j.ejps.2012.12.012 Klose, 2011, Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3, Br. J. Pharmacol., 162, 1757, 10.1111/j.1476-5381.2010.01186.x Ewing, 2014, Stability of indomethacin with relevance to the release from amorphous solid dispersions studied with ATR-FTIR spectroscopic imaging, Eur. J. Pharm. Sci., 60, 64, 10.1016/j.ejps.2014.05.001 Keen, 2014, Investigation of process temperature and screw speed on properties of a pharmaceutical solid dispersion using corotating and counter-rotating twin-screw extruders, J. Pharm. Pharmacol., 66, 204, 10.1111/jphp.12106 Konno, 2006, Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine, J. Pharm. Sci., 95, 2692, 10.1002/jps.20697 Sathigari, 2012, Amorphous-state characterization of efavirenz—polymer hot-melt extrusion systems for dissolution enhancement, J. Pharm. Sci., 101, 3456, 10.1002/jps.23125 Sree Giri Prasad, 2013, Formulation and evaluation of taste masked orodispersible tablets of amlodipine besylate by direct compression, Int. Res. J. Pharm., 2230 Singh, 2013, Development and characterization of taste masked efavirenz pellets utilizing hot melt extrusion, J. Drug Deliv. Sci. Tech., 23, 157, 10.1016/S1773-2247(13)50024-4 Chiappetta, 2009, Indinavir-loaded pH-sensitive microparticles for taste masking: toward extemporaneous pediatric anti-HIV/AIDS liquid formulations with improved patient compliance, AAPS PharmSciTech, 10, 1, 10.1208/s12249-008-9168-z Walsh, 2014, Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients, Adv. Drug Deliv. Rev., 73, 14, 10.1016/j.addr.2014.02.012 Wang, 2014, Preparation and evaluation of taste masked oral suspension of arbidol hydrochloride, AJPS Chiappetta, 2010, A highly concentrated and taste-improved aqueous formulation of efavirenz for a more appropriate pediatric management of the anti-HIV therapy, Curr. HIV Res., 8, 223, 10.2174/157016210791111142