The effect of phenobarbital on rate of forgetting and proactive interference in delayed matching to sample
Tóm tắt
The barbiturate phenobarbital impairs the performance of nonhumans in delayed matching-to-sample procedures. In the present study, the performance of pigeons in a delayed matching-to-sample task was examined as a function of dose level of intraperitoneal phenobarbital administration. Percent-correct matching accuracy decreased with increasing delay-interval duration to a greater extent under 20- and 30-mg/kg doses of phenobarbital than for vehicle control and 10-mg/kg conditions. That is, phenobarbital accentuated rate of forgetting. Rate of forgetting was also assessed in terms of the rate parameter of negative exponential functions fitted to discriminability measures for different delay intervals, thus allowing a separation of memorial from attentional influences. Proactive interference was evident as a greater rate of forgetting for trials in which the sample stimulus to be remembered differed from that on the preceding trial, compared with trials in which the consecutive sample stimuli were the same. Increasing dose levels of phenobarbital attenuated proactive interference. Phenobarbital therefore impairs memorial function and limits the influence of information gained from previous trials in guiding or steering performance on the current trial.
Tài liệu tham khảo
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