Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

Cell Chemical Biology - Tập 29 - Trang 215-225.e5 - 2022
Erin E. Soule1,2, Haixiang Yu2, Lyra Olson1,2, Ibtehaj Naqvi2, Shekhar Kumar3, Sriram Krishnaswamy3, Bruce A. Sullenger1,2
1Department of Pharmacology & Cancer Biology, Duke University, Durham, NC 27710, USA
2Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
3The Children’s Hospital of Philadelphia, Division of Hematology, Department of Pediatrics, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA

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