Regulation of Ceramide Biosynthesis by TOR Complex 2
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Audhya, 2004, Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton, EMBO J., 23, 3747, 10.1038/sj.emboj.7600384
Beeler, 1998, The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant, J. Biol. Chem., 273, 30688, 10.1074/jbc.273.46.30688
Bultynck, 2006, Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease, Mol. Cell. Biol., 26, 4729, 10.1128/MCB.01973-05
Canton, 2006, The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton, Cell. Signal., 18, 267, 10.1016/j.cellsig.2005.07.008
Clarke, 2006, Neutral sphingomyelinases and nSMase2: bridging the gaps, Biochim. Biophys. Acta, 1758, 1893, 10.1016/j.bbamem.2006.06.025
Cowart, 2007, Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function, Biochim. Biophys. Acta, 1771, 421, 10.1016/j.bbalip.2006.08.005
Cowart, 2006, Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae, Biochem. J., 393, 733, 10.1042/BJ20050643
Daquinag, 2007, The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress, Mol. Cell. Biol., 27, 633, 10.1128/MCB.00461-06
Dickson, 1999, Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae, Biochim. Biophys. Acta, 1438, 305, 10.1016/S1388-1981(99)00068-2
Dickson, 2002, Sphingolipid functions in Saccharomyces cerevisiae, Biochim. Biophys. Acta, 1583, 13, 10.1016/S1388-1981(02)00210-X
Dickson, 1997, Sphingolipids are potential heat stress signals in Saccharomyces, J. Biol. Chem., 272, 30196, 10.1074/jbc.272.48.30196
Dickson, 2006, Functions and metabolism of sphingolipids in Saccharomyces cerevisiae, Prog. Lipid Res., 45, 447, 10.1016/j.plipres.2006.03.004
Dilova, 2004, Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1p/Rtg3p-dependent genes, J. Biol. Chem., 279, 46527, 10.1074/jbc.M409012200
Dunn, 1998, Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain, Yeast, 14, 311, 10.1002/(SICI)1097-0061(19980315)14:4<311::AID-YEA220>3.0.CO;2-B
Ferguson-Yankey, 2002, Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast, Yeast, 19, 573, 10.1002/yea.861
Friant, 2001, Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast, EMBO J., 20, 6783, 10.1093/emboj/20.23.6783
Geitz, 1998, Transformation of yeast by the lithium acetate/single-stranded carrier DNA/PEG method, 10.1016/S0580-9517(08)70325-8
Guillas, 2001, C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p, EMBO J., 20, 2655, 10.1093/emboj/20.11.2655
Guillas, 2003, Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast, J. Biol. Chem., 278, 37083, 10.1074/jbc.M307554200
Haak, 1997, Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p, J. Biol. Chem., 272, 29704, 10.1074/jbc.272.47.29704
Hanna, 1995, Casein kinase II is required for cell cycle progression during G1 and G2/M in Saccharomyces cerevisiae, J. Biol. Chem., 270, 25905, 10.1074/jbc.270.43.25905
Hannun, 1996, Functions of ceramide in coordinating cellular responses to stress, Science, 274, 1855, 10.1126/science.274.5294.1855
Hannun, 2002, The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind, J. Biol. Chem., 277, 25847, 10.1074/jbc.R200008200
Helliwell, 1998, TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae, Genetics, 148, 99, 10.1093/genetics/148.1.99
Ho, 2005, Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex, Curr. Genet., 47, 273, 10.1007/s00294-005-0570-8
Horton, 1993, Gene splicing by overlap extension, Methods Enzymol., 217, 270, 10.1016/0076-6879(93)17067-F
Huwiler, 2007, Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy, Crit. Rev. Oncol. Hematol., 63, 150, 10.1016/j.critrevonc.2007.04.010
Hwang, 2001, Synthetic phytoceramides induce apoptosis with higher potency than ceramides, Mol. Pharmacol., 59, 1249, 10.1124/mol.59.5.1249
Jenkins, 1997, Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae, J. Biol. Chem., 272, 32566, 10.1074/jbc.272.51.32566
Kamada, 2005, Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization, Mol. Cell. Biol., 25, 7239, 10.1128/MCB.25.16.7239-7248.2005
Kim, 2000, Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae, Genetics, 156, 1519, 10.1093/genetics/156.4.1519
Kobayashi, 2003, Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p, Eukaryot. Cell, 2, 284, 10.1128/EC.2.2.284-294.2003
Kohlwein, 2001, Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae, Mol. Cell. Biol., 21, 109, 10.1128/MCB.21.1.109-125.2001
Lester, 2001, High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate, Anal. Biochem., 298, 283, 10.1006/abio.2001.5368
Liu, 2005, The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9, J. Biol. Chem., 280, 22679, 10.1074/jbc.M502972200
Liu, 2005, Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae, Biochem. Soc. Trans., 33, 1170, 10.1042/BST20051170
Loewith, 2002, Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control, Mol. Cell, 10, 457, 10.1016/S1097-2765(02)00636-6
Longtine, 1998, Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae, Yeast, 14, 953, 10.1002/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U
Muhlrad, 1992, A rapid method for localized mutagenesis of yeast genes, Yeast, 8, 79, 10.1002/yea.320080202
Mulet, 2006, Mutual antagonism of target of rapamycin and calcineurin signaling, J. Biol. Chem., 281, 33000, 10.1074/jbc.M604244200
Nagiec, 1998, The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases, J. Biol. Chem., 273, 19437, 10.1074/jbc.273.31.19437
Obeid, 2003, Ceramide, stress, and a “LAG” in aging, Sci. Aging Knowledge Environ., 2003, PE27, 10.1126/sageke.2003.39.pe27
Obeid, 2002, Yeast sphingolipids: metabolism and biology, Biochim. Biophys. Acta, 1585, 163, 10.1016/S1388-1981(02)00337-2
Posse de Chaves, 2006, Sphingolipids in apoptosis, survival and regeneration in the nervous system, Biochim. Biophys. Acta, 1758, 1995, 10.1016/j.bbamem.2006.09.018
Powers, 2007, TOR signaling and S6 kinase 1: Yeast catches up, Cell Metab., 6, 1, 10.1016/j.cmet.2007.06.009
Pringle, 1989, Fluorescence microscopy methods for yeast, Methods Cell Biol., 31, 357, 10.1016/S0091-679X(08)61620-9
Ramjit, 2005, A novel coaxial electrospray ionization method for characterizing hexacosanoylceramides by Fourier transform ion cyclotron resonance mass spectrometry, Rapid Commun. Mass Spectrom., 19, 1257, 10.1002/rcm.1926
Reinke, 2004, TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae, J. Biol. Chem., 279, 14752, 10.1074/jbc.M313062200
Rethinaswamy, 1998, Temperature-sensitive mutations of the CKA1 gene reveal a role for casein kinase II in maintenance of cell polarity in Saccharomyces cerevisiae, J. Biol. Chem., 273, 5869, 10.1074/jbc.273.10.5869
Schorling, 2001, Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae, Mol. Biol. Cell, 12, 3417, 10.1091/mbc.12.11.3417
Sikorski, 1989, A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae, Genetics, 122, 19, 10.1093/genetics/122.1.19
Sims, 2004, Yeast sphingolipid metabolism: clues and connections, Biochem. Cell Biol., 82, 45, 10.1139/o03-086
Skrzypek, 1999, Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces, J. Bacteriol., 181, 1134, 10.1128/JB.181.4.1134-1140.1999
Spiegel, 2000, Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors, Ann. N Y Acad. Sci., 905, 54, 10.1111/j.1749-6632.2000.tb06537.x
Spiegel, 2000, Sphingosine-1-phosphate: signaling inside and out, FEBS Lett., 476, 55, 10.1016/S0014-5793(00)01670-7
Sun, 2000, Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast, Mol. Cell. Biol., 20, 4411, 10.1128/MCB.20.12.4411-4419.2000
Tabuchi, 2006, The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation, Mol. Cell. Biol., 26, 5861, 10.1128/MCB.02403-05
Taha, 2006, Sphingosine kinase: biochemical and cellular regulation and role in disease, J. Biochem. Mol. Biol., 39, 113, 10.5483/BMBRep.2006.39.2.113
Tani, 2006, Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis, Biochem. J., 394, 237, 10.1042/BJ20051354
Umen, 1996, Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3′ splice site selection, Genetics, 143, 723, 10.1093/genetics/143.2.723
Vallee, 2005, Lip1p: a novel subunit of acyl-CoA ceramide synthase, EMBO J., 24, 730, 10.1038/sj.emboj.7600562
Venable, 1995, Role of ceramide in cellular senescence, J. Biol. Chem., 270, 30701, 10.1074/jbc.270.51.30701
Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016
Yamaoka, 2004, Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells, J. Biol. Chem., 279, 18688, 10.1074/jbc.M401205200