Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

Centers for Disease Control and Prevention. Severe acute respiratory syndrome (SARS) case definition (http://www.cdc.gov/ncidod/sars/casedefinition.htm). Chan, 2004, Immunofluorescence assay for serological diagnosis of severe acute respiratory syndrome, Emerg. Infect. Dis., 10, 530, 10.3201/eid1003.030493 Cheng, 2004, Viral replication in the nasopharynx is associated with diarrhea in patients with severe acute respiratory syndrome, Clin. Infect. Dis., 38, 467, 10.1086/382681 Cyranoski, 2003, Critics slam treatment for SARS as ineffective and perhaps dangerous, Nature, 423, 4, 10.1038/423004a Ho, 2003, High dose pulse versus non-pulse corticosteroid regimens in severe acute respiratory syndrome, Am. J. Respir. Crit. Care Med., 168, 1449, 10.1164/rccm.200306-766OC Hui DSC, Wong KT, Antonio GE, Lee N, Wu A, Wong V, et al. Severe Acute Respiratory Syndrome (SARS): correlation of clinical outcome and radiological features. Radiology, in press. Lee, 2003, A major outbreak of severe acute respiratory syndrome in Hong Kong, N. Engl. J. Med., 348, 1986, 10.1056/NEJMoa030685 Loutfy, 2003, Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study, J. Am. Med. Assoc., 290, 3222, 10.1001/jama.290.24.3222 Ng, 2003, Quantitative analysis and prognostic implication of SARS—Coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome, Clin. Chem., 49, 1976, 10.1373/clinchem.2003.024125 Oba, 2003, The use of corticosteroids in SARS. Correspondence, N. Engl. J. Med., 348, 2034, 10.1056/NEJM200305153482017 O’Donnell, 2003, SARS: understanding the Coronavirus: apoptosis may explain lymphopenia of SARS, Br. Med. J., 327, 620, 10.1136/bmj.327.7415.620-b Peiris, 2003, The severe acute respiratory syndrome, N. Engl. J. Med., 349, 2431, 10.1056/NEJMra032498 Peiris, 2003, Clinical progression and viral load in a community outbreak of Coronavirus-associated SARS pneumonia: a prospective study, Lancet, 361, 1767, 10.1016/S0140-6736(03)13412-5 Sung, 2004, Severe Acute Respiratory Syndrome: report of treatment and outcome after a major outbreak, Thorax, 59, 414, 10.1136/thx.2003.014076 Tsang, 2003, Coronavirus-positive nasopharyngeal aspirate as predictor for Severe Acute Respiratory Syndrome mortality, Emerg. Infect. Dis., 9, 1381, 10.3201/eid0911.030400 Wang, 2003, Fatal aspergillosis in a patient with SARS who was treated with corticosteroids, N. Engl. J. Med., 349, 507, 10.1056/NEJM200307313490519 Wong, 2003, Severe acute respiratory syndrome (SARS): epidemiology, diagnosis and management, Thorax, 58, 558, 10.1136/thorax.58.7.558 Wong, 2003, Severe Acute Respiratory Syndrome: radiographic appearances and pattern of progression in 138 patients, Radiology, 228, 401, 10.1148/radiol.2282030593 Wong, 2003, Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis, Br. Med. J., 21, 1358, 10.1136/bmj.326.7403.1358 World Health Organization. PCR primers for SARS developed by WHO Network Laboratories. http://www.who.int/csr/sars/primers/en/.