High-yield production of erythritol from raw glycerol in fed-batch cultures of Yarrowia lipolytica
Tóm tắt
An acetate-negative mutant of Yarrowia lipolytica Wratislavia K1 was selected that, when grown with 300 g raw glycerol l−1 at pH 3, produced 170 g erythritol l−1 after 7 days, corresponding to a 56% yield and a productivity of 1 g l−1 h−1. The Wratislavia K1 strain did not produce citric acid.
Tài liệu tham khảo
Aoki MAY, Pastore GM, Park YK (1993) Microbial transformation of sucrose and glucose to erythritol. Biotechnol Lett 15:338–383
Baek H, Song KH, Park SM, Kim SY, Hyun HH (2003) Role of glucose in the bioconversion of fructose into mannitol by Candida magnoliae. Biotechnol Lett 25:761–765
Ishizuka H, Wako K, Kasumi T, Sasaki T (1989) Breeding of a mutant of Aureobasidium sp with high erythritol production. J Ferment Bioeng 68:310–314
Kawanabe J, Hiraswa M, Takeuchi T, Oda T, Ikeda T (1992) Non-cariogenicity of erythritol as a substrate. Caries Res 26:358–362
Kim SY, Lee KH, Kim JH, Oh DK (1997) Erythritol production by controlling osmotic pressure in Trigonopsis variabilis. Biotechnol Lett 19(8):727–729
Kim KA, Noh BS, Lee JK, Kim SY, Park YC, Oh DK (2000) Optimization of culture conditions for erythritol production by Torula sp. J Microbiol Biotechnol 10:69–74
Koutinas AA, Wang RH, Webb C (2007) The biochemurgist–Bioconversion of agricultural raw materials for chemical production. Biofuels Bioprod Bioref 1(1):24–38
Lee JK, Ha SJ, Kim SY, Oh DK (2000) Increased erythritol production in Torula sp by Mn2+ and Cu2+. Biotechnol Lett 22:983–986
Lin SJ, Wen CY, Liau JC, Chu WS (2001) Screening and production of erythritol by newly isolated osmophilic yeast-like fungi. Process Biochem 36:1249–1258
Marina AYA, Glaucia MP, Park YK (1993) Microbial transformation of sucrose and glucose to erythritol. Biotechnol Lett 15:383–388
Papanikolaou S, Fakas S, Fick M, Chevalot I, Galiotou-Panayotou M (2008) Biotechnological valorisation of raw glycerol discharged after bio-diesel (fatty acid methyl esters) manufacturing process: Production of 1, 3-propanediol, citric acid and single cell oil. Biomass Bioeng 32:60–71
Park J, Seo B, Kim J, Park J (1998) Production of erythritol in fed-batch cultures of Trichosporon sp. J Ferment Bioeng 86(6):577–580
Rymowicz W, Rywińska A, Żarowska B, Juszczyk P (2006) Citric acid production from raw glycerol by acetate mutants of Yarrowia lipolytica. Chem Pap 60(5):391–394
Rymowicz W, Rywińska A, Gładkowski W (2008) Simultaneous production of citric acid and erythritol from crude glycerol by Yarrowia lipolytica Wratislavia K1. Chem Pap 62(3):239–246
Ryu YW, Park CY, Park JB, Kim SY, Seo JH (2000) Optimization of erythritol production by Candida magnoliae in fed-batch culture. J Ind Microbiol Biotechnol 25:100–103
Veigada-Cunha M, Firme P, San-Romao MV, Santos H (1992) Application of 13C nuclear magnetic resonance to elucidate the unexpected biosynthesis of erythritol by Leuconostoc oenos. Appl Environ Microbiol 58:2271–2279
Yang SW, Park JB, Han NS, Ryu YW, Seo JH (1999) Production of erythrytol from glucose by an osmophilic mutant of Candida magnoliae. Biotechnol Lett 21:887–890